Kathmandu University Medical Journal最新文献

Epidemiological Characteristics of the Spine Tumors in a Single Tertiary Centre of Nepal. 尼泊尔单一三级中心脊柱肿瘤的流行病学特征。

Kathmandu University Medical Journal Pub Date : 2025-07-01

S R Kayastha, A Pandey, S Lamichhane, J Thapa, B Parajuli, D Shrestha

{"title":"Epidemiological Characteristics of the Spine Tumors in a Single Tertiary Centre of Nepal.","authors":"S R Kayastha, A Pandey, S Lamichhane, J Thapa, B Parajuli, D Shrestha","doi":"","DOIUrl":"","url":null,"abstract":"Background Spine tumors can be primary or secondary, depending on their origin. Metastasis compromises the majority of spine tumors. Primary tumors of the spine are rare and mostly asymptomatic; consequently, their real incidence cannot be investigated. Primary malignancies of the spine are even rarer. Most epidemiological data for spine tumors comes from registries in developed countries. Objective To provide epidemiological data on spine tumors in a single tertiary hospital in Nepal. Method This is a descriptive cross-sectional study done at the department of orthopaedics at Dhulikhel Hospital. The study was done using retrospective hospital records from January 2010 to December 2024. The data related to all the spine tumors admitted under the department of orthopedics during the study's duration were included. Records without complete, relevant information were excluded. We took data from 135 patients admitted for spine tumors. The information related to the demography, site of tumors, types of tumors, and histological diagnosis was entered in Google Sheets and exported for descriptive analysis in Statistical Package for Social Sciences (SPSS) version 20. Result Among the 135 patients, the most common site of spine tumor was thoracic (42.22%). Primary benign neoplasms were the most common (n=68), and among the 61 malignancies, 36 were secondary and 25 were primary malignancies. Schwannomas were the most common benign tumors in the spine (n=23). The most common site for secondaries in the spine was the lungs (n=11). Conclusion This study's results represent data on the epidemiology of spinal tumors from a single institute. Although this data is far too small to represent the whole country, in the absence of registries or other large multicentric databases, it can shed some light on the less studied spine tumors in Nepal.","PeriodicalId":35493,"journal":{"name":"Kathmandu University Medical Journal","volume":"23 91","pages":"301-306"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge, Attitude and Practice Towards Antimicrobial Resistance and Antimicrobial Adherence among Female Community Health Volunteers Before and After an Educational Intervention. 教育干预前后女性社区卫生志愿者抗微生物药物耐药性和抗微生物药物依从性的知识、态度和行为

Kathmandu University Medical Journal Pub Date : 2025-07-01

N Jha, S Kafle, M Joshi, A Pandey, P Koirala, S Bhandary, P R Shankar

{"title":"Knowledge, Attitude and Practice Towards Antimicrobial Resistance and Antimicrobial Adherence among Female Community Health Volunteers Before and After an Educational Intervention.","authors":"N Jha, S Kafle, M Joshi, A Pandey, P Koirala, S Bhandary, P R Shankar","doi":"","DOIUrl":"","url":null,"abstract":"Background Antimicrobial resistance is a serious problem in Nepal. Knowledge, attitude, practice and adherence of female community healthcare volunteers of an intervention area about antimicrobials before and immediately after a workshop conducted on 24th February 2024 was measured. Objective To compare the knowledge, attitude and practice towards antimicrobial resistance and antimicrobial adherence among female community health volunteers. Method A questionnaire containing four sections related to various themes of antimicrobials was developed. Knowledge, Attitude and Practice questions were analyzed using two sample proportion tests. Feedback regarding the educational intervention was also obtained using a 7-item tool and open responses. Result All Female Community Health care Volunteers from Mahalaxmi municipality participated. Most participants were aged between 41-50 years [19 (42.2%)] and [25 (55.6%)] had working experience greater than 10 years. The scores for statements antimicrobial resistance are a serious problem worldwide, [84.4% vs 60% (p=0.004)] and antibiotics are used to inhibit the growth of bacteria improved post- intervention [100% vs 77.8% (p ≤ 0.001)]. Scores for attitude statements like, taking antibiotics without consulting a physician [91.1% vs 60% (p ≤ 0.001)], missing a dose or two of antibiotic treatment contribution to antibiotic resistance, [75.5% vs 46.6% (p = 0.002)] among others improved. The scores for certain practice statements also improved post-intervention. The median scores for attitude scale, [31 vs 26 (p ≤ 0.001)] and practice scale, [31 vs 34 (p = 0.011)] were different before and after the workshop. Participant feedback on the workshop was positive. Conclusion The session was effective in increasing participants' practice scores and may lead to more rational use of antimicrobials. The attitude, practice and total scores were different before and after the workshop.","PeriodicalId":35493,"journal":{"name":"Kathmandu University Medical Journal","volume":"23 91","pages":"353-358"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonsyndromic Complete Second Branchial Cleft Fistulas: A Clinicosurgical Experience. 非综合征完全性第二鳃裂瘘管：临床外科经验。

Kathmandu University Medical Journal Pub Date : 2025-07-01

S B Ghimire, A Dhakal, A Pandey, S Vaidya

{"title":"Nonsyndromic Complete Second Branchial Cleft Fistulas: A Clinicosurgical Experience.","authors":"S B Ghimire, A Dhakal, A Pandey, S Vaidya","doi":"","DOIUrl":"","url":null,"abstract":"Branchial cleft anomalies are congenital malformations resulting from the abnormal persistence of branchial clefts during embryogenesis, often presenting as cysts, sinuses, or fistulae. These anomalies account for approximately 20% of pediatric head and neck masses, with bilateral cases being particularly rare. This report discusses a case of an 11-year-old boy with complete bilateral second branchial cleft fistulae, characterized by intermittent mucopurulent discharge and recurrent inflammation, primarily following upper respiratory infections. Diagnostic imaging, including CT scans, confirmed the presence of bilateral fistulous tracts. Surgical management involved a combined transoral and transcervical approach, including bilateral tonsillectomy and complete excision of the fistulous tracts. The procedure resulted in successful removal of the anomalies without postoperative complications. This case emphasizes the importance of thorough diagnostic evaluation and the effectiveness of complete surgical excision in managing bilateral branchial cleft anomalies to prevent recurrence and improve patient outcomes. Further research is warranted to optimize surgical techniques and postoperative results.","PeriodicalId":35493,"journal":{"name":"Kathmandu University Medical Journal","volume":"23 91","pages":"395-397"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Allergic Biomarkers in Patients with Chronic Rhinosinusitis With or Without Asthma. 慢性鼻窦炎伴或不伴哮喘患者过敏生物标志物的相关性

Kathmandu University Medical Journal Pub Date : 2025-07-01

R P Pangeni, M Pokhare, V Vaidya, P Sapkota, S Karki, M Bhusal, D Basnet, A Dhakal, B Sapkota, S Madhup

{"title":"Association of Allergic Biomarkers in Patients with Chronic Rhinosinusitis With or Without Asthma.","authors":"R P Pangeni, M Pokhare, V Vaidya, P Sapkota, S Karki, M Bhusal, D Basnet, A Dhakal, B Sapkota, S Madhup","doi":"","DOIUrl":"","url":null,"abstract":"Background Chronic rhinosinusitis and asthma are considered under unified airway diseases which describes the shared epidemiologic and pathophysiologic relationship among the chronic inflammatory diseases of the upper and lower airways Objective To assess the asthma in patients with chronic rhinosinusitis and determine the relationship of allergic biomarkers, tissue eosinophilia and radiological bone changes in patients with chronic rhinosinusitis with or without asthma. Method Prospective study involving 74 adult patients attending the Department of Otorhinolaryngology and Pulmonology at the Kathmandu University Dhulikhel Hospital for treatment of chronic rhinosinusitis and / or asthma and for functional endoscopic sinus surgery between May 2023 and May 2024. Absolute eosinophil count, total serum IgE and spirometry tests were performed. Radiological evidence of osteitis and tissue eosinophilia from surgical samples was evaluated. Correlations between allergic biomarkers,spirometry values, tissue eosinophilia, and radiological bone changes were determined in patients of chronic rhinosinusitis with or without asthma using the Mann Whitney U test, Student t test and the chi square test. Result A positive association was observed between the radiological bone score with tissue eosinophilia (p=.018), and smoking (p < 0.001) in between the two groups. Chronic eosinophilic rhinosinusitis was observed in 39 (52.7%) patients. 15 patients with Chronic rhinosinusitis had asthma ,and among these asthmatic patients 11 had eosinophilic chronic rhinosinusitis. Mild osteitis was evident in 34 (45.9%) ,moderate osteitis in 39 (52.7%) and severe in 1 (1.4%). Among 15 asthmatic patients, 10 had moderate osteitis and 5 had mild osteitis. Conclusion A rigorous exentration of osteitic bony nidus appears necessary for successful treatment outcomes in all chronic rhinosinusitis patients and to prevent acute exacerbation in the asthmatic group of chronic rhinosinusitis patients.","PeriodicalId":35493,"journal":{"name":"Kathmandu University Medical Journal","volume":"23 91","pages":"273-278"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Medical Students' Level of Empathy and its Correlation with Prosocial Behaviour in Jharkhand, India. 印度贾坎德邦医学生共情水平及其与亲社会行为的相关性研究

Kathmandu University Medical Journal Pub Date : 2025-07-01

A Raj, S Mittal, S Sinha, S B Singh

{"title":"Exploring Medical Students' Level of Empathy and its Correlation with Prosocial Behaviour in Jharkhand, India.","authors":"A Raj, S Mittal, S Sinha, S B Singh","doi":"","DOIUrl":"","url":null,"abstract":"Background Empathy was first introduced in the context of the doctor-patient relationship by Southard in 1918. It plays a crucial role in enhancing patient compliance and improving clinical outcomes. Recognizing its significance, there has been a global emphasis on integrating empathy into medical education. Objective To assess empathy levels among medical undergraduate students across different academic phases and to examine its relationship with self-reported social distancing behaviour during COVID-19. Method A multicentric cross-sectional, observational study was conducted among 459 undergraduate medical students from Phase one to Phase four of medical training across multiple medical schools in the state of Jharkhand, India. Empathy levels were assessed using the Jefferson Scale of Empathy - Student Version. Online data was analysed using SPSS Software version 24.0. Gender based score were tested with Student's unpaired t-test, MBBS phase-wise comparisons with ANOVA, and correlations between empathy and social distancing with Pearson's coefficient test. Result A total of 459 medical students participated in the study. The mean empathy score across all participants was 105.96 ± 16.55. A significant decline in empathy scores was observed up to the third phase of medical education, followed by an increase in the fourth phase. Correlation analysis revealed a positive but non-significant relationship (r = 0.079, p = 0.093) between empathy and self-reported social distancing behaviour. Conclusion The study findings highlight significant variations in empathy levels across different phases of medical education. Female students exhibited higher empathy levels than their male counterparts. Additionally, the 'perspective-taking' component of empathy showed a positive correlation with self-reported social distancing behaviour during COVID-19.","PeriodicalId":35493,"journal":{"name":"Kathmandu University Medical Journal","volume":"23 91","pages":"337-342"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profile of Pediatric patients with Foreign Body Aspiration requiring Bronchoscopy in a Tertiary Care Center. 小儿异物吸入需要支气管镜检查在三级保健中心的概况。

Kathmandu University Medical Journal Pub Date : 2025-07-01

M Paneru, A Nepal, D Yadav, B Dangol, N Shrestha, L Maharjan, R Maharjan

{"title":"Profile of Pediatric patients with Foreign Body Aspiration requiring Bronchoscopy in a Tertiary Care Center.","authors":"M Paneru, A Nepal, D Yadav, B Dangol, N Shrestha, L Maharjan, R Maharjan","doi":"","DOIUrl":"","url":null,"abstract":"Background Foreign body aspiration (FBA) is a common pediatric emergency, particularly in children under five, due to immature airway protection reflexes and their tendency to explore objects orally. It is the fourth leading cause of accidental death in children under three, making early diagnosis and prompt management crucial. Objective To assess the profile of pediatric patients requiring bronchoscopy, identify associated clinical presentations, evaluate complications, identify the types of foreign bodies, and the most frequent site of lodgment. Method Clinical data of three years, from April 2021 to April 2024, were retrospectively collected from medical records. The study included children below 14 years of age who underwent rigid bronchoscopy for suspected foreign body aspiration at a tertiary care center. Their clinical profiles and various presenting symptoms were analyzed. Result Among 37 cases, the highest incidence (43.2%) was in children aged 1-3 years, with males comprising 73%. Cough and wheezing were the most common symptoms (19 cases). Organic foreign bodies, mainly peanuts and beans, were found in 22 cases, while metallic sharp objects (pins) were present in 5 cases. The right main bronchus was the most affected site (22 cases), and post-procedural pneumonia developed in 5 cases. Conclusion Foreign body Aspiration predominantly affects young children, with organic objects being the most common. Rigid bronchoscopy remains the gold standard for diagnosis and treatment, emphasizing the need for early intervention to prevent complications.","PeriodicalId":35493,"journal":{"name":"Kathmandu University Medical Journal","volume":"23 91","pages":"285-290"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Obesity Indices in Predicting Hyperglycemia in Adults of Duwakot, Bhaktapur. 评价肥胖指数在预测成人高血糖的Duwakot， Bhaktapur。

Kathmandu University Medical Journal Pub Date : 2025-07-01

G Khakurel, K Gautam, P K Karki, S Chalise

{"title":"Assessment of Obesity Indices in Predicting Hyperglycemia in Adults of Duwakot, Bhaktapur.","authors":"G Khakurel, K Gautam, P K Karki, S Chalise","doi":"","DOIUrl":"","url":null,"abstract":"Background Obesity is a major risk factor for metabolic disorders, including hyperglycemia, which is a precursor to diabetes. Various obesity indices, such as Body Mass Index (BMI), Waist Circumference (WC) and Waist-to-Height Ratio (WHtR), are used to assess adiposity. Objective To evaluate and compare the effectiveness of obesity indices in predicting hyperglycemia among adults in Duwakot, Bhaktapur. Method This was a cross-sectional study conducted among 128 adults visiting Kathmandu Medical College Public Limited, Duwakot from August 2024 to January 2025. Anthropometric measurements (BMI, WC and WHtR) were recorded, and fasting blood glucose (FBG) levels were measured to define hyperglycemia (FBG ≥ 126 mg/ dL). Pearson correlation was used to evaluate the relationship between obesity indices and FBG levels, while an independent t-test compared the mean values between males and females. The predictive ability of obesity indices was assessed using Receiver Operating Characteristic (ROC) curve analysis, and the area under the curve (AUC) and optimal cut-off values were determined. Values of p≤0.05 were considered statistically significant. Result The prevalence of hyperglycemia among the participants was 17.2 %. Pearson correlation analysis showed that FBG was significantly correlated with WC (Male: r = 0.233, p < 0.05; Female: r = 0.459, p < 0.05), and WHtR (Male: r = 0.227, p < 0.05; Female: r = 0.482, p < 0.05). Independent t-test analysis revealed a statistically significant difference in WC (p = 0.025) and WHtR (p = 0.014), with males having higher WC and females having higher WHtR. However, BMI (p = 0.179) did not show a significant difference between the two groups. ROC curve analysis revealed that WHtR had the highest AUC (Male:0.607, Female:0.721), followed by WC and BMI. Conclusion This study found that WHtR was the strongest predictor of hyperglycemia, followed by WC, and BMI. WHtR could be an effective screening tool for early hyperglycemia detection in community settings.","PeriodicalId":35493,"journal":{"name":"Kathmandu University Medical Journal","volume":"23 91","pages":"312-316"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Thyroid Dysfunction and Common Mental Disorders (Anxiety and Depression): A university hospital-based cross-sectional study. 甲状腺功能障碍与常见精神障碍（焦虑和抑郁）之间的关系：一项基于大学医院的横断面研究。

Kathmandu University Medical Journal Pub Date : 2025-07-01

B Shrestha, S K Upadhaya, M Shrestha, S Regmi, D Kunwar, A Risal

{"title":"Association between Thyroid Dysfunction and Common Mental Disorders (Anxiety and Depression): A university hospital-based cross-sectional study.","authors":"B Shrestha, S K Upadhaya, M Shrestha, S Regmi, D Kunwar, A Risal","doi":"","DOIUrl":"","url":null,"abstract":"Background Anxiety and depression have been frequently reported to be associated with thyroid dysfunctions. Many symptoms of anxiety and depression overlap with thyroid disorders sometimes masking the diagnosis. Objective To look for association between thyroid diseases and newly diagnosed case of anxiety or depression in out-patient department. Method It was a hospital based descriptive, cross-sectional study conducted in a period of six months after ethical approval from institutional review committee with participants aged 18-65 years, who wished to give consent for the study and investigations. Cases of anxiety and depression was diagnosed as per the International Classification of Diseases-10, clinical description and diagnostic guideline and self-administered proforma was used for demographic profile. Sample analysis and comparison of different groups in the study was done using chi-square test; p-value < 0.05 was considered for statistical significance. Result Anxiety disorders was higher in individuals with normal thyroid function (54.5%), and depression appeared to be more common among individuals with abnormal thyroid function (60.9%); it did not have any statistical significance. Conclusion Depressive disorders were common among thyroid disorder patients. Further study is needed to examine the relationship between thyroid disorder and common mental disorders to help improve mental health outcomes.","PeriodicalId":35493,"journal":{"name":"Kathmandu University Medical Journal","volume":"23 91","pages":"359-363"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patients' Perceptions and Experience towards Root Canal Treatment: A Prospective Analytical Study. 患者对根管治疗的认知和体验：一项前瞻性分析研究。

Kathmandu University Medical Journal Pub Date : 2025-07-01

S P Pradhan, M Nepal, A Chakradhar, S K Mahanta, S Adhikari

{"title":"Patients' Perceptions and Experience towards Root Canal Treatment: A Prospective Analytical Study.","authors":"S P Pradhan, M Nepal, A Chakradhar, S K Mahanta, S Adhikari","doi":"","DOIUrl":"","url":null,"abstract":"Background Although Root Canal Treatment (RCT) is considered to be a painful procedure, it actually alleviates the pain of endodontic origin. Patient may avoid root canal treatment mainly due to anxiety and fear of pain, resulting in treatment avoidance and eventual tooth loss through extraction. Objective To overview the patients' perceptions towards Root Canal Treatments and compare those perceptions to their post treatment actual experiences. Method A prospective analytical study was conducted at the Department of Conservative Dentistry and Endodontics, Kathmandu University School of Medical Sciences (KUSMS), Dhulikhel. A structured questionnaire was administered to the patients before starting of the root canal treatment and immediately after placement of the root canal filling materials. Multiple-choice questions were used to assess patient concerns, levels of nervousness, and perceptions of anticipated versus experienced pain. Result Before initiation of treatment 38 patients (16.7%) anticipated root canal treatment to be painless, while 171 (75.3%) and 18 (7.9%) expected it to be painful and extremely painful respectively. Following treatment 123 patients (54.2%) reported no pain, whereas 98 (43.2%) and 6 (2.6%) experienced it as painful and extremely. While pain associated with the treatment was the highest pretreatment concern 60 (26.4%), the post treatment concern was time 38 (16.7%). Conclusion The study provided insights into patient's perceptions regarding root canal treatment. Pain experienced during endodontic treatment was frequently less than anticipated pain. There was a 100% satisfaction rate with root canal treatment, and most patients expressed willingness to undergo the treatment again if needed.","PeriodicalId":35493,"journal":{"name":"Kathmandu University Medical Journal","volume":"23 91","pages":"375-380"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitivity and Specificity of Ankle Brachial Index for Diagnosis of Peripheral Arterial Disease in Diabetic Patients Presenting to University Hospital of Nepal. 踝肱指数诊断尼泊尔大学医院糖尿病患者外周动脉病变的敏感性和特异性

Kathmandu University Medical Journal Pub Date : 2025-07-01

R M Karmacharya, S Vaidya, B Yadav, S Sharma, S Bhatt, N Bhandari, S Bhandari, S Maharjan, J Bhusal

{"title":"Sensitivity and Specificity of Ankle Brachial Index for Diagnosis of Peripheral Arterial Disease in Diabetic Patients Presenting to University Hospital of Nepal.","authors":"R M Karmacharya, S Vaidya, B Yadav, S Sharma, S Bhatt, N Bhandari, S Bhandari, S Maharjan, J Bhusal","doi":"","DOIUrl":"","url":null,"abstract":"Background Diabetes is a significant risk factor for peripheral arterial disease (PAD) that increases morbidity and mortality. Hence, early detection of peripheral arterial disease is necessary. Evidence shows Ankle Brachial Index (ABI) as a promising test to diagnose peripheral arterial disease. However, sensitivity and specificity need to be evaluated before clinical use. Objective To determine Ankle Brachial Index sensitivity and specificity for the diagnosis of peripheral arterial disease in diabetic patients. Method Diabetic patients were recruited from Dhulikhel Hospital. Doppler ultrasonography (DUS) was done in all the recruited participants and peripheral arterial disease was assessed. Based on Jager's criteria, those with grade III and IV stenosis were diagnosed as peripheral arterial disease and underwent ankle brachial index. Ankle brachial indexscores below 0.9 and above 1.5 were considered abnormal. The diagnosis by ankle brachial index was matched against the gold standard doppler ultrasonography to determine its specificity and sensitivity. Descriptive statistics and independent t-tests were used for statistics. P-value < 0.05 was considered statistically significant. Result There were total of 237 diabetic patients of which 31.2% had peripheral arterial disease. We found high sensitivity and specificity of ankle brachial index when tested against doppler ultrasonography with the values ranging from 88.68-89.66% and 86.67-90% respectively. Conclusion Ankle brachial index can be used in clinical settings to diagnose peripheral arterial disease in individuals with diabetes mellitus.","PeriodicalId":35493,"journal":{"name":"Kathmandu University Medical Journal","volume":"23 91","pages":"333-336"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0