Review Article: Understanding the Role of the Microbiome in Breast Cancer Progression.

Q4 Biochemistry, Genetics and Molecular Biology
Seema Kumari, Mundla Srilatha, Ganji Purnachndra Nagaraju
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引用次数: 0

Abstract

The breast cancer fatality rate poses a global health concern. Dysbiosis of the gut and breast microbiome plays a crucial role in both the onset and metastasis of breast cancer by influencing immune response and hormone metabolism. Probiotics, antibiotics, and KEY WORDS: breast cancer, immunotherapy, microbiome, exosomes, gut microbiota are used in microbiome-targeted drugs as therapy alternatives. Metabolic alterations accelerate the development of cancer. For instance, 27-hydroxycholesterol promotes tamoxifen resistance and estrogen receptor-positive (ER+) breast cancer. Malignant breast tissues differ from healthy breast tissues by their unique microbial profiles. The microbiome influences metabolic pathways such as lipid and glucose metabolism and microbial compounds like β-glucuronidases and short-chain fatty acids (SCFAs) influence metabolism, drug resistance, and progression of cancer. New approaches to treating breast cancer include immunotherapies, nanoparticle drug delivery systems, and emerging therapeutics based on interactions among the microbiome, the immune system, and exosomes. These approaches may improve immune responses, decrease chemotherapy resistance, and stop the spread of cancer. Here, we discuss dysbiosis in breast cancer and therapeutic approaches.

综述文章:了解微生物组在乳腺癌进展中的作用。
乳腺癌的死亡率是一个全球性的健康问题。肠道和乳房微生物群的失调通过影响免疫反应和激素代谢在乳腺癌的发生和转移中起着至关重要的作用。益生菌、抗生素和关键词:乳腺癌、免疫治疗、微生物组、外泌体、肠道微生物群被用于微生物组靶向药物作为治疗方案。代谢的改变加速了癌症的发展。例如,27-羟基胆固醇促进他莫昔芬耐药性和雌激素受体阳性(ER+)乳腺癌。恶性乳腺组织因其独特的微生物特征而不同于健康乳腺组织。微生物组影响代谢途径,如脂质和葡萄糖代谢,微生物化合物,如β-葡萄糖醛酸酶和短链脂肪酸(SCFAs)影响代谢、耐药性和癌症进展。治疗乳腺癌的新方法包括免疫疗法、纳米颗粒药物递送系统和基于微生物组、免疫系统和外泌体之间相互作用的新兴疗法。这些方法可以改善免疫反应,减少化疗耐药性,并阻止癌症的扩散。在这里,我们讨论乳腺癌的生态失调和治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Critical Reviews in Oncogenesis
Critical Reviews in Oncogenesis Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
1.70
自引率
0.00%
发文量
17
期刊介绍: The journal is dedicated to extensive reviews, minireviews, and special theme issues on topics of current interest in basic and patient-oriented cancer research. The study of systems biology of cancer with its potential for molecular level diagnostics and treatment implies competence across the sciences and an increasing necessity for cancer researchers to understand both the technology and medicine. The journal allows readers to adapt a better understanding of various fields of molecular oncology. We welcome articles on basic biological mechanisms relevant to cancer such as DNA repair, cell cycle, apoptosis, angiogenesis, tumor immunology, etc.
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