International Journal of Digestive Diseases最新文献

{"title":"Patient Satisfaction with IBS Symptom Relief Using a Novel Peppermint Oil Delivery System in a Randomized Clinical Trial and in the General Population","authors":"Cash Bd, Epstein Ms, Shahani Sm","doi":"10.4172/2472-1891.100027","DOIUrl":"https://doi.org/10.4172/2472-1891.100027","url":null,"abstract":"Background: A recent randomized clinical trial (RCT) of a novel peppermint oil preparation (PO-SST) demonstrated significant relief of irritable bowel syndrome (IBS) symptoms versus placebo. In addition to efficacy, patient satisfaction and post-marketing utilization are also important to assess. \u0000 \u0000Methods: The RCT included an end-of-study questionnaire for subjects in the active arm to evaluate overall satisfaction with IBS symptom relief. A separate post-marketing study was conducted in the general population to assess real world satisfaction and dosing frequency of open label PO-SST in patients with IBS. The dosing frequency in the RCT was fixed at 2 capsules three times daily (TID), while the post-marketing patient population was allowed flexible dosing. \u0000 \u0000Results: Thirty-five subjects randomized to PO-SST in the RCT and 285 patients in the post-marketing study were included in this analysis. There was a high satisfaction rate (>80%) with PO-SST in both studies. Most patients in the postmarketing population (60.8%) used 1 to 2 capsules per day, and 75.6% reported IBS symptom reduction within 1-2 hours of ingestion. Patients in the RCT reported significant reduction in IBS symptoms 24 hours after the first dose of PO-SST. \u0000 \u0000Discussion: PO-SST showed a high rate of satisfaction among patients participating in an RCT and the general patient population. Symptom improvement was rapid and remarkably similar in both groups, despite the lower daily capsule intake by patients in the general population.","PeriodicalId":355284,"journal":{"name":"International Journal of Digestive Diseases","volume":"372 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133227345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the Best Way for Helicobacter pylori Treatment","authors":"E. Shahverdi, M. Khani","doi":"10.4172/2472-1891.100029","DOIUrl":"https://doi.org/10.4172/2472-1891.100029","url":null,"abstract":"2Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran 3Department of Medicine, Najafabad Branch, Islamic Azad University, Najafabad, Iran *Corresponding author: Shahverdi E, Immunohematology Department, Blood Transfusion Research Center/High Institute for Research Center and Education in Transfusion Medicine, Tehran, Iran, Tel: +982188601606; E-mail: shahverdi_ehsan@yahoo.com","PeriodicalId":355284,"journal":{"name":"International Journal of Digestive Diseases","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116857602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Spontaneous Isolated Dissecting Aneurysm of Distal Celiac Artery\"- A Rare and Lethal Incidental Finding","authors":"U. Chauhan, N. Jain, L. Garg, A. Goel, S. Puri","doi":"10.4172/2472-1891.100019","DOIUrl":"https://doi.org/10.4172/2472-1891.100019","url":null,"abstract":"Aneurysm of celiac artery is an uncommon occurrence with nearly 180 cases being reported in the literature so far [1]. These have been attributed to traumatic, iatrogenic and inflammatory being amongst few associated etiological factors. Spontaneous isolated dissecting aneurysm of celiac trunk is a rare occurrence with very few cases being mentioned in the published literature. Although the rate of rupture was 72% to 87% during the 1st half of the 20th century, advances in diagnostic imaging and early surgical intervention have reduced the rupture rate to 7% in recent years [1]. Early recognition and urgent intervention is required to prevent fatal complications like intraperitoneal rupture. Authors present a case of isolated spontaneous dissecting aneurysm of distal celiac artery in a fifty five year old male patient with alcoholic cirrhosis.","PeriodicalId":355284,"journal":{"name":"International Journal of Digestive Diseases","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121655650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leptin and Non-Alcoholic Fatty Liver Disease: Hints From Preliminary Clinical Studies","authors":"Li Zhang, G. Ji","doi":"10.4172/2472-1891.100008","DOIUrl":"https://doi.org/10.4172/2472-1891.100008","url":null,"abstract":"The product of the ob gene leptin was first identified and cloned from rodent adipose tissue in 1994. It was pioneerly considered to play a role in the regulation of the energy balance, as leptin deficient ob/ob mice showed typical features of metabolic syndrome (MS). Individuals that less responsive to the action of leptin led to the concept of leptin resistance. Multiple biological processes can promote leptin resistance and thus interfere with related diseases. Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of MS became world epidemics along with other MS components such as diabetes, obesity, and leptin resistance is indicated in the process.","PeriodicalId":355284,"journal":{"name":"International Journal of Digestive Diseases","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132859671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Take Irritable Bowel Syndrome,Causes and Treatment","authors":"E. Shahverdi, M. Khani, A. Asadollah","doi":"10.4172/2472-1891.100031","DOIUrl":"https://doi.org/10.4172/2472-1891.100031","url":null,"abstract":"Citation: Shahverdi E, Khani MA, Asadollah A. Take Irritable Bowel Syndrome, Causes and Treatment. Int J Dig Dis. 2017, 3:1. Irritable Bowel Syndrome (IBS) is a functional bowel disorder that is associated with chronic abdominal pain, the discomfort of defecation, bloating and changes in bowel habits, determined without any other organic causes. The etiology of the syndrome appears to be multifactorial, but pathology is unknown. Although several mechanisms affect the type and severity of symptoms of IBS. A stressful event or the onset of puberty can be the initiator of this syndrome without other medical reason.","PeriodicalId":355284,"journal":{"name":"International Journal of Digestive Diseases","volume":"48 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132974617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatotoxicity and the Role of Some Herbal Hepatoprotective Plants in PresentScenario","authors":"R. Srivastava, P. Srivastava","doi":"10.4172/2472-1891.100034","DOIUrl":"https://doi.org/10.4172/2472-1891.100034","url":null,"abstract":"Liver is the principal site for metabolism and excretion in body. The human liver metabolizes substances by various biochemical pathways including oxidation, reduction, hydration, condensation, hydrolysis, conjugation or isomerization. Disorder of any of the afore mentioned process may lead to liver cell injury, what we call as hepatotoxicity which in turn leads to many diseases. Such diseases are responsible for higher mortality rates worldwide. Hepatotoxicity can be due to medicines, chemicals, dietary disturbances or herb induced liver damage via hepatotoxins. A number of herbal and herbomineral preparations are available in the Ayurveda, the traditional Indian Medicine which have been investigated for their hepatoprotective potential to treat different types of liver disorders. The present review is focused on different herbal plants that have potential to cure the hepatotoxicity.","PeriodicalId":355284,"journal":{"name":"International Journal of Digestive Diseases","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126310434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levels in Decision Making and Techniques for Clinicians","authors":"M. Molinari, S. Guler, S. Hurton, M. Winn","doi":"10.4172/2472-1891.100002","DOIUrl":"https://doi.org/10.4172/2472-1891.100002","url":null,"abstract":"In the last century, there has been tremendous advancements in medicine and surgery and this progress has resulted in an over expansion of the number of treatment options that are available to treat many conditions. The enlarging armamentarium available to modern physicians should be celebrated. However, this has come with a significant increase in the complexity of decisions that physicians have to make when they select a therapy among many that have comparable efficacy. For example, small hepatocellular carcinomas can be treated with liver transplantation, surgical resection or locoregional therapies, with similar overall survival but different disease free survival and morbidities. One of the primary goals of decision analysis is to help decision makers. In healthcare, this translates in more cost-effective treatments, higher patients’ satisfaction and overall better outcomes. Because judgments of uncertainty are a critical part of medical decision-making, decision analysis tends to improve the accuracy of these judgments by using specific algorithms and techniques. The main aim of this review is to make clinicians familiar with the different levels of decision analysis. In this paper, we will describe common techniques that are used to elicit patients’ preferences, the meaning of utilities and the benefit and limitations of decision analysis in health care.","PeriodicalId":355284,"journal":{"name":"International Journal of Digestive Diseases","volume":"7 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120806775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing the Learning Curve and Accuracy of Wireless Capsule Endoscopy Interpretation amongst Digestive Healthcare Practitioners","authors":"V. Ch, rasekhara, R. Shinohara, K. Dunbar, Monica Riegert, Eric Tomakin, G. Mullin","doi":"10.4172/2472-1891.100016","DOIUrl":"https://doi.org/10.4172/2472-1891.100016","url":null,"abstract":"Goals: To prospectively evaluate the accuracy and learning curve of trainees to interpret wireless capsule endoscopy (WCE). \u0000Background: Trainees and mid-level providers are often used as first-line readers to earmark WCE images that are subsequently reviewed by an attending gastroenterologist. This practice has been demonstrated to be cost-effective and highly accurate, but the learning curve of trainees and physician extenders has not been well described. \u0000Study: Each WCE trainee individually reviewed and interpreted 48 fulllength de-identified WCE studies and recorded significant findings, time required to interpret each study, and confidence of the interpretation. After every 10 studies, each trainee reviewed WCE findings with the expert. The first 10 studies were considered the training period with the next 19 studies considered study period 1 and last 19 studies considered study period 2. Reading times were compared using Wilcoxon rank-sum tests. Results: The median time for WCE interpretation improved significantly from the training period to the first study period for each trainee; GI fellow (41 min vs. 21 min, p<0.002), CRNP fellow (67 min vs. 33 min, p<0.002), RN (82 min vs. 30 min, p<0.001). Median reading times appeared to plateau for the GI fellow and CRNP fellow after 10 and 20-25 studies, respectively. This finding suggests that additional studies are unlikely to improve reading efficiency. The GI nurse never plateaus during the study. Confidence improved for all trainees during the study; however, in the final study period, the GI fellow reported higher confidence than the CRNP fellow, who reported higher confidence than the GI nurse. After the training period of 10 capsule studies, the MD fellow was found to have a higher sensitivity (89%), specificity (95%) and accuracy (92%) compared to other trainees. \u0000Conclusion: Reading time, self-reported confidence, and accuracy appear to be good markers for assessing learning. Twenty-five capsule studies appear to be sufficient for trainees enrolled in a GI fellowship program who are actively performing endoscopy; however physician extenders who do not perform endoscopy appear to require interpretation of more than 25 WCE studies before adequate proficiency is achieved.","PeriodicalId":355284,"journal":{"name":"International Journal of Digestive Diseases","volume":"196 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121098105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 14-3-3 Proteins and Their Function in Intestine","authors":"Qiongqiong Zhou, Cheng Zhang","doi":"10.4172/2472-1891.100007","DOIUrl":"https://doi.org/10.4172/2472-1891.100007","url":null,"abstract":"The 14-3-3 family proteins exert their functions by interacting with their target proteins. In the intestine cells, 14-3-3 family proteins participate many critical signaling cascades governing cell differentiation, survival, apoptosis and polarity. The expression levels of 14-3-3 family proteins were mis-regulated in most colorectal cancers, and thus they may serve as progonostic biomarker for colorectal cancers. The 14-3-3 proteins may also have roles in protecting intestine cells from radiation exposure and parasites infection. Overall, the 14-3-3 family proteins play multiple roles in intestine and are critical in maintaining intestine health.","PeriodicalId":355284,"journal":{"name":"International Journal of Digestive Diseases","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115678264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Topical 5-Aminosalicylic Acid Use inVeterans with Ulcerative Colitis","authors":"R. Shah, J. Hou, H. Malaty, S. Sansgiry","doi":"10.4172/2472-1891.100005","DOIUrl":"https://doi.org/10.4172/2472-1891.100005","url":null,"abstract":"Aims: The aim of our study was to identify the determinants of topical 5-ASA therapy in a large ulcerative colitis cohort. \u0000Methods: We performed a cross sectional study of patients receiving care through the Veterans Administration (VA) from 2003 to 2009. Patients with UC were identified using ICD-9 codes. Patient demographic and prescription data were obtained from national VA datasets. Univariate and multivariate logistic regression were used to identify the effect of age, gender and race on topical 5-ASA therapy use. \u0000Results: We identified 20,259 UC patients for inclusion in the analysis. The prevalence of topical 5-ASA therapy use was 27%. With univariate logistic regression, female gender and non-Caucasian race were associated with a higher odds of topical 5-ASA therapy use. Increasing age was associated with lower odds of topical 5-ASA therapy use. On multivariate logistic regression, Blacks and Hispanics remained more likely to use topical 5-ASA therapies compared to Caucasians and increasing age remained associated with a lower odds of topical 5-ASA therapy; however, other demographic features lost significance. \u0000Conclusions: In a large, national cohort of patients with UC, Blacks and Hispanics were more likely to use topical 5-ASA therapies compared to patients of other ethnicities.","PeriodicalId":355284,"journal":{"name":"International Journal of Digestive Diseases","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124785130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}