Neurologia-Neurocirugia Psiquiatria最新文献_第5页

[Group psychotherapy. Operative groups at the Instituto del servico de seguridad Social de los Trabajadores del Estado (ISSSTE)]. [Group心理。国家工人社会保障服务研究所(ISSSTE)的运作小组。

Neurologia-Neurocirugia Psiquiatria Pub Date : 1977-01-01

J Margolis

引用次数: 0

Leukapheresis in multiple sclerosis. 多发性硬化症中的白细胞摘除术。

Neurologia-Neurocirugia Psiquiatria Pub Date : 1977-01-01

W A Sibley, D W Heustis, M M Griffith

{"title":"Leukapheresis in multiple sclerosis.","authors":"W A Sibley, D W Heustis, M M Griffith","doi":"","DOIUrl":"","url":null,"abstract":"Since there is no satisfactory animal model for multiple sclerosis (MS), a need exists to study various tissues of the affected patient himself. Leukapheresis is a relatively non-invasive technique for obtaining large numbers of leucocytes from patients and control patients. Using ACD-B solution as anticoagulant, the procedure can process 3 500 ml. of blood in about 2 hours, and yield an average of 6.7 billion lymphocytes. The circulating blood count and differential leucocyte count are not changed significantly at the end of the procedure, although the platelet count drops slightly. Leukapheresis has been performed 6 times in four MS patients representing all stages of the illness. The data indicate that the procedure, as performed, is safe in MS patients and do not adversely alter the course of the illness. Leukapheresis is not suggested for therapy at this time. However, if further study suggests that circulating lymphocytes in the MS patient have a cytolytic function in the central nervous system (CNS), the procedure might merit a trial in a controlled treatment program. At present, leukapheresis will probably be most useful as a research tool, to aid study of the role of the lymphocyte in the pathogenesis of MS.","PeriodicalId":35515,"journal":{"name":"Neurologia-Neurocirugia Psiquiatria","volume":"18 2-3 Suppl","pages":"521-5"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11819129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virological and immunological studies in experimental SSPE. 实验性SSPE的病毒学和免疫学研究。

Neurologia-Neurocirugia Psiquiatria Pub Date : 1977-01-01

K P Johnson, D P Byington, L Gaddis

{"title":"Virological and immunological studies in experimental SSPE.","authors":"K P Johnson, D P Byington, L Gaddis","doi":"","DOIUrl":"","url":null,"abstract":"Subacute sclerosing panencephalitis (SSPE) is a progressive, fatal inclusion cell encephalitis of children and adolescents caused by persistent measles virus within the central nervous system (CNS). Because studies in man have failed to elucidate the pathogenesis of this condition, animal studies are necessary. Persistent infection of the hamster CNS can be achieved with a hamster adapted SSPE agent. Animals inoculated intracerebrally with this virus raise antibodies to all known antigens of measles virus and some display clinical signs and pathological changes similar to those noted in human SSPE. Persistent CNS infection occurs only if the hamster is inoculated at a critical age (18 to 25 days of life) or if adults are given transient immunosuppression during acute infection. The biological behavior of the virus isolated from hamster CNS appears to change from a complete to a defective state coincidents with the appearance of serum antibodies to measles virus. Adult hamsters from whom the thymus was removed in the newborn period develop a subacute, uniformly fatal infection when exposed to the SSPE agent. These studies suggest that SSPE may develop in man when measles virus invades the immature CNS at a critical age or when the immune system is uncompletely developed or is inhibited. The finding that transient immunosuppression allows development of persistent CNS infection in adults suggest that immunological malfunction is the significant factor. Of interest, antibody appears to alter viral behavior to a defective, intracellular state thus enhancing viral survival in the host. Once a defective, CNS infection is achieved, lack of, or inhibition of the host cellular immunes response allows it to persist. Methods of therapy in light of these findings will be discussed.","PeriodicalId":35515,"journal":{"name":"Neurologia-Neurocirugia Psiquiatria","volume":"18 2-3 Suppl","pages":"495-507"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11819222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current status of the search for virus in amyotrophic lateral sclerosis (ALS). 肌萎缩性侧索硬化症(ALS)病毒的研究现状。

Neurologia-Neurocirugia Psiquiatria Pub Date : 1977-01-01

F H Norris

{"title":"Current status of the search for virus in amyotrophic lateral sclerosis (ALS).","authors":"F H Norris","doi":"","DOIUrl":"","url":null,"abstract":"Clinicians have noted resemblance between ALS with predominantly lower motor involvement and a chronic type of poliomyelitis. Occasional cases of ALS show lymphocytic infiltrations in the neuropathology. Cytoplasmic inclusion bodies as well as possible transmission of ALS to the monkey, were noted by Soviet investigators. Major questions about the latter remain, but inclusion bodies have been seen in cases outside the USSR, and search for a virus has been pursued. So far, efforts at culture, including the technique of co-cultivation, have not been successful in 3 different laboratories using material from ALS autopsied within 2 hours of death. Nor has such material and specimens from other cases produced transmissible disease in animals of laboratories where kuru, Jakob's disease and SSPE have been transmitted. Study of serum antibodies has also been negative. These negative culture, transmission and antibody studies do not exclude a viral etiology: in kuru, for example, many years passed before transmission was demonstrated, which remains the only evidence of kuru's infectivity. Evidence of an immunologic disorder in ALS has been obtained from kidney biopsies, the lack of any clinical benefit from immunosuppression may indicate that the kidney finding reveals a response to infection, though whether viral or even relevant is unknown. Two recent ALS cases will be illustrated in which virus-like particles were demonstrated post mortem by electronmicroscopy. In one, myxovirus-like tubules were seen mainly in motor neurons; in the other, picorna-virus-like crystals were found in skeletal muscles. Different viruses can cause identical disease, but 2 different viruses in different sites in ALS also suggest that at least one type of particle is an adventitious finding of no general significance. An additional impetus to continue the search is the slowly progressive type C-virus myelitis in wild mice. This disease has many dissimilarities to ALS, including different morphology of the virus, but may provide a model for slow-virus amyotrophy.","PeriodicalId":35515,"journal":{"name":"Neurologia-Neurocirugia Psiquiatria","volume":"18 2-3 Suppl","pages":"443-54"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11318780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Experiences in neurology education in Cuba]. 【古巴神经学教育经验】。

Neurologia-Neurocirugia Psiquiatria Pub Date : 1977-01-01

R Estrada González

引用次数: 0

Nervous system affections caused by the mumps virus. 由腮腺炎病毒引起的神经系统疾病。

Neurologia-Neurocirugia Psiquiatria Pub Date : 1977-01-01

S C Leonberg

引用次数: 0

Immunological response of subacute sclerosing panencephalitis patients to measles virus. 亚急性硬化性全脑炎患者对麻疹病毒的免疫反应。

Neurologia-Neurocirugia Psiquiatria Pub Date : 1977-01-01

D L Madden, D A Fuccillo, G Castellano, R Traub, A Krezlewicz, J L Sever

引用次数: 0

[Status epilepticus. Study of 105 cases 1972-73]. 癫痫持续状态。105例[1972-73]。

Neurologia-Neurocirugia Psiquiatria Pub Date : 1977-01-01

L S Cantón, R Estrada, H Roselló, R Beguería

{"title":"[Status epilepticus. Study of 105 cases 1972-73].","authors":"L S Cantón, R Estrada, H Roselló, R Beguería","doi":"","DOIUrl":"","url":null,"abstract":"We have analyzed 105 cases of Status Epilepticus of variable etiology, cared for over a period of 3 years at the \"Instituto de Neurología y Neurocirugía\". Age, sex, origin, duration of illness before attending the Institute, Conscience variations, clinical crisis types, condition of Status Epilepticus appearance and unleashing factors were considered. Various complementary investigations were performed, although dissimilar in each case. Follow up EEG's were realized in 60% of the patients and pretherapeutic EEG's were done in less than 50%. The necessary time to control the Status was explained, depending on its duration before commencing treatment. Of 93 surviving patients, it was possible to learn the cause of epilepsy only in 43. The necroscopy study of 12 cases demonstrated that death in 9 patients was inevitable for various causes (tumorous, infectious, vascular, etc.) almost always intricate. In other 3 autopsied patients, only signs of cerebral hypoxia and non-neurologic infectious complications were found. In the discussion, the hypoxia-edema-hypoxia mechanism is insisted upon, as well as the need of breaking this circle as an important part of the treatment of these patients.","PeriodicalId":35515,"journal":{"name":"Neurologia-Neurocirugia Psiquiatria","volume":"18 2-3 Suppl","pages":"325-37"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11819317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Language and verbal memory functions during and after human thalamic stimulation. 语言和言语记忆功能在人类丘脑刺激期间和之后。

Neurologia-Neurocirugia Psiquiatria Pub Date : 1977-01-01

G Ojemann

引用次数: 0

Cerebrospinal fluid immunoglobulins in cysticercosis of the central nervous system. 脑脊液免疫球蛋白在中枢神经系统囊虫病中的作用。

Neurologia-Neurocirugia Psiquiatria Pub Date : 1977-01-01

A Spina-França, J A Livramento, L A Bacheschi, P García-Lopes

引用次数: 0