Archive of Oncology最新文献

{"title":"Sanatoria in the first half of the XX century in the Province of Vojvodina","authors":"D. Dobanovacki, M. Breberina, B. Vujošević, M. Pećanac, Nenad Zakula, Velimir Trajkovic","doi":"10.2298/AOO1301034D","DOIUrl":"https://doi.org/10.2298/AOO1301034D","url":null,"abstract":"Following the shift in therapy of tuberculosis in the mid-19th century, by the beginning of the 20th century numerous tuberculosis sanatoria were established in Western Europe. Being an institutional novelty in the medical practice, sanatoria spread within the first 20 years of the 20th century to Central and Eastern Europe, including the southern region of the Panonian plain, the present-day Province of Vojvodina in Serbia north of the rivers Sava and Danube. The health policy and regulations of the newly built state - the Kingdom of Serbs, Croats and Slovenians/Yugoslavia, provided a rather liberal framework for introducing the concept of sanatorium. Soon after the World War I there were 14 sanatoria in this region, and the period of their expansion was between 1920 and 1939 when at least 27 sanatoria were founded, more than half of the total number of 46 sanatoria in the whole state in that period. However, only two of these were for pulmonary diseases. One of them was privately owned the open public sanatorium the English-Yugoslav Hospital for Paediatric Osteo-Articular Tuberculosis in Sremska Kamenica, and the other was state-run (at Iriski venac, on the Fruska Gora mountain, as a unit of the Department for Lung Disease of the Main Regional Hospital). All the others were actually small private specialized hospitals in 6 towns (Novi Sad, Subotica, Sombor, Vrbas, Vrsac, Pancevo,) providing medical treatment of well-off, mostly gynaecological and surgical patients. The majority of sanatoria founded in the period 1920-1939 were in or close to the city of Novi Sad, the administrative headquarters of the province (the Danube Banovina at that time) with a growing population. A total of 10 sanatoria were open in the city of Novi Sad, with cumulative bed capacity varying from 60 to 130. None of these worked in newly built buildings, but in private houses adapted for medical purpose in accordance with legal requirements. The decline of sanatoria in Vojvodina began with the very outbreak of the World War II and they never regained their social role. Soon after the Hungarian fascist occupation the majority of owners/ founders were terrorized and forced to close their sanatoria, some of them to leave country and some were even killed or deported to concentration camps.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2298/AOO1301034D","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68401847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infantile hepatic hemangioendothelioma: Report of two cases","authors":"D. Dobanovacki, N. Vuckovic, S. Marinković, J. Kolarovic, Svetlana Stefanovic-Saravolac","doi":"10.2298/AOO1302072D","DOIUrl":"https://doi.org/10.2298/AOO1302072D","url":null,"abstract":"We described two cases of infantile hepatic hemangioendothelioma: one with a solitary lesion and the other with multicentric lesions. Clinical presentation was with no liver symptoms in case 1, and hepatomegaly, failure to thrive, and palpable abdominal mass in case 2. Diagnostic imaging revealed single tumor formation in case 1 and multiple nodules in the liver in case 2. Dilemmas related to nature of the tumor were solved by microscopic analysis. The patient with the clinical appearance of a single lesion was successfully operated. The patient with multiple lesions in the liver tissue showed complete involution after corticotherapy.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2298/AOO1302072D","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68401990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of an up-to-date evidence based diet planning for colorectal cancer patients","authors":"I. Banjari, Josipa Fako","doi":"10.2298/AOO1304160B","DOIUrl":"https://doi.org/10.2298/AOO1304160B","url":null,"abstract":"","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Misinterpretation of calcified oligoastrocytoma on magnetic resonance imaging","authors":"D. Kozic, Aleksandar Ragaji, R. Semnic","doi":"10.2298/AOO1301023K","DOIUrl":"https://doi.org/10.2298/AOO1301023K","url":null,"abstract":"© 2013, Oncology Institute of Vojvodina, Sremska Kamenica Magnetic resonance imaging (MRI) of the brain revealed the presence of abnormal heterogeneous lesion in the left frontal lobe in a 59-year-old woman after the first grand mal seizure attack. The lesion showed the presence of central hypointense area surrounded with perifocal edema with no significant mass effect (Figure 1A). Several foci of increased T1 signal were noted within the lesion (Figure 1B). The signal abnormality was interpreted as hemorrhagic brain infarct. However, computed tomography (CT) of the brain detected the presence of calcified mass (Figure 2). Surgical removal of the tumor was performed. The histological diagnosis was grade 3 oligoastrocytoma. Since MRI is a method of choice for establishing the correct diagnosis in a great majority of neurologic disorders, especially in detection the causes of seizures, CT is becoming more frequently excluded from obligate spectrum of diagnostic protocol (1). However not only small calcifications, but even huge calcified tumors could be misinterpreted.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2298/AOO1301023K","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68401774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enterprise of fasting and vocation of a physician","authors":"Ilija Kajtez","doi":"10.2298/AOO1301044K","DOIUrl":"https://doi.org/10.2298/AOO1301044K","url":null,"abstract":"In this paper, the author considers the enterprise of fasting, in which the man faces the important issues of his existence, the purpose and worldly life. The author is aware that all social, philosophical and theological phenomena are very complex, profound and obscure and quotes the French philosopher and scientist Pascal, who claimed: “We do not possess enough knowledge to…understand the life of human body…While in nature everything is closely intertwined … No part can be recognized unless we have studied the unit. The life of each body will be understood only when we learn all that it needs; and in order to achieve this, it is necessary to study the universe. But the universe is infinite and it is beyond the human ability to grasp it…”It is clear from this quotation that we are facing many complex issues whenever we try to reveal one of the secrets of Christian life - the secret of fasting. The second part of the essay has to do with people and the time we live in, the relations between believing doctors and their profession and whether and to what extent a believing doctor who observes fasts is closer to the Truth and Goodness that the one who does not believe. The author argues that the doctor who is a believer and who observes a fast seeing it as the time when values of human life should be put to test and the meaning of medical profession reconsidered is closer to the truth of Existence and love of the world. There is no duty that is more important for a modern, egotistic, materialistic man than resuming fasts. A fast as a profound rethinking of the whole of a human being, as a human effort, as Solzhenitsyn would say, to self-restriction, abstinence, nurturing of his own freedom.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2298/AOO1301044K","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68401905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papillary thyroid cancer found in struma ovarii: A case report","authors":"I. Majdevac, D. Lukić, M. Ranisavljevic","doi":"10.2298/AOO1304141M","DOIUrl":"https://doi.org/10.2298/AOO1304141M","url":null,"abstract":"Struma ovarii is composed of thyroid tissue originated from germ cells in a mature teratoma. Thyroid carcinoma found in struma ovarii is very rare. Primary thyroid carcinoma should be excluded. We present a 62-year-old female with papillary thyroid carcinoma in a mature teratoma as a incidentally found diagnosis. The patient underwent the surgery because of the endometrial carcinoma, while the histopathological examination found endometrial carcinoma as well as malignant struma ovarii. From the surgical point of view, it is very important to evaluate thyroid gland status in patients with malignant struma ovarii.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic DNA changes and stem cells therapy","authors":"M. Stupar, V. Vidović, V. Baltic, Ljuba Štrbac, D. Lukač","doi":"10.2298/AOO1301024S","DOIUrl":"https://doi.org/10.2298/AOO1301024S","url":null,"abstract":"We are starting to understand the fundamental biological processes which underlie the DNA physical properties. Of particular importance is the field of epigenetics, which literally means 'outside conventional genetics', now used to describe the study of stable alterations in gene expression potential that arise during development and cell proliferation. Epigenetic changes are modifications of DNA, which occur without any alteration in the DNA sequence. Modern directions in the field of epigenetic research aimed to decipher the epigenetic signals that give stem cells their unique ability to self-renew and differentiate into different types. Stem cell-based regenerative medicine holds great promise for repair of diseased tissue. If epigenetic process are reversible, than there is the ability to cure cancer through stem cell therapy.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2298/AOO1301024S","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68401790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial flora on the surface of oral squamous cell carcinoma","authors":"M. Čanković, M. Bokor-Bratić, J. Loncar, Jovan Marinoski, M. Ilić","doi":"10.2298/AOO1302062C","DOIUrl":"https://doi.org/10.2298/AOO1302062C","url":null,"abstract":"4 patients (13.3%), mucocele in 4 patients (13.3%), capillary mucous haemangioma in 3 patients (10.0%), mucosal polyp in 3 patients (10.0%), chronic nonspecific sialadenitis in 3 patients (10.0%), mucosal papilloma in 2 patients (6.7%), retention cyst in 2 patients (6.7%), and subacute nonspecific inflammation in 1 patient (3.3%).","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2298/AOO1302062C","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68401933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of neoadjuvant chemotherapy on wound complications after breast surgery","authors":"M. Ranisavljevic, V. Selaković, D. Lukić, Z. Radovanovic, F. Vicko","doi":"10.2298/aoo1304105r","DOIUrl":"https://doi.org/10.2298/aoo1304105r","url":null,"abstract":"","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic value of MMP-9 expression in lung adenocarcinoma","authors":"Ljiljana Tadić-Latinović, Aleksandra Salapura-Dugonjic, Ž. Eri, S. Knežević-Ušaj, Milana Panjković, L. Amidžić, I. Baroš, B. Jakovljević","doi":"10.2298/AOO1304109T","DOIUrl":"https://doi.org/10.2298/AOO1304109T","url":null,"abstract":"www.onk.ns.ac.rs/Archive Vol 21, No. 3-4, December 2013 INTRODUCTION Lung cancer is one of the leading causes of death throughout the world. Approximately one million people, 850,000 men and 330,000 women, die of lung cancer per year (1). Despite some advances in the diagnosis and treatment of lung cancer in the last several decades, the prognosis of lung cancer remains poor. The overall 5-year survival rate of lung cancer is approximately 12.4% of all newly detected cases in the world, and <9% in developing countries (2, 3). The MMP family comprises 23 human enzymes that traditionally have long been associated with cancer invasion and metastasis because of their ability to degrade the extracellular matrix. However, recent studies have showed that the roles of MMPs in tumour development and metastasis are much more complex than was originally envisioned. In vitro and animal studies have demonstrated that MMPs are also the key mediators of growth factor activation, bioavailability and receptor signalling, cell adhesion and motility, apoptosis and survival mechanisms, angiogenesis, and inflammatory responses and immune surveillance (4). Matrix metalloproteinases (MMP) are the group of enzymes responsible for degradation of certain extracellular matrix proteins such as collagen, proteoglycan, elastin, laminin and fibronectin. Malignant diseases are accompanied with higher expression of matrix metalloproteinases and lower concentrations of the tissue inhibitors of matrix metalloproteinases (TIMP), also resulting in an increased proteolytic activity. The presence of matrix metalloproteinases was discovered on the surface of invasive tumor cells (5). Degradation of the basal membrane and extracellular matrix presents the key step in the process of intravasation and extravasation of tumor cells (6). MMP-9 belongs to the gelatinases group, synthesized by keratinocytes, monocytes, alveolar macrophages, polymorphonuclear neutrophil granulocytes, and in many cancer cells. Tumor invasion is a multi-phase process in which the cell motility is associated with controlled proteolysis and includes interaction between tumor cells and extracellular matrix. During the invasion process, malignant tumor cells are detached from the primary tumor, migrate through structural barriers such as the basal membrane and surrounding extracellular matrix rich in collagen. Degradation of the stromal extracellular matrix is also considered one of the key steps in the process of tumor angiogenesis (7). It has been proved that the activity of matrix metalloproteinases is necessary for increased motility of epithelial cells, as well as for the growth of metastatic deposits. Research has confirmed that MMP-2 and MMP-9 have an exceptionally significant role in metastasizing, due to their ability to degrade type IV The prognostic value of mmp-9 expression in lung adenocarcinoma","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}