NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY最新文献_第3页

Prevalence, diagnosis and treatment of Helicobacter pylori infection in Nigeria 尼日利亚幽门螺杆菌感染的流行、诊断和治疗

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2022-01-01 DOI: 10.4103/njgh.njgh_10_22

Stella I Smith, A. Ajayi, T. Jolaiya, U. Essiet

引用次数: 0

HBsAg Loss among a Cohort of Nigerians with chronic hepatitis B virus infection 尼日利亚慢性乙型肝炎病毒感染患者的HBsAg损失

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2022-01-01 DOI: 10.4103/njgh.njgh_7_22

O. Adekanle, O. Ijarotimi, I. Umenze, D. Ndububa

{"title":"HBsAg Loss among a Cohort of Nigerians with chronic hepatitis B virus infection","authors":"O. Adekanle, O. Ijarotimi, I. Umenze, D. Ndububa","doi":"10.4103/njgh.njgh_7_22","DOIUrl":"https://doi.org/10.4103/njgh.njgh_7_22","url":null,"abstract":"Background: Chronic hepatitis B (CHB) virus is an infection that has lasted for 6 months or more without a complete resolution. Nigeria has a hyper-endemic CHB infection rate. There are few or no reports of HBsAg loss among Nigerians on treatment for CHB. We therefore report seven cases of CHB that cleared HBsAg with treatment from the Obafemi Awolowo University Teaching hospital Ile-Ife, Nigeria. Materials and Methods: Case records of patients that cleared HBsAg during follow-up treatment in the gastrointestinal clinic were reviewed and information on biodata, prescribed medication, duration of treatment, and hepatitis B viral quantity among others were extracted and presented in a table and as percentages. Results: Seven patients had lost HBsAg among our treated cases; they were five males and two females. Duration of treatment ranged from 6 months to about 4 years. All were HBeAg negative. Serum HBV-DNA ranged from 22 to 3.2 x 106 IU/mL at the start and was not detectable at the end of treatment. Anti-HBs were detectable in three cases. Serum alanine aminotransferase (ALT) reduced significantly in five cases. Tenofovir disoproxil fumarate (TDF) was prescribed in four cases, one had PEGylated interferon (PegIFN), and two other cases switched between TDF and PegIFN. Conclusion: Antivirals for CHB are effective and HBsAg loss may follow undetectable viral suppression. Antivirals are therefore beneficial among Nigerians who are infected with CHB.","PeriodicalId":354969,"journal":{"name":"NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116926518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gangrenous Cholecystitis: A case report 坏疽性胆囊炎1例

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2022-01-01 DOI: 10.4103/njgh.njgh_1_21

A. Adenuga

引用次数: 0

From the editor’s desk 从编辑的桌子上

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2022-01-01 DOI: 10.4103/njgh.njgh_13_22

F. Abdulkareem

引用次数: 0

Primary Hepatic Neuroendocrine Tumour: A case report 原发性肝脏神经内分泌肿瘤1例

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2022-01-01 DOI: 10.4103/njgh.njgh_4_22

R. Inuganti, Chaitra Boregowda, Tejeswini Vaddati, Ramya Potti

引用次数: 0

The efficacy of the EncephalApp in diagnosing minimal hepatic encephalopathy (MHE) among patients with liver cirrhosis in Jos Nigeria 在尼日利亚乔斯的肝硬化患者中，EncephalApp诊断轻度肝性脑病(MHE)的疗效

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2022-01-01 DOI: 10.4103/njgh.njgh_9_22

N. David, M. Duguru, P. Davwar, P. Omaiye, E. Okeke, Ameh Ojonugwa Alufiya, C. Umejiaku, S. Kenis, J. Makpu, Nenman Bitrus Sekat

{"title":"The efficacy of the EncephalApp in diagnosing minimal hepatic encephalopathy (MHE) among patients with liver cirrhosis in Jos Nigeria","authors":"N. David, M. Duguru, P. Davwar, P. Omaiye, E. Okeke, Ameh Ojonugwa Alufiya, C. Umejiaku, S. Kenis, J. Makpu, Nenman Bitrus Sekat","doi":"10.4103/njgh.njgh_9_22","DOIUrl":"https://doi.org/10.4103/njgh.njgh_9_22","url":null,"abstract":"Background and Objectives: Minimal hepatic encephalopathy is a condition in which patients with liver cirrhosis with normal mental and neurological status on clinical examination show cognitive dysfunction detectable on psychometric or neurophysiologic tests. Routine detection of this condition is not commonly carried out despite the high prevalence among patients with liver cirrhosis and a high risk of progression to overt hepatic encephalopathy. We compared the smartphone based EncephalApp with the standard psychometric hepatic encephalopathy score (PHES) in diagnosing MHE in patients with liver cirrhosis in Jos University Teaching Hospital. Materials and Methods: Fifty healthy subjects and 42 patients with liver cirrhosis who did not have overt hepatic encephalopathy and who fulfilled other study criteria were recruited in this cross-sectional analytical study. Both healthy subjects and patients were tested with the EncephalApp, and with the paper-pencil PHES test. Data analysis was done using Statistical Package for the Social Sciences (SPSS) 23.0. A value of P < 0.05 was considered statistically significant. Results: The mean age of the control group was 35.9 ± 8.7 years, whereas that of the patient group was 38.9 ± 8.7, P = 0.099. The mean number of years in school for the control group was 16.5 ± 3.4 years, whereas that of the patients was 16.1 ± 3.1, P = 0.471. The prevalence of MHE by PHES was 40.5%. The prevalence of MHE by EncephalApp was 51.4% based on the cutoff of 241.8 s, sensitivity = 54.1% and specificity = 90.0%, AUROC = 0.77. Conclusion: The prevalence of MHE in patients with liver cirrhosis in Jos, Nigeria, is about the same with values documented in other parts of the world. The EncephalApp was shown to be a reliable screening tool with good sensitivity, specificity and AUROC in our patients with liver cirrhosis.","PeriodicalId":354969,"journal":{"name":"NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122005502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal tuberculosis complicated by pulmonary embolism and deep vein thrombosis 肠结核并发肺栓塞和深静脉血栓

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2022-01-01 DOI: 10.4103/njgh.njgh_5_22

M. Abdulla

引用次数: 0

Metastatic ovarian cancer presenting as multiple hepatic cysts and paraneoplastic manifestation 转移性卵巢癌表现为多发性肝囊肿和副肿瘤表现

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2021-07-01 DOI: 10.4103/njgh.njgh_9_21

D. Dayar, Yusuf Raheem, A. Yerima, Lawan Mohammed, A. Zarami

{"title":"Metastatic ovarian cancer presenting as multiple hepatic cysts and paraneoplastic manifestation","authors":"D. Dayar, Yusuf Raheem, A. Yerima, Lawan Mohammed, A. Zarami","doi":"10.4103/njgh.njgh_9_21","DOIUrl":"https://doi.org/10.4103/njgh.njgh_9_21","url":null,"abstract":"Background: Metastatic ovarian diseases are often found on the peritoneal surfaces including the liver, bowel, bladder, and uterus. Recent studies showed liver metastases as the most common presentation of stage-IV disease in patients with epithelial ovarian cancer (EOC). Paraneoplastic syndromes in ovarian cancers may be associated with rheumatologic disorders like polymyositis due to autoimmune mechanisms. Case Presentation: We report a case of a 61-year-old postmenopausal woman who presented with a 2-month history of progressive right hypochondrial swelling and pain, with progressive weight loss and weakness of the limbs. Examination revealed tender hepatomegaly with proximal muscle weakness. Abdominopelvic computed tomography (CT) scan revealed enlarged liver with multiple cystic lesions and right adnexal mass. CA125 and creatine kinase were elevated and ultrasound scan (USS)-guided trucut biopsy of both the hepatic and adnexal masses revealed papillary cystadenocarcinoma. Conclusion: We, therefore, concluded that the diagnosis in our patient is metastatic ovarian cancer to the liver with paraneoplastic phenomenon of polymyositis.","PeriodicalId":354969,"journal":{"name":"NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121251859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consensus molecular subtyping of colorectal cancer by immunohistochemistry, an imperative for a resource limited setting: Report of a Nigerian study 通过免疫组织化学对结直肠癌进行一致的分子分型，在资源有限的情况下势在必行:尼日利亚的一项研究报告

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2021-07-01 DOI: 10.4103/njgh.njgh_1_22

F. Abdulkareem, G. Khramtsova, L. Odukoya, K. Badmos, T. Adedokun, O. Rotimi, Abiola Ibraheem, A. Khramtsov, L. Sveen, Ian Hurley, M. Hattori, D. Huo, O. Olopade

{"title":"Consensus molecular subtyping of colorectal cancer by immunohistochemistry, an imperative for a resource limited setting: Report of a Nigerian study","authors":"F. Abdulkareem, G. Khramtsova, L. Odukoya, K. Badmos, T. Adedokun, O. Rotimi, Abiola Ibraheem, A. Khramtsov, L. Sveen, Ian Hurley, M. Hattori, D. Huo, O. Olopade","doi":"10.4103/njgh.njgh_1_22","DOIUrl":"https://doi.org/10.4103/njgh.njgh_1_22","url":null,"abstract":"Background and Objectives: Studies of colorectal cancer (CRC) molecular heterogeneity have used genome-wide gene expression-based data to group patients into four consensus molecular subtypes (CMS), but the cost and sophistication of analysis has limited its clinical application. This study aimed at using immunohistochemistry (IHC) to classify CRC specimens in a cohort of patients in Lagos University Teaching Hospital. Materials and Methods: Tissue microarrays were constructed from 75 FFPE tissue blocks of CRC. These were stained for mismatch repair (MMR) proteins (MLH1, MSH2, MSH6, and PMS2) and four other markers (CDX2, HTR2B, ZEB1, and Ki-6) by IHC. Semi-quantitative scoring was performed for the other four markers. A panel of CDX2, HTR2B, and ZEB1 was then used to distinguish between CMS4 and CMS2/CMS3 subtypes, whereas Ki-67 was used to separate CMS2 from CMS3 subtype. MMR status was used to identify CMS1 subtype. Results: Of the total evaluable 75 CRC cases, 38% were <40 years old, 60% were males, with mean of 44.8 years (standard deviation [SD] = 16.1). Fifty-nine patients (79%) had microsatellite stable (MSS) tumor, and the remaining 16 (21%) had microsatellite unstable (MSI) tumor (i.e., CMS1). Thirty-seven (49%) were classified as CMS2 (n = 24) or CMS3 (n = 13) and 22 (29%) of the cases were classified as CMS4. The CMS4 subtype was significantly more likely to occur among young patients (P < 0.001). CMS1 subtype was more in patients older than 40 years and 75% of right-sided cancers were CMS1 (P < 0.001). Conclusion: The study confirms that IHC-based CMS classification and stratification of CRC patients could be a cost-effective prognostic and predictive tool suitable for resource-limited settings.","PeriodicalId":354969,"journal":{"name":"NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130264616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Abstracts Presented at the 13th Scientific Conference of Society for Gastroenterology and Hepatology in Nigeria Held July 26–30, 2021 于2021年7月26日至30日在尼日利亚举行的第13届胃肠病学和肝病学会科学会议上发表

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2021-07-01 DOI: 10.4103/njgh.njgh_2_22

引用次数: 0