Prague medical report最新文献_第8页

Side Effects of Antihypertensives Induced by Switching to Different Generic Medications: Case Reports. 切换不同非专利药物引起的降压药副作用:病例报告。

Prague medical report Pub Date : 2023-01-01 DOI: 10.14712/23362936.2023.13

Apichai Wattanapisit, Penpun Lertwatanachai, Thittita Pongsawat, Sanhapan Wattanapisit, Jaruporn Thongruch

{"title":"Side Effects of Antihypertensives Induced by Switching to Different Generic Medications: Case Reports.","authors":"Apichai Wattanapisit, Penpun Lertwatanachai, Thittita Pongsawat, Sanhapan Wattanapisit, Jaruporn Thongruch","doi":"10.14712/23362936.2023.13","DOIUrl":"https://doi.org/10.14712/23362936.2023.13","url":null,"abstract":"Generic medication is a product that contains the same active substance and pharmaceutical characteristics as brand-name medications. Generic medications are cost-effective and comparable to brand-name medications in terms of clinical endpoints. However, the use of generic medications instead of brand-name medications is a debatable issue among patients and healthcare providers. Two patients with essential hypertension experienced side effects after switching to different generic antihypertensives (one generic medication to another generic medication). Adverse drug reactions, including, hypersensitivity, side effects, and intolerance, should be identified through present and past medical history and clinical characteristics. The adverse drug reactions in both patients were more likely to be side effects of the medications after switching to different generic antihypertensives produced by different companies (patient 1: enalapril and patient 2: amlodipine). The side effects were possibly caused by the different inactive ingredients or excipients. These two case reports emphasise the importance of monitoring adverse drug reactions throughout the course of treatment and communicating with patients prior to switching to a new generic medication.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"124 2","pages":"172-176"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Cannabidiol in Inflammation: A Review of Pre-clinical and Clinical Findings. 大麻二酚在炎症中的作用：临床前和临床研究综述。

Prague medical report Pub Date : 2023-01-01 DOI: 10.14712/23362936.2023.17

Michaela Sklenárová, Martin Šíma, Ondřej Slanař

{"title":"Effects of Cannabidiol in Inflammation: A Review of Pre-clinical and Clinical Findings.","authors":"Michaela Sklenárová, Martin Šíma, Ondřej Slanař","doi":"10.14712/23362936.2023.17","DOIUrl":"https://doi.org/10.14712/23362936.2023.17","url":null,"abstract":"Cannabidiol (CBD) is the second most abundant component of the plant Cannabis sativa. Currently, CBD is approved for Lennox-Gastaut and Dravet syndrome and newly for tuberous sclerosis complex. However, based on the available data, CBD migth have a broad spectrum of potential therapeutic uses. Therefore, the aim of this review was to summarize the evidence on the effects of CBD on pain and inflammation of various causes. PubMed and Web of Science databases were searched until January 2023. The medical keyword term \"cannabidiol\" was combined with \"pain\", \"arthritis\", and \"inflammation\". Based on the initial search for these terms, 9, 5, and 5 relevant publications have been selected. Based on the available data, it is not possible to draw a clear conclusion about the effect of CBD to releave pain, because each study used a different route of administration or treatment regimen. The studies also differed in etiopathogenesis of pain (chronic, neuropathic, and possibly inflammatory pain), and in general included only small number of subjects. In case of anti-inflammatory qualities of CBD, its effect on the intestinal system is negligible. On the other hand, positive treatment results were observed in all publications dealing with the effect of CBD on arthritis.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"124 3","pages":"216-229"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41150627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Practical and Applicable New Index as an Indicator of Inflammation in the Diagnosis of Erectile Dysfunction: C-reactive Protein-to-Albumin Ratio. 诊断勃起功能障碍时作为炎症指标的实用新指标：C 反应蛋白-白蛋白比值。

Prague medical report Pub Date : 2023-01-01 DOI: 10.14712/23362936.2023.33

Mesut Cilli, Kemal Turker Ulutas

{"title":"A Practical and Applicable New Index as an Indicator of Inflammation in the Diagnosis of Erectile Dysfunction: C-reactive Protein-to-Albumin Ratio.","authors":"Mesut Cilli, Kemal Turker Ulutas","doi":"10.14712/23362936.2023.33","DOIUrl":"https://doi.org/10.14712/23362936.2023.33","url":null,"abstract":"Current evidence suggests that the significant underlying pathophysiological mechanism in erectile dysfunction (ED) is endothelial dysfunction. It is clinically essential to monitor ED because inflammatory processes lead to dysfunctional endothelium and the progression of atherosclerosis. The current retrospective analysis assessed the registers of 90 patients with ED complaints (ED group) and 78 healthy people without ED complaints (control group) who were being managed at the urology units of the surgical outpatient clinic. The international index of erectile function-5 (IIEF-5) evaluated the ED. C-reactive protein (CRP)/albumin ratio (CAR) value was determined by manually dividing serum CRP value by the albumin value in patients whose CRP value was between 0 and 5 mg/l. The average CAR was 0.45 ± 0.37 (ED group) versus 0.22 ± 0.1 in the control group (p=0.0001). IIEF-5 results were negatively correlated with CAR values (r=-0.299; p=0.0001). The strongest cut-off of CAR for predicting ED was 0.025, with 81.8% sensitivity and 75% specificity (p=0.0001). The ED group showed higher levels of CAR and CRP than the control group. CAR can be used as a practical, easy-to-calculate, and cost-effective index in diagnosing ED patients.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"124 4","pages":"435-443"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of COVID-19 Infection and Acute Mesenteric Ischemia. COVID-19 感染与急性肠系膜缺血的关系

Prague medical report Pub Date : 2023-01-01 DOI: 10.14712/23362936.2023.31

Ognen Kostovski, Irena Lazarova, Bojan Popchanovski, Irena Kostovska

{"title":"Association of COVID-19 Infection and Acute Mesenteric Ischemia.","authors":"Ognen Kostovski, Irena Lazarova, Bojan Popchanovski, Irena Kostovska","doi":"10.14712/23362936.2023.31","DOIUrl":"https://doi.org/10.14712/23362936.2023.31","url":null,"abstract":"COVID-19 is an infectious disease that is considered to be a thromboinflammatory disorder. The study was aimed to determine the prevalence of COVID-19 in patients with acute mesenteric ischemia (AMI) and the outcomes of surgical treatment in relation to COVID-19. A total of 140 patients were included in this multicentric study divided into two groups: the test group (n=65) consisted of cases of AMI detected during the COVID-19 pandemic and the control group (n=65) consisted of cases of AMI detected before the pandemic. Test group patients were classified as COVID-positive (COVID+), or COVID-negative (COVID-) if they tested positive, respectively negative test for COVID-19 on admission. Primary outcomes were: prevalence of COVID-19 infection among test group patients, association between COVID-19 infection and inoperability, and between COVID-19 and treatment outcome. Secondary outcomes were association between each blood parameter and inoperability and treatment outcome. There were no statistically significant differences between inoperability and COVID-19 positivity on admission, overall mortality between the control group and the test group and overall mortality between COVID+ and COVID- patients, as well as among those patients that have been surgically treated (p>0.05). There were statistically significant differences between serum amylase levels (p=0.034), and serum LDH levels (p=0.0382) and inoperability, between serum LDH levels and postoperative mortality (p=0.0151), and overall mortality (p=0.00163). High level of LDH and serum pancreatic amylase are associated with a higher rate of inoperability and a higher postoperative and overall mortality rate. COVID-19 does not seem to independently influence the treatment outcome of AMI.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"124 4","pages":"413-420"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demonstration of the Rationale for Therapeutic Drug Monitoring of Isavuconazole: A Case Report with a Lung Transplant Recipient. 证明对异维康唑进行治疗药物监测的合理性：肺移植受者的病例报告。

Prague medical report Pub Date : 2023-01-01 DOI: 10.14712/23362936.2023.34

Eliška Dvořáčková, Andrea Zajacová, Jan Havlín, Eva Klapková, Robert Lischke, Ondřej Slanař, Martin Šíma

引用次数: 0

Identification of Pathogenic Microflora and Its Sensitivity to Antibiotics in Cases of the Odontogenic Purulent Periostitis and Abscesses in the Oral Cavity. 牙源性化脓性骨膜炎及口腔脓肿病原菌群的鉴定及其对抗生素的敏感性。

Prague medical report Pub Date : 2023-01-01 DOI: 10.14712/23362936.2023.2

Iurii Mochalov, Maryna Kryvtsova, Andrij Chobey, Mariya Kulynych

{"title":"Identification of Pathogenic Microflora and Its Sensitivity to Antibiotics in Cases of the Odontogenic Purulent Periostitis and Abscesses in the Oral Cavity.","authors":"Iurii Mochalov, Maryna Kryvtsova, Andrij Chobey, Mariya Kulynych","doi":"10.14712/23362936.2023.2","DOIUrl":"https://doi.org/10.14712/23362936.2023.2","url":null,"abstract":"Odontogenic infections are the most common infectious and inflammatory diseases of the maxillofacial area and problem of the causative pathogen identification is an actual task, part of a permanent process of updating and modernization of treatment and diagnostic protocols and standards. In presented study a purulent exudate from 13 patients with acute purulent odontogenic intraoral lesions was studied by bacteriological method with detection of sensitivity to antibacterial agents. Bacteriological studies showed that genus Streptococcus predominated in 69.23% cases. Pathogenic microorganisms in clinically significant concentrations (105 per 1 ml and above) (Streptococcus and Staphylococcus) were resistant to Tetracycline and Doxycycline, had moderate sensitivity to macrolides in 22.22% and resistance in 77.78%. Amoxicillin/clavulanate caused effective growth retardation in 22.22% cases and moderate delay - in 77.78% without cases of resistance. Sensitivity to cephalosporins was detected in 50.00% cases, moderate sensitivity - in 38.89%, resistance - in 11.11%. Fluoroquinolones were the most effective - sensitivity in 72.22% cases, moderate sensitivity - in 22.22%, resistance - in 5.56%. The most effective fluoroquinolones were Moxifloxacin and Ciprofloxacin. The highest resistance to antifungal agents was shown by genus Candida, antifungal susceptibility was observed only in 20.00% cases. The microbiota of purulent odontogenic inflammation in the oral cavity was identified in clinically significant concentrations in only 61.54% cases with predominance of Streptococcus. The most effective antibacterial agents for odontogenic purulent process may be considered among cephalosporins and fluoroquinolones. There is a need to repeat similar studies in other regions of Ukraine and at other times of the year.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"124 1","pages":"16-32"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10699380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effective Treatment of a Melanoma Patient with Hemophagocytic Lymphohistiocytosis after Nivolumab and Ipilimumab Combined Immunotherapy. Nivolumab和Ipilimumab联合免疫治疗一名黑色素瘤患者的噬血细胞淋巴组织细胞增多症的有效治疗。

Prague medical report Pub Date : 2022-01-01 DOI: 10.14712/23362936.2022.4

R. Pacholczak-Madej, A. Grela-Wojewoda, Joanna Lompart, B. Żuchowska-Vogelgesang, M. Ziobro

{"title":"Effective Treatment of a Melanoma Patient with Hemophagocytic Lymphohistiocytosis after Nivolumab and Ipilimumab Combined Immunotherapy.","authors":"R. Pacholczak-Madej, A. Grela-Wojewoda, Joanna Lompart, B. Żuchowska-Vogelgesang, M. Ziobro","doi":"10.14712/23362936.2022.4","DOIUrl":"https://doi.org/10.14712/23362936.2022.4","url":null,"abstract":"Immune checkpoint inhibitors have significantly improved the prognosis of melanoma patients. However, these therapies may trigger unexpected immune-related adverse events (irAEs), which are challenging in making the proper diagnosis and providing treatment. Hematological toxicities are possible irAEs, but were poorly evaluated in clinical trials and treatment recommendations of this specific complications are limited. We present a stage IV melanoma patient who developed an extremely rare toxicity - hemophagocytic lymphohistiocytosis (HLH) after the 4th course of combined immunotherapy with nivolumab and ipilimumab. The patient was steroid resistant and only the treatment with various immunosuppressive agents provided control of the disease and finally melanoma regression. In this report, we evaluated the methods of HLH treatment and described our modification of available protocols. Immediate immunosuppression can be life-saving and due to rarity of this condition as well as lack of specific recommendations, every report is valuable for clinicians, especially when treatment was effective.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"123 1 1","pages":"35-42"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67044584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

WALANT as an Optimal Approach in Hand Surgery during Pandemics. WALANT作为大流行期间手部手术的最佳方法。

Prague medical report Pub Date : 2022-01-01 DOI: 10.14712/23362936.2022.9

Gordana Georgieva, Blagoja Srbov, Bisera Nikolovska, Sofija Tusheva, Katerina Jovanovska, Tomislav Jovanoski, B. Dzonov, Smilja Tudzarova Gjorgova, S. Pejkova

引用次数: 2

A Response of the Pineal Gland in Sexually Mature Rats under Long-term Exposure to Heavy Metal Salts. 长期暴露于重金属盐对性成熟大鼠松果体的影响。

Prague medical report Pub Date : 2022-01-01 DOI: 10.14712/23362936.2022.21

Nataliia Hryntsova, Ingrid Hodorová, Josef Mikhaylik, Anatoly Romanyuk

{"title":"A Response of the Pineal Gland in Sexually Mature Rats under Long-term Exposure to Heavy Metal Salts.","authors":"Nataliia Hryntsova, Ingrid Hodorová, Josef Mikhaylik, Anatoly Romanyuk","doi":"10.14712/23362936.2022.21","DOIUrl":"https://doi.org/10.14712/23362936.2022.21","url":null,"abstract":"Pollution with heavy metal salts is an important environmental problem today, having an adverse effect on public health. The endocrine system maintains homeostasis in the body. The antioxidant protection (GPX-1) of the pineal gland in mature rats was studied. Animals of the experimental group represented a model of microelementosis, achieved by adding a mixture of heavy metal salts for 90 days to drinking water: zinc (ZnSO4×7H2O) - 5 mg/l, copper (CuSO4×5H2O) - 1 mg/l, iron (FeSO4) - 10 mg/l, manganese (MnSO4×5H2O) - 0.1 mg/l, lead (Pb(NO3)2) - 0.1 mg/l, and chromium (K2Cr2O7) - 0.1 mg/l. Morphological, statistical and immunohistochemical (GPX-1) research methods were used. Long-term (90-days) intake of heavy metal salts mixture in the body of experimental animals brought about development of the general adaptation syndrome, the stage of chronic stress \"subcompensation\" in the pineal gland. Morphological rearrangements were of nonspecific polymorphic nature as severe hemodynamics disorder in the organ, impairment of vascular wall morphology, development of tissue hypoxia and oxidative stress, accompanied by processes of accelerated apoptosis in part of pinealocytes, by a significant decrease in glutathione peroxidase level in the organ and reactive astrogliosis as a response to the damaging agent's action. Along with the negative changes in the pineal gland, a compensatory-adaptive processes with signs of functional stress also occurred. A sufficiently high degree of glutathione peroxidase activity in 39% of pinealocytes located perivascularly, active adaptive glial reaction and activation of synthetic processes in some pinealocytes were also observed.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"123 4","pages":"225-242"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40480350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Delayed Spontaneous Pneumothorax in a Previously Healthy Nonventilated COVID-19 Patient. 既往健康非通气COVID-19患者的延迟自发性气胸

Prague medical report Pub Date : 2022-01-01 DOI: 10.14712/23362936.2022.26

Ondrej Zahornacký, Štefan Porubčin, Alena Rovňáková, Pavol Jarčuška

{"title":"Delayed Spontaneous Pneumothorax in a Previously Healthy Nonventilated COVID-19 Patient.","authors":"Ondrej Zahornacký, Štefan Porubčin, Alena Rovňáková, Pavol Jarčuška","doi":"10.14712/23362936.2022.26","DOIUrl":"https://doi.org/10.14712/23362936.2022.26","url":null,"abstract":"Spontaneous pneumothorax is a serious and life-threatening complication of SARS-CoV-2 pneumonia. It most commonly occurs during the acute phase of the disease in patients with pre-existing lung disease (e.g. emphysema, bronchiectasis, cystic fibrosis, etc.) and in patients who require oxygen supplementation in any form (low-flow oxygen therapy, high-flow non-invasive or mechanical invasive or mechanical invasion). A rare case of a 52-year-old patient with a spontaneous pneumothorax who developed four weeks after PCR SARS-CoV-2 positivity was described. Interestingly, the patient did not have any factors that the literature considered risky for the development of this complication. During the acute phase of the disease, his condition did not require hospitalization. Imaging examinations could not clarify the cause of pneumothorax. With this case report, we want to point out the fact that spontaneous pneumothorax, as a rare and life-threatening complication of COVID-19 infection, may develop during recovery, and it is necessary to think about this complication in the differential diagnosis of dyspnoea.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"123 4","pages":"279-286"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40482764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0