NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY最新文献

Gall bladder heterotopia: Uncommon two cases and review of variations 胆囊异位症：两例罕见病例及变异综述

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2023-07-01 DOI: 10.4103/njgh.njgh_2_23

Manideep Robbi, R. Chakravarthy, Jai Lomte, Veena Madhuri

{"title":"Gall bladder heterotopia: Uncommon two cases and review of variations","authors":"Manideep Robbi, R. Chakravarthy, Jai Lomte, Veena Madhuri","doi":"10.4103/njgh.njgh_2_23","DOIUrl":"https://doi.org/10.4103/njgh.njgh_2_23","url":null,"abstract":"Background and Objectives: Heterotopia in the gallbladder is a rare condition where normal tissue occurs in an abnormal location. This case report aimed to describe two cases of heterotopia in the gallbladder, one with gastric mucosa and the other with pancreatic tissue. The objective is to provide a better understanding of the clinical presentation, histological findings, and associated anomalies of heterotopia in the gallbladder. Materials and Methods: The cases were identified through patient records and macroscopic examination. Clinical data, radiological findings, and histopathological analysis were collected and analyzed. Results: Case 1 presented with intermittent abdominal pain and was diagnosed with cholelithiasis. Gross examination revealed a gallbladder with ulcerated mucosa and a cystic area. Histological examination confirmed the presence of gastric heterotopia. Case 2 underwent laparoscopic cholecystectomy for a firm lesion in the neck of the gallbladder. Histopathological analysis showed chronic cholecystitis and heterotopic pancreatic tissue. Conclusion: Heterotopia in the gallbladder is a rare condition associated with various types of heterotopic tissues. Gastric heterotopia is the most common type, followed by pancreatic, hepatic, thyroid, and adrenal heterotopias. The exact cause of heterotopia in the gallbladder is unknown, but it is believed to be a congenital disorder. Treatment options vary, and further studies are needed to understand the incidence and development of heterotopia in the gallbladder.","PeriodicalId":354969,"journal":{"name":"NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY","volume":"59 1","pages":"52 - 56"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139365995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Annona senegalensis stem bark extracts attenuated doxorubicin-induced hepatotoxicity and mitochondrial oxidative damage in Wistar strain albino rats 黑木耳茎皮提取物可减轻多柔比星诱导的白化大鼠肝毒性和线粒体氧化损伤

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2023-07-01 DOI: 10.4103/njgh.njgh_7_23

R. Adisa, Oluwole-Banjo Kolawole, R. Lawal, Gbemisola Bamiduro, Fatimah Abdulkareem

{"title":"Annona senegalensis stem bark extracts attenuated doxorubicin-induced hepatotoxicity and mitochondrial oxidative damage in Wistar strain albino rats","authors":"R. Adisa, Oluwole-Banjo Kolawole, R. Lawal, Gbemisola Bamiduro, Fatimah Abdulkareem","doi":"10.4103/njgh.njgh_7_23","DOIUrl":"https://doi.org/10.4103/njgh.njgh_7_23","url":null,"abstract":"Background and Objective: Doxorubicin (DOX)- an anthracycline is a well-known anticancer agent but its limitation lies in it hepato- and cardio-toxicity involving the mitochondrial redox pathway. Thus, there is need for chemoprotective agents to serve as interventions for militating against toxicity during cancer management. This study investigated the protective potential of Annona senegalensis stem bark extracts (ASE) on DOX-induced mitochondrial membrane damage and oxidative stress in albino rats’ livers. Materials and Methods: ASE was subjected to phytochemical screening. Thirty male Wistar strain albino rats (13 weeks old; 150–160 g) were randomly divided into Groups A (control) received distilled water, Groups B, C, D, E, and F received DOX-only (20 mg/kg), DOX (20 mg/kg) + ASE (100 mg/kg), DOX (20 mg/kg) + ASE (200 mg/kg), DOX (20 mg/kg) + ASE (400 mg/kg), ASE (400 mg/kg) only, respectively (n = 5 per group). Groups that received ASE were pre-administered for 7 days before intraperitoneal administration of DOX on day 7. Rats were sacrificed, oxidative stress and liver membrane damage were evaluated. Results: Tannin, saponin, phenol, flavonoids, alkaloids, terpenoids, reducing sugar, and cardiac glycosides were present, while combined and free anthraquinone were absent in ASE. The total flavonoid, phenol, tannin, and reducing sugar content of ASE were 13.11 ± 1.09, 27.19 ± 0.61, 8.98 ± 1.2, and 27.3 ± 1.6 mg gallic acid equivalent, respectively. Activities of catalase, superoxide dismutase, and level of glutathione in both hepatic mitochondrial membrane and post-mitochondrial fractions (PMF) increased concentration-dependently in ASE pretreated compared to DOX-only-treated animals. Malondialdehyde levels significantly (P < 0.05) decreased concentration-dependently. Conclusions: ASE has chemoprotective potential on liver mitochondria and PMF against DOX-induced toxicity attributable to its constituent phytochemicals.","PeriodicalId":354969,"journal":{"name":"NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY","volume":"17 1","pages":"43 - 51"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139365765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical presentation of hydatid cyst with anchovy sauce liver aspirate 鳀鱼酱肝吸出物囊水瘤的非典型表现

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2023-07-01 DOI: 10.4103/njgh.njgh_10_23

O. Ijarotimi, Yusuf Raheem, Andrew Akinbolaji Akinkuolie, Tajudin Adesegun Adetunji, O. Adekanle, Abdulhakeem Adekilekun Tijani, Ibukunoluwa John Enesi, Adedapo Oluwarotimi Adeyemo, Emmanuel Segun Oladimeji

{"title":"Atypical presentation of hydatid cyst with anchovy sauce liver aspirate","authors":"O. Ijarotimi, Yusuf Raheem, Andrew Akinbolaji Akinkuolie, Tajudin Adesegun Adetunji, O. Adekanle, Abdulhakeem Adekilekun Tijani, Ibukunoluwa John Enesi, Adedapo Oluwarotimi Adeyemo, Emmanuel Segun Oladimeji","doi":"10.4103/njgh.njgh_10_23","DOIUrl":"https://doi.org/10.4103/njgh.njgh_10_23","url":null,"abstract":"Background: Hydatid disease is a zoonotic parasitic infestation caused by cysts containing the larva stages of tapeworm of the genus Echinococcus. Cystic echinococcosis (CE) and alveolar echinococcosis are the two most important forms in humans. CE accounts for 95% of human infection and is usually a clear fluid cystic disease with the liver being the most frequently affected organ. Other organs that could be affected include the lungs, muscles, bone, spleen, heart, and brain. Case Presentation: We report a case of a 53-year-old man who presented with 5-week history of cough, 2-week history of abdominal pain, and 1-day history of difficulty with breathing. Examination revealed a middle-aged man in respiratory distress with tender hepatomegaly and features of bilateral pleural effusion. An abdominal ultrasound scan revealed cysts in both lobes of the liver. He also had elevated liver enzymes as well as eosinophilia. The patient could not afford to do a serological test for hydatid cyst. The patient had percutaneous liver aspiration which revealed an anchovy paste aspirate. We initially entertained the possibility of an amoebic liver abscess for which he had antibiotics for one month without any improvement. We eventually considered hydatid cyst as our diagnosis, and he made a remarkable improvement after the commencement of a therapeutic trial of albendazole. Informed consent was obtained from the patient for this case report. Conclusion: Hydatid cysts should be strongly considered as part of the differential diagnosis when in contact with any patient with cystic liver disease irrespective of the color or appearance of the liver aspirate.","PeriodicalId":354969,"journal":{"name":"NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY","volume":"43 1","pages":"57 - 60"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139366032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prognostic significance of the Rockall score evaluation in patients admitted for upper gastrointestinal bleeding in Yaoundé (Cameroon) 雅温得（喀麦隆）上消化道出血住院患者的 Rockall 评分对预后的重要意义

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2023-07-01 DOI: 10.4103/njgh.njgh_9_23

Antonin Ndjitoyap Ndam, Michèle Ayissi Mete, Guy Roger Nsenga Djapa, Bekolo Nga, Moselle Chipekam Ndjifoum, M. Kowo, Firmin Ankouane Andoulo

{"title":"The prognostic significance of the Rockall score evaluation in patients admitted for upper gastrointestinal bleeding in Yaoundé (Cameroon)","authors":"Antonin Ndjitoyap Ndam, Michèle Ayissi Mete, Guy Roger Nsenga Djapa, Bekolo Nga, Moselle Chipekam Ndjifoum, M. Kowo, Firmin Ankouane Andoulo","doi":"10.4103/njgh.njgh_9_23","DOIUrl":"https://doi.org/10.4103/njgh.njgh_9_23","url":null,"abstract":"Background and Objectives: Upper gastrointestinal bleeding (UGIB) is a major emergency. The Rockall score (RS) could be a tool to predict the outcome of patients regarding their risk of re-bleeding and/or death 30 days after admission. This study aimed to evaluate the prognostic value of the RS in patients admitted for UGIB in Yaoundé (Cameroon). Materials and Methods: We conducted a retrospective cohort study at two emergency units inYaoundé. We included 101 patients admitted from 2020 to 2021 for a UGIB and obtained the sociodemographic, clinical, and paraclinical data. The outcome 30 days after the admission was assessed (re-bleeding and/or death). We calculated the RS and analyzed the association of an RS ≥ 5 with the death of the patient and/or a re-bleeding 30 days after admission. Results: The mean age of patients was 48.5 years, 75 of the 101 were males (74.3%). The main bleeding lesions were portal hypertension in 35 patients (34.7%), gastric ulcers in 32 patients (31.7%), and duodenal ulcers in 30 patients (29.7%). During the 30 days after the admission, we recorded re-bleeding in 21 patients (20.8%) and death in 9 patients (8.9%). The RS was ≥ 5 in 49 patients (48.5%), and this was significantly associated with the re-bleeding (RR 4.5; CI 95% 1.631–12.459; P = 0.001) and with the death (P = 0.001). Conclusion: The RS ≥ 5 is associated with a risk of re-bleeding and/or death in patients admitted for a UGIB in Yaoundé regardless of the aetiology.","PeriodicalId":354969,"journal":{"name":"NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY","volume":"47 8 1","pages":"33 - 37"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139366186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selected Abstracts Presented At The Annual General Meeting And Scientific Conference Of The Society For Gastroenterology and Hepatology in Nigeria (Soghin), Enugu, July 2023 尼日利亚胃肠病学和肝病学学会（Soghin）年度大会暨科学会议摘要选编，埃努古，2023 年 7 月

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2023-07-01 DOI: 10.4103/njgh.njgh_15_23

引用次数: 0

Spectrum of endoscopic findings in patients with Helicobacter pylori infection in a Nigerian tertiary institution 尼日利亚一家高等院校幽门螺杆菌感染患者的内窥镜检查结果范围

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2023-07-01 DOI: 10.4103/njgh.njgh_8_23

Asa Itam-Eyo, M. Kooffreh-Ada, E. Chukwudike, U. Okonkwo, O. Ngim, Ubong Udoh, Joanah Moses Ikobah, K. Uhegbu, Ugbong Emmanuel, Essien Aniekan, Rowland Ndoma-Egba, Benedicta Eko, Esther Effiong

{"title":"Spectrum of endoscopic findings in patients with Helicobacter pylori infection in a Nigerian tertiary institution","authors":"Asa Itam-Eyo, M. Kooffreh-Ada, E. Chukwudike, U. Okonkwo, O. Ngim, Ubong Udoh, Joanah Moses Ikobah, K. Uhegbu, Ugbong Emmanuel, Essien Aniekan, Rowland Ndoma-Egba, Benedicta Eko, Esther Effiong","doi":"10.4103/njgh.njgh_8_23","DOIUrl":"https://doi.org/10.4103/njgh.njgh_8_23","url":null,"abstract":"Background and Objectives: Helicobacter pylori is a widely prevalent infection considered a significant public health challenge. Nigeria has the highest worldwide H. pylori prevalence. It is a notable cause of gastric cancer; thus, prompt diagnosis and treatment are required for eradication. The study aimed to determine the spectrum of endoscopic findings in patients with H. pylori infection at the University of Calabar Teaching Hospital. Materials and Methods: This was a retrospective cross-sectional study over a 4-year period on dyspeptic patients who presented at the hospital. Diagnosis of H. pylori infection was made through non-invasive techniques and patients who tested positive for H. pylori and were further assessed with upper gastrointestinal endoscopy were included in the study. A descriptive analysis of the data obtained was carried out using SPSS version 20. Results: One hundred and twenty-nine patients tested positive for H. pylori infection (46%) out of the two hundred and eighty dyspeptic patients evaluated during the period under study. However, only fifty-two (52) out of 129 dyspeptic patients who tested positive for H. pylori had upper gastrointestinal endoscopy and thus met the inclusion criteria. Upper gastrointestinal endoscopy revealed predominantly gastritis 37 (71.15%). This was followed by esophagitis in two (7.7%), duodenal ulcer two (3.8%), gastric ulcer three (5.8%), gastro-duodenitis four (7.7%), and gastric malignancy in two (3.8%) patients. Conclusion: Our study revealed that gastritis was the predominant endoscopic finding in patients with H. pylori infection. This finding is particularly significant because of the risk of development of gastric cancer in these patients from recurrent episodes of gastritis following late diagnosis and inappropriate treatment.","PeriodicalId":354969,"journal":{"name":"NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY","volume":"50 1","pages":"27 - 32"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139364511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upper gastrointestinal endoscopy findings in adults with dyspepsia younger than 60 years in Lagos, Nigeria 尼日利亚拉各斯 60 岁以下消化不良成人的上消化道内窥镜检查结果

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2023-07-01 DOI: 10.4103/njgh.njgh_11_23

Emuobor Odeghe, A. Oluyemi, G. Oyeleke, O. Adeniyi, V. Nwude

{"title":"Upper gastrointestinal endoscopy findings in adults with dyspepsia younger than 60 years in Lagos, Nigeria","authors":"Emuobor Odeghe, A. Oluyemi, G. Oyeleke, O. Adeniyi, V. Nwude","doi":"10.4103/njgh.njgh_11_23","DOIUrl":"https://doi.org/10.4103/njgh.njgh_11_23","url":null,"abstract":"Background and Objectives: Recent guidelines from international gastroenterology bodies recommend that upper gastrointestinal endoscopy (UGIE) should not be routinely performed in patients with dyspepsia who are younger than 60 years old as the yield for major abnormalities is low. The objectives of this study were to determine the spectrum of UGIE findings in patients with dyspepsia who are younger than 60 years and to document the association of alarm features with UGIE findings in them. Materials and Methods: This is a retrospective study of the UGIE records of adult patients younger than 60 years with dyspepsia at five centers in Lagos, Nigeria, between June 2016 and December 2020. UGIE findings were categorized as major (gastric or duodenal ulcers, esophageal varices, masses suspected to be cancer, strictures, and foreign bodies), minor (erosions or inflammation), or normal. Results: There were 1499 adult patients with dyspepsia who were younger than 60 years, 796 (53.1%) females, mean age 40.9 ± 9.8 years, and 158 (10.5%) with at least one alarm feature. Major findings were seen in 194 (12.9%), minor findings in 1023 (68.2%), and no abnormalities were seen in 282 (18.8%). Alarm features, or age 40 years and above, were associated with major findings. Half of all gastric cancers were seen in patients younger than 50 years, and of these, 70% occurred within the 40–49 age group. Conclusion: This study shows that the prevalence of UGIE findings in patients with dyspepsia who are younger than 60 years is high, and major findings are common in those with alarm features or who are aged 40 years and above. We recommend endoscopy for the evaluation of dyspepsia in those who have alarm features or are aged at least 40 years.","PeriodicalId":354969,"journal":{"name":"NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY","volume":"49 1","pages":"38 - 42"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139364901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rectal xanthomatous polyp within the context of a normal serum lipid Profile: A case report 正常血脂背景下的直肠黄色瘤性息肉:1例报告

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2023-01-01 DOI: 10.4103/njgh.njgh_22_22

A. Rahman, Olutoyin Asaolu, U. Ezenkwa

引用次数: 0

Generalized peritonitis secondary to a ruptured schistosoma appendix: A case series 继发于血吸虫阑尾破裂的广泛性腹膜炎:一个病例系列

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2023-01-01 DOI: 10.4103/njgh.njgh_20_22

B. Bello, I. Umar, Faruk Emetuma

引用次数: 0

Concurrent Sarcina ventriculi infection in a patient with Helicobacter pylori-associated chronic gastritis: A case report 幽门螺杆菌相关慢性胃炎并发脑室肌瘤感染1例报告

NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Pub Date : 2023-01-01 DOI: 10.4103/njgh.njgh_3_23

N. Awolola, Dolapo Akinjo, Kalanne Cookey, M. Haruna, Ejiroghene Arhere, C. Onyekwere, F. Abdulkareem

{"title":"Concurrent Sarcina ventriculi infection in a patient with Helicobacter pylori-associated chronic gastritis: A case report","authors":"N. Awolola, Dolapo Akinjo, Kalanne Cookey, M. Haruna, Ejiroghene Arhere, C. Onyekwere, F. Abdulkareem","doi":"10.4103/njgh.njgh_3_23","DOIUrl":"https://doi.org/10.4103/njgh.njgh_3_23","url":null,"abstract":"Sarcina ventriculi is a Gram-positive, nonmotile, chemo-organotrophic anaerobic organism, which is rare in humans. Although its role as a pathogen in humans remains poorly characterized, it has been associated with delayed gastric emptying, emphysematous gastritis, and gastric perforation in existing literature. The index case was a 34-year-old male who presented with a history of abdominal pain, 1-month history of frequent vomiting, bloating, and abdominal distension. He was evaluated for gastric-outlet obstruction secondary to a possible gastric tumor. Upper gastrointestinal endoscopy showed a stomach that is filled with food debris, hyperemia, and deformed pylorus but no mass was seen. Histology of a mucosal biopsy sample showed active antral predominant gastritis with concurrent H. pylori and S. ventriculi infections. A repeat endoscopy following antibiotic treatment showed the absence of H pylori and S. ventriculi and the patient reported a cessation of symptoms. S. ventriculi was found in association with H. pylori infection.","PeriodicalId":354969,"journal":{"name":"NIGERIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116822640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0