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Current Understanding of Epidemiology and Clinical Manifestation of Coronavirus Disease 2019 (COVID-19) 2019冠状病毒病(COVID-19)流行病学及临床表现研究现状
Infektološki glasnik Pub Date : 2021-02-22 DOI: 10.37797/IG.40.3.4
L. Lukić, D. Dušek
{"title":"Current Understanding of Epidemiology and Clinical Manifestation of Coronavirus Disease 2019 (COVID-19)","authors":"L. Lukić, D. Dušek","doi":"10.37797/IG.40.3.4","DOIUrl":"https://doi.org/10.37797/IG.40.3.4","url":null,"abstract":"Since it emerged in China in the late 2019, the SARS-CoV-2 virus has spread throughout the world and caused the newest pandemic. The epidemiological characteristics of the virus and the clinical manifestations of the COVID-19 disease are currently being studied. The new data is emerging continuously but not yet fully understood. So far, we have\u0000learned a lot about the virus and the disease but more research is needed as many issues are still being explored.","PeriodicalId":354348,"journal":{"name":"Infektološki glasnik","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124074481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the novel Uroquattro HB&L™ system and classical phenotypic method for rapid screening of multidrug-resistant organism colonization at the University Hospital Centre Split, Croatia 克罗地亚斯普里特大学医院中心新型Uroquattro HB&L™系统与经典表型法快速筛选多药耐药生物定植的比较
Infektološki glasnik Pub Date : 2020-09-17 DOI: 10.37797/IG.40.1.3
J. Marinović, A. Novak, Žana Rubić, I. Goic-Barisic, M. Radić, Miroslav Barišić, M. Tonkić
{"title":"Comparison of the novel Uroquattro HB&L™ system and classical phenotypic method for rapid screening of multidrug-resistant organism colonization at the University Hospital Centre Split, Croatia","authors":"J. Marinović, A. Novak, Žana Rubić, I. Goic-Barisic, M. Radić, Miroslav Barišić, M. Tonkić","doi":"10.37797/IG.40.1.3","DOIUrl":"https://doi.org/10.37797/IG.40.1.3","url":null,"abstract":"Background. Infections caused by multidrug-resistant organisms (MDRO) are difficult to treat and associated with poor outcomes for patients. Therefore, early identification and management of colonization are essential as first steps in infection prevention. Culture-based methods have been widely used for MDRO screening. The turnaround time (TAT) for the identification of carriers varies between 48-72 h with this method. The aim of our study was to compare the performance of the new rapid semiautomatic method for detection of MDRO (HB&L Uroquattro, Alifax) with standard cultivation on selective media.\u0000Methods. Twenty-one axillary, 20 nose and 19 rectal swabs were taken in duplicate on two selected days at the University Hospital Centre Split, Croatia. Swabs were cultivated and MDRO isolates were identified on selective media (Chromagar MRSA and Chromagar ESBL) according to the standard operating procedure. Novel Alifax method was performed according to manufacturer’s instructions.\u0000Results. TAT for the new method was significantly lower (6.5 h) in comparison to the classical method. With classical method, 10 extended spectrum ß-lactamases (ESBL) producing strains from 10 different rectal specimens were isolated on Chromagar ESBL media. Exactly the same specimens were positive for the presence of ESBL-producing bacteria by rapid Alifax method. On selective Chromagar MRSA media, 11 MDRO were isolated, while rapid method detected 11 MDRO from the same specimens.\u0000Conclusions. High concordance of positive and negative results obtained with classical and rapid method is encouraging. However, our study was performed on a small sample size and further research with larger sample size is needed.","PeriodicalId":354348,"journal":{"name":"Infektološki glasnik","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127877691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Utjecaj prethodne terapije statinima na težinu kliničke slike sepse iz opće populacije
Infektološki glasnik Pub Date : 2020-09-17 DOI: 10.37797/IG.40.1.1
Marijan Križić, Ivica Miškulin, Marija Santini, B. Baršić
{"title":"Utjecaj prethodne terapije statinima na težinu kliničke slike sepse iz opće populacije","authors":"Marijan Križić, Ivica Miškulin, Marija Santini, B. Baršić","doi":"10.37797/IG.40.1.1","DOIUrl":"https://doi.org/10.37797/IG.40.1.1","url":null,"abstract":"Uvod: Smrtnost sepse je visoka usprkos antimikrobnim lijekovima, stoga se ispituju imunomodulatorni lijekovi, između ostalih i statini.\u0000Cilj: Pokazati imaju li bolesnici prethodno liječeni statinima lakši klinički oblik i manju smrtnost sepse.\u0000Ustroj: Retrospektivno kohortno, opservacijsko istraživanje, usporedba prethodno liječenih i prethodno neliječenih statinima.\u0000Ispitanici: Sepsa iz opće populacije, bakterijski izolat iz hemokultura, dob ≥ 50 god.\u0000Rezultati: Uključeno 899 bolesnika, 116 (12.9%) prethodno liječenih statinima. Bez statistički značajnih razlika u izraženosti parametara sustavnog upalnog odgovora. Medijan SOFA zbroja u prethodno liječenih statinima iznosio je 2.0 kao i u skupini prethodno neliječenih (p=0.117). Ukupna smrtnost 9.2%, prethodno liječeni 6.0%, prethodno neliječeni 9.7%, (p=0.231). Nema razlike u 28-dnevnoj smrtnosti (log-rank test, p=0.693).\u0000Zaključak: Nema statistički značajne razlike u težini kliničke slike kao ni u smrtnosti sepse između bolesnika prethodno liječenih i prethodno neliječenih statinima.","PeriodicalId":354348,"journal":{"name":"Infektološki glasnik","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123891180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the effectiveness of manual cleaning, hydrogen peroxide vapor and ultraviolet-c in disinfection of hospital equipment 人工清洁、双氧水蒸汽和紫外线c消毒医院设备的效果比较
Infektološki glasnik Pub Date : 2020-07-05 DOI: 10.37797/ig.39.3.2
Yosra Sedaghat, S. Gholampour, F. T. Ghomshe
{"title":"Comparison of the effectiveness of manual cleaning, hydrogen peroxide vapor and ultraviolet-c in disinfection of hospital equipment","authors":"Yosra Sedaghat, S. Gholampour, F. T. Ghomshe","doi":"10.37797/ig.39.3.2","DOIUrl":"https://doi.org/10.37797/ig.39.3.2","url":null,"abstract":"Hospitals are the focus of many infections which cause the intensification of the patients’ illness and even their death. The number of bacteria on various hospital equipment was counted before and after being disinfected with manual cleaning (MC), hydrogen peroxide vapour (HPV) and ultraviolet-C (UV-C). The effectiveness of disinfection of hospital beds in intensive care unit (ICU) using the three methods MC, HPV and UV-C has been 66.67%, 100% and 50%, respectively. Hence, the effectiveness of HPV method in the disinfection of this unit has been higher than others. The effectiveness of otoscope disinfection in the ICU and blood pressure meter in the operating room with three methods of MC, HPV and UV-C has been 0%, 50% and 100%, respectively. So, for disinfecting these small outfits, UV-C method has proven to be the best one. In case of programming, the correct move of portable UV-Cs for complete coverage of massive equipment, disinfection with UV-C method may be considered more effective than other methods.","PeriodicalId":354348,"journal":{"name":"Infektološki glasnik","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125740163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Changes in the stage of fibrosis and steatosis in patients with chronic hepatitis C virus treated with direct-acting antiviral drugs who achieved sustained virological response 使用直接作用抗病毒药物治疗获得持续病毒学应答的慢性丙型肝炎病毒患者纤维化和脂肪变性阶段的变化
Infektološki glasnik Pub Date : 2020-07-05 DOI: 10.37797/ig.39.3.1
L. Radmanić, A. Vince, S. Židovec Lepej, D. Dušek, I. Kurelac, N. Papić
{"title":"Changes in the stage of fibrosis and steatosis in patients with chronic hepatitis C virus treated with direct-acting antiviral drugs who achieved sustained virological response","authors":"L. Radmanić, A. Vince, S. Židovec Lepej, D. Dušek, I. Kurelac, N. Papić","doi":"10.37797/ig.39.3.1","DOIUrl":"https://doi.org/10.37797/ig.39.3.1","url":null,"abstract":"Hepatitis C vodeći je uzrok kronične bolesti jetre, hepatocelularnog karcinoma i važna indikacija za transplantaciju jetre. Glavni cilj liječenja je postizanje trajnog virološkog odgovora koji označava negativnu viremiju 12 tjedana nakon završetka liječenja (SVR, od engl. sustained virological response). Uvođenjem antivirusnih lijekova s izravnim djelovanjem, povećala se stopa SVR-a, skratilo vrijeme trajanja terapije i utjecalo se na stadij fibroze i steatoze jetre nakon liječenja. Cilj ovog rada bio je analizirati promjenu stadija fibroze (F1-F4) i steatoze (S0-S3) primjenom tranzijentne elastografije u prethodno neliječenih bolesnika s kroničnim hepatitisom C (n=205) koji su postigli trajni virološki odgovor, a bili liječeni isključivo direktno djelujućim antivirusnim lijekovima (DAA).","PeriodicalId":354348,"journal":{"name":"Infektološki glasnik","volume":"145 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130356488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Percepcija rizika od spolnih bolesti i HIV-a, kiberohondrija i zdravstvena pismenost u doba pandemije COVID-19
Infektološki glasnik Pub Date : 1900-01-01 DOI: 10.37797/ig.40.4.3
Tamara Bajčić, Iva Sorta-Bilajac Turina, Ksenija Baždarić
{"title":"Percepcija rizika od spolnih bolesti i HIV-a, kiberohondrija i zdravstvena pismenost u doba pandemije COVID-19","authors":"Tamara Bajčić, Iva Sorta-Bilajac Turina, Ksenija Baždarić","doi":"10.37797/ig.40.4.3","DOIUrl":"https://doi.org/10.37797/ig.40.4.3","url":null,"abstract":"Cilj ovog rada je prikazati pregled dosadašnjih znanstvenih spoznaja o percepciji rizika zaraze HIV-om i drugim spolno prenosivim bolestima, kiberohondrije i zdravstvene pismenosti s naglaskom na trenutnu situaciju pandemije COVID-19. Republika Hrvatska je još uvijek zemlja niskog rizika epidemije HIV-a, dijelom zahvaljujući osnivanju 10 Centara za dobrovoljno, anonimno i besplatno savjetovanje i testiranje na HIV (CST). Percepcija rizika zaraze spolno prenosivom bolešću se opisuje kao vlastita procjena mogućnosti dobivanja iste. Zdravstvena ponašanja, pa tako i percepcija rizika, mogu se objasniti različitim modelima i teorijama, a jedan od prihvaćenih modela je socijalno-kognitivni model uvjerenja vezanih uz zdravlje (engl. Health Belief Model – HBM). Zdravstvena pismenost se definira kao osobne, kognitivne i socijalne vještine koje određuju sposobnost pojedinca da pristupi podacima o zdravlju, razumije ih i koristi. Kiberohodrija je anksiozni poremećaj karakteriziran ekscesivnim istraživanjem zdravstvenih sadržaja preko interneta. Pandemija COVID-19 je veliki događaj digitalne ere, uzimajući u obzir poremećaj izazvan u svim područjima života širom svijeta. Zbog izazvanog straha predstavlja plodno tlo za kiberohondriju.","PeriodicalId":354348,"journal":{"name":"Infektološki glasnik","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115759336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coronavirus Disease 19 (COVID-19) Pharmacologic Treatment 冠状病毒病19 (COVID-19)的药物治疗
Infektološki glasnik Pub Date : 1900-01-01 DOI: 10.37797/ig.40.4.4
N. Bogdanić, L. Lukić, J. Begovac
{"title":"Coronavirus Disease 19 (COVID-19) Pharmacologic Treatment","authors":"N. Bogdanić, L. Lukić, J. Begovac","doi":"10.37797/ig.40.4.4","DOIUrl":"https://doi.org/10.37797/ig.40.4.4","url":null,"abstract":"Since the first cases of COVID-19 were reported from China the disease became pandemic within a few months. The viral genome was sequenced soon after the outbreak of COVID-19 which enabled development of diagnostic tests and therapeutic options. As the knowledge of SARS-CoV-2 virology increased, many potential drugs appeared. At this moment (January 12th 2021), 4426 studies of COVID-19 are registered, and more than 2680 studies are investigating therapeutic options. This is a short narrative review of currently available evidence on pharmacological treatment of COVID-19.","PeriodicalId":354348,"journal":{"name":"Infektološki glasnik","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122327760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Dijagnoza i liječenje legionarske bolesti
Infektološki glasnik Pub Date : 1900-01-01 DOI: 10.37797/ig.41.3.4
Maša Puljiz, Dalibor Vukelić
{"title":"Dijagnoza i liječenje legionarske bolesti","authors":"Maša Puljiz, Dalibor Vukelić","doi":"10.37797/ig.41.3.4","DOIUrl":"https://doi.org/10.37797/ig.41.3.4","url":null,"abstract":"Retrospektivno su analizirane kliničke značajke i antimikrobna terapija u 60 bolesnika s legionarskom bolesti koji su hospitalizirani u Klinici za infektivne bolesti „Dr. Fran Mihaljević“ u Zagrebu u dvogodišnjem razdoblju, 2018. - 2019. godine. Dijagnoza legionarske bolesti utvrđena je serološkim testovima i/ili određivanjem antigena L. pneumophila serotip 1 u urinu. Vodeći simptomi bolesti bili su vrućica (100,0%), kašalj (83,3%) i zimice (81,7%), a najvažniji laboratorijski pokazatelji povišena vrijednost C-reaktivnog proteina (100,0%), ubrzana sedimentacija eritrocita (98,1%) i leukocitoza (79,7%). U više od dvije trećine bolesnika opisuje se bronhopneumonički infiltrat na plućima (68,3%), a pleuralni izljev u 41,7% bolesnika. Najčešća inicijalna antimikrobna terapija u bolnici bila je kombinacija beta laktamskog antibiotika i azitromicina (53,3%). Inicijalna antimikrobna terapija je korigirana u (48.3%), najčešće u monoterapiju azitromicinom (35,4%), potom levofloksacin (6,7%) te moksifloksacin (5,0%). Nije zabilježena razlika u liječenju bolesnika između azitromicina, levofloksacina i moksifloksacina. Tri (5,0 %) bolesnika su umrla.","PeriodicalId":354348,"journal":{"name":"Infektološki glasnik","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133084740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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