Review Article: Night Shift Work, Circadian Disruption, and the Gut Microbiome: Implications for Human Health.

Abstract

The gut microbiome (GM) plays a critical role in regulating a number of physiological processes within the human host, including metabolism, immune function, and protection from pathogens. Emerging evidence suggests that occupational exposures, particularly working night shifts or during irregular hours, significantly influence the GM composition and functionality. These disruptions are closely tied to the misalignment between the host's circadian rhythms and the GM's internal clocks, leading to dysbiosis and increased systemic inflammation. This misalignment has been linked to the development of several health conditions, including dysmetabolism, type 2 diabetes, obesity, cardiovascular diseases, and gastrointestinal disorders. This review provides a thorough analysis of the current research on workers who are exposed to night shifts, highlighting the profound impact of circadian misalignment on both the GM wellbeing and the overall human health. Innovative interventions, such as dietary supplementation with probiotics, prebiotics, circadian-aligned nutrition, and time-restricted eating, offer promising strategies for restoring the GM balance and synchronizing the microbiome with the host's circadian rhythms affected by occupational stressors. Precision-based interventions tailored to specific occupational exposures and circadian patterns may provide effective solutions for improving worker's health and preventing long-term chronic diseases associated with detrimental exposures. In light of these findings, integrating microbiome-targeted approaches into occupational health policies could lead to better health outcomes, reduce the risk of chronic diseases, and enhance the overall well-being of at-risk workers. Occupational research should continue to explore these personalized approaches, together with novel assessment strategies, to optimize health interventions and mitigate the long-term effects of night shift work.