Kaveh Shahveisi , Seyedeh Marziyeh Hadi , Hamed Ghazvini , Mehdi Khodamoradi
{"title":"Role of Cannabinoid CB1, Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats","authors":"Kaveh Shahveisi , Seyedeh Marziyeh Hadi , Hamed Ghazvini , Mehdi Khodamoradi","doi":"10.24920/004087","DOIUrl":"https://doi.org/10.24920/004087","url":null,"abstract":"<div><h3>Objective</h3><p>We aimed to investigate whether antagonism of the cannabinoid CB<sub>1</sub> receptor (CB<sub>1</sub>R) could affect novel object recognition (NOR) memory in chronically rapid eye movement sleep-deprived (RSD) rats.</p></div><div><h3>Methods</h3><p>The animals were examined for recognition memory following a 7-day chronic partial RSD paradigm using the multiple platform technique. The CB<sub>1</sub>R antagonist rimonabant (1 or 3 mg/kg, i.p.) was administered either at one hour prior to the sample phase for acquisition, or immediately after the sample phase for consolidation, or at one hour before the test phase for retrieval of NOR memory. For the reconsolidation task, rimonabant was administered immediately after the second sample phase.</p></div><div><h3>Results</h3><p>The RSD episode impaired acquisition, consolidation, and retrieval, but it did not affect the reconsolidation of NOR memory. Rimonabant administration did not affect acquisition, consolidation, and reconsolidation; however, it attenuated impairment of the retrieval of NOR memory induced by chronic RSD.</p></div><div><h3>Conclusions</h3><p>These findings, along with our previous report, would seem to suggest that RSD may affect different phases of recognition memory based on its duration. Importantly, it seems that the CB<sub>1</sub>R may, at least in part, be involved in the adverse effects of chronic RSD on the retrieval, but not in the acquisition, consolidation, and reconsolidation, of NOR memory.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"38 1","pages":"Pages 29-37"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50176544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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