Clinical autonomic research : official journal of the Clinical Autonomic Research Society最新文献

{"title":"Lateral medullary infarction with cardiovascular autonomic dysfunction: an unusual presentation with review of the literature.","authors":"Tridu R Huynh,&nbsp;Barbara Decker,&nbsp;Timothy J Fries,&nbsp;Ajay Tunguturi","doi":"10.1007/s10286-018-0502-6","DOIUrl":"https://doi.org/10.1007/s10286-018-0502-6","url":null,"abstract":"<p><strong>Purpose: </strong>We report an unusual case of lateral medullary infarction presenting with orthostatic hypotension with pre-syncope without vertigo or Horner's syndrome.</p><p><strong>Methods: </strong>Case report with review of the literature.</p><p><strong>Results: </strong>A 67-year-old man presented with pre-syncope and ataxia without vertigo. Initial brain CT and MRI were normal. Neurological evaluation revealed right-beating nystagmus with left gaze, vertical binocular diplopia, right upper-extremity dysmetria, truncal ataxia with right axial lateropulsion, and right-facial and lower extremity hypoesthesia. Bedside blood pressure measurements disclosed orthostatic hypotension. He had normal sinus rhythm on telemetry and normal ejection fraction on echocardiogram. A repeat brain MRI disclosed an acute right dorsolateral medullary infarct. Autonomic testing showed reduced heart rate variability during paced deep breathing, attenuated late phase II and phase IV overshoot on Valsalva maneuver, and a fall of 25 mmHg of blood pressure at the end of a 10-min head-up tilt with no significant change in heart rate. These results were consistent with impaired sympathetic and parasympathetic cardiovascular reflexes. He was discharged to acute rehabilitation a week later with residual right dysmetria and ataxia.</p><p><strong>Conclusion: </strong>Lateral medullary infarctions are usually reported as partial presentations of classical lateral medullary syndrome with accompanying unusual symptoms ranging from trigeminal neuralgias to hiccups. Pre-syncope from orthostatic hypotension is a rare presentation. In the first 3-4 days, absence of early DWI MRI findings is possible in small, dorsolateral medullary infarcts with sensory disturbances. Physicians should be aware of this presentation, as early diagnosis and optimal therapy are associated with good prognosis.</p>","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":" ","pages":"569-576"},"PeriodicalIF":5.8,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10286-018-0502-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35765303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant transient global amnesia and takotsubo cardiomyopathy following a stressful event.","authors":"Logan M Pyle,&nbsp;Fahad J Laghari,&nbsp;Daniel J Kinem","doi":"10.1007/s10286-018-0554-7","DOIUrl":"https://doi.org/10.1007/s10286-018-0554-7","url":null,"abstract":"<p><p></p>","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":" ","pages":"597-598"},"PeriodicalIF":5.8,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10286-018-0554-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36385647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel autosomal recessive orthostatic hypotension syndrome: and other updates on recent autonomic research.","authors":"Mitchell G Miglis,&nbsp;Srikanth Muppidi","doi":"10.1007/s10286-018-0578-z","DOIUrl":"https://doi.org/10.1007/s10286-018-0578-z","url":null,"abstract":"<p><p></p>","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":" ","pages":"565-567"},"PeriodicalIF":5.8,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10286-018-0578-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36666459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular autonomic dysfunction in sudden infant death syndrome.","authors":"Rosemary S C Horne","doi":"10.1007/s10286-017-0490-y","DOIUrl":"https://doi.org/10.1007/s10286-017-0490-y","url":null,"abstract":"<p><p>A failure of cardiorespiratory control mechanisms, together with an impaired arousal response from sleep, are believed to play an important role in the final event of sudden infant death syndrome (SIDS). The 'triple risk model' describes SIDS as an event that results from the intersection of three overlapping factors: (1) a vulnerable infant, (2) a critical developmental period in homeostatic control and (3) an exogenous stressor. In an attempt to understand how the triple risk hypothesis is related to infant cardiorespiratory physiology, many researchers have examined how the known risk and protective factors for SIDS alter infant cardiovascular control during sleep. This review discusses the association between the three components of the triple risk hypothesis and major risk factors for SIDS, such as prone sleeping, maternal smoking, together with three \"protective\" factors, and cardiovascular control during sleep in infants, and discusses their potential involvement in SIDS.</p>","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":" ","pages":"535-543"},"PeriodicalIF":5.8,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10286-017-0490-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35707501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REM sleep behavior disorder, autonomic dysfunction and synuclein-related neurodegeneration: where do we stand?","authors":"Giacomo Chiaro,&nbsp;Giovanna Calandra-Buonaura,&nbsp;Annagrazia Cecere,&nbsp;Francesco Mignani,&nbsp;Luisa Sambati,&nbsp;Giuseppe Loddo,&nbsp;Pietro Cortelli,&nbsp;Federica Provini","doi":"10.1007/s10286-017-0460-4","DOIUrl":"https://doi.org/10.1007/s10286-017-0460-4","url":null,"abstract":"<p><strong>Introduction: </strong>From newfound parasomnia to a marker of future synucleinopathy, since its first description in 1986, REM sleep behavior disorder (RBD) has been systematically tackled from virtually many viewpoints in basic, translational, and clinical studies. The time delay between RBD and synucleinopathy onset offers an exceptional window for observation and design of neuroprotective trials. In the last few years, research has focused on characterizing possible differences within RBD patients in order to draw potential profiles more or less susceptible to further neurodegeneration. Attention has been drawn towards autonomic dysfunction in RBD as one of such variables.</p><p><strong>Overview: </strong>In this review, REM sleep physiology and relevant brain anatomy is briefly mentioned and integrated with neuroanatomical and physiological concepts regarding the central autonomic network. A detailed summary of works showing the presence of autonomic dysfunction in RBD is provided, and clinical and electrophysiological features of RBD in synucleinopathies are discussed. A short overview of RBD in other neurodegenerative diseases is also provided.</p>","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":" ","pages":"519-533"},"PeriodicalIF":5.8,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10286-017-0460-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35325282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate variability in Parkinson disease and idiopathic REM sleep behavior disorder.","authors":"Paulo Bugalho,&nbsp;Marcelo Mendonça,&nbsp;Tânia Lampreia,&nbsp;Rita Miguel,&nbsp;Raquel Barbosa,&nbsp;Manuel Salavisa","doi":"10.1007/s10286-018-0557-4","DOIUrl":"https://doi.org/10.1007/s10286-018-0557-4","url":null,"abstract":"<p><strong>Purpose: </strong>Heart rate variability, a marker of autonomic function modulation, is known to be blunted in Parkinson disease, although data remains conflicting and a putative modifying role of REM sleep behavior disorder persists unclarified.</p><p><strong>Methods: </strong>We assessed ten patients with idiopathic REM sleep behavior disorder patients, 18 patients with Parkinson disease and REM behavior disorder and eight patients with Parkinson disease without REM sleep behavior disorder. Heart rate variability analysis was performed in 5-min epochs selected from wake, Non-REM and REM polysomnography records. We compared heart rate variability measures by stage between two sets of groups: Parkinson disease vs. idiopathic RBD and patients with vs. without RBD, by using repeated measures ANOVA.</p><p><strong>Results: </strong>There were no heart rate variability differences between Parkinson disease and idiopathic REM sleep behavior disorder groups. There were significant stage vs. group interactions (p = 0.045) regarding the high frequencies components when comparing patients with and without REM sleep behavior disorder, with the former presenting lower values and attenuation of sleep stage variations.</p><p><strong>Conclusion: </strong>Our study suggests that RBD is related with reduction in parasympathetic modulation of heart rate variability and blunting of sleep stage related variations.</p>","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":" ","pages":"557-564"},"PeriodicalIF":5.8,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10286-018-0557-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36414947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological assessment of the arterial baroreflex in a young healthy obese male with extremely low baseline muscle sympathetic nerve activity.","authors":"Anthony V Incognito,&nbsp;Milena Samora,&nbsp;Roberta A Cartafina,&nbsp;Gabriel M N Guimarães,&nbsp;Mauricio Daher,&nbsp;Philip J Millar,&nbsp;Lauro C Vianna","doi":"10.1007/s10286-018-0559-2","DOIUrl":"https://doi.org/10.1007/s10286-018-0559-2","url":null,"abstract":"<p><p></p>","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":" ","pages":"593-595"},"PeriodicalIF":5.8,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10286-018-0559-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36414949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Some thoughts about concomitant transient global amnesia and takotsubo syndrome.","authors":"John E Madias","doi":"10.1007/s10286-018-0561-8","DOIUrl":"https://doi.org/10.1007/s10286-018-0561-8","url":null,"abstract":"<p><p></p>","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":" ","pages":"599-600"},"PeriodicalIF":5.8,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10286-018-0561-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36435539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomic dysfunction in sleep disorders: introduction to the series.","authors":"Jose-Alberto Palma","doi":"10.1007/s10286-018-0571-6","DOIUrl":"https://doi.org/10.1007/s10286-018-0571-6","url":null,"abstract":"<p><p></p>","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":" ","pages":"507-508"},"PeriodicalIF":5.8,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10286-018-0571-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36634329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomic regulation during sleep and wakefulness: a review with implications for defining the pathophysiology of neurological disorders.","authors":"Anne M Fink,&nbsp;Ulf G Bronas,&nbsp;Michael W Calik","doi":"10.1007/s10286-018-0560-9","DOIUrl":"https://doi.org/10.1007/s10286-018-0560-9","url":null,"abstract":"<p><p>Cardiovascular and respiratory parameters change during sleep and wakefulness. This observation underscores an important, albeit incompletely understood, role for the central nervous system in the differential regulation of autonomic functions. Understanding sleep/wake-dependent sympathetic modulations provides insights into diseases involving autonomic dysfunction. The purpose of this review was to define the central nervous system nuclei regulating sleep and cardiovascular function and to identify reciprocal networks that may underlie autonomic symptoms of disorders such as insomnia, sleep apnea, restless leg syndrome, rapid eye movement sleep behavior disorder, and narcolepsy/cataplexy. In this review, we examine the functional and anatomical significance of hypothalamic, pontine, and medullary networks on sleep, cardiovascular function, and breathing.</p>","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":" ","pages":"509-518"},"PeriodicalIF":5.8,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10286-018-0560-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36439688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}