Clinical autonomic research : official journal of the Clinical Autonomic Research Society最新文献

{"title":"Hypotensive episodes at 24-h ambulatory blood pressure monitoring predict adverse outcomes in Parkinson's disease.","authors":"Fabrizio Vallelonga, Matteo Valente, Marta Maria Tangari, Anna Covolo, V. Milazzo, C. Di Stefano, G. Sobrero, M. Giudici, Alberto Milan, Franco Veglio, L. Lopiano, Simona Maule, A. Romagnolo","doi":"10.1007/s10286-024-01030-7","DOIUrl":"https://doi.org/10.1007/s10286-024-01030-7","url":null,"abstract":"","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140654748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report illustrating the 'hypotensive twilight zone' in Parkinson's disease; an under-recognised presentation of orthostatic hypotension.","authors":"J. G. van Dijk, Bastiaan R Bloem","doi":"10.1007/s10286-024-01032-5","DOIUrl":"https://doi.org/10.1007/s10286-024-01032-5","url":null,"abstract":"","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":"5 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140653860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sympathetic dysfunction as an early indicator of autonomic involvement in Parkinson's disease.","authors":"Jin-Woo Park, L. Okamoto, Sung-Hwan Kim, Chan-Nyoung Lee, Kun Woo Park, S. Baek, Joo Hye Sung, Namjoon Jeon, Seong-Beom Koh, Alfredo Gamboa, C. Shibao, André Diedrich, B. Kim, I. Biaggioni","doi":"10.1007/s10286-024-01031-6","DOIUrl":"https://doi.org/10.1007/s10286-024-01031-6","url":null,"abstract":"","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":"79 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140667892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysautonomia and response to guanfacine in individuals with an SCN9A variant.","authors":"J. Palma","doi":"10.1007/s10286-024-01029-0","DOIUrl":"https://doi.org/10.1007/s10286-024-01029-0","url":null,"abstract":"","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":"13 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140666588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Faintly tired: a systematic review of fatigue in patients with orthostatic syncope.","authors":"Ryan E Y Wu, Farhaan M Khan, Brooke C D Hockin, Trudie C A Lobban, Shubhayan Sanatani, Victoria E Claydon","doi":"10.1007/s10286-022-00886-x","DOIUrl":"https://doi.org/10.1007/s10286-022-00886-x","url":null,"abstract":"","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":" ","pages":"533"},"PeriodicalIF":5.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40371952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postural orthostatic tachycardia syndrome after mRNA COVID-19 vaccine.","authors":"Ahmed M Eldokla, Mohammed T Numan","doi":"10.1007/s10286-022-00880-3","DOIUrl":"https://doi.org/10.1007/s10286-022-00880-3","url":null,"abstract":"","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":" ","pages":"307-311"},"PeriodicalIF":5.8,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40616949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular adjustments to cold pressor test in postmenopausal women and the impact of α1-adrenergic blockade.","authors":"Eliza Prodel,&nbsp;Maitê L Gondim,&nbsp;Helena N M Rocha,&nbsp;Pedro A C Mira,&nbsp;Antonio C L Nobrega","doi":"10.1007/s10286-022-00879-w","DOIUrl":"https://doi.org/10.1007/s10286-022-00879-w","url":null,"abstract":"<p><strong>Purpose: </strong>We investigate the impact of menopause on cardiovascular adjustments to the cold pressor test (CPT) and the role of the α1-adrenergic receptor.</p><p><strong>Methods: </strong>Ten young women (YW) and nine postmenopausal women (MW) underwent 1 min of CPT in control and α1-blockade conditions (0.03 mg‧kg^-1 of oral prazosin).</p><p><strong>Results: </strong>CPT increased heart rate (HR) (YW: ∆20 ± 3 bpm; MW: ∆13 ± 2 bpm) and stroke volume (SV; YW: ∆15 ± 8 ml; MW: ∆9 ± 6 ml; p = 0.01 for time) and evoked a greater increase in cardiac output (CO) in YW (YW: ∆2.1 ± 0.2 l‧m^-1; MW: ∆1.3 ± 0.5 l‧m^-1; p = 0.01). α1-Blockade increased baseline HR and did not change HR, SV, and CO responses to CPT. MW presented an exaggerated systolic blood pressure (BP) response (YW: ∆38 ± 9 mmHg; MW: ∆56 ± 24 mmHg; p = 0.03). The α1-blockade did not change baseline BP while blunting its response. Total vascular resistance (TVR) was similar between groups at baseline and increased during CPT only in MW (YW: ∆2.3 ± 1.4 mmHg‧L^-1‧min; MW:∆6.8 ± 5.9 mmHg‧L^-1‧min). Under α1-blockade, the TVR increase during CPT was attenuated in MW and abolished in YW (YW: ∆0.3 ± 1.2 mmHg‧L^-1‧min and MW: ∆3.0 ± 2.0 mmHg‧L^-1‧min). CPT did not change femoral vascular conductance (FVC) in either group before the blockade (YW: ∆-0.3 ± 4.0 ml‧min^-1‧mmHg^-1; MW: ∆-0.2 ± 0.8 ml‧min^-1‧mmHg^-1); however, FVC tended to increase in young women (YW: ∆1.3 ± 1.0 ml‧min^-1‧mmHg^-1; MW: ∆0.1 ± 1.5 ml‧min^-1‧mmHg^-1; p = 0.06) after the α1-blockade.</p><p><strong>Conclusion: </strong>In postmenopausal women, the cardiac ability to adjust to CPT is blunted and α1-adrenergic receptor stimulation is important for the increase in stroke volume. In addition, the peripheral effect of α1-adrenergic receptor stimulation seems to be increased in postmenopausal women.</p>","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":" ","pages":"261-269"},"PeriodicalIF":5.8,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40616950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between cardiac damage biomarkers and heart rate variability following 60 min of running.","authors":"Kerem Özgünen,&nbsp;Özgür Günaştı,&nbsp;Çiğdem Özdemir,&nbsp;Selcen Korkmaz Eryılmaz,&nbsp;Ertuğrul Gezgin,&nbsp;Cumhur Boyraz,&nbsp;Abdullah Kılcı,&nbsp;Ümit Adaş,&nbsp;Sadi S Kurdak","doi":"10.1007/s10286-022-00878-x","DOIUrl":"https://doi.org/10.1007/s10286-022-00878-x","url":null,"abstract":"<p><strong>Purpose: </strong>Endurance exercise may cause transient alterations in cardiac tissue. The number of studies evaluating the relationship between changes in heart rate variability (HRV) and cardiac biomarkers following an endurance event is limited. We hypothesized that there would be a time-dependent correlation between biomarkers of cardiac damage and the reduction in parasympathetic indices of HRV within 24 h after 60 min of running in middle-aged recreational runners.</p><p><strong>Methods: </strong>The trained, middle-aged runners who participated in this study ran 60 min at a half-marathon pace on a treadmill. Blood samples (before and 0, 4, and 24 h after the running test) and HRV data (before and 0, 1, 4, and 24 h after the running test) were obtained.</p><p><strong>Results: </strong>After running, cardiac biomarkers (total creatine kinase, cardiac isoform of creatine kinase, creatine kinase-index [CK-Index], cardiac troponin [cTnI]) increased significantly, and HRV measures related to parasympathetic nervous system activity decreased significantly; these measures returned to baseline levels within 24 h. Finally, there were significant correlations (all p < 0.05) between the change (4 h post-running vs. pre-running) in the CK-Index and the changes (post- vs pre-running) in time-domain and nonlinear measures of HRV (r - 0.61 to - 0.67). In addition, significant correlations (all p < 0.05) were found between the area under the cTnI curve and change (1-h post- and pre-running) in time-domain and nonlinear measures of HRV (r - 0.48 to - 0.51).</p><p><strong>Conclusions: </strong>The correlation between HRV and cardiac biomarkers indicates that HRV analysis may be an alternative approach to determine the magnitude of cardiac stress after endurance exercises.</p>","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":" ","pages":"249-260"},"PeriodicalIF":5.8,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40537037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term changes in insula-mesolimbic structural and functional connectivity in obese patients after laparoscopic sleeve gastrectomy.","authors":"Hao Li,&nbsp;Yang Hu,&nbsp;Guanya Li,&nbsp;Wenchao Zhang,&nbsp;Jia Wang,&nbsp;Zongxin Tan,&nbsp;Zhenzhen Jia,&nbsp;Lei Zhang,&nbsp;Shuai Lv,&nbsp;Juan Yu,&nbsp;Yu Han,&nbsp;Guangbin Cui,&nbsp;Peter Manza,&nbsp;Nora D Volkow,&nbsp;Yongzhan Nie,&nbsp;Gang Ji,&nbsp;Gene-Jack Wang,&nbsp;Yi Zhang","doi":"10.1007/s10286-022-00877-y","DOIUrl":"https://doi.org/10.1007/s10286-022-00877-y","url":null,"abstract":"<p><strong>Objective: </strong>Brain imaging studies have shown insula-related functional and structural abnormalities in patients with obesity. Laparoscopic sleeve gastrectomy is currently an effective procedure for treating obesity, which promotes acute recovery of brain functional and structural abnormalities in obese patients. The aim of this study was to investigate the long-term impact of laparoscopic sleeve gastrectomy on insula-related structural and functional connectivity.</p><p><strong>Methods: </strong>Diffusion tensor imaging and resting-state functional magnetic resonance imaging were employed to investigate laparoscopic sleeve gastrectomy-induced changes in insula-related structural connectivity and corresponding resting-state functional connectivity in 25 obese patients prior to (PreLSG) and 12 months post-surgery (PostLSG₁₂).</p><p><strong>Results: </strong>Results showed significant increases in fractional anisotropy and axial diffusivity between the right insula and anterior cingulate cortex, and higher fractional anisotropy of left insula-putamen, left insula-caudate and anterior cingulate cortex-right posterior cingulate cortex/precuneus at PostLSG12 compared with PreLSG. There were significant negative correlations between axial diffusivity of right insula-anterior cingulate cortex and body mass index, and fractional anisotropy of right insula-anterior cingulate cortex with scores on external eating at PostLSG12. Anxiety and depressive status ratings were negatively correlated with fractional anisotropy of left insula-putamen at PostLSG12. In addition, there was a significant decrease in resting-state functional connectivity between left insula and left caudate.</p><p><strong>Conclusions: </strong>These findings demonstrate long-term changes in insula-related structural and functional connectivity abnormalities promoted by laparoscopic sleeve gastrectomy, which highlight its strong association with long-term weight loss and improvement in eating behaviors.</p>","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":" ","pages":"237-247"},"PeriodicalIF":5.8,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40528344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of pulmonary vein isolation on the relationship between left atrial reverse remodeling and sympathetic nerve activity in patients with atrial fibrillation.","authors":"Yusuke Mukai,&nbsp;Hisayoshi Murai,&nbsp;Takuto Hamaoka,&nbsp;Hiroyuki Sugimoto,&nbsp;Oto Inoue,&nbsp;Chiaki Goten,&nbsp;Takashi Kusayama,&nbsp;Shin-Ichiro Takashima,&nbsp;Takeshi Kato,&nbsp;Soichiro Usui,&nbsp;Kenji Sakata,&nbsp;Shigeo Takata,&nbsp;Masayuki Takamura","doi":"10.1007/s10286-022-00873-2","DOIUrl":"https://doi.org/10.1007/s10286-022-00873-2","url":null,"abstract":"<p><strong>Purpose: </strong>Catheter ablation (CA) to isolate the pulmonary vein, which is an established treatment for atrial fibrillation (AF), is associated with left atrium reverse remodeling (LARR). The intrinsic cardiac autonomic nervous system includes the ganglion plexi adjacent to the pulmonary vein in the left atrium (LA). However, little is known about the effect of CA on the relationship between LARR and sympathetic nerve activity in patients with AF.</p><p><strong>Methods: </strong>This study enrolled 22 AF patients with a normal left ventricular ejection fraction (LVEF) aged 64.6 ± 12.9 years who were scheduled for CA. Sympathetic nerve activity was evaluated by direct recording of muscle sympathetic nerve activity (MSNA) before and 12 weeks after CA. Blood pressure, heart rate (HR), HR variability, and echocardiography were also measured.</p><p><strong>Results: </strong>The heart rate increased significantly after CA (63 ± 10.9 vs. 70.6 ± 7.7 beats/min, p < 0.01), but blood pressure did not change. A high frequency (HF) and low frequency (LF) of HR variability decreased significantly after ablation, but no significant change in LF/HF was observed. CA significantly decreased MSNA (38.9 ± 9.9 vs. 28 ± 9.1 bursts/min, p < 0.01). Moreover, regression analysis revealed a positive correlation between the percentage change in MSNA and the LA volume index (r = 0.442, p < 0.05).</p><p><strong>Conclusions: </strong>Our results show that CA for AF reduced MSNA and the decrease was associated with the LA volume index in AF patients with a normal LVEF. These findings suggest that LARR induced by CA for AF decrease sympathetic nerve activity.</p>","PeriodicalId":354493,"journal":{"name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","volume":" ","pages":"229-235"},"PeriodicalIF":5.8,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40268395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}