Bulletin of National Institute of Health Sciences最新文献_第5页

[Effects of transplacental and trans-breast milk exposure to the organophosphate compound chlorpyrifos on the developing immune system of mice]. [经胎盘和经母乳接触有机磷化合物毒死蜱对小鼠免疫系统发育的影响]。

Bulletin of National Institute of Health Sciences Pub Date : 2011-01-01

Ryosuke Nakamura, Yoshie Kimura, Hideki Matsuoka, Akiko Hachisuka, Rika Nakamura, Atsushi Nakamura, Makoto Shibutani, Reiko Teshima

引用次数: 0

Chemical category approach of genotoxicity studies for branched alkylphenols. 支链烷基酚遗传毒性研究的化学分类方法。

Bulletin of National Institute of Health Sciences Pub Date : 2011-01-01

Mariko Matsumoto, Tomoaki Harada, Tohru Shibuya, Shuichi Hamad, Masamitsu Honma, Akihiko Hirose

{"title":"Chemical category approach of genotoxicity studies for branched alkylphenols.","authors":"Mariko Matsumoto, Tomoaki Harada, Tohru Shibuya, Shuichi Hamad, Masamitsu Honma, Akihiko Hirose","doi":"","DOIUrl":"","url":null,"abstract":"A chemical category is a group of chemicals whose toxicological properties are expected to be similar or follow a regular pattern as a result of structural similarity. The category approach is beneficial for decreasing in the resource of risk assessment for huge amount of unevaluated existing chemicals, and also in the use of all kinds of animal tests including even in vivo genotoxicity tests from a point of view of the animal welfare. The present paper reports the results of in vivo micronucleus tests of o-sec-butylphenol (CAS:89-72-5) and 2-isopropyl-5-methylphenol (CAS:89-83-8) and discusses genotoxic potential of seven alkylphenols, o-sec-butylphenol, 2-isopropyl-5-methylphenol, p-sec-butylphenol (CAS:99-71-8), 2-tert-butylphenol (CAS:88-18-6), 2, 4-di-tert-butylphenol (CAS:96-76-4), 4-tert-butylphenol (CAS:98-54-4) and 6-tert-butyl-m-cresole (CAS:88-60-8) by the category approach. Based on the negative results of in vivo micronucleus tests, it can be concluded that these category chemicals are not likely clastogenic in vivo. Further in vivo micronucleus assays on untested substances may not be required by using the category approach, but further supporting information such as physicochemical profiles and (Q) SAR predictions may be necessary to strengthen the rationale for the category approach.","PeriodicalId":35462,"journal":{"name":"Bulletin of National Institute of Health Sciences","volume":" 129","pages":"68-75"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30399031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Volatile organic compounds (VOCs) emitted from large furniture]. [大型家具排放的挥发性有机化合物]。

Bulletin of National Institute of Health Sciences Pub Date : 2011-01-01

Toshiko Tanaka-Kagawa, Mitsuko Furuta, Masayoshi Shibatsuji, Hideto Jinno, Tetsuji Nishimura

{"title":"[Volatile organic compounds (VOCs) emitted from large furniture].","authors":"Toshiko Tanaka-Kagawa, Mitsuko Furuta, Masayoshi Shibatsuji, Hideto Jinno, Tetsuji Nishimura","doi":"","DOIUrl":"","url":null,"abstract":"Indoor air pollution by volatile organic compounds (VOCs), which may cause a hazardous influence on human being such as sick building (sick house) syndrome, has become a serious problem. In this study, VOCs emitted from nine pieces of home furniture, three sets of dining tables, three sets of chest of drawers and three sofas, were analyzed as potential sources of indoor air pollution by large chamber test method (JIS A 1911). Based on the emission rates of total VOC (TVOC), the impacts on the indoor TVOC was estimated by the sample model with a volume of 20 m3 and ventilation frequency of 0.5 times/h. The estimated TVOC increment values were exceeded the provisional target value for indoor air (400 microg/m3) in three sets of dining tables, one set of chest of drawer and one sofa. The estimated increment of formaldehyde were exceeded the guideline value (100 microg/m3) in one set of dining table, two sets of chest of drawers and one sofa. These results revealed that VOC emissions from furniture may influence significantly indoor air quality. Also, in this study, to establish the alternative method for large chamber test methods, emission rates from representative three parts of furniture unit were evaluated using the small chamber and emission rate from full-sized furniture was predicted. Emission rates of TVOC and formaldehyde predicted by small chamber test were 3-46% and 6-252% of the data obtained using large chamber test, respectively.","PeriodicalId":35462,"journal":{"name":"Bulletin of National Institute of Health Sciences","volume":" 129","pages":"76-85"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30399032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Analysis of volcanic-ash-based insoluble ingredients of facial cleansers]. [洗面奶中火山灰不溶性成分分析]。

Bulletin of National Institute of Health Sciences Pub Date : 2011-01-01

Yoshiaki Ikarashi, Tadashi Uchino, Tetsuji Nishimura

{"title":"[Analysis of volcanic-ash-based insoluble ingredients of facial cleansers].","authors":"Yoshiaki Ikarashi, Tadashi Uchino, Tetsuji Nishimura","doi":"","DOIUrl":"","url":null,"abstract":"The substance termed \"Shirasu balloons\", produced by the heat treatment of volcanic silicates, is in the form of hollow glass microspheres. Recently, this substance has gained popularity as an ingredient of facial cleansers currently available in the market, because it lends a refreshing and smooth feeling after use. However, reports of eye injury after use of a facial cleanser containing a substance made from volcanic ashes are on the rise. We presumed that the shape and size of these volcanic-ash-based ingredients would be the cause of such injuries. Therefore, in this study, we first developed a method for extracting water-insoluble ingredients such as \"Shirasu balloons\" from the facial cleansers, and then, we examined their shapes and sizes. The insoluble ingredients extracted from the cleansers were mainly those derived from volcanic silicates. A part of the ingredients remained in the form of glass microspheres, but for the most part, the ingredients were present in various forms, such as fragments of broken glass. Some of the fragments were larger than 75 microm in length. Foreign objects having a certain hardness, shape, and size (e.g., size greater than 75 microm) can possibly cause eye injury. We further examined insoluble ingredients of facial scrubs, such as artificial mineral complexes, mud, charcoal, and polymers, except for volcanic-silicate-based ingredients. The amounts of insoluble ingredients extracted from these scrubs were small and did not have a sharp edge. Some scrubs had ingredients with particles larger than 75 microm in size, but their specific gravities were small and their hardness values were much lower than those of glass microspheres of ingredients such as \"Shirasu balloons\". Because the fragments of glass microspheres can possibly cause eye injury, the facial cleansers containing large insoluble ingredients derived from volcanic ashes should be avoided to use around eyes.","PeriodicalId":35462,"journal":{"name":"Bulletin of National Institute of Health Sciences","volume":" 129","pages":"93-9"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30399034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Analytical method for natamycin in wine using high-performance liquid chromatography]. [高效液相色谱法分析葡萄酒中纳他霉素]。

Bulletin of National Institute of Health Sciences Pub Date : 2011-01-01

Noriko Furusho, Hiroki Kubota, Kyoko Sato, Hiroshi Akiyama, Yoko Kawamura

引用次数: 0

[Food-poisoning bacterial contamination on food: a comparison between European countries and Japan]. [食物中毒细菌污染:欧洲国家与日本的比较]。

Bulletin of National Institute of Health Sciences Pub Date : 2011-01-01

Hodaka Suzuki, Shigeki Yamamoto

引用次数: 0

[Determination of the particle size and relative light scattering intensity of aggregates of human IgG and humanized monoclonal antibody product induced by various stress using dynamic light scattering]. [动态光散射法测定不同应激诱导的人IgG和人源化单克隆抗体产物聚集体的粒径和相对光散射强度]。

Bulletin of National Institute of Health Sciences Pub Date : 2011-01-01

Shingo Niimi

引用次数: 0

[Regenerative medicine and characteristics of stem cells]. 【再生医学与干细胞特性】。

Bulletin of National Institute of Health Sciences Pub Date : 2011-01-01

Kazuhiro Suzuki

引用次数: 0

[Detection methods of enterohemorrhagic Escherichia coli O111 in beef: a collaborative study]. [牛肉肠出血性大肠杆菌O111的检测方法:合作研究]。

Bulletin of National Institute of Health Sciences Pub Date : 2011-01-01

Midori Hiroi, Kayoko Ohtsuka, Shinji Iizuka, Kenichiro Taga, Kanji Sugiyamai, Yoshiko Sugita-Konishi, Yukiko Hara-Kudo

{"title":"[Detection methods of enterohemorrhagic Escherichia coli O111 in beef: a collaborative study].","authors":"Midori Hiroi, Kayoko Ohtsuka, Shinji Iizuka, Kenichiro Taga, Kanji Sugiyamai, Yoshiko Sugita-Konishi, Yukiko Hara-Kudo","doi":"","DOIUrl":"","url":null,"abstract":"To establish a detection method for enterohemorrhagic Escherichia coli (EHEC) O111 in meat, a single-laboratory evaluation and a collaborative study were conducted focusing on comparisons of the efficiencies in combination with enrichment, a direct plating method and a plating method with immunomagnetic separation (IMS-plating method) using various agar media for EHEC O111, loop-mediated isothermal amplification (LAMP) assay targeting the Verocytotoxin (VT) gene as a molecular detection method. On a single-laboratory evaluation, enrichment in modified EC at 36 degrees C was inferior to that in modified EC supplemented with novobiocin (NmEC) and mEC at 42 degrees C to isolate EHEC O111 by plating methods. On a collaborative study, there were no significant differences between combinations of enrichment in NmEC at 42 degrees C-LAMP assay and enrichment in mEC at 42 degrees C-LAMP assay. The combinations of enrichment in NmEC at 42 degrees C-direct plating and enrichment in NmEC at 42 degrees C-IMS-plating were superior to combinations of enrichment in mEC at 42 degrees C-direct plating and enrichment in mEC at 42 degrees C-IMS-plating (p<0.05). There were no significant differences among the six different agar media by the direct plating and IMS-plating methods. As a result, it was suggested that the following methods are adequate for detection of EHEC O111 in beef: combinations of enrichment in NmEC at 42 degrees C, and direct plating and IMS-plating methods, or LAMP assay as a screening assay to detect VT gene followed by direct plating and IMS-plating methods.","PeriodicalId":35462,"journal":{"name":"Bulletin of National Institute of Health Sciences","volume":" 129","pages":"61-7"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30399030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Structural activity relationship approaches for assessing genotoxicity]. [评价遗传毒性的结构活性关系方法]。

Bulletin of National Institute of Health Sciences Pub Date : 2010-01-01

Masamitsu Honma

引用次数: 0