中国实验血液学杂志最新文献

{"title":"[Predictive Value of Peripheral Blood cfDNA Combined with IL-10 in Central Nervous System Infiltration of Diffuse Large B-Cell lymphoma].","authors":"Yuan Zhang, Li-Hua Wang, Yan Guo, Guo-Qing Lyu, Sun Wu, Jing-Hang Zhang","doi":"10.19746/j.cnki.issn.1009-2137.2025.04.020","DOIUrl":"10.19746/j.cnki.issn.1009-2137.2025.04.020","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the predictive value of circulating free DNA (cfDNA) combined with interleukin 10 (IL-10) in predicting central nervous system infiltration (CNSI) in diffuse large B-cell lymphoma (DLBCL).</p><p><strong>Methods: </strong>The clinical data of 63 patients with DLBCL in our hospital from May 2021 to April 2023 were retrospectively analyzed. The 63 patients were divided into CNSI group (15 cases) and non-CNSI group (48 cases) base on whether CNSI occurred. The age, sex, Ann Arbor stage, ECOG score, IPI risk, CNS-IPI risk, number of extranodal sites involved, bone marrow involvement, hypertrophic disease, B symptoms, source cells, glucose quantification, Pandy test, cerebrospinal fluid (CSF) chlorine, CSF nucleated cell count, CSF protein, peripheral blood cfDNA, and IL-10 status were compared between the two groups. The correlation between cfDNA, IL-10 in peripheral blood and CSF protein was analyzed by Pearson correlation analysis. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of peripheral blood cfDNA and IL-10 on secondary CNSI in DLBCL patients. The last follow-up was on November 30, 2023. Kaplan-Meier method was used to calculate the time of secondary CNSI in the non-CNSI group.</p><p><strong>Results: </strong>The IPI risk, CNS-IPI risk, number of extranodal sites involved, and CSF protein in the CNSI group were significantly higher than those in the non-CNSI group (all <i>P</i> <0.05). The levels of cfDNA and IL-10 in peripheral blood of CNSI group were significantly higher than those of non-CNSI group (both <i>P</i> <0.01). cfDNA and IL-10 in peripheral blood were both positively correlated with CSF protein (<i>r</i> =0.402 4, 0.315 1). ROC curve analysis showed that peripheral blood cfDNA and IL-10 had certain predictive value for CNSI, and the area under the curve (AUC) was 0.829 and 0.742, respectively. The AUC of the combined detection was 0.910, with a sensitivity of 80.00% and a specificity of 93.70%. The diagnostic efficacy was significantly higher than that of the two prediction values alone. The median follow-up time was 20 (6-31) months. Non-CNSI patients were grouped based on peripheral blood cfDNA combined with IL-10 positive or negative pairs. The time of secondary CNSI in positive group was significantly shorter than that in negative group (<i>P</i> <0.05).</p><p><strong>Conclusion: </strong>cfDNA and IL-10 in peripheral blood of DLBCL patients with CNSI are significantly increased, and the combined detection of cfDNA and IL-10 has good predictive value for CNSI.</p>","PeriodicalId":35777,"journal":{"name":"中国实验血液学杂志","volume":"33 4","pages":"1063-1068"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expression of CSF-1/CSF-1R in the Peripheral Blood of Children with Immune Thrombocytopenia and Its Clinical Significance].","authors":"Dan-Lu Li, Hai-Chen Song, Yong-Feng Cheng, Mei Yan","doi":"10.19746/j.cnki.issn.1009-2137.2025.04.030","DOIUrl":"10.19746/j.cnki.issn.1009-2137.2025.04.030","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the expression of CSF-1 and CSF-1R in the peripheral blood of children with immune thrombocytopenia (ITP) and its clinical significance.</p><p><strong>Methods: </strong>Forty-four children with ITP treated in our hospital from February 2023 to January 2024 were selected as the observation group, and 40 healthy children were selected as the control group during the same period, and relevant clinical data were collected. Peripheral blood mononuclear cells (PBMC) of children with ITP and healthy children were separated, and the plasma levels of M1 macrophage-associated cytokines (TNF-α, IL-6), M2 macrophage-associated cytokines (IL-10, TGF-β), and CSF-1 were detected by ELISA in the children of both groups. The mRNA levels of M1 macrophage surface markers (CD86, iNOS), M2 macrophage surface markers (CD206, Arg-1) and CSF-1R were detected by RT-PCR in PBMC of children in both groups. Western blot was used to detect the expression of CSF-1R protein in PBMC of the two groups of children. The correlation between platelet count and CSF-1R mRNA expression in PBMC, TNF-α, IL-6, IL-10, TGF-β and CSF-1 in plasma was analyzed.</p><p><strong>Results: </strong>Compared with the control group, the levels of IL-10, TGF-β, CSF-1 and platelet count in plasma of children with ITP were significantly decreased (<i>P</i> < 0.01), and the levels of TNF-α and IL-6 were significantly increased (<i>P</i> < 0.01); the mRNA levels of the M1 macrophage surface markers (CD86, iNOS) in PBMC of children with ITP were significantly increased (<i>P</i> < 0.05), mRNA levels of M2 macrophage surface marker CD206 in PBMC of children with ITP were decreased compared with controls but the difference was not statistically significant ( <i>P</i> >0.05), mRNA levels of Arg-1 were decreased, the difference was statistically significant (<i>P</i> < 0.05). The mRNA and protein levels of CSF-1R in PBMC of ITP children were higher than that in controls. CSF-1R expression in PBMC of ITP was positively correlated with platelet count, IL-10, CSF-1 were positively correlated (<i>r</i> =0.822,0.481,0.405).</p><p><strong>Conclusion: </strong>CSF-1 is significantly reduced in the plasma of ITP, and CSF-1R mRNA and protein expression is significantly elevated in PBMC of ITP, which are involved in the regulation of macrophage M1/M2 imbalance, and could serve as a potential therapeutic target for ITP.</p>","PeriodicalId":35777,"journal":{"name":"中国实验血液学杂志","volume":"33 4","pages":"1131-1137"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of Artificial Intelligence Bone Marrow Cell Recognition and Analysis System in Auxiliary Diagnosis of Hematological Disease].","authors":"Yan Huang, Yun-Ke Wan, Jian-Lan Li","doi":"10.19746/j.cnki.issn.1009-2137.2025.04.041","DOIUrl":"10.19746/j.cnki.issn.1009-2137.2025.04.041","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical application value of artificial intelligence (AI)-based bone marrow cell recognition and analysis system in the diagnosis of hematological diseases.</p><p><strong>Methods: </strong>The bone marrow smears of hematological patients who were admitted to The Second Hospital of Shanxi Medical University from 2018 to 2020 were retrospectively analyzed. A total of 115 bone marrow smears with clear diagnosis and typical cell morphology characteristics were selected, including 20 cases of immune thrombocytopenia(ITP), 11 cases of iron deficiency anemia (IDA), 17 cases of megaloblastic anemia (MA), 20 cases of chronic myeloid leukemia (CML), 17 cases of acute lymphoblastic leukemia (ALL), 23 cases of acute promyelocytic leukemia (APL), and 7 cases of acute myeloid leukemia unclassified (AML-M2). The samples were analyzed by manual microscopic examination, AI automatic recognition, and manual correction after AI recognition.</p><p><strong>Results: </strong>The images captured by the AI device were clear, and the cell morphological structures were distinct. The average experimental diagnostic efficiency parameters of the bone marrow nucleated cells classified in this system were calculated. The sensitivity was 74.90%, specificity was 99.03%, and accuracy was 98.29%. In the comparison between the AI recognition group and the manual examination group, the data of IDA, ITP, MA, and CML diseases were all greater than 0.85 in ICC correlation coefficient, with excellent consistency; the data of APL, AML-M2, and ALL three diseases were between 0.6 and 0.85 in ICC correlation coefficient, with moderate consistency. However, after manual review and correction, the ICC correlation coefficient between the data of the AI correction group and the data from the manual examination group was greatly improved.</p><p><strong>Conclusion: </strong>The AI bone marrow cell recognition and analysis system has the characteristics of high accuracy, high specificity, good sensitivity and fast detection. When used in combination with manual review, it can improve the detection efficiency of bone marrow cells morphological analysis and meet the needs of clinical work.</p>","PeriodicalId":35777,"journal":{"name":"中国实验血液学杂志","volume":"33 4","pages":"1203-1208"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Juglone on Proliferation Inhibition and RIPK1/RIPK3/MLKL Expression in Acute Myeloid Leukemia Cells].","authors":"Chun-Yi Lyu, Xue-Wei Yin, Zong-Hong Li, Chen Han, Yan Wang, Zhen-Zhen Wang, Lyu-Ye Liu, Rui-Rong Xu","doi":"10.19746/j.cnki.issn.1009-2137.2025.04.008","DOIUrl":"10.19746/j.cnki.issn.1009-2137.2025.04.008","url":null,"abstract":"<p><strong>Objective: </strong>To study the effects and mechanisms of juglone on the proliferation and apoptosis of acute myeloid leukemia (AML) cells.</p><p><strong>Methods: </strong>Juglone and AML targets were collected from public databases, and the intersecting target clusters were taken for functional enrichment analysis to explore the potential mechanism of juglone in the treatment of AML. Then wet experiments were performed to verify. AML cell lines including KG-1a, MV-411, THP-1 and MOLM-13 were treated with different concentrations of juglone for 24 h. MTT assay was used to detect cell viability and determine the IC₅₀, and the most sensitive cell line was screened for subsequent experiments. Flow cytometry was used to detect the apoptosis of cells treated with different concentrations of juglone. Western blot was performed to check the expression of relevant proteins.</p><p><strong>Results: </strong>Eleven targets were obtained as potential targets for juglone in the treatment of AML, and the top ten significantly enriched pathways were intrinsic pathway of apoptosis, programmed cell death, cytochrome c-mediated apoptotic response, apoptosis, apoptotic factor-mediated response, regulated necrosis, cytokine signaling in immune system, signaling by interleukins, oncogene induced senescence, and signal transduction. The cell viability of KG-1a, MV-411, THP-1 and MOLM-13 was decreased with increasing juglone concentration after 24 h of juglone treatment (<i>r</i> =-0.992, -0.886, -0.956, -0.910). Among them, MOLM-13 was the most sensitive to juglone. The results of flow cytometry showed that the apoptosis rate of MOLM-13 tended to significantly increase with the increasing concentration of juglone (<i>r</i> =0.99). At the same time point, p-RIPK1/RIPK1, p-RIPK3/RIPK3, and p-MLKL/MLK were decreased in each juglone concentration group compared with control group.</p><p><strong>Conclusion: </strong>Juglone inhibits the viability of KG-1a, MV-411, THP-1 and MOLM-13 cells, and induces apoptosis of MOLM-13 cells, the mechanism of which may be related to the inhibition of RIPK1/RIPK3/MLKL signaling pathway.</p>","PeriodicalId":35777,"journal":{"name":"中国实验血液学杂志","volume":"33 4","pages":"980-985"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research Progress of Flow Cytometry in Diagnosis and Treatment of Myelodysplastic Syndrome--Review].","authors":"Qiu-Cheng Zhang, Bao-An Chen, Jian Cheng","doi":"10.19746/j.cnki.issn.1009-2137.2025.04.044","DOIUrl":"10.19746/j.cnki.issn.1009-2137.2025.04.044","url":null,"abstract":"<p><p>Flow cytometry (FCM), as an important method for the diagnosis of acute myeloid leukemia (AML), has been widely used in myelodysplastic syndrome (MDS) in recent years. FCM can effectively identify and characterize abnormal hematopoietic cells through immunophenotyping, particularly in the diagnosis of MDS with insignificant morphological abnormalities. Additionally, FCM can monitor disease progression and minimal residual disease (MRD) by detecting phenotypic changes and evaluate treatment efficacy. This article reviews the latest research progress of FCM in the immunophenotyping, prognosis and efficacy evaluation of MDS.</p>","PeriodicalId":35777,"journal":{"name":"中国实验血液学杂志","volume":"33 4","pages":"1222-1227"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Case Analysis of <i>MYH9</i> Related Disease with Non-Hodgkin Lymphoma Caused by Rare Mutations].","authors":"Xue-Ting Kong, Dan-Yu Wang, Ze-Lin Liu, Zhao-Gui Zhou, Nan Zhong, Lei Liu, Meng-Di Jin, Hai-Yan Cui","doi":"10.19746/j.cnki.issn.1009-2137.2025.04.032","DOIUrl":"10.19746/j.cnki.issn.1009-2137.2025.04.032","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the <i>MYH9</i> gene sequence of a patient with hereditary thrombocytopenia and diffuse large B-cell lymphoma and his family members, and to explore the relationship between <i>MYH9</i> gene and tumors.</p><p><strong>Methods: </strong>Peripheral blood samples were collected from the patients and their family members for complete blood count analysis. The platelet morphology was observed under microscope. The <i>MYH9</i> gene sequence was analyzed by Whole Exon Sequencing and Sanger Sequencing.</p><p><strong>Results: </strong>The mutation site c.279C>A:p.(Asn93Lys) in exon 2 of the <i>MYH9</i> gene were found in patient and his family members, both presenting as thrombocytopenia. The platelet count was significantly increased after the administration of Avatrombopag.</p><p><strong>Conclusion: </strong>A novel mutation of <i>MYH9</i> was found in this study, and the case was sensitive to Avatrombopag, by exploring the relationship between the <i>MYH9</i> gene and tumors, suggesting that the <i>MYH9</i> gene may be associated with the development of diffuse large B-cell lymphoma.</p>","PeriodicalId":35777,"journal":{"name":"中国实验血液学杂志","volume":"33 4","pages":"1145-1149"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of Third-Generation Sequencing Technology in <i>RHD</i> Genotyping of a Chinese Pedigree with Weak D Phenotype].","authors":"Ling Ma, Tai-Xiang Liu, Li-Li Shi, Chen-Chen Feng, Ruo-Yang Zhang, Fang Zhao","doi":"10.19746/j.cnki.issn.1009-2137.2025.04.040","DOIUrl":"10.19746/j.cnki.issn.1009-2137.2025.04.040","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the molecular mechanism of weak D phenotype in a Chinese family.</p><p><strong>Methods: </strong>Routine Rh typing tests were performed first, and <i>RHD</i> exons 1-10 of the proband and his family members were sequenced by first-generation sequencing. <i>RHD</i> zygosity was also determined. Third-generation sequencing was used to analyze the haplotypes of the <i>RHD</i> gene.</p><p><strong>Results: </strong>The proband showed a weak D serological phenotype. First-generation sequencing revealed a c.787G>A point mutation in exon 5. The family pedigree investigation showed that the proband and his younger sister had the same serological phenotype and molecular mechanism. His father carried this gene mutation, while his mother and younger brother were normal. Hybrid box was not detected, suggesting that all the family members did not have a haplotype with a complete deletion of the <i>RHD</i> gene. The results of third-generation sequencing showed that the proband and his sister inherited the weak D allele from their father and the non-functional allele <i>RHD -CE(3-9)-D</i> from their mother, respectively.</p><p><strong>Conclusion: </strong>Third-generation sequencing technology enables haplotype analysis of the <i>RHD</i> gene and can detect complex genotypes such as genetic exchanges between <i>RHD</i> and <i>RHCE</i> combined with other mutations.</p>","PeriodicalId":35777,"journal":{"name":"中国实验血液学杂志","volume":"33 4","pages":"1199-1202"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Efficacy Analysis of Stanozolol Combined with Avatrombopag in the Treatment of Chemotherapy-Induced Thrombocytopenia in Relapsed/Refractory Tumors].","authors":"Yan He, Wei-Yi Liu, Yan-Yu Zhang, Yan Lyu, Shan-Shan Zhang, Ri-Cheng Quan","doi":"10.19746/j.cnki.issn.1009-2137.2025.04.029","DOIUrl":"10.19746/j.cnki.issn.1009-2137.2025.04.029","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the efficacy and safety of stanozolol combined with avatrombopag in the treatment of chemotherapy-induced thrombocytopenia (CIT) in patients with relapsed/refractory tumors.</p><p><strong>Methods: </strong>Twenty-five patients with relapsed/refractory CIT admitted to the Hematology Department of Xiyuan Hospital, China Academy of Chinese Medical Sciences between March 2023 to December 2023 were enrolled. These patients received a combined therapy of stanozolol and avatrombopag. The clinical efficacy, onset time, changes in platelet levels and blood cell counts before and after treatment, and adverse reactions of patients were evaluated.</p><p><strong>Results: </strong>The combination therapy demonstrated remarkable efficacy with a total effective rate of 100%. Among the 25 patients, 19 achieved complete remission and 6 achieved partial remission. The median onset time was 42.5（range: 35-48）days. The average platelet count of the 25 patients increased from (25.73±17.75)×10⁹/L before treatment to (146.4±49.59)×10⁹/L after 3 months of treatment, with a statistically significant difference ( <i>P</i> < 0.05). 18 patients who previously required platelet transfusion were all weaned off platelet transfusion after 3 months of treatment, with a median time to be free from platelet transfusion was 26 (range: 18-51) days. During the treatment, both neutrophils and hemoglobin exhibited various degrees of elevation. Two patients experienced a slight increase in alanine aminotransferase(ALT) levels, which normalized after treatment with oral hepatoprotective drug. One patient had a PLT increase exceeding 350×10⁹/L, and the treatment with avatrombopag was suspended, and aspirin and other drugs were given to prevent thrombosis. No thrombose events or CIT-related bleeding events were observed in all patients.</p><p><strong>Conclusion: </strong>The combination therapy of stanozolol and avatrombopag is significantly effective for treating relapsed/refractory CIT patients, with a high response rate and good safety, making it a suitable clinical treatment option.</p>","PeriodicalId":35777,"journal":{"name":"中国实验血液学杂志","volume":"33 4","pages":"1127-1130"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research Progress of Artemisinin and Its Derivatives Based on Ferroptosis in Lymphatic System Malignancies--Review].","authors":"Yu-Xin Wei, Yi-Fan Yang, Jiong-Ping Han, Wei-Ying Feng","doi":"10.19746/j.cnki.issn.1009-2137.2025.04.047","DOIUrl":"10.19746/j.cnki.issn.1009-2137.2025.04.047","url":null,"abstract":"<p><p>Ferroptosis, an iron-dependent form of regulated cell death, is mechanistically characterized by disrupted iron homeostasis, lipid peroxidation, and compromised antioxidant defense systems. Recent studies have demonstrated that artemisinin and its derivatives, such as dihydroartemisinin and artesunate, exhibit therapeutic potential against lymphatic system malignancies through ferroptosis induction. These compounds exert their antitumor effects by modulating critical regulatory proteins including SLC7A11, GPX4, and STAT3, as well as activating pivotal signaling pathways such as ATF4-CHOP and SREBP2-IPP-GPX4 axes. Notably, synergistic therapeutic effects have been observed when artemisinin derivatives are combined with conventional chemotherapeutic agents or targeted therapies, demonstrating enhanced tumor-suppressive activity and circumvention of drug resistance mechanisms. This review systematically summarizes recent advancements in understanding the ferroptosis-mediated antitumor mechanisms of artemisinin compounds in lymphoid malignancies, with particular emphasis on their molecular targets and clinical translational potential.</p>","PeriodicalId":35777,"journal":{"name":"中国实验血液学杂志","volume":"33 4","pages":"1237-1240"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of Allogeneic Hematopoietic Stem Cell Transplantation in Elderly Patients with Acute Myeloid Leukemia--Review].","authors":"Xu-Er Bi, Pei-Pei Ye","doi":"10.19746/j.cnki.issn.1009-2137.2025.04.045","DOIUrl":"10.19746/j.cnki.issn.1009-2137.2025.04.045","url":null,"abstract":"<p><p>The development of medical technology and the extension of lifespan have promoted population aging, and malignant blood diseases are gradually becoming common in the elderly. Among them, the most common is acute myeloid leukemia (AML), with a median age at diagnosis of 68 years old. Due to poor clinical conditions, severe comorbidities, poor tolerance to intensive therapy, as well as unfavorable or complex cytogenetics and multidrug resistance, elderly AML patients have a poorer prognosis and increased risks of treatment-related toxicity and mortality. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the optimal treatment strategies for elderly AML patients. With improvements in reduced-intensity conditioning (RIC), the expansion of donor selection, the optimization of graft-versus-host disease (GVHD) prevention regimen, and the progress of supportive care, more elderly AML patients have been choosing allo-HSCT. This article reviews the recent applications of allo-HSCT in elderly AML patients.</p>","PeriodicalId":35777,"journal":{"name":"中国实验血液学杂志","volume":"33 4","pages":"1228-1232"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}