Chinese Medical Sciences Journal最新文献

{"title":"Analysis of Medication Rules of Traditional Chinese Medicine for Malaria Treatment Based on Data Mining","authors":"Wen-Long Guo ,&nbsp;Hui-Juan Jiang ,&nbsp;Yan-Rong Li ,&nbsp;Jin-Long Yang","doi":"10.24920/004214","DOIUrl":"10.24920/004214","url":null,"abstract":"<div><h3>Objective</h3><p>To analyze the medication rules of traditional Chinese medicine (TCM) for malaria treatment.</p></div><div><h3>Methods</h3><p>Statistical analysis was conducted on the basic attributes of TCM drugs with regard to property, therapeutic methods, flavor, and meridian tropism. A complex network of TCM drug associations was constructed. Cluster analysis was applied to obtain the core drugs for malaria treatment. The Apriori algorithm was applied to analyze the association rules of these core drugs.</p></div><div><h3>Results</h3><p>A total of 3S7 herbs were used 3,194 times in 461 prescriptions for malaria treatment. <em>Radix Glycyrrhizae</em> (<figure><img></figure>), <em>Rhizoma Pinelliae</em> (<figure><img></figure>), <em>Radix Bupleuri</em> (<figure><img></figure>), and <em>Radix Dichroae</em> (<figure><img></figure>) were the frequently used herbs through supplementing, exterior-releasing, heat-clearing, qi-rectifying, and damp-resolving therapeutic methods. Such herbs had warm, natural, and cold herbal properties; pungent, bitter, and sweet flavors; and spleen, lung, and stomach meridian tropisms. Cluster analysis showed 61 core drugs, including <em>Radix Glycyrrhizae, Rhizoma Pinelliae, Radix Bupleuri,</em> and <em>Radix Scutellariae</em> (<figure><img></figure>). Apriori association rule analysis yielded 12 binomial rules (herb pairs) and 6 trinomial rules (herb combinations). <em>Radix Bupleuri</em> plus <em>Radix Scutellariae</em> was the core herbal pair for treating malaria. This pair could be combined with <em>Rhizoma Atractylodis Macrocephalae</em> (<figure><img></figure>) for treating warm or cold malaria, combined with <em>Pericarpium Citri Reticulatae</em> (<figure><img></figure>) or <em>Radix Dichroae</em> (<figure><img></figure>) for treating miasmic malaria, or combined with turtle shells (<figure><img></figure>) for treating malaria with splenomegaly.</p></div><div><h3>Conclusions</h3><p>TCM can be used to classify and treat malaria in accordance with the different stages of development. As the core herbal pair, <em>Radix Bupleuri</em> and <em>Radix Scutellariae</em> can be combined with other drugs to treat malaria with different syndrome types.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"38 3","pages":"Pages 218-227"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9690740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening the Disciplinary Construction of History of Medicine: A Call for Action by Chinese Academy of Medical Sciences & Peking Union Medical College","authors":"Jian-Hong Yao ,&nbsp;Da-Qing Zhang ,&nbsp;Xin-Zhong Yu ,&nbsp;Shu-Jian Zhang ,&nbsp;Yong-An Zhang ,&nbsp;Xiang-Yin Yang ,&nbsp;Zhong He ,&nbsp;Huan Liu ,&nbsp;Yong Wang ,&nbsp;Yue-Ying Jin","doi":"10.24920/004270","DOIUrl":"10.24920/004270","url":null,"abstract":"","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"38 2","pages":"Pages 94-96"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9917830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese Guideline on the Management of Polypoidal Choroidal Vasculopathy (2022)","authors":"You-Xin Cher ,&nbsp;Yu-Qing Zhang ,&nbsp;Chang-Zheng Chen ,&nbsp;Hong Dai ,&nbsp;Su-Yan Li ,&nbsp;Xiang Ma ,&nbsp;Xiao-Dong Sun ,&nbsp;Shi-Bo Tang ,&nbsp;Yu-Sheng Wang ,&nbsp;Wen-Bin Wei ,&nbsp;Feng Wen ,&nbsp;Ge-Zhi Xu ,&nbsp;Wei-Hong Yu ,&nbsp;Mei-Xia Zhang ,&nbsp;Ming-Wei Zhao ,&nbsp;Yang Zhang ,&nbsp;Fang Qi ,&nbsp;Xun Xu ,&nbsp;Xiao-Xin Li","doi":"10.24920/004213","DOIUrl":"10.24920/004213","url":null,"abstract":"<div><h3>Background</h3><p>In mainland China, patients with neovascular age-related macular degeneration (nAMD) have approximately an 40% prevalence of polypoidal choroidal vasculopathy (PCV). This disease leads to recurrent retinal pigment epithelium detachment (PED), extensive subretinal or vitreous hemorrhages, and severe vision loss. China has introduced various treatment modalities in the past years and gained comprehensive experience in treating PCV.</p></div><div><h3>Methods</h3><p>A total of 14 retinal specialists nationwide with expertise in PCV were empaneled to prioritize six questions and address their corresponding outcomes, regarding opinions on inactive PCV, choices of anti-vascular endothelial growth factor (anti-VEGF) monotherapy, photodynamic therapy (PDT) monotherapy or combined therapy, patients with persistent subretinal fluid (SRF) or intraretinal fluid (IRF) after loading dose anti-VEGF, and patients with massive subretinal hemorrhage. An evidence synthesis team conducted systematic reviews, which informed the recommendations that address these questions. This guideline used the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach to assess the certainty of evidence and grade the strengths of recommendations.</p></div><div><h3>Results</h3><p>The panel proposed the following six conditional recommendations regarding treatment choices. (1) For patients with inactive PCV, we suggest observation over treatment. (2) For treatment-naive PCV patients, we suggest either anti-VEGF monotherapy or combined anti-VEGF and PDT rather than PDT monotherapy. (3) For patients with PCV who plan to initiate combined anti-VEGF and PDT treatment, we suggest later/rescue PDT over initiate PDT. (4) For PCV patients who plan to initiate anti-VEGF monotherapy, we suggest the treat and extend (T&amp;E) regimen rather than the <em>pro re nata</em> (PRN) regimen following three monthly loading doses. (5) For patients with persistent SRF or IRF on optical coherence tomography (OCT) after three monthly anti-VEGF treatments, we suggest proceeding with anti-VEGF treatment rather than observation. (6) For PCV patients with massive subretinal hemorrhage (equal to or more than four optic disc areas) involving the central macula, we suggest surgery (vitrectomy in combination with tissue-plasminogen activator (tPA) intraocular injection and gas tamponade) rather than anti-VEGF monotherapy.</p></div><div><h3>Conclusions</h3><p>Six evidence-based recommendations support optimal care for PCV patients’ management.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"38 2","pages":"Pages 77-93"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9845803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity of Outcomes Reporting in Trials Evaluating Traditional Chinese Medicine Breast Massage for Stasis Acute Mastitis: A Methodological Review","authors":"Yun-Peng Lv ,&nbsp;Ting Yuan ,&nbsp;Xiao-Ying Mu ,&nbsp;Ying-Yi Fan ,&nbsp;Ming-Yang An ,&nbsp;Fen Zhou","doi":"10.24920/004164","DOIUrl":"10.24920/004164","url":null,"abstract":"<div><h3>Objective</h3><p>To systematically analyze the current status of outcomes reporting in clinical trials on treating stasis acute mastitis with Traditional Chinese Medicine breast massage.</p></div><div><h3>Methods</h3><p>We searched CNKI, Wanfang, VIP, SinoMed, PubMed, Web of Science, Embase, Cochrane library, JBI, CINAHL, PsycINFO, Clinical Trials Registry Platform portal, Clinical Trials Registry, Australian New Zealand Clinical Trials Registry, Center Watch Registry from inception to May IS, 2022 to find randomized controlled trials, non-randomized controlled trials, case series and cohort studies which reported the outcomes of stasis acute mastitis managed with Traditional Chinese Medicine breast massage, with search terms of mastitis, acute mastitis, lactation mastitis, puerperal mastitis, breast problem, breast engorgement, milk stasis, blocked ducked, breast pain, breast massage, and acupoint massage. Outcomes and the measurement schemes (measurement methods, timing of assessing outcome, frequency of assessing outcome, measurers) were extracted from the included studies. We used the Management of Otitis Media with Effusion in Children with Cleft Palate (MOMENT) to assess the quality of each study, then categorized outcomes derived from the included studies into different domains according to the Outcome Measures in Rheumatology Arthritis Clinic Trials (OMERACT) Filter 2.1 framework.</p></div><div><h3>Results</h3><p>We identified 85 clinical trials, in which 54 different outcomes were reported. A total of 81.2% (69/85) of studies were assessed as medium quality with a mean score of 2.6, and 18.8% (16/85) as low quality with a mean score of 0.9. These outcomes were organized in three core areas. Lump size (89.4%, 76/85) was the most frequently reported outcome, followed by breast pain (69.4%, 59/85) and milk excretion (68.2%, 58/85). Five methods were used to assess lump size and four methods to assess breast pain.</p></div><div><h3>Conclusions</h3><p>The outcomes reported in clinical trials regarding stasis acute mastitis treated by Traditional Chinese Medicine breast massage are heterogeneous. Developing a core outcome set to achieve consistent standards for reporting outcomes and modalities for validation of the outcomes is clearly warranted.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"38 2","pages":"Pages 147-158"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Appraisal of Clinical Competence in Echocardiography of Chinese Intensivists Post Basic Echocardiography Training","authors":"Wei He ,&nbsp;Xue-Ying Zeng ,&nbsp;Hong-Min Zhang ,&nbsp;Xiao-Ting Wang ,&nbsp;Yan-Gong Chao ,&nbsp;Critical Care Ultrasound Study Group","doi":"10.24920/004174","DOIUrl":"10.24920/004174","url":null,"abstract":"<div><h3>Objectives</h3><p>To learn the echocardiography skills of intensivists after receiving a basic critical care echocardiography training course, and investigate factors that may influence their performance.</p></div><div><h3>Methods</h3><p>We completed a web-based questionnaire that assessed the skills in ultrasound scanning techniques of intensivists who took a training course on basic critical care echocardiography held in 2019 and 2020. Mann-Whitney test was used to analyze the factors which might affect their performance on image acquisition, recognizing clinical syndrome, and measuring the diameter of inferior vena cava, left ventricular ejection fraction and left ventricular outflow tract velocity-time integral.</p></div><div><h3>Results</h3><p>We enrolled 554 physicians from 412 intensive care units across China. Among them, 185 (33.4%) reported that they had 10%–30% chance of being misled by critical care echocardiography when making therapeutic decision, and 34 (6.1%) reported that the chance was greater than 30%. Intensivists who performed echocardiography under the guidance of a mentor and finished ultrasound scanning more than 10 times per week reported significant higher scores in image acquisition, clinical syndrome recognition, and quantitative measurement of inferior vena cava diameter, left ventricular ejection fraction and left ventricular outflow tract velocity-time integral than those without mentor and performing echocardiography 10 times or less per week respectively (all <em>p &lt;</em> 0.05).</p></div><div><h3>Conclusion</h3><p>The skills in diagnostic medical echocardiography of Chinese intensivists after a basic echocardiographic training course remain low, and further quality assurance training program is clearly warranted.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"38 2","pages":"Pages 125-129"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9916247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Mean Value of Central Venous Pressure from Monitor Digital Display: Influence of Amplitude of Central Venous Pressure during Respiration","authors":"Meng-Ru Xu ,&nbsp;Wang-Lin Liu ,&nbsp;Huai-Wu He ,&nbsp;Xiao-Li Lai ,&nbsp;Mei-Ling Zhao ,&nbsp;Da-Wei Liu ,&nbsp;Yun Long","doi":"10.24920/004158","DOIUrl":"10.24920/004158","url":null,"abstract":"<div><h3>Background</h3><p>A simple measurement of central venous pressure (CVP)-mean by the digital monitor display has become increasingly popular. However, the agreement between CVP-mean and CVP-end (a standard method of CVP measurement by analyzing the waveform at end-expiration) is not well determined. This study was designed to identify the relationship between CVP-mean and CVP-end in critically ill patients and to introduce a new parameter of CVP amplitude (ΔCVP= CVPmax – CVPmin) during the respiratory period to identify the agreement/disagreement between CVP-mean and CVP-end.</p></div><div><h3>Methods</h3><p>In total, 291 patients were included in the study. CVP-mean and CVP-end were obtained simultaneously from each patient. CVP measurement difference (| CVP-mean – CVP-end |) was defined as the difference between CVP-mean and CVP-end. The ΔCVP was calculated as the difference between the peak (CVPmax) and the nadir value (CVPmin) during the respiratory cycle, which was automatically recorded on the monitor screen. Subjects with | CVP-mean – CVP-end | ≥ 2 mmHg were divided into the inconsistent group, while subjects with | CVP-mean – CVP-end | &lt; 2 mmHg were divided into the consistent group.</p></div><div><h3>Results</h3><p>ΔCVP was significantly higher in the inconsistent group [7.17(2.77) <em>vs</em>.5.24(2.18), <em>p</em>&lt;0.001] than that in the consistent group. There was a significantly positive relationship between ΔCVP and | CVP-mean – CVP-end | (<em>r</em>=0.283, <em>p</em> &lt;0.0001). Bland-Altman plot showed the bias was -0.61 mmHg with a wide 95% limit of agreement (–3.34, 2.10) of CVP-end and CVP-mean. The area under the receiver operating characteristic curves (AUC) of ΔCVP for predicting | CVP-mean – CVP-end | ≥ 2 mmHg was 0.709. With a high diagnostic specificity, using ΔCVP&lt;3 to detect | CVP-mean – CVP-end | lower than 2mmHg (consistent measurement) resulted in a sensitivity of 22.37% and a specificity of 93.06%. Using ΔCVP&gt;8 to detect | CVP-mean – CVP-end | &gt;8 mmHg (inconsistent measurement) resulted in a sensitivity of 31.94% and a specificity of 91.32%.</p></div><div><h3>Conclusions</h3><p>Conclusions CVP-end and CVP-mean have statistical discrepancies in specific clinical scenarios. ΔCVP during the respiratory period is related to the variation of the two CVP methods. A high ΔCVP indicates a poor agreement between these two methods, whereas a low ΔCVP indicates a good agreement between these two methods.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"38 2","pages":"Pages 117-124"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9860033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Constipation and a Reduction in Lower Limb Muscle Strength in Preoperative Patients with Thoracic Spinal Tumors","authors":"Yong Liu,&nbsp;Si-Yuan Yao,&nbsp;Xi Zhou,&nbsp;Shu-Zhong Liu,&nbsp;Yan-Yan Bian","doi":"10.24920/004154","DOIUrl":"10.24920/004154","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the clinical symptoms experienced by patients with thoracic spinal tumors and verify the associated symptoms that are predictive of a decline in muscle strength in the lower limbs.</p></div><div><h3>Methods</h3><p>A single-center, retrospective cross-sectional study was conducted on in-patients diagnosed with epidural thoracic spinal tumors between January 2011 and May 2021. The study involved a review of electronic medical records and radiographs and the collection of clinical data. The differences in clinical manifestations between patients with constipation and those without constipation were analyzed. Binary logistic regression analyses were performed to identify risk factors associated with a decline in muscle strength in the lower limbs.</p></div><div><h3>Results</h3><p>A total of 227 patients were enrolled, including 131 patients with constipation and 96 without constipation. The constipation group had a significantly higher proportion of patients who experienced difficulty walking or paralysis compared to those without constipation prior to surgery (83.2% <em>vs.</em> 17.7%, <em>χ</em>² <em>=</em> 99.035, <em>p</em> &lt; 0.001). Constipation (<em>OR =</em> 9.522, 95%<em>CI</em>: 4.150-21.849, <em>p</em> &lt; 0.001) and urinary retention (<em>OR =</em> 14.490, 95%<em>CI</em>: 4.543–46.213, <em>p</em> &lt; 0.001) were independent risk factors for muscle strength decline in the lower limbs.</p></div><div><h3>Conclusions</h3><p>The study observed that patients with thoracic spinal tumors who experienced constipation symptoms had a higher incidence of lower limb weakness. Moreover, the analysis revealed that constipation and urinary retention were independent risk factors associated with a preoperative decline in muscle strength of lower limbs.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"38 2","pages":"Pages 109-116"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9851475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab for Treatment of Food-Dependent, Exercise-Induced Anaphylaxis: Report of One Case","authors":"Li-Ping Zhu ,&nbsp;Rui Tang ,&nbsp;Qing Wang,&nbsp;Hong Li","doi":"10.24920/004208","DOIUrl":"10.24920/004208","url":null,"abstract":"<div><p>Food-dependent, exercise-induced anaphylaxis (FDEIA) is a potentially life-threatening disorder that often occurs with exercise, and patients typically have eaten a specific food within hours before disease onset. This disease is exceedingly rare, with a prevalence of 0.02%. No well-recognized prevention or treatment strategy has been available for FDEIA except avoiding triggers strictly. Here we report an 11-year-old boy with a history of recurrent anaphylaxis of unknown etiology more than 10 times within two years. As the anaphylactic symptoms had not been controlled after traditional treatments, the patient was given subcutaneous injection of dupilumab seven times within 33 weeks. During dupilumab treatments, the patient was exposed to culprit mushrooms plus exercises at least twice a month but without notable anaphylaxis. Thus, dupilumab may improve the allergic reactions in FDEIA patients.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"38 2","pages":"Pages 159-162"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9858131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures","authors":"Xu Chen ,&nbsp;Hong-Ling Liu ,&nbsp;Jin-Sui Wang ,&nbsp;Feng-Hui Zhao","doi":"10.24920/004183","DOIUrl":"10.24920/004183","url":null,"abstract":"<div><h3>Objective</h3><p>Primary ovarian small cell carcinoma of pulmonary type (SCCOPT) is a rare ovarian tumor with a poor prognosis. The platinum-based chemotherapy is the standard treatment. However, there is little research on the clinical characteristics of SCCOPT and the potential benefits of other treatments due to its low incidence. The study aims to investigate clinicopathological characteristics and treatment of SCCOPT.</p></div><div><h3>Methods</h3><p>We summarized the clinical, imaging, laboratorical and pathological characteristics of 37 SCCOPT cases, in which 6 cases were admitted to the Gansu Provincial Hospital from the year of 2008 to 2022 and 31 cases reported in 17 English and 3 Chinese literatures.</p></div><div><h3>Results</h3><p>The median age of the studied SCCOPT cases (<em>n</em>=37) was 56.00 (range, 22–80) years. Almost 80% of them had a stage III or IV tumor. All patients underwent an operation and postoperative chemotherapy. Nevertheless, all cases had a poor prognosis, with a median overall survival time of 12 months. Immunohistochemically, the SCCOPT of all patients showed positive expressions of epithelial markers, such as CD56 and sex-determining region of Y chromosome-related high-mobility-group box 2 (SOX-2), and negative expressions of estrogen receptor, progesterone receptor, vimentin, Leu-7, and somatostatin receptor 2. The tumor of above 80% cases expressed synaptophysin. Only a few cases expressed neuron-specific enolase, chromogranin A, and thyroid transcription factor-1.</p></div><div><h3>Conclusions</h3><p>SCCOPT had a poor prognosis. SOX-2 could be a biomarker to be used to diagnose SCCOPT.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"38 2","pages":"Pages 130-137"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9852028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central Granular Cell Odontogenic Tumor: A Literature Review of Cases Reported in the Last 71 Years with a New Case Report","authors":"Fatemeh Mashhadiabbas ,&nbsp;Sanaz GholamiToghchi ,&nbsp;Roohollah Safarpour","doi":"10.24920/004159","DOIUrl":"10.24920/004159","url":null,"abstract":"<div><p>Central granular cell odontogenic tumors (CGCOTs) are rare, benign, slowly growing odontogenic neoplasms. Due to their uncertain histogenesis, CGCOTs are still not included as a distinct entity in the WHO classification (2017) of odontogenic tumors. We report a case of CGCOT involving the right side of maxillary anterior region of a 39-year-old white female. Immunohistochemical staining showed that granular cells positively expressed CD68 and vimentin, and negatively expressed S-100 protein. Meanwhile, we searched PubMed, Google Scholar, and Scopus databases to summary the clinico-pathological features of 51 reported cases of CGCOT. The results showed that the granular cells of 28.6% cases were immunopositive for vimentin and CD68, and odontogenic epithelial cells were positive immunoreactivity for cytokeratin. These findings reinforced the mesenchymal origin of granular cells and the odontogenic nature of epithelium islands.</p></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"38 2","pages":"Pages 138-146"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9914356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}