2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)最新文献_第8页

Decoding ECoG High Gamma Power from Cellular Calcium Response using Transparent Graphene Microelectrodes 使用透明石墨烯微电极解码细胞钙响应的ECoG高伽马功率

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8717147

Xin Liu, Chi Ren, Yichen Lu, Ryoma Hattori, Yuhan Shi, Ruoyu Zhao, David Ding, T. Komiyama, D. Kuzum

引用次数: 3

Optimizing a novel nerve cuff electrode to record bidirectional neural activity* 优化一种新型神经袖电极记录双向神经活动*

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8717079

P. Sabetian, P. Yoo

引用次数: 3

Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing 无袖带外周神经接口的轴突尺寸微针穿透阵列

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8717097

Dongxiao Yan, Ahmad A. Jiman, David C. Ratze, Shuo Huang, Saman Parizi, Elissa J. Welle, Zhonghua Ouyang, Paras R. Patel, M. Kushner, C. Chestek, T. Bruns, E. Yoon, J. Seymour

{"title":"Microneedle Penetrating Array with Axon-Sized Dimensions for Cuff-less Peripheral Nerve Interfacing","authors":"Dongxiao Yan, Ahmad A. Jiman, David C. Ratze, Shuo Huang, Saman Parizi, Elissa J. Welle, Zhonghua Ouyang, Paras R. Patel, M. Kushner, C. Chestek, T. Bruns, E. Yoon, J. Seymour","doi":"10.1109/NER.2019.8717097","DOIUrl":"https://doi.org/10.1109/NER.2019.8717097","url":null,"abstract":"Autonomic nerves are typically only hundreds of microns in diameter near their organ targets and these carry all of the sympathetic and parasympathetic control signals. We present a cuff-less microneedle array specifically designed to potentially map small autonomic nerves. The focus of this paper is the design and fabrication of an ultra-miniaturized silicon needle array on a silicone substrate. We demonstrate arrays having 25 to 100 microneedles. Each needle has a 1-micron tip and dual-taper shaft. We demonstrate an ability to control the tip shape, angle, and shaft angle which is important for balancing sharpness and stiffness. These high-density arrays also include a special backside anchor embedded in silicone for stability in the elastic substrate, yet the array freely wraps over a 300-µm nerve. Another critical method presented here is a surgical technique for inserting and securing an array without a cuff (as small as 0.3 mm wide and 1.2 mm long) by photochemical bonding of collagen/Rose Bengal adhesive agents to epineurium. Future work will focus on device functionalization and histological characterization in a rat vagus model.","PeriodicalId":356177,"journal":{"name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133448633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Flexible, Monolithic, High-Density µLED Neural Probes for Simultaneous Optogenetics Stimulation and Recording* 柔性，单片，高密度微LED神经探针，用于同时光遗传学刺激和记录*

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8717116

Jay W. Reddy, I. Kimukin, E. Towe, M. Chamanzar

{"title":"Flexible, Monolithic, High-Density µLED Neural Probes for Simultaneous Optogenetics Stimulation and Recording*","authors":"Jay W. Reddy, I. Kimukin, E. Towe, M. Chamanzar","doi":"10.1109/NER.2019.8717116","DOIUrl":"https://doi.org/10.1109/NER.2019.8717116","url":null,"abstract":"Modern optogenetic experiments require high spatio-temporal resolution stimulation deep in brain tissue. Implantable optoelectrical neural probes with integrated recording electrodes and photonic devices offer unique opportunities for simultaneous electrical recording and optical stimulation of neural activity. Micro-light-emitting diodes (µLEDs) have been used for optical stimulation. However, such µLEDs are mostly fabricated on rigid substrates such as silicon and sapphire. Flexible, polymer substrates are preferred for realizing neural probes that reduce damage to brain tissue. Commercial off-the-shelf LED chips have been packaged in polymer substrates; however, the prohibitively large sizes of such LED chips limit the density of the probes and process scalability. Here, we demonstrate a novel monolithic design in which recording electrodes and GaN µLEDs (30 µm x 30 µm) are realized directly in a flexible, biocompatible Parylene C substrate. Due to its biocompatibility and compliance, Parylene C is widely used as insulation or substrate in neural probes. We demonstrate one-dimensional and two-dimensional individually-addressable µLED arrays that emit blue light at the wavelength of 453 nm for stimulation of Channelrhodopsin-2 (ChR2), with output intensities greater than 15 mW/mm2, well above the threshold for stimulation of ChR2. High-density (400 µLEDs/mm2) two-dimensional electrode arrays are realized on a 3.5 cm x 920 µm flexible probe shank.","PeriodicalId":356177,"journal":{"name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"158 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134143195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Computation Based Approach for Modeling the Efficacy of Neurostimulation Therapies on Neural Functioning 基于计算的神经刺激疗法对神经功能影响的建模方法

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8716907

Kaia R. Lindberg, Abigail T. Small, E. Dougherty

{"title":"A Computation Based Approach for Modeling the Efficacy of Neurostimulation Therapies on Neural Functioning","authors":"Kaia R. Lindberg, Abigail T. Small, E. Dougherty","doi":"10.1109/NER.2019.8716907","DOIUrl":"https://doi.org/10.1109/NER.2019.8716907","url":null,"abstract":"Neurostimulation demonstrates success as a medical treatment for patients suffering from neurodegenerative diseases and psychiatric disorders. Despite promising clinical results, the cellular-level processes by which they achieve these favorable outcomes are not completely understood. Specifically, the neuronal mechanisms by which neurostimulation impacts ion channel gating and transmembrane ionic flux are unknown. To help elucidate these mechanisms, we have developed a novel mathematical model that integrates the Poisson-Nernst-Planck system of PDEs and Hodgkin-Huxley based ODEs to model the effects of this neurotherapy on transmembrane voltage, ion channel gating, and ionic mobility. Using a biologically-inspired domain, in silico simulations are used to assess the impact of TES and DBS on neuronal electrodynamics. Results show that an instantaneous polarization of the membrane’s resting potential occurs in a location specific manner, where the type and degree of polarization depends on the position on the membrane. This polarization in turn leads ion channel gating and transmembrane ionic flux to change in a site specific fashion. In addition, results show differences in polarization, membrane voltage, and transmembrane ion mobility resulting from highly distinct forms of neurostimulation, namely tran-scranial electrical stimulation and deep brain stimulation.","PeriodicalId":356177,"journal":{"name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132670131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospective study of percutaneous bone-anchored implants in transfemoral amputees: Brain-machine platform technology for external prosthetic control and feedback 经股骨截肢患者经皮骨锚定植入物的前瞻性研究:脑机平台技术用于外部假肢控制和反馈

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8716952

M. Zaid, R. Wustrack, M. Garibaldi, Erik J. Geiger, V. Andaya, R. O'Donnell

引用次数: 0

Assessment of Single Use Dry Epidermal Electrodes for Surface Electromyography Recordings* 用于表面肌电记录的一次性干表皮电极的评估*

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8716981

Jinfeng Li, G. Barnes, Pulin Wang, Helen J. Huang

{"title":"Assessment of Single Use Dry Epidermal Electrodes for Surface Electromyography Recordings*","authors":"Jinfeng Li, G. Barnes, Pulin Wang, Helen J. Huang","doi":"10.1109/NER.2019.8716981","DOIUrl":"https://doi.org/10.1109/NER.2019.8716981","url":null,"abstract":"Alternatives to conventional wet Silver/Silver Chloride (Ag/AgCl) hydrogel electrodes could greatly improve the ability to record long-term surface electromyography (sEMG). This paper presents preliminary evaluation of dry epidermal electronic system (EES) electrodes over 8 days measurements. We tested 3 subjects and recorded sEMG signals of right rectus femoris during static and dynamic tasks from epidermal electrodes and traditional Ag/AgCl electrodes. For epidermal electrodes that remained intact and maintained adhesion to the skin, signal-to-noise ratio (SNR) values were greater than 16.9 dB and signal-to-motion ratio (SMR) values were greater than 13.1 dB, which were both above the accepted thresholds for good signal quality (SNR > 15 dB and SMR > 12dB). We also developed a new metric, the Signal Quality Index, SQI to help determine whether higher SNR or higher SMR were necessarily indicative of better EMG signal quality. Our results indicated that the single use dry epidermal electrodes were able to maintain high signal quality over 8 days and suggested that dry epidermal electrodes have the potential ability for long-term sEMG recording.","PeriodicalId":356177,"journal":{"name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116412008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A Bayesian Demonstration of Reliability for Encapsulated Implanted Electronics 封装植入电子器件可靠性的贝叶斯论证

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8717034

C. Lamont, Federico Mazza, N. Donaldson

{"title":"A Bayesian Demonstration of Reliability for Encapsulated Implanted Electronics","authors":"C. Lamont, Federico Mazza, N. Donaldson","doi":"10.1109/NER.2019.8717034","DOIUrl":"https://doi.org/10.1109/NER.2019.8717034","url":null,"abstract":"The long term performance of implanted medical devices is critically affected by their packaging materials. Traditional hermetic enclosures are a hindrance to miniaturisation which might be avoided by polymer encapsulation. However, much uncertainty remains regarding such an approach for chronic implants. It is difficult to extract meaning from lifetime experiments performed on arbitrary test structures and before many highly reliable devices have actually failed. In this study, we describe an accelerated aging experiment on devices that employ test structures fabricated on a silicone encapsulated 0.35 μm CMOS technology. Samples are aged at 47, 67 and 87 °C under a constant 5V DC bias. After over 300 days of aging, of the 36 samples under test, there have only been four failures. Three failures are attributed to the interconnect to the measurement system, with the remaining failure due to delamination of the silicone encapsulant over wirebonds. By employing a Bayesian reliability analysis of the near-zero failure data we demonstrate a 1st failure percentile for the CMOS components of greater than 92 days when aged at 87 °C, calculated at a 95% confidence level, which approximately corresponds to over 8 years at 37 °C.","PeriodicalId":356177,"journal":{"name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117345978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Behavioral Monitoring and Neuromodulation of Feline Voiding Function 猫排尿功能的行为监测和神经调节

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8717187

Zhonghua Ouyang, Nikolas D. Barrera, Vlad I. Marcu, Alec Socha, Jacob H. Schwartz, Zachariah J. Sperry, T. Bruns

{"title":"Behavioral Monitoring and Neuromodulation of Feline Voiding Function","authors":"Zhonghua Ouyang, Nikolas D. Barrera, Vlad I. Marcu, Alec Socha, Jacob H. Schwartz, Zachariah J. Sperry, T. Bruns","doi":"10.1109/NER.2019.8717187","DOIUrl":"https://doi.org/10.1109/NER.2019.8717187","url":null,"abstract":"Neuromodulation is a standard treatment for bladder dysfunction. Although preclinical studies continue to develop new approaches, these experiments are often performed under anesthesia that can affect normal bladder system activity. The goal of this study was to evaluate the use of typical neuromodulation parameters in an awake, behaving large-animal model. During an aseptic surgery, catheters were inserted into the bladder of two male felines and a cuff electrode was placed around the left pudendal nerve. Catheters and electrode leads were housed in an enclosure mounted on the lower back. After recovery, test sessions in an open enclosure were performed approximately weekly. In each session, body-temperature saline was infused while the bladder pressure was monitored until the animal voided one or more times. During some bladder fills, electrical stimulation of the pudendal nerve was applied (5 or 33 Hz; 1.5 or 2 x motor threshold - MT) to determine whether stimulation parameters affected the interval between voiding events or the voiding efficiency. Animals tolerated supra-threshold stimulation as long as the current was slowly increased to a target level. Five-Hz stimulation increased the voiding interval over 33 Hz and no stimulation trials while 33 Hz stimulation at 2 MT led to a greater voiding efficiency. These results follow trends observed in non-behavioral studies, and support the use of this animal model in further translational bladder neuromodulation research.","PeriodicalId":356177,"journal":{"name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"27 15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132790271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Kilohertz Frequency Stimulation of Renal Nerves for Modulating Blood Glucose Concentration in Diabetic Rats 千赫兹刺激肾神经对糖尿病大鼠血糖浓度的调节作用

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8717153

Ahmad A. Jiman, Kavaljit H. Chhabra, David C. Ratze, A. Lewis, P. Cederna, R. Seeley, M. Low, T. Bruns

{"title":"Kilohertz Frequency Stimulation of Renal Nerves for Modulating Blood Glucose Concentration in Diabetic Rats","authors":"Ahmad A. Jiman, Kavaljit H. Chhabra, David C. Ratze, A. Lewis, P. Cederna, R. Seeley, M. Low, T. Bruns","doi":"10.1109/NER.2019.8717153","DOIUrl":"https://doi.org/10.1109/NER.2019.8717153","url":null,"abstract":"In recent years, the role of the kidney in glucose homeostasis has gained global interest. The kidneys are innervated by renal nerves, and renal denervation studies to control hypertension have shown improved glucose regulation. We hypothesized that kilohertz frequency stimulation, which can block propagation of action potentials, applied to renal nerves would reduce blood glucose concentration levels by increasing urinary glucose excretion. We performed experiments on 8 anesthetized, streptozotocin-induced diabetic rats. The renal nerves were encircled by a cuff electrode. Blood glucose concentrations were obtained from tail blood samples. Urine glucose concentrations were obtained from bilateral cannulation of the ureters. Electrical stimulation (50 kHz, 15 V) was applied for 60 minutes. The average blood glucose concentration rate was lower during stimulation (−0.78 ± 1.20 mg/dL/min), compared to before stimulation (+1.14 ± 1.83 mg/dL/min; p < 0.05) and after stimulation (+0.63 ± 1.32 mg/dL/min). The average area under the curve for urine glucose concentration was higher during stimulation (7687.4 ± 4006.1 mg/dL) compared to before (6466.9 ± 2772.8 mg/dL) and after stimulation (5277.2 ± 3381.5 mg/dL). Overall, our results show that kilohertz frequency stimulation of renal nerves is a possible approach for the modulation of blood glucose concentration and may introduce an alternative treatment modality for glycemic control in patients with diabetes.","PeriodicalId":356177,"journal":{"name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134232091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5