Chinese Medical Sciences Journal最新文献

{"title":"Body Positions Alter Hemodynamics and Respiration in Healthy Adults: A Systematic Review and Meta-Analysis","authors":"Ruchada Sriamad,&nbsp;Sirinut Chaiduang,&nbsp;Thaniya Klinsophon,&nbsp;Premtip Thaveeratitham","doi":"10.24920/004281","DOIUrl":"10.24920/004281","url":null,"abstract":"<div><h3>Objective</h3><p>Different body positions can exert both positive and negative physiological effects on hemodynamics and respiration. This study aims to conduct a literature review and examine hemodynamic and respiratory alterations to different body positions.</p></div><div><h3>Methods</h3><p>The study protocol was registered with the International Prospective Registry of Systematic Reviews (register no. CRD42021291464). Two independent reviewers evaluated the methodological quality of all included studies using the Down and Black checklist, while the quality of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluations approach. The overall effects of different body positions were reported from random effects meta-analysis.</p></div><div><h3>Results</h3><p>Three studies with low risk of bias and ten with high risk of bias met the eligibility criteria. The supine resulted in the highest cardiac output compared to the 70 deg head-up tilt, sitting, and standing positions (very low- to moderate-quality evidences) and the lowest systemic vascular resistance compared to the 70 deg head-up tilt and standing positions (moderate-quality evidence). Additionally, the supine was associated with the highest total respiratory resistance compared to the 70 deg head-up tilt, left lateral, and standing positions (very low-to moderate-quality evidence) and higher alveolar ventilation than the prone (low-quality evidence).</p></div><div><h3>Conclusions</h3><p>The supine position has the most positive association with hemodynamic variables, resulting in the highest cardiac output and the lowest systemic vascular resistance. The upright positions (70 deg head-up tilt and standing positions) has the most positive association with the respiratory variables, resulting in the lowest total respiratory resistance.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 1","pages":"Pages 29-45"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effect of Dihydromyricetin Against ExerciseInduced Muscle Damage and Its Mechanism","authors":"Ying Wu ,&nbsp;Da-Wei Wang ,&nbsp;Jun Li ,&nbsp;Xian-Jie Xu ,&nbsp;Zhi-Dan Gao ,&nbsp;Hong-Yan Li ,&nbsp;Yong Zhang ,&nbsp;Peng Liu","doi":"10.24920/004272","DOIUrl":"10.24920/004272","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the protective effect of dihydromyricetin (DHM) against exercise-induced muscle damage (EIMD) in mice and its potential mechanism.</p></div><div><h3>Methods</h3><p>Adult male C57BL/6J mice were randomly divided into control group (CG), exercise group (EG), and exercise + 100 mg/kg weight •d DHM (DHM) group. The intervention lasted for four weeks, during which the animals in the EG and DHM groups were subjected to exercise training for 1 h per day. The day after the training, a 90-min treadmill exercise (slope: 0 and speed: 18 m/min) was conducted in both EG and DHM groups. Samples of blood and gastrocnemius muscles were harvested from the three groups 24 h after the exercise, followed by the measurement of serum creatine kinase (CK) and lactate dehydrogenase (LDH) activities, total superoxide dismutase (T-SOD) activity, malondialdehyde (MDA), and skeletal muscle mitochondrial enzyme complex I and II activities. Histological changes in the skeletal muscle were observed by transmission electron microscopy, and the protein expressions of mitochondrial function-related pathways were detected by Western blotting.</p></div><div><h3>Results</h3><p>Skeletal muscle morphological changes and mitochondrial damage were alleviated in the DHM group compared to those in the EG. The activities of EIMD markers CK and LDH and the level of lipid peroxidation were notably repressed and the serum T-SOD activity was enhanced after DHM intervention. Western blotting demonstrated that the expressions of sirtuin type 3 (SIRT3), estrogen-related receptor alpha, and peroxisome proliferator-activated receptor-gamma coactivator-1 alpha in the skeletal muscle of mice increased after the DHM intervention.</p></div><div><h3>Conclusion</h3><p>DHM can relieve EIMD in mice, possibly by promoting the recovery of the mitochondrial structure and function in the skeletal muscle of mice after high-intensity exercise <em>via</em> the activation of the SIRT3 signaling pathway.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 1","pages":"Pages 46-53"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data-lndependent Acquisition-Based Quantitative Proteomic Analysis Reveals Potential Salivary Biomarkers of Primary Sjogren's Syndrome","authors":"Yi-Chao Tian ,&nbsp;Chun-Lan Guo ,&nbsp;Zhen Li ,&nbsp;Xin You ,&nbsp;Xiao-Yan Liu ,&nbsp;Jin-Mei Su ,&nbsp;Si-Jia Zhao ,&nbsp;Yue Mu ,&nbsp;Wei Sun ,&nbsp;Qian Li","doi":"10.24920/004338","DOIUrl":"https://doi.org/10.24920/004338","url":null,"abstract":"<div><h3>Objective</h3><p>As primary Sjogren's syndrome (pSS) primarily affects the salivary glands, saliva can serve as an indicator of the glands’ pathophysiology and the disease's status. This study aims to illustrate the salivary proteomic profiles of pSS patients and identify potential candidate biomarkers for diagnosis.</p></div><div><h3>Methods</h3><p>The discovery set contained 49 samples (24 from pSS and 25 from age- and gender-matched healthy controls [HCs]) and the validation set included 25 samples (12 from pSS and 13 from HCs). Totally 36 pSS patients and 38 HCs were centrally randomized into the discovery set or to the validation set at a 2:1 ratio. Unstimulated whole saliva samples from pSS patients and HCs were analyzed using a data-independent acquisition (DIA) strategy on a 2D LC–HRMS/MS platform to reveal differential proteins. The crucial proteins were verified using DIA analysis and annotated using gene ontology (GO) and International Pharmaceutical Abstracts (IPA) analysis. A prediction model for SS was established using random forests.</p></div><div><h3>Results</h3><p>A total of 1,963 proteins were discovered, and 136 proteins exhibited differential representation in pSS patients. The bioinformatic research indicated that these proteins were primarily linked to immunological functions, metabolism, and inflammation. A panel of 19 protein biomarkers was identified by ranking order based on <em>P</em>-value and random forest algorichm, and was validated as the predictive biomarkers exhibiting good performance with area under the curve (AUC) of 0.817 for discovery set and 0.882 for validation set.</p></div><div><h3>Conclusions</h3><p>The candidate protein panel discovered may aid in pSS diagnosis. Salivary proteomic analysis is a promising non-invasive method for prognostic evaluation and early and precise treatments for pSS patients. DIA offers the best time efficiency and data dependability and may be a suitable option for future research on the salivary proteome.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 1","pages":"Pages 19-28"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140631244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of GPRC5A-Regulated ABCB1 Expression on Lung Adenocarcinoma Proliferation","authors":"Yun Li ,&nbsp;Wen-Wen Cui ,&nbsp;Zhong-Fa Yang ,&nbsp;Wen-Hao Liu ,&nbsp;Mao-Wang Bian ,&nbsp;Jiong Deng ,&nbsp;Tong Wang","doi":"10.24920/004216","DOIUrl":"10.24920/004216","url":null,"abstract":"<div><h3>Objective</h3><p>Aberrant expression of ATP binding cassette subfamily B member 1 (<em>ABCB1</em>) plays a key role in several cancers. However, influence of G protein coupled receptor family C group 5 type A (GPRCSA)-regulated <em>ABCB1</em> expression on lung adenocarcinoma proliferation remains unclear. Therefore, this study investigated the effect of <em>GPRC5A</em> regulated <em>ABCB1</em> expression on the proliferation of lung adenocarcinoma.</p></div><div><h3>Methods</h3><p><em>ABCBI</em> expressions in lung adenocarcinoma cell lines, human lung adenocarcinoma tissues, and tracheal epithelial cells and lung tissues of <em>GPRC5A</em> knockout mice and wild-type mice were analyzed with RT-PCR, Western blot, or immunohistochemical analysis. Cell counting kit-8 assay was performed to analyze the sensitivity of tracheal epithelial cells from <em>GPRC5A</em> knockout mice to chemotherapeutic agents. Subcutaneous tumor formation assay was performed to confirm whether down-regulation of <em>ABCBI</em> could inhibit the proliferation of lung adenocarcinoma <em>in vivo.</em> To verify the potential regulatory relationship between GPRCS A and ABCB1, immunofluorescence and immunoprecipitation assays were performed.</p></div><div><h3>Results</h3><p>ABCB1 expression was up-regulated in lung adenocarcinoma cell lines and human lung adenocarcinoma tissues. ABCBI expression in the tracheal epithelial cells and lung tissues of <em>GPRC5A</em> deficient mice was higher than that in the wild type mice. Tracheal epithelial cells of <em>GPRC5A</em> knockout mice were much more sensitive to tariquidar and doxorubicin than those of <em>GPRC5A</em> wild type mice. Accordingly, 28 days after injection of the transplanted cells, the volume and weight of lung tumor in <em>ABCBI</em> knockout cell-transplanted GPRCS A^-/C57BL/6 mice were significantly smaller than those in wild type cell-transplanted mice (P = 0.0043, P = 0.0060). Furthermore, immunofluorescence and immunoprecipitation assays showed that GPRC5A regulated ABCBI expression by direct binding.</p></div><div><h3>Conclusion</h3><p>GPRC5A reduces lung adenocarcinoma proliferation <em>via</em> inhibiting <em>ABCBI</em> expression. The pathway by which GPRC5A regulates <em>ABCBI</em> expression needs to be investigated.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 1","pages":"Pages 9-18"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139997713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopic Dermatitis Associated Retinal Detachment and Retinal Vasculitis: A Case Report","authors":"Shi-Yu Cheng ,&nbsp;Zao-Wen Wang ,&nbsp;Rong-Ping Dai","doi":"10.24920/004321","DOIUrl":"10.24920/004321","url":null,"abstract":"<div><p>Atopic dermatitis is usually associated with various ocular complications. We report a 21-year-old Chinese male who presented to our ophthalmology clinic with bilateral retinal detachment and cataracts. The patient had a clear medical history of atopic dermatitis, which had been diagnosed eight years earlier and had been treated with loratadine and pimecrolimus. Cataract surgery was performed for both eyes, combined with scleral buckling for the right eye and pars plana vitrectomy for the left eye. During postoperative follow-up, fundus fluorescein angiography showed retinal vasculitis in both eyes and macular edema in the left eye, which coincided with an exacerbation of atopic dermatitis. Macular edema improved after four months of regular dupilumab treatment in the dermatology department. The ocular condition remained stable three years postoperatively.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 1","pages":"Pages 74-78"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Dexmedetomidine on Intraoperative Hemodynamics and Blood Loss in Patients Undergoing Spine Surgery: A Systematic Review and Meta-Analysis","authors":"Mei Wang ,&nbsp;Jian-Xiang Che ,&nbsp;Lei Chen ,&nbsp;Ting-Ting Song ,&nbsp;Jin-Tao Qu","doi":"10.24920/004294","DOIUrl":"10.24920/004294","url":null,"abstract":"<div><h3>Objective</h3><p>Dexmedetomidine (Dex) is a highly selective α2 adrenoceptor agonist that reduces blood pressure and heart rate. However, its ability to provide stable hemodynamics and a clinically significant reduction in blood loss in spine surgery is still a matter of debate. This study aimed to investigate the effects of Dex on intraoperative hemodynamics and blood loss in patients undergoing spine surgery.</p></div><div><h3>Methods</h3><p>The Web of Science, MEDLINE, EMBASE, and the Cochrane Library were searched up to February 2023 for randomized controlled trials (RCTs) including patients undergoing spine surgeries under general anaesthesia and comparing Dex and saline. A fixed- or random-effect model was used depending on heterogeneity. Results Twenty-one RCTs, including 1388 patients, were identified. Dex added the overall risk of intraoperative hypotension (odds ratio [OR]: 2.11; 95% confidence interval [<em>CI</em>]: 1.24 – 3.58; <em>P</em>=0.006) and bradycardia (OR: 2.48; 95%<em>CI</em>: 1.57 – 3.93; <em>P</em>=0.0001). The use of a loading dose of Dex led to significantly increased risks of intraoperative hypotension (OR: 2.00; 95%<em>CI</em>: 1.06 – 3.79; <em>P</em>=0.03) and bradycardia (OR: 2.28; 95%<em>CI</em>: 1.42 3.66; <em>P</em>=0.0007). For patients receiving total intravenous anesthesia, there was an increased risk of hypotension (OR: 2.90; 95%<em>CI</em>: 1.24 – 6.82; P=0.01) and bradycardia (OR: 2.66; 95%<em>CI</em>: 1.53 - 4.61; <em>P</em>=0. 0005). For patients in the inhalation anesthesia group, only an increased risk of bradycardia (OR: 4.95; 95%<em>CI</em>: 1.41 – 17.37; P=0.01) was observed. No significant increase in the risk of hypotension and bradycardia was found in the combined intravenous-inhalation anesthesia group. The incidence of severe hypotension (OR: 2.57; 95%<em>CI</em>: 1.05 – 6.32; <em>P</em>=0.04), but not mild hypotension, was increased. Both mild (OR: 2.55; 95%<em>CI</em>: 1.06 – 6.15; <em>P</em>=0.04) and severe (OR: 2.45; 95%<em>CI</em>: 1.43 – 4.20; <em>P</em>=0.001) bradycardia were associated with a higher risk. The overall analyses did not reveal significant reduction in intraoperative blood loss. However, a significant decrease in blood loss was observed in total inhalation anesthesia subgroup (mean difference [MD]: –82.97; 95%<em>CI</em>: -109.04––56.90; <em>P</em> &lt; 0.001).</p></div><div><h3>Conclusions</h3><p>Dex increases the risks of intraoperative hypotension and bradycardia in major spine surgery. The administration of a loading dose of Dex and the utilization of various anesthesia maintenance methods may potentially impact hemodynamic stability and intraoperative blood loss.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 1","pages":"Pages 54-68"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139997712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiviral Effect of Extracellular Matrix Protein ABI3BP on Vesicular Stomatitis Virus and Its Mechanism: A Preliminary Study In Vitro","authors":"Xiang-Bo Meng ,&nbsp;Mei-Hua Chen ,&nbsp;Nuo Xu ,&nbsp;Tian-Qi Li ,&nbsp;Shuai-Chen Li ,&nbsp;Sun-Xin Zhou ,&nbsp;Huan Chen ,&nbsp;Tong Zhang","doi":"10.24920/004319","DOIUrl":"10.24920/004319","url":null,"abstract":"<div><h3>Objective</h3><p>To explore the influence of extracellular matrix protein ABI-interactor 3-binding protein (ABI3BP) on vesicular stomatitis virus (VSV) genome replication and innate immune signaling pathway.</p></div><div><h3>Methods</h3><p>The small interfering RNA (siRNA) was transfected to knock down <em>ABI3BP</em> gene in human skin fibroblast BJ-Sta cells. VSV-green fluorescent protein (VSV-GFP)-infected cell model was established. The morphological changes and F-actin stress fiber formation were detected on <em>ABI3BP</em> knockdown cells by phalloidin immunofluorescence staining. The mRNA level of virus replication was detected by RT-qPCR in BJ-Sta cells after VSV-GFP infection; western blotting was performed to detect the changes in interferon regulatory factor 3 (IRF3) and TANK-binding kinase 1 (TBK1) phosphorylation levels.</p></div><div><h3>Results</h3><p>The VSV-GFP-infected BJ-Sta cell model was successfully established. Efficient knockdown of <em>ABI3BP</em> in BJ-Sta cells was achieved. Phalloidin immunofluorescence staining revealed structural rearrangement of intracellular F-actin after <em>ABI3BP</em> gene knockdown. Compared with the control group, the gene copy number of VSV-GFP in <em>ABI3BP</em> knockdown cells increased by 2.2 – 3.5 times (<em>P</em>&lt;0.01) and 2.2 – 4.0 times (<em>P</em>&lt;0.01) respectively when infected with VSV of multiplicity of infection 0.1 and 1. The expression of viral protein significantly increased in <em>ABI3BP</em> knockdown cells after virus infection. The activation of type-I interferon pathway, as determined by phosphorylated IRF3 and phosphorylated TBK1, was significantly decreased in <em>ABI3BP</em> knockdown cells after VSV-GFP infection.</p></div><div><h3>Conclusions</h3><p>Extracellular matrix protein ABI3BP plays an important role in maintaining the formation and rearrangement of actin structure. <em>ABI3BP</em> gene deletion promotes RNA virus replication, and ABI3BP is an important molecule that maintains the integrity of type I interferon pathway.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 1","pages":"Pages 1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139933239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopic Dermatitis Associated Retinal Detachment and Retinal Vasculitis: A Case Report.","authors":"Shi-Yu Cheng, Zao-Wen Wang, Rong-Ping Dai","doi":"10.24920/004321","DOIUrl":"10.24920/004321","url":null,"abstract":"<p><p>Atopic dermatitis is usually associated with various ocular complications. We report a 21-year-old Chinese male who presented to our ophthalmology clinic with bilateral retinal detachment and cataracts. The patient had a clear medical history of atopic dermatitis, which had been diagnosed eight years earlier and had been treated with loratadine and pimecrolimus. Cataract surgery was performed for both eyes, combined with scleral buckling for the right eye and pars plana vitrectomy for the left eye. During postoperative follow-up, fundus fluorescein angiography showed retinal vasculitis in both eyes and macular edema in the left eye, which coincided with an exacerbation of atopic dermatitis. Macular edema improved after four months of regular dupilumab treatment in the dermatology department. The ocular condition remained stable three years postoperatively.</p>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 1","pages":"74-78"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Tranexamic Acid in Shoulder Arthroscopic Surgery: A Randomised Controlled Trial","authors":"Tian-Ci Wang ,&nbsp;Jia-Liang Guo ,&nbsp;Qiu-Ping Tian ,&nbsp;He-Ping Deng ,&nbsp;Bing Yin ,&nbsp;Zeng Xiao ,&nbsp;Bo Lu","doi":"10.24920/004295","DOIUrl":"10.24920/004295","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the optimal administration route of tranexamic acid (TXA) in shoulder arthroscopic surgery.</div></div><div><h3>Methods</h3><div>Patients undergoing arthroscopic rotator cuff repair were randomly divided into four groups: control group (without TXA treatment), intravenous group (TXA was intravenously administered 10 minutes before surgery), irrigation group (TXA was added to the irrigation fluid during subacromial decompression and acromioplasty), and intravenous plus irrigation group (TXA was applied both intravenously and <em>via</em> intra-articular irrigation). The primary outcome was visual clarity assessed with visual analog scale (VAS) score, and the secondary outcomes included irrigation fluid consumption and time to subacromial decompression and acromioplasty procedure.</div></div><div><h3>Results</h3><div>There were 134 patients enrolled in the study, including 33 in the control group, 35 in the intravenous group, 32 in the irrigation group, and 34 in the intravenous plus irrigation group. The median and interquartile range of VAS scores for the intravenous, irrigation, and intravenous plus irrigation groups were 2.70 (2.50, 2.86) (<em>Z</em> = -3.677, <em>P</em> = 0.002), 2.67 (2.50, 2.77) (<em>Z</em> = -3.058, <em>P</em> &lt; 0.001), and 2.91 (2.75, 3.00) (<em>Z</em> = -6.634, <em>P</em> &lt; 0.001), respectively, significantly higher than that of the control group [2.44 (2.37, 2.53)]. Moreover, the control group consumed more irrigation fluid than the intravenous group, irrigation group, and intravenous plus irrigation group (all <em>P</em> &lt; 0.05). The intravenous plus irrigation group consumed less irrigation fluid than either the intravenous group or the irrigation group (both <em>P</em> &lt; 0.001). There was no difference in subacromial decompression and acromioplasty operative time among the four groups.</div></div><div><h3>Conclusion</h3><div>TXA applied both topically and systematically can improve intraoperative visual clarity, and the combined application is more effective.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"38 4","pages":"Pages 273-278"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139075267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Strategies of Surface Modifications to Polyurethane Biomaterials for Vascular Grafts","authors":"Huai-Gu Huang ,&nbsp;Tao Xiang ,&nbsp;Yue-Xin Chen","doi":"10.24920/004178","DOIUrl":"10.24920/004178","url":null,"abstract":"<div><div>As the number of patients suffering from cardiovascular diseases and peripheral vascular diseases rises, the constraints of autologous transplantation remain unavoidable. As a result, artificial vascular grafts must be developed. Adhesion of proteins, platelets and bacteria on implants can result in stenosis, thrombus formation, and postoperative infection, which can be fatal for an implantation. Polyurethane, as a commonly used biomaterial, has been modified in various ways to deal with the adhesions of proteins, platelets, and bacteria and to stimulate endothelium adhesion. In this review, we briefly summarize the mechanisms behind adhesions, overview the current strategies of surface modifications of polyurethane biomaterials used in vascular grafts, and highlight the challenges that need to be addressed in future studies, aiming to gain a more profound understanding of how to develop artificial polyurethane vascular grafts with an enhanced implantation success rate and reduced side effect.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"38 4","pages":"Pages 279-285"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9874253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}