Particulate Matter and Its Impact on Macrophages: Unraveling the Cellular Response for Environmental Health.

Q4 Biochemistry, Genetics and Molecular Biology

Critical Reviews in Oncogenesis Pub Date : 2024-01-01 DOI:10.1615/CritRevOncog.2024053305

Nyayapathi Priyanka Priyadarshini, Daka Gopamma, Namuduri Srinivas, Rama Rao Malla, Kolli Suresh Kumar

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引用次数: 0

Abstract

Particulate matter (PM) imposes a significant impact to environmental health with deleterious effects on the human pulmonary and cardiovascular systems. Macrophages (Mφ), key immune cells in lung tissues, have a prominent role in responding to inhaled cells, accommodating inflammation, and influencing tissue repair processes. Elucidating the critical cellular responses of Mφ to PM exposure is essential to understand the mechanisms underlying PM-induced health effects. The present review aims to give a glimpse on literature about the PM interaction with Mφ, triggering the cellular events causing the inflammation, oxidative stress (OS) and tissue damage. The present paper reviews the different pathways involved in Mφ activation upon PM exposure, including phagocytosis, intracellular signaling cascades, and the release of pro-inflammatory mediators. Potential therapeutic strategies targeting Mφ-mediated responses to reduce PM-induced health effects are also discussed. Overall, unraveling the complex interplay between PM and Mφ sheds light on new avenues for environmental health research and promises to develop targeted interventions to reduce the burden of PM-related diseases on global health.

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颗粒物质及其对巨噬细胞的影响：揭示细胞对环境健康的反应。

颗粒物（PM）对环境健康造成了重大影响，并对人类的肺部和心血管系统产生了有害影响。巨噬细胞（Mφ）是肺组织中的关键免疫细胞，在对吸入细胞做出反应、适应炎症和影响组织修复过程方面发挥着重要作用。阐明巨噬细胞（Mφ）对可吸入颗粒物暴露的关键细胞反应对于了解可吸入颗粒物诱发健康影响的机制至关重要。本综述旨在介绍有关可吸入颗粒物与 Mφ 相互作用、引发细胞事件导致炎症、氧化应激（OS）和组织损伤的文献。本文回顾了暴露于 PM 时 Mφ 激活所涉及的不同途径，包括吞噬作用、细胞内信号级联和促炎介质的释放。此外，还讨论了针对 Mφ 介导的反应以减少 PM 引起的健康影响的潜在治疗策略。总之，揭示可吸入颗粒物与 Mφ 之间复杂的相互作用为环境健康研究提供了新的途径，并有望开发出有针对性的干预措施，减轻可吸入颗粒物相关疾病对全球健康造成的负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Oncogenesis Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： The journal is dedicated to extensive reviews, minireviews, and special theme issues on topics of current interest in basic and patient-oriented cancer research. The study of systems biology of cancer with its potential for molecular level diagnostics and treatment implies competence across the sciences and an increasing necessity for cancer researchers to understand both the technology and medicine. The journal allows readers to adapt a better understanding of various fields of molecular oncology. We welcome articles on basic biological mechanisms relevant to cancer such as DNA repair, cell cycle, apoptosis, angiogenesis, tumor immunology, etc.