Critical Reviews in Oncogenesis最新文献_第4页

Proton Beam Therapy for Breast Cancer. 质子束疗法治疗乳腺癌。

Critical Reviews in Oncogenesis Pub Date : 2024-01-01 DOI: 10.1615/CritRevOncog.2023050319

Seraphina Choi, Isabella Dreyfuss, Crystal Seldon Taswell, Jonathan Cyriac, Michael Butkus, Cristiane Takita

引用次数: 0

Immune Evasion in Cancer Is Regulated by Tumor-Asociated Macrophages (TAMs): Targeting TAMs. 癌症中的免疫逃避受肿瘤相关巨噬细胞（TAMs）调控：靶向 TAMs。

Critical Reviews in Oncogenesis Pub Date : 2024-01-01 DOI: 10.1615/CritRevOncog.2024053096

Megan Jung, Benjamin Bonavida

{"title":"Immune Evasion in Cancer Is Regulated by Tumor-Asociated Macrophages (TAMs): Targeting TAMs.","authors":"Megan Jung, Benjamin Bonavida","doi":"10.1615/CritRevOncog.2024053096","DOIUrl":"10.1615/CritRevOncog.2024053096","url":null,"abstract":"Recent advancements in cancer treatment have explored a variety of approaches to address the needs of patients. Recently, immunotherapy has evolved as an efficacious treatment for various cancers resistant to conventional therapies. Hence, significant milestones in immunotherapy were achieved clinically in a large subset of cancer patients. Unfortunately, some cancer types do not respond to treatment, and among the responsive cancers, some patients remain unresponsive to treatment. Consequently, there is a critical need to examine the mechanisms of immune resistance and devise strategies to target immune suppressor cells or factors, thereby allowing for tumor sensitivity to immune cytotoxic cells. M2 macrophages, also known as tumor-associated macrophages (TAMs), are of interest due to their role in suppressing the immune system and influencing antitumor immune responses through modulating T cell activity and immune checkpoint expression. TAMs are associated with signaling pathways that modulate the tumor microenvironment (TME), contributing to immune evasion. One approach targets TAMs, focusing on preventing the polarization of M1 macrophages into the protumoral M2 phenotype. Other strategies focus on direct or indirect targeting of M2 macrophages through understanding the interaction of TAMs with immune factors or signaling pathways. Clinically, biomarkers associated with TAMs' immune resistance in cancer patients have been identified, opening avenues for intervention using pharmacological agents or immunotherapeutic approaches. Ultimately, these multifaceted approaches are promising in overcoming immune resistance and improving cancer treatment outcomes.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":"29 4","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Particulate Matter and Its Impact on Macrophages: Unraveling the Cellular Response for Environmental Health. 颗粒物质及其对巨噬细胞的影响：揭示细胞对环境健康的反应。

Critical Reviews in Oncogenesis Pub Date : 2024-01-01 DOI: 10.1615/CritRevOncog.2024053305

Nyayapathi Priyanka Priyadarshini, Daka Gopamma, Namuduri Srinivas, Rama Rao Malla, Kolli Suresh Kumar

{"title":"Particulate Matter and Its Impact on Macrophages: Unraveling the Cellular Response for Environmental Health.","authors":"Nyayapathi Priyanka Priyadarshini, Daka Gopamma, Namuduri Srinivas, Rama Rao Malla, Kolli Suresh Kumar","doi":"10.1615/CritRevOncog.2024053305","DOIUrl":"10.1615/CritRevOncog.2024053305","url":null,"abstract":"Particulate matter (PM) imposes a significant impact to environmental health with deleterious effects on the human pulmonary and cardiovascular systems. Macrophages (Mφ), key immune cells in lung tissues, have a prominent role in responding to inhaled cells, accommodating inflammation, and influencing tissue repair processes. Elucidating the critical cellular responses of Mφ to PM exposure is essential to understand the mechanisms underlying PM-induced health effects. The present review aims to give a glimpse on literature about the PM interaction with Mφ, triggering the cellular events causing the inflammation, oxidative stress (OS) and tissue damage. The present paper reviews the different pathways involved in Mφ activation upon PM exposure, including phagocytosis, intracellular signaling cascades, and the release of pro-inflammatory mediators. Potential therapeutic strategies targeting Mφ-mediated responses to reduce PM-induced health effects are also discussed. Overall, unraveling the complex interplay between PM and Mφ sheds light on new avenues for environmental health research and promises to develop targeted interventions to reduce the burden of PM-related diseases on global health.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":"29 4","pages":"33-42"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine Evaluation of Catchment Area Relevance through Text Mining. 通过文本挖掘对集水区相关性进行机器评估。

Critical Reviews in Oncogenesis Pub Date : 2024-01-01 DOI: 10.1615/CritRevOncog.2023049949

Philip A Arlen, Joseph Chakko, Geoffrey DeGennaro, Erin Kobetz, Brandon Mahal

引用次数: 0

Role of the Tumor Microenvironment in Mediating Resistance to Anti-HER2 Antibodies. 肿瘤微环境在调节抗 HER2 抗体耐药性中的作用

Critical Reviews in Oncogenesis Pub Date : 2024-01-01 DOI: 10.1615/CritRevOncog.2024053419

Manoj Kumar Gupta, Gayatri Gouda, Ramakrishna Vadde

{"title":"Role of the Tumor Microenvironment in Mediating Resistance to Anti-HER2 Antibodies.","authors":"Manoj Kumar Gupta, Gayatri Gouda, Ramakrishna Vadde","doi":"10.1615/CritRevOncog.2024053419","DOIUrl":"10.1615/CritRevOncog.2024053419","url":null,"abstract":"Breast cancer (BC) is the most common cancer and the second leading cause of cancer-related deaths in women globally. Despite advancements in treatment strategies, many patients still develop challenging-to-treat metastatic disease. The development and progression of tumors are influenced by genetic/epigenetic changes within tumor cells and alterations in the tumor microenvironment (TME) through a dynamic communication. The TME comprises various elements, including immune, tumor, and stromal cells. Tumor cells at the core of the TME orchestrate complex signals that lead to tumor growth, survival, and resistance to treatment. Human epidermal growth factor receptor 2 (HER2) is overexpressed in a significant proportion of invasive breast cancers, influencing prognosis and prediction. Novel therapeutic approaches target HER2-positive breast cancers by leveraging HER2-targeted therapeuirtcs such as antibody-drug conjugates, monoclonal antibodies, and tyrosine kinase inhibitors. The TME in HER2-positive breast cancers also involves cancer-associated fibroblasts and cancer-associated adipocytes, which play critical roles in tumor progression and therapy resistance. The immune microenvironment also plays a significant role, with studies indicating its impact on outcomes in HER2-positive breast cancer. Trastuzumab, one of the first monoclonal antibodies targeting HER2, has shown promise in enhancing survival rates in HER2-overexpressing breast cancer. Integration of trastuzumab with chemotherapy has demonstrated significant enhancements in disease-free survival as well as overall survival rates during early breast cancer treatment. Trastuzumab functions by inhibiting HER2 signaling pathways, leading to cell cycle arrest and induction of apoptosis. Overall, understanding the complex interplay between HER2, the tumor microenvironment, and therapeutic interventions is essential for improving outcomes in HER2-positive BC.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":"29 4","pages":"43-54"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Genetic Paradigm of Hereditary Breast and Ovarian Cancer (HBOC) in the Afro-Caribbean Population. 非洲-加勒比人口中遗传性乳腺癌和卵巢癌 (HBOC) 的基因范例。

Critical Reviews in Oncogenesis Pub Date : 2024-01-01 DOI: 10.1615/CritRevOncog.2024051599

Danielle Cerbon, Daphanie Taylor, Priscila Barreto-Coelho, Estelamari Rodriguez, Matthew Schlumbrecht, Judith Hurley, Sophia H L George

{"title":"The Genetic Paradigm of Hereditary Breast and Ovarian Cancer (HBOC) in the Afro-Caribbean Population.","authors":"Danielle Cerbon, Daphanie Taylor, Priscila Barreto-Coelho, Estelamari Rodriguez, Matthew Schlumbrecht, Judith Hurley, Sophia H L George","doi":"10.1615/CritRevOncog.2024051599","DOIUrl":"10.1615/CritRevOncog.2024051599","url":null,"abstract":"Differences in tumor biology and genetic predisposition have been suggested as factors influencing overall survival and increased mortality in Black breast and ovarian cancer patients. Therefore, it is key to evaluate genetic susceptibilities in Afro-Caribbean patients because the black population in the US is not homogeneous. Identifying a high incidence of hereditary breast and ovarian cancer (HBOC) in Afro-Caribbean countries can lead to understanding the pattern of inherited traits in US-Caribbean immigrants and their subsequent generations. The paucity of projects studying the genetic landscape in these populations makes it difficult to design studies aimed at optimizing screening and prophylaxis strategies, which in turn, improve survival and mortality rates. This scoping review identifies and categorizes current research on the genetic paradigm of HBOC in the Afro-Caribbean population. We performed an evaluation of the evidence and generated a summary of findings according to preferred reporting items for systematic review and meta-analysis (PRISMA) Extension for Scoping Reviews guidelines. We included articles that assessed the incidence and prevalence of pathologic germline mutations and experience/barriers for genetic testing in Afro-Caribbean Countries and US-Caribbean patients. Our results highlight countries where genetic landscapes remain severely understudied and support recommending multigene testing in Caribbean-born patients. They highlight a need for further research on the genetic paradigm of HBOC in the Afro-Caribbean population to improve genetic testing/counseling and the subsequent adoption of early detection and risk reduction strategies.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":"29 3","pages":"99-112"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Loving Memory of Dr. Rana Lynn Samuels-Ofran and Dr. Beth Sharon Samuels. 深切悼念 Rana Lynn Samuels-Ofran 博士和 Beth Sharon Samuels 博士。

Critical Reviews in Oncogenesis Pub Date : 2024-01-01 DOI: 10.1615/CritRevOncog.v29.i3.90

Benjamin Bonavida, Ofra Bonavida

引用次数: 0

Targeting the Depletion of M2 Macrophages: Implication in Cancer Immunotherapy. 靶向消耗 M2 巨噬细胞：癌症免疫疗法的意义

Critical Reviews in Oncogenesis Pub Date : 2024-01-01 DOI: 10.1615/CritRevOncog.2024053580

Talia Festekdjian, Benjamin Bonavida

{"title":"Targeting the Depletion of M2 Macrophages: Implication in Cancer Immunotherapy.","authors":"Talia Festekdjian, Benjamin Bonavida","doi":"10.1615/CritRevOncog.2024053580","DOIUrl":"10.1615/CritRevOncog.2024053580","url":null,"abstract":"We have witnessed the emergence of immunotherapy against various cancers that resulted in significant clinical responses and particularly in cancers that were resistant to chemotherapy. These milestones have ignited the development of novel strategies to boost the anti-tumor immune response for immune-suppressed tumors in the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are the most abundant cells in the TME, and their frequency correlates with poor prognosis. Hence, several approaches have been developed to target TAMs in effort to restore the anti-tumor immune response and inhibit tumor growth and metastasis. One approach discussed herein is targeting TAMs via their depletion. Several methods have been reported for TAMs depletion including micro-RNAs, transcription factors (e.g., PPARγ, KLF4, STAT3, STAT6, NF-κB), chemokines and chemokine receptors, antibodies-mediated blocking the CSF-1/CSF-1R pathway, nanotechnology, and various combination treatments. In addition, various clinical trials are currently examining the targeting of TAMs. Many of these methods also have side effects that need to be monitored and reduced. Future perspectives and directions are discussed.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":"29 4","pages":"55-73"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Papilloma Virus-Associated Oral Pharyngeal Squamous Cell Carcinoma: Prevalence, Prevention, and Awareness of Vaccination in the Indian Population. 人类乳头状瘤病毒相关口腔咽鳞状细胞癌：印度人群的患病率、预防和疫苗接种意识。

Critical Reviews in Oncogenesis Pub Date : 2023-01-01 DOI: 10.1615/CritRevOncog.2023048944

Vigi Chaudhary, Naveen Chaudhary, Smitha Mathews, Ragini D Singh

{"title":"Human Papilloma Virus-Associated Oral Pharyngeal Squamous Cell Carcinoma: Prevalence, Prevention, and Awareness of Vaccination in the Indian Population.","authors":"Vigi Chaudhary, Naveen Chaudhary, Smitha Mathews, Ragini D Singh","doi":"10.1615/CritRevOncog.2023048944","DOIUrl":"10.1615/CritRevOncog.2023048944","url":null,"abstract":"Human papilloma virus (HPV), one of the most common sexually transmitted infections, plays a pivotal role in head and neck cancer, primarily oral and oropharyngeal squamous cell carcinomas. HPV is a vaccine-preventable disease that also contributes to cervical cancer. Although HPV vaccination effectively protects the individual against all HPV-associated human carcinomas, the awareness of HPV vaccination and its acceptance is poor in developing nations like India. India has a very high burden of oral cancer, and, unfortunately, the morbidity and mortality rates are also high as the cancer is often detected at an advanced stage. In this review, we explore the prevalence of HPV-associated head and neck squamous cell carcinoma among the Indian population and the awareness of HPV vaccination among Indian youth. Since the prognosis for HPV-associated head and neck squamous cell carcinoma is good, early diagnosis of the cancer is crucial in improving the outcome of the treatment modalities. Efforts are needed to create and increase awareness of HPV vaccination. Routine screening for HPV infection in oral mucosa can prevent the silent epidemic from taking the lives of many young people.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":"28 2","pages":"63-72"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41214814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyper-Aggressiveness of Bystander Cells in an Anti-Tumor Photodynamic Therapy Model: Role of Nitric Oxide Produced by Targeted Cells. 抗肿瘤光动力治疗模型中旁观者细胞的超侵袭性：靶向细胞产生的一氧化氮的作用。

Critical Reviews in Oncogenesis Pub Date : 2023-01-01 DOI: 10.1615/CritRevOncog.2022040016

Jerzy Bazak, Witold Korytowski, Albert W Girotti

{"title":"Hyper-Aggressiveness of Bystander Cells in an Anti-Tumor Photodynamic Therapy Model: Role of Nitric Oxide Produced by Targeted Cells.","authors":"Jerzy Bazak, Witold Korytowski, Albert W Girotti","doi":"10.1615/CritRevOncog.2022040016","DOIUrl":"10.1615/CritRevOncog.2022040016","url":null,"abstract":"When selected tumor cells in a large in vitro population are exposed to ionizing radiation, they can send pro-survival signals to non-exposed counterparts (bystander cells). If there is no physical contact between irradiated and bystander cells, the latter respond to mediators from targeted cells that diffuse through the medium. One such mediator is known to be nitric oxide (NO). It was recently discovered that non-ionizing anti-tumor photodynamic therapy (PDT) can also elicit pro-survival/expansion bystander effects in a variety of human cancer cells. A novel silicone ring-based approach was used for distinguishing photodynamically-targeted cells from non-targeted bystanders. A key finding was that NO from upregulated iNOS in surviving targeted cells diffused to the bystanders and caused iNOS/NO upregulation there, which in turn stimulated cell proliferation and migration. The intensity of these responses depended on the extent of iNOS/NO induction in targeted cells of different cancer lines. Moreover, the responses could be replicated using NO from the chemical donor DETA/NO. This review will focus on these and related findings, their negative implications for clinical PDT, and how these might be averted by using pharmacologic inhibitors of iNOS activity or transcription.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":"28 1","pages":"15-25"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41214822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0