Critical Reviews in Oncogenesis最新文献

Review Article: Night Shift Work, Circadian Disruption, and the Gut Microbiome: Implications for Human Health. 综述文章：夜班工作、昼夜节律中断和肠道微生物组：对人类健康的影响。

Critical Reviews in Oncogenesis Pub Date : 2025-01-01 DOI: 10.1615/CritRevOncog.2025059579

Silvia Vivarelli, Andrea Marconi, Serena Matera, Luca Falzone, Concettina Fenga

{"title":"Review Article: Night Shift Work, Circadian Disruption, and the Gut Microbiome: Implications for Human Health.","authors":"Silvia Vivarelli, Andrea Marconi, Serena Matera, Luca Falzone, Concettina Fenga","doi":"10.1615/CritRevOncog.2025059579","DOIUrl":"https://doi.org/10.1615/CritRevOncog.2025059579","url":null,"abstract":"The gut microbiome (GM) plays a critical role in regulating a number of physiological processes within the human host, including metabolism, immune function, and protection from pathogens. Emerging evidence suggests that occupational exposures, particularly working night shifts or during irregular hours, significantly influence the GM composition and functionality. These disruptions are closely tied to the misalignment between the host's circadian rhythms and the GM's internal clocks, leading to dysbiosis and increased systemic inflammation. This misalignment has been linked to the development of several health conditions, including dysmetabolism, type 2 diabetes, obesity, cardiovascular diseases, and gastrointestinal disorders. This review provides a thorough analysis of the current research on workers who are exposed to night shifts, highlighting the profound impact of circadian misalignment on both the GM wellbeing and the overall human health. Innovative interventions, such as dietary supplementation with probiotics, prebiotics, circadian-aligned nutrition, and time-restricted eating, offer promising strategies for restoring the GM balance and synchronizing the microbiome with the host's circadian rhythms affected by occupational stressors. Precision-based interventions tailored to specific occupational exposures and circadian patterns may provide effective solutions for improving worker's health and preventing long-term chronic diseases associated with detrimental exposures. In light of these findings, integrating microbiome-targeted approaches into occupational health policies could lead to better health outcomes, reduce the risk of chronic diseases, and enhance the overall well-being of at-risk workers. Occupational research should continue to explore these personalized approaches, together with novel assessment strategies, to optimize health interventions and mitigate the long-term effects of night shift work.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":"30 2","pages":"67-81"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review Article: Probiotics-Mediated Enhancement of Checkpoint Inhibitor Blockade for HER2+ Breast Cancer. 综述文章：益生菌介导的HER2+乳腺癌检查点抑制剂阻断增强。

Critical Reviews in Oncogenesis Pub Date : 2025-01-01 DOI: 10.1615/CritRevOncog.2025058633

Mai Ho, Benjamin Bonavida

{"title":"Review Article: Probiotics-Mediated Enhancement of Checkpoint Inhibitor Blockade for HER2+ Breast Cancer.","authors":"Mai Ho, Benjamin Bonavida","doi":"10.1615/CritRevOncog.2025058633","DOIUrl":"https://doi.org/10.1615/CritRevOncog.2025058633","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) have significantly improved survival rates for many types of cancer, giving patients survival prognoses that had been previously unattainable. Unfortunately, in many advanced cancers, including breast cancer (BC), objective response rates (ORRs) have been reported to be between 5% and 25% and immune-related adverse events (irAEs) can be severe, emphasizing the need to improve the effectiveness of ICIs while minimizing irAEs. In recent years, probiotics and various bacteria consortia have gained growing recognition for their application in immunotherapies for various cancers. Many preclinical models have demonstrated that probiotics significantly influence the gut microbiome, enhancing the production of beneficial metabolites and promoting interactions with cytotoxic T cells to amplify the antitumor effects of ICIs. For the treatment of HER2+ BC, current clinical trials have administered ICIs in combination with anti-HER2 agents (e.g., trastuzumab) to enhance treatment efficacy. Thus far, this combination has shown promising results, especially in patients with advanced PDL1-positive disease. However, as these trials are still ongoing, the efficacy of immune checkpoint blockade (ICB) therapy for HER2+ BCs remains inconclusive and requires further investigation. Thus, this review discusses the use of probiotics in ICB therapy, focusing on the potential role of probiotics in HER2+ BC response to ICIs, their underlying mechanisms and challenges.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":"30 2","pages":"37-47"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review Article: Understanding the Role of the Microbiome in Breast Cancer Progression. 综述文章：了解微生物组在乳腺癌进展中的作用。

Critical Reviews in Oncogenesis Pub Date : 2025-01-01 DOI: 10.1615/CritRevOncog.2024056468

Seema Kumari, Mundla Srilatha, Ganji Purnachndra Nagaraju

{"title":"Review Article: Understanding the Role of the Microbiome in Breast Cancer Progression.","authors":"Seema Kumari, Mundla Srilatha, Ganji Purnachndra Nagaraju","doi":"10.1615/CritRevOncog.2024056468","DOIUrl":"https://doi.org/10.1615/CritRevOncog.2024056468","url":null,"abstract":"The breast cancer fatality rate poses a global health concern. Dysbiosis of the gut and breast microbiome plays a crucial role in both the onset and metastasis of breast cancer by influencing immune response and hormone metabolism. Probiotics, antibiotics, and KEY WORDS: breast cancer, immunotherapy, microbiome, exosomes, gut microbiota are used in microbiome-targeted drugs as therapy alternatives. Metabolic alterations accelerate the development of cancer. For instance, 27-hydroxycholesterol promotes tamoxifen resistance and estrogen receptor-positive (ER+) breast cancer. Malignant breast tissues differ from healthy breast tissues by their unique microbial profiles. The microbiome influences metabolic pathways such as lipid and glucose metabolism and microbial compounds like β-glucuronidases and short-chain fatty acids (SCFAs) influence metabolism, drug resistance, and progression of cancer. New approaches to treating breast cancer include immunotherapies, nanoparticle drug delivery systems, and emerging therapeutics based on interactions among the microbiome, the immune system, and exosomes. These approaches may improve immune responses, decrease chemotherapy resistance, and stop the spread of cancer. Here, we discuss dysbiosis in breast cancer and therapeutic approaches.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":"30 2","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review Article: Disrupted Oral Microbiota and Its Implications in Cancer Onset and Progression: A Narrative Review. 综述文章：口腔微生物群紊乱及其在癌症发生和发展中的意义：一篇叙述性综述。

Critical Reviews in Oncogenesis Pub Date : 2025-01-01 DOI: 10.1615/CritRevOncog.2025059551

Giovanni Cultrera, Sabrina Franco, Graziana Spoto, Massimo Libra, Luca Falzone

{"title":"Review Article: Disrupted Oral Microbiota and Its Implications in Cancer Onset and Progression: A Narrative Review.","authors":"Giovanni Cultrera, Sabrina Franco, Graziana Spoto, Massimo Libra, Luca Falzone","doi":"10.1615/CritRevOncog.2025059551","DOIUrl":"https://doi.org/10.1615/CritRevOncog.2025059551","url":null,"abstract":"The oral microbiota plays a pivotal role in maintaining oral health, but its dysbiosis has been increasingly implicated in the development of systemic diseases, including cancer. Emerging evidence highlights the potential contribution of oral microorganisms to carcinogenesis in the oral cavity and distant organs, such as the lungs, pancreas, and genitourinary tract. This review explores the mechanisms through which the oral microbiota influences cancer development and treatment response, mainly driven by microbial translocation, systemic inflammation, immune modulation, and the release of carcinogenic metabolites. Additionally, the review discusses how oral microbiota perturbations interact with host factors, such as diet, systemic diseases, genetics, and cancer therapies, to influence tumor initiation, progression, and response to treatment. A critical analysis of past and emerging literature shows that specific microbial taxa potentially influence tumor progression and immune responses, including Fusobacterium, Porphyromonas, Aggregatibacter and Treponema. The detection of these microorganisms and the study of oral microbiome profiling in cancer care may offer new diagnostic and therapeutic strategies; however, further studies with homogeneous patient populations are needed to fully understand the contributions of oral dysbiosis in cancer development and treatment responses.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":"30 2","pages":"83-106"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review Article: Probiotics and Oncogenesis: Clinical Implications. 综述文章：益生菌和肿瘤发生：临床意义。

Critical Reviews in Oncogenesis Pub Date : 2025-01-01 DOI: 10.1615/CritRevOncog.2025058336

Brayden K Leyva, Benjamin Bonavida

{"title":"Review Article: Probiotics and Oncogenesis: Clinical Implications.","authors":"Brayden K Leyva, Benjamin Bonavida","doi":"10.1615/CritRevOncog.2025058336","DOIUrl":"https://doi.org/10.1615/CritRevOncog.2025058336","url":null,"abstract":"The interplay between probiotics and cancer development has emerged as a complex but important field in oncology research. While probiotics are known gut microbiome modulators and have the ability to modulate an immune response, their role in the prevention and treatment of cancer are inadequately understood. Evidence from peer-reviewed literature suggests that probiotics-mediated effects contribute to cancer prevention and treatment. Such effects include the enhancement of barrier function, production of anti-inflammatory agents, modulation of immune responses, and regulation of the tumor microenvironment. Clinical studies offer promising results in terms of therapeutic applications in certain cancers where probiotic bacteria may help reduce risk factors while enhancing treatment efficacy. Emerging evidence indicates potential benefits in the combination of probiotics with immunotherapy, including improved response rates and reduced side effects. Significant challenges remain, however, including the standardization of probiotic bacterial constituents, the route of administration, optimal delivery methods and safety concerns. Future research should focus on personalized treatment plans with emphasis on strain-specific effects and the development of next-generation probiotics specifically targeted for cancer applications, in combination with current treatment therapeutics.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":"30 2","pages":"49-66"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine Learning Approaches for Neuroblastoma Risk Prediction and Stratification. 神经母细胞瘤风险预测和分层的机器学习方法。

Critical Reviews in Oncogenesis Pub Date : 2025-01-01 DOI: 10.1615/CritRevOncog.2024056447

Ramakrishna Vadde, Manoj Kumar Gupta

引用次数: 0

Identification of Glucose-6-Phosphate Dehydrogenase (G6PD) Inhibitors by Cheminformatics Approach. 葡萄糖-6-磷酸脱氢酶（G6PD）抑制剂的化学信息学鉴定

Critical Reviews in Oncogenesis Pub Date : 2025-01-01 DOI: 10.1615/CritRevOncog.2024056445

Srilatha Mundla, Madhu Sudhana Saddala

{"title":"Identification of Glucose-6-Phosphate Dehydrogenase (G6PD) Inhibitors by Cheminformatics Approach.","authors":"Srilatha Mundla, Madhu Sudhana Saddala","doi":"10.1615/CritRevOncog.2024056445","DOIUrl":"10.1615/CritRevOncog.2024056445","url":null,"abstract":"Glucose-6-phosphate dehydrogenase (G6PD) is an essential enzyme in the pentose phosphate pathway (PPP), a critical glucose metabolism pathway linked to cancer cell proliferation and metastasis. Inhibiting the PPP presents a promising approach to cancer treatment. The G6PD enzyme structure was obtained from the Protein Data Bank (PDB). The active site responsible for NADP+ binding was identified and used for structure-based pharmacophore design. This pharmacophore model was applied to the ZINC database to screen for small molecules. Molecular docking was accomplished using AutoDock Vina, and protein-ligand interactions were analyzed. Additionally, compounds were validated based on in silico ADMET properties to select the most promising candidates. A comprehensive screening and docking procedure identified several potential G6PD inhibitors. These compounds showed favorable interactions with the active site and met the criteria for optimal ADMET properties. The newly proposed G6PD inhibitors, with their potential to revolutionize cancer therapy, could serve as lead molecules for further research and development, inspiring the audience about the possibilities in cancer therapy.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":"30 1","pages":"59-70"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction of Heat Shock Protein 90 (HSP90), Ganetespib, and 5-Fluorouracil by Computational Approach for Colorectal Cancer Therapy. 热休克蛋白90 （HSP90）、Ganetespib和5-氟尿嘧啶在结直肠癌治疗中的相互作用的计算方法

Critical Reviews in Oncogenesis Pub Date : 2025-01-01 DOI: 10.1615/CritRevOncog.2024056394

Yuvasri Golivi, Santosh Kumar Behera, Afroz Alam, Sujatha Peela

{"title":"Interaction of Heat Shock Protein 90 (HSP90), Ganetespib, and 5-Fluorouracil by Computational Approach for Colorectal Cancer Therapy.","authors":"Yuvasri Golivi, Santosh Kumar Behera, Afroz Alam, Sujatha Peela","doi":"10.1615/CritRevOncog.2024056394","DOIUrl":"10.1615/CritRevOncog.2024056394","url":null,"abstract":"The heat shock protein 90 kDa (HSP90) is highly conserved across diverse species, including humans, and upregulated in various cancers. As a result, it has been identified as a promising target for advancing anticancer medicine. The introduction of combinatorial chemistry in drug discovery has emphasized the need to develop new technologies in screening, designing, decoding, synthesizing, and screening combinatorial drug libraries. The current investigation was carried out to report improved inhibition efficacy of ganetespib, fluorouracil (5-FU), and its combinatorial drug treatment (ganetespib + 5-FU) against the HSP90 molecular chaperone through an in silico approach. Both drugs and their combination are ATP-competitive inhibitors; they inhibit the HSP90α N-terminal and block the ATP binding site. The structural and functional basis and their combination were confirmed through molecular docking interaction with HSP90α. The inhibitors' conformational effects and their combination against the HSP90α protein were studied using powerful MD simulations. The key interacting residues of HSP90α with ganetespib, 5-FU, and ganetespib + 5-FU were identified via energy binding calculations and molecular dynamics. This study is the first to offer atomistic insights into the interaction between ganetespib, 5-FU, and ganetespib + 5-FU with the HSP90α protein N-terminal domain. The results of our in silico study will open better avenues for developing potential cancer inhibitors in the near future.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":"30 1","pages":"31-42"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review Article: Involvement of the Gut Microbiome and Probiotic Interventions in Pediatric Acute Lymphoblastic Leukemia. 综述文章：肠道微生物组和益生菌干预在儿童急性淋巴细胞白血病中的作用。

Critical Reviews in Oncogenesis Pub Date : 2025-01-01 DOI: 10.1615/CritRevOncog.2025058176

Inesa Navasardyan

引用次数: 0

Molecular Docking: An Emerging Tool for Target-Based Cancer Therapy. 分子对接：靶向肿瘤治疗的新兴工具。

Critical Reviews in Oncogenesis Pub Date : 2025-01-01 DOI: 10.1615/CritRevOncog.2024056533

Pavithra Uppathi, Suraj Rajakumari, Kallimakula Venkareddy Saritha

{"title":"Molecular Docking: An Emerging Tool for Target-Based Cancer Therapy.","authors":"Pavithra Uppathi, Suraj Rajakumari, Kallimakula Venkareddy Saritha","doi":"10.1615/CritRevOncog.2024056533","DOIUrl":"10.1615/CritRevOncog.2024056533","url":null,"abstract":"Molecular docking is a structure-based computational technique that plays a major role in drug discovery. Molecular docking enhances the efficacy of determining the metabolic interaction between two molecules, i.e., the small molecule (ligand) and the target molecule (protein), to find the best orientation of a ligand to its target molecule with minimal free energy in forming a stable complex. By stimulating drug-target interactions, docking helps identify small molecules that might inhibit cancer-promoting proteins, aiding in the development of novel targeted therapies. Molecular docking enables researchers to screen vast reorganization, identifying potential anti-cancer drugs with enhanced specificity and reduced toxicity. The growing importance of molecular docking underscores its potential to revolutionize cancer treatment by accelerating the identification of novel drugs and improving clinical outcomes. As a wide approach, this computational drug design technique can be considered more effective and timesaving than other cancer treatment methods. In this review, we showcase brief information on the role of molecular docking and its importance in cancer research for drug discovery and target identification. Therefore, in recent years, it can be concluded that molecular docking can be scrutinized as one of the novel strategies at the leading edge of cancer-targeting drug discovery.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":"30 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0