Review Article: Night Shift Work, Circadian Disruption, and the Gut Microbiome: Implications for Human Health.

Q4 Biochemistry, Genetics and Molecular Biology
Silvia Vivarelli, Andrea Marconi, Serena Matera, Luca Falzone, Concettina Fenga
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引用次数: 0

Abstract

The gut microbiome (GM) plays a critical role in regulating a number of physiological processes within the human host, including metabolism, immune function, and protection from pathogens. Emerging evidence suggests that occupational exposures, particularly working night shifts or during irregular hours, significantly influence the GM composition and functionality. These disruptions are closely tied to the misalignment between the host's circadian rhythms and the GM's internal clocks, leading to dysbiosis and increased systemic inflammation. This misalignment has been linked to the development of several health conditions, including dysmetabolism, type 2 diabetes, obesity, cardiovascular diseases, and gastrointestinal disorders. This review provides a thorough analysis of the current research on workers who are exposed to night shifts, highlighting the profound impact of circadian misalignment on both the GM wellbeing and the overall human health. Innovative interventions, such as dietary supplementation with probiotics, prebiotics, circadian-aligned nutrition, and time-restricted eating, offer promising strategies for restoring the GM balance and synchronizing the microbiome with the host's circadian rhythms affected by occupational stressors. Precision-based interventions tailored to specific occupational exposures and circadian patterns may provide effective solutions for improving worker's health and preventing long-term chronic diseases associated with detrimental exposures. In light of these findings, integrating microbiome-targeted approaches into occupational health policies could lead to better health outcomes, reduce the risk of chronic diseases, and enhance the overall well-being of at-risk workers. Occupational research should continue to explore these personalized approaches, together with novel assessment strategies, to optimize health interventions and mitigate the long-term effects of night shift work.

综述文章:夜班工作、昼夜节律中断和肠道微生物组:对人类健康的影响。
肠道微生物组(GM)在调节人类宿主体内的许多生理过程中起着关键作用,包括代谢、免疫功能和对病原体的保护。新出现的证据表明,职业性接触,特别是夜班或不规律的工作时间,显著影响转基因成分和功能。这些破坏与宿主的昼夜节律和GM的内部时钟之间的不一致密切相关,导致生态失调和全身炎症增加。这种错位与几种健康状况的发展有关,包括代谢障碍、2型糖尿病、肥胖、心血管疾病和胃肠道疾病。这篇综述对目前对夜班工人的研究进行了全面分析,强调了昼夜节律失调对转基因健康和整体人类健康的深远影响。创新的干预措施,如膳食中补充益生菌、益生元、符合昼夜节律的营养和限时饮食,为恢复转基因平衡和使微生物群与受职业压力源影响的宿主昼夜节律同步提供了有希望的策略。针对特定职业暴露和昼夜节律模式量身定制的精准干预措施,可为改善工人健康和预防与有害暴露有关的长期慢性疾病提供有效解决办法。根据这些发现,将针对微生物组的方法纳入职业卫生政策可能会带来更好的健康结果,降低慢性疾病的风险,并提高高危工人的整体福祉。职业研究应继续探索这些个性化的方法,以及新的评估策略,以优化健康干预措施,减轻夜班工作的长期影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Critical Reviews in Oncogenesis
Critical Reviews in Oncogenesis Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
1.70
自引率
0.00%
发文量
17
期刊介绍: The journal is dedicated to extensive reviews, minireviews, and special theme issues on topics of current interest in basic and patient-oriented cancer research. The study of systems biology of cancer with its potential for molecular level diagnostics and treatment implies competence across the sciences and an increasing necessity for cancer researchers to understand both the technology and medicine. The journal allows readers to adapt a better understanding of various fields of molecular oncology. We welcome articles on basic biological mechanisms relevant to cancer such as DNA repair, cell cycle, apoptosis, angiogenesis, tumor immunology, etc.
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