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Progress on fluorescent RNA and fluorescent NA-based biosensing technology. 基于荧光 RNA 和荧光 NA 的生物传感技术的进展。
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji Pub Date : 2024-02-20 DOI: 10.16288/j.yczz.23-306
Fang-Ting Zuo, Ya-Qiang Zhang, Hui-Min Yang, Yi Yang, Xian-Jun Chen
{"title":"Progress on fluorescent RNA and fluorescent NA-based biosensing technology.","authors":"Fang-Ting Zuo, Ya-Qiang Zhang, Hui-Min Yang, Yi Yang, Xian-Jun Chen","doi":"10.16288/j.yczz.23-306","DOIUrl":"10.16288/j.yczz.23-306","url":null,"abstract":"<p><p>Fluorescent RNA is a kind of emerging RNA labeling technique that can be used for <i>in situ</i> labeling and imaging of RNA in live cells, which plays an important role in understanding the function and regulation mechanism of RNA. Biosensing technology based on fluorescent RNA can be applied in dynamic detection of small molecule metabolites and proteins in real time, offering valuable tools for basic life science research and biomedical sensing technology development. In this review, we introduce the development of genetically encoded fluorescent RNA, and the application of fluorescent RNA in RNA imaging and biosensing technology based on fluorescent RNA in biosensing in live cell. Meanwhile, we discuss the direction and challenge of future development of fluorescent RNA technology to provide valuable insights for further development and application of this technology in relevant fields.</p>","PeriodicalId":35536,"journal":{"name":"Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji","volume":"46 2","pages":"92-108"},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification and characterization analysis of the HDM gene family in melon (Cucumis melo L.). 甜瓜(Cucumis melo L.)中 HDM 基因家族的鉴定和特征分析。
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji Pub Date : 2024-02-20 DOI: 10.16288/j.yczz.23-226
Zhi Zhang, Jing Zhang, Jin Zhang, Agula Hasi, Jin-Feng Hao
{"title":"Identification and characterization analysis of the HDM gene family in melon (<i>Cucumis melo</i> L.).","authors":"Zhi Zhang, Jing Zhang, Jin Zhang, Agula Hasi, Jin-Feng Hao","doi":"10.16288/j.yczz.23-226","DOIUrl":"10.16288/j.yczz.23-226","url":null,"abstract":"<p><p>Histone demethylase (HDM) play crucial roles in regulating plant growth and environmental adaptation. In this study, the HDM gene family in melon was identified by bioinformatics methods and the expression patterns of the CmHDM family members in different melon tissues were analyzed using transcriptome data. The results showed that 20 <i>CmHDM</i> genes were identified in the melon genome, which were unevenly distributed across each chromosome. These members fall into two major categories: LSD1 and JmjC. The JmjC group could be further divided into five subgroups with different numbers. The results of collinearity analysis of intraspecific and interspecific relationships showed that there were only one pair of segmental duplication in melon <i>HDM</i> genes, and more collinearity in genetic relationship of <i>HDM</i> genes between melon and tomato. The numbers of conserved domains, exons and introns in each member vary and various <i>cis</i>-acting elements responding to hormones and environmental signals existed in the respective promoter regions. Expression analysis showed that the respective gene members were expressed at different levels in male flowers, female flowers, roots, stems, leaves, ovary, and mature fruits of melon. These results will contribute to the understanding on the potential functions of the <i>HDM</i> genes and their potential functions in regulating melon growth and environmental adaptation.</p>","PeriodicalId":35536,"journal":{"name":"Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji","volume":"46 2","pages":"168-180"},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paternal genetic structure analysis of the modern Han populations based on Y-SNP and Y-STR. 基于 Y-SNP 和 Y-STR 的现代汉族人群父系遗传结构分析。
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji Pub Date : 2024-02-20 DOI: 10.16288/j.yczz.23-260
Xin Zhu, Xin Jin, Jun Liu, Lan Yang, Li-Xin Zou, Cai-Xia Li, Jiang Huang, Li Jiang
{"title":"Paternal genetic structure analysis of the modern Han populations based on Y-SNP and Y-STR.","authors":"Xin Zhu, Xin Jin, Jun Liu, Lan Yang, Li-Xin Zou, Cai-Xia Li, Jiang Huang, Li Jiang","doi":"10.16288/j.yczz.23-260","DOIUrl":"10.16288/j.yczz.23-260","url":null,"abstract":"<p><p>The Han populations represent the largest ethnic group in China. Previous studies have primarily focused on investigating their genetic origins, migration and integration, as well as paternal genetic relationships within specific regional Han populations. However, a comprehensive analysis of the global paternal genetic structure of Han populations is lacking. In this study, we performed Y-chromosome sequencing on 362 unrelated male samples from Chinese Han individuals collected from Qinghai, Sichuan and Liaoning provinces. We then integrated relevant data from reported studies. Our final dataset comprised 1830 samples from 16 Han populations across 15 provinces in China, encompassing information on 89 Y-SNPs and 16 Y-STRs. Statistical analyses were conducted to assess Y-STR haplotype diversity (HD) and Y-SNP haplogroup frequencies. Additionally, we employed principal component analysis (PCA), phylogenetic tree and haplotype network to explore genetic differentiation within Han populations and the genetic relationships between Han populations and ethnic minorities surrounding them. Our results demonstrated that the O-M175 haplogroup represents the predominant paternal lineage in Han populations, with frequencies ranging from 60.53% (Qinghai Han) to 92.7% (Guangdong Han). Moreover, the subclades downstream of O-M175 showed distinct regional variations in their distribution patterns. The O2-M122 haplogroup was prevalent in all Han populations and demonstrated a gradual decline in frequency from north to south. Conversely, the distribution frequency of the O1b-M268 haplogroup decreased from south to north, particularly showed significant presence among Han populations in the Lingnan region. Haplogroup O1a-M119 distributed more frequently in the central Han populations. Our findings revealed that Chinese Han populations can be categorized into three subgroups: northern, central, and southern. Notably, there were significant differences among Han in Qinghai and other regions. Regarding the genetic relationships between Han populations and surrounding ethnic minorities, we observed a closer genetic affinity between different Han populations, but northern Han demonstrated a stronger relationship with the Hui ethnic group, while southern Han exhibited a closer connection with the Gelao and Li ethnic groups. In summary, this study presented a systematic analysis of haplogroup distribution, genetic substructure of Han populations and genetic relationships between Han populations and surrounding ethnic minorities based on 89 Y-SNPs and 16 Y-STRs systematically. Our research supplemented valuable insights into population genetics and forensic genetics, and provided data support for the forensic application of Y chromosome. The integration of Y-SNP haplogroups with Y-STR haplotypes offers enhanced understanding of the genetic substructure within Han populations, which holds significance for both population genetics research and forensic science applicati","PeriodicalId":35536,"journal":{"name":"Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji","volume":"46 2","pages":"149-167"},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of chromosomal genetic characteristics and identification of structural variation in the offspring of hexaploid triticale×hexaploid wheat. 六倍体三倍体小麦×六倍体小麦后代染色体遗传特征的调查和结构变异的鉴定。
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji Pub Date : 2024-01-20 DOI: 10.16288/j.yczz.23-212
Man-Yu Yang, Fang-Jie Yao, Zu-Jun Yang, En-Nian Yang
{"title":"Investigation of chromosomal genetic characteristics and identification of structural variation in the offspring of hexaploid triticale×hexaploid wheat.","authors":"Man-Yu Yang, Fang-Jie Yao, Zu-Jun Yang, En-Nian Yang","doi":"10.16288/j.yczz.23-212","DOIUrl":"10.16288/j.yczz.23-212","url":null,"abstract":"<p><p>Hexaploid triticale is an important genetic resource for genetic improvement of common wheat, which can broaden the genetic basis of wheat. In order to lay a foundation for the subsequent research and utilization of triticale germplasm materials, the chromosomal genetic characteristics of cross and backcross offspring of hexaploid triticale×hexaploid wheat were investigated in the process of transferring rye chromatin from hexaploid triticale to hexaploid wheat. Hybrid and backcross combinations were prepared with hexaploid triticale 16yin171 as the maternal parent and hexaploid wheat Chuanmai62 as the paternal parent. The chromosomes in root tip cells of F<sub>1</sub>, BC<sub>1</sub>F<sub>1</sub> and BC<sub>1</sub>F<sub>2</sub> plants were traced and identified non-denaturing florescence in situ hybridization (ND-FISH). The results indicated that the backcross setting rate of hybrid F<sub>1</sub> was 2.61%. The transmission frequency of 2R chromosome was the highest in BC<sub>1</sub>F<sub>1</sub> plants while the transmissibility of rye chromosome in BC<sub>1</sub>F<sub>2</sub> plant was 6R>4R>2R, and the 5B-7B wheat translocation in BC<sub>1</sub>F<sub>2</sub> plants showed severe segregation. A total of 24 structural variant chromosomes were observed both in BC<sub>1</sub>F<sub>1</sub> and BC<sub>1</sub>F<sub>2</sub> plants, including chromosome fragments, isochromosomes, translocations, and dicentric chromosomes. In addition, the seed length and 1000-grain weight of some BC<sub>1</sub>F<sub>2</sub> plants were better than that of the hexaploid wheat parent Chuanmai 62. Therefore, multiple backcrosses should be adopted as far as possible to make the rapid recovery of group D chromosomes, ensuring the recovery of fertility in offspring, when hexaploid tritriale is used as a bridge to introduce rye genetic material into common wheat. At the same time, the potential application value of chromosomal structural variation materials should be also concerned.</p>","PeriodicalId":35536,"journal":{"name":"Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji","volume":"46 1","pages":"63-77"},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139479180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of Mycobacterium biofilm development and novel measures against antibiotics resistance. 分枝杆菌生物膜发展的调控和抗生素耐药性的新措施。
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji Pub Date : 2024-01-20 DOI: 10.16288/j.yczz.23-205
Abulimiti Abudukadier, Qi-Ao Zhang, Pei-Bo Li, Jian-Ping Xie
{"title":"Regulation of Mycobacterium biofilm development and novel measures against antibiotics resistance.","authors":"Abulimiti Abudukadier, Qi-Ao Zhang, Pei-Bo Li, Jian-Ping Xie","doi":"10.16288/j.yczz.23-205","DOIUrl":"10.16288/j.yczz.23-205","url":null,"abstract":"<p><p>Currently, there are over 170 recognized species of Mycobacterium, the only genus in the family Mycobacteriaceae. Organisms belonging to this genus are quite diverse with respect to their ability to cause disease in humans. The Mycobacterium genus includes human pathogens (Mycobacterium tuberculosis complex and Mycobacterium leprae) and environmental microorganisms known as non-tuberculosis mycobacteria (NTM). A common pathogenic factor of Mycobacterium is the formation of biofilms. Bacterial biofilms are usually defined as bacterial communities attached to the surface, and are also considered as shared spaces of encapsulated microbial cells, including various extracellular polymeric substrates (EPS), such as polysaccharides, proteins, amyloid proteins, lipids, and extracellular DNA (EDNA), as well as membrane vesicles and humic like microorganisms derived refractory substances. The assembly and dynamics of the matrix are mainly coordinated by second messengers, signaling molecules, or small RNAs. Fully deciphering how bacteria provide structure for the matrix, thereby promoting extracellular reactions and benefiting from them, remains a challenge for future biofilm research. This review introduces a five step development model for biofilms and a new model for biofilm formation, analyses the pathogenicity of biofilms, their interactions with bacteriophages and host immune cells, and the key genes and regulatory networks of mycobacterial biofilms, as well as mycobacterial biofilms and drug resistance, in order to provide a basis for clinical treatment of diseases caused by biofilms.</p>","PeriodicalId":35536,"journal":{"name":"Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji","volume":"46 1","pages":"34-45"},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139479235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular and evolutionary mechanisms of self-incompatibility in angiosperms. 被子植物自相容性的分子和进化机制。
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji Pub Date : 2024-01-20 DOI: 10.16288/j.yczz.23-300
Hong Zhao, Yong-Biao Xue
{"title":"Molecular and evolutionary mechanisms of self-incompatibility in angiosperms.","authors":"Hong Zhao, Yong-Biao Xue","doi":"10.16288/j.yczz.23-300","DOIUrl":"10.16288/j.yczz.23-300","url":null,"abstract":"<p><p>As an intraspecific outcrossing mechanism, self-incompatibility (SI) widely adopted by hermaphroditic plants is usually controlled by a polymorphic multi-allelic S locus. Typically, six molecular types of SI have been found, including type-I controlled by the pistil S S-RNase and pollen S SLFs commonly spread in Plantaginaceae, Solanaceae, Rosaceae and Rutaceae, type-II by SRK and SCR in Brassicaceae, type-III by PrsS and PrpS in Papaveraceae, type-IV by CYP-GLO2-KFB-CCM-PUM in Primulaceae, type-V by TsSPH1-TsYUC6-TsBAHD in Turneraceae and type-VI by HPS10-S and DUF247I-S in Poaceae, with type-I characterized as a non-self recognition system but types-II, -III and -VI self ones. Furthermore, remarkable progresses have been made in their origin and evolutionary mechanisms recently. Among them, type-I SI possessed a single origin in the most recent common ancestor of eudicots and types II-V dynamically evolved following its losses, while type-VI SI exclusively existed in monocot Poaceae may be regained after the loss of the ancient type-I. Here, we mainly review the molecular and evolutionary mechanisms of angiosperm SI systems, thus providing a helpful reference for their theoretical research and breeding application.</p>","PeriodicalId":35536,"journal":{"name":"Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji","volume":"46 1","pages":"3-17"},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139479267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genes that escape from X-chromosome inactivation and sexual dimorphism of systemic lupus erythematosus. 摆脱 X 染色体失活的基因与系统性红斑狼疮的性别二态性。
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji Pub Date : 2024-01-20 DOI: 10.16288/j.yczz.23-214
Qian Ma, Shao-Lan Zhou, Jie Dang, Zheng-Hao Huo, Zhan-Bing Ma
{"title":"Genes that escape from X-chromosome inactivation and sexual dimorphism of systemic lupus erythematosus.","authors":"Qian Ma, Shao-Lan Zhou, Jie Dang, Zheng-Hao Huo, Zhan-Bing Ma","doi":"10.16288/j.yczz.23-214","DOIUrl":"10.16288/j.yczz.23-214","url":null,"abstract":"<p><p>X chromosome inactivation can balance the effects of the two X chromosomes in females, and emerging evidence indicates that numerous genes on the inactivated X chromosome have the potential to evade inactivation. The mechanisms of escape include modification of DNA, RNA, histone, epitope, and various regulatory proteins, as well as the spatial structure of chromatin. The study of X chromosome inactivation escape has paved the way for investigating sex dimorphism in human diseases, particularly autoimmune diseases. It has been demonstrated that the presence of TLR7, CD40L, IRAK-1, CXCR3, and CXorf21 significantly contributes to the prevalence of SLE (systemic lupus erythematosus) in females. This article mainly reviews the molecular mechanisms underlying these genes that escape from X-chromosome inactivation and sexual dimorphism of systemic lupus erythematosus. Therefore, elucidating the molecular mechanisms underlying sexual dimorphism in SLE is not only crucial for diagnosing and treating the disease, but also holds theoretical significance in comprehensively understanding the development and regulatory mechanisms of the human immune system.</p>","PeriodicalId":35536,"journal":{"name":"Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji","volume":"46 1","pages":"18-33"},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139479260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PTBP1 promotes the progression of hepatocellular carcinoma by enhancing the oncogenic splicing switch of FGFR2. PTBP1 通过增强 FGFR2 的致癌剪接转换来促进肝细胞癌的进展。
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji Pub Date : 2024-01-20 DOI: 10.16288/j.yczz.23-224
Yu-Ying Chen, Qian Zhang, Meng-Hui Gui, Lan Feng, Peng-Bo Cao, Gang-Qiao Zhou
{"title":"PTBP1 promotes the progression of hepatocellular carcinoma by enhancing the oncogenic splicing switch of FGFR2.","authors":"Yu-Ying Chen, Qian Zhang, Meng-Hui Gui, Lan Feng, Peng-Bo Cao, Gang-Qiao Zhou","doi":"10.16288/j.yczz.23-224","DOIUrl":"10.16288/j.yczz.23-224","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer accounting for 90% of cases. It is a highly invasive and deadly cancer with a gradual onset. Polypyrimidine tract-binding protein 1 (PTBP1) is an important RNA-binding protein involved in RNA metabolism and has been linked to oncogenic splicing events. While the oncogenic role of PTBP1 in HCC cells has been established, the exact mechanism of action remains unclear. This study aimed to investigate the functional connection between PTBP1 and dysregulated splicing events in HCC. Through immunoprecipitation-mass spectrometry analyses, we discovered that the proteins bound to PTBP1 were significantly enriched in the complex responsible for the alternative splicing of FGFR2 (fibroblast growth factor receptor 2). Further RNA immunoprecipitation and quantitative PCR assays confirmed that PTBP1 down-regulated the FGFR2-IIIb isoform levels and up-regulated the FGFR2-IIIc isoform levels in HCC cells, leading to a switch from FGFR2-IIIb to FGFR2-IIIc isoforms. Subsequent functional evaluations using CCK-8, transwell, and plate clone formation assays in HCC cell lines HepG2 and Huh7 demonstrated that FGFR2-IIIb exhibited tumor-suppressive effects, while FGFR2-IIIc displayed tumor-promoting effects. In conclusion, this study provides insights into the PTBP1-mediated alternative splicing mechanism in HCC progression, offering a new theoretical basis for the prevention and treatment of this malignancy. Mechanistically, the isoform switch from FGFR2-IIIb to FGFR2-IIIc promoted epithelial-mesenchymal transformation (EMT) of HCC cells and activated the FGFR cascades ERK and AKT pathways.</p>","PeriodicalId":35536,"journal":{"name":"Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji","volume":"46 1","pages":"46-62"},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139479276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation on the construction of teaching case base in medical genetics. 医学遗传学教学案例库建设调查。
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji Pub Date : 2024-01-20 DOI: 10.16288/j.yczz.23-241
Mao Zhang, Yan-Yan Wang, Yun Bai, Xue-Dan Chen, Hong Guo
{"title":"Investigation on the construction of teaching case base in medical genetics.","authors":"Mao Zhang, Yan-Yan Wang, Yun Bai, Xue-Dan Chen, Hong Guo","doi":"10.16288/j.yczz.23-241","DOIUrl":"10.16288/j.yczz.23-241","url":null,"abstract":"<p><p>Medical genetics is a basic medical course that discusses the diagnosis, prevention and treatment of diseases in relation with genetic factors. This course requires students who have abilities of strong logical thinking, independent thinking, problem analyzing and solving. Single \"cramming\" teaching is difficult to mobilize students' autonomous learning, and hardly achieves teaching effect of medical genetics. Teaching of case-based discussion breaks passive teaching mode in traditional class. The teacher throws out typically clinical cases. The students prepare materials around relevant problems of cases, and carry out class discussion. Then, key and difficult points of the course are integrated in teaching and learning interaction, which reaches a remarkable effect of teaching. Since 2013, the teaching and research group has carried out teaching of case-based discussion in undergraduates majoring in clinical medicine. In this paper, we screen and sort clinical cases on the basis of course teaching plan and case-based discussion in the teaching of medical genetics. The cases are summarized into 8 chapters in teaching case base, which basically cover the teaching of disease genetics and clinical genetics.The construction of teaching case base in medical genetics has realized the deep integration of clinical cases and teaching. Students can understand and master important and difficult points of teaching in a more intuitive way, which is helpful to stimulate students' innovative thinking, improve students' learning interest and class participation.</p>","PeriodicalId":35536,"journal":{"name":"Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji","volume":"46 1","pages":"78-87"},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139479185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetics comprehensive experimental course based on the integration of science and education to cultivate students' ability of cutting-edge innovation. 表观遗传学综合实验课程立足于科教融合,培养学生前沿创新能力。
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji Pub Date : 2023-12-20 DOI: 10.16288/j.yczz.23-179
Xiu-Fang Ou, Ying Wu, Ning Li, Li-Li Jiang, Bao Liu, Lei Gong
{"title":"Epigenetics comprehensive experimental course based on the integration of science and education to cultivate students' ability of cutting-edge innovation.","authors":"Xiu-Fang Ou, Ying Wu, Ning Li, Li-Li Jiang, Bao Liu, Lei Gong","doi":"10.16288/j.yczz.23-179","DOIUrl":"10.16288/j.yczz.23-179","url":null,"abstract":"<p><p>The integration of science and education is an effective way for universities to cultivate students in cutting-edge innovative interests. Epigenetics is the expansion of classical genetics, the corresponding experimental courses of which have not been integrated into the current teaching system. In this paper, by taking advantage of our laboratory's research on the DNA methylation maintenance gene, OsMET1-2 in rice, we have integrated our innovative findings in the education curriculum, and built a comprehensive teaching system on experimentation research, which greatly stimulates the curiosity of the students. Taking the OsMET1-2 mutants and its isogenic wild-type rice plants as experimental materials, this course has successfully demonstrated a causal link between genetic mutation and epigenetic variation, a topic widely interested by the students in learning genetics and epigenetics. Through the practice of this course, students have a deeper understanding of the important role of epigenetic modifications, their scientific research capabilities have been greatly improved, thereby strongly supporting the cultivation of top innovative talents among the students.</p>","PeriodicalId":35536,"journal":{"name":"Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji","volume":"45 12","pages":"1158-1168"},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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