Jornal Brasileiro de Patologia e Medicina Laboratorial最新文献_第6页

Nonconformities in clinical laboratories in Macapá, Amapá, Brazil, based on the RDC no. 302/2005/Anvisa 根据RDC no. 1，巴西macapap<e:1>临床实验室不符合项。302/2005 / Anvisa的

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-07-01 DOI: 10.5935/1676-2444.20200039

Mylner O. F. Souza, Keren Hapuque da Silva Souza, Juvanete A. Távora, É. Costa, R. Resque, Madson R F Gomes, D. S. Dantas

{"title":"Nonconformities in clinical laboratories in Macapá, Amapá, Brazil, based on the RDC no. 302/2005/Anvisa","authors":"Mylner O. F. Souza, Keren Hapuque da Silva Souza, Juvanete A. Távora, É. Costa, R. Resque, Madson R F Gomes, D. S. Dantas","doi":"10.5935/1676-2444.20200039","DOIUrl":"https://doi.org/10.5935/1676-2444.20200039","url":null,"abstract":"ABSTRACT Introduction: Clinical analysis laboratories are health care facilities that provide resources for outpatient and/or emergency diagnoses; they are regulated in Brazil by the Resolution of the Collegiate Board of Directors (RDC) no. 302, of October 13, 2005, of the Brazilian National Agency of Sanitary Surveillance (Anvisa). Objective: The aim of this study was to perform a normative evaluation in clinical analysis laboratories, based on RDC no. 302, of October 13, 2005. Material and method: This is a cross-sectional and descriptive study. Twelve clinical laboratories participated in the study. The data were obtained through a structured questionnaire and answered by the technical leaders of the participating laboratories, in the municipality of Macapa, Amapa, Brazil. Results: The average nonconformity found among the participants was 9.64%, which allowed an overall evaluation among them as satisfactory, in relation to the minimum requirements demanded by the standardization recommended by Anvisa. When the participants were analyzed individually, there was a variation from 4.82% to 21.69% of the nonconformities index. Other studies agree with the results, however there is disagreement in a research carried out in Porto Alegre, Rio Grande do Sul, Brazil, possibly due to the fact that the laboratories present in this study do not have a quality management system in their processes. Conclusion: Laboratories 2, 3, 4, 6, 9, 11, and 12 were rated as satisfactory. Laboratories 1, 5, 7, 8 and 10 were rated as partially satisfactory. No laboratories were rated as unsatisfactory.","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47376111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sociodemographic and clinicopathological profile of 80 cases of oral squamous cell carcinoma 80例口腔鳞状细胞癌的社会人口学及临床病理分析

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200001

Carolina Emerick, Tamires G. Magalhães, Maria Carolina De Lima Jacy Monteiro Barki, Lívia Ramalho Crescencio, Renata Tucci, Eleni Maria Vianna Brandão Barros, R. D. Azevedo

{"title":"Sociodemographic and clinicopathological profile of 80 cases of oral squamous cell\u0000 carcinoma","authors":"Carolina Emerick, Tamires G. Magalhães, Maria Carolina De Lima Jacy Monteiro Barki, Lívia Ramalho Crescencio, Renata Tucci, Eleni Maria Vianna Brandão Barros, R. D. Azevedo","doi":"10.5935/1676-2444.20200001","DOIUrl":"https://doi.org/10.5935/1676-2444.20200001","url":null,"abstract":"Objective: To describe demographic and clinicopathologic profile of oral squamous cell carcinoma (OSCC) cases from incisional biopsies collected at the Nova Friburgo Health Institute of the Fluminense Federal University [Instituto de Saúde de Nova Friburgo da Universidade Federal Fluminense (ISNF/UFF)] and at the Raul Sertã Municipal Hospital [Hospital Municipal Raul Sertã (HMRS)]. Methods: Oral Pathology Laboratory records from the ISNF/UFF were reviewed and all cases of OSCC were primarily selected. Cases from ISNF/UFF and HMRS were selected and had their demographic data collected from the medical records. Clinical characteristics were evaluated using the images of the lesions taken on the biopsy day and the laboratory files. The histological slides were later reviewed. Results: Eighty cases of OSCC were identified. Most patients were male (56.7%), with a mean age of 60 years, smoker (62.71%) and/or alcoholic (44.55%). The most affected anatomic site was the tongue (39.49%), presenting mainly as an ulcer (39.49%). Microscopically, the well-differentiated lesions were more common (35.44%), and the mean counting of mitoses was 5.5/10 high-power field. Conclusion: The profile of OSCC patients in Nova Friburgo partly reflects the world literature, with emphasis on the following differences: low average number of mitoses found in the histopathological analysis and prevalence of well-differentiated lesions. Such differences may be a result of the characteristic variations of the local population, reinforcing the importance of conducting epidemiological studies that demonstrate OSCC peculiarities in different regions.","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71115820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Multi-categorical classification using deep learning applied to the diagnosis of gastric cancer 基于深度学习的多类别分类在胃癌诊断中的应用

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200013

J. Kloeckner, Tatiana K. Sansonowicz, Á. L. Rodrigues, Tatiana W. N. Nunes

{"title":"Multi-categorical classification using deep learning applied to the diagnosis of\u0000 gastric cancer","authors":"J. Kloeckner, Tatiana K. Sansonowicz, Á. L. Rodrigues, Tatiana W. N. Nunes","doi":"10.5935/1676-2444.20200013","DOIUrl":"https://doi.org/10.5935/1676-2444.20200013","url":null,"abstract":"Introduction: Pathologists currently face a substantial increase in workload and complexity of their diagnosis work on different types of cancer. This is due to the increased incidence and detection of neoplasms, associated with diagnostic subspecialization and the advent of personalized medicine. There are numerous treatments available for different types of cancer, and the diagnosis must be dispensed quickly and accurately for each case. Deep learning is a tool that has been used in daily life, including image detection, and there is growing interest in its application in Medicine and especially in Pathology, where it has a revolutionary potential. Objective: In this article, we present deep learning, in particular convolutional neural networks, as a potential technique for the analysis of digitized images of histopathological slides, detecting identifiable patterns in an automated manner, introducing the possibility of applying this technology as an auxiliary tool in the diagnosis of neoplasms, especially in gastric cancer, the object of this preliminary study. Method: From a database of digitized images of histopathological slides representative of gastric cancer, we identified three morphological patterns of neoplasia, as well as non-neoplastic tissue patterns, with which we train a convolutional neural network algorithm, designed to identify and categorize similar images within these standards, in an automated manner. Results: The results of identification and automatic classification in the defined categories were satisfactory, with ROC curves above 0.9. Conclusion: The results show the potential application of convolutional neural networks for digitized slides of gastric cancer, in accordance with international literature findings.","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71116094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Comparison of micronuclei frequency between smokers and non-smokers: a systematic review 吸烟者与非吸烟者微核频率的比较:一项系统综述

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200022

R. Andrade, N. A. Campos

{"title":"Comparison of micronuclei frequency between smokers and non-smokers: a\u0000 systematic review","authors":"R. Andrade, N. A. Campos","doi":"10.5935/1676-2444.20200022","DOIUrl":"https://doi.org/10.5935/1676-2444.20200022","url":null,"abstract":"Introduction: Cancer results from the accumulation of several modifications in the genetic material and, therefore, it is possible to carry out its cytogenetic detection using biomarkers. Micronuclei (MN) have been addressed in the literature as biomarkers of genotoxic damage. These markers provide information on biological or biochemical changes in a target tissue at early stage, enabling a favorable prognosis. Objective: To compare whether the frequency of MN in active smokers is higher than that in nonsmokers. Material and method: The search was performed in the Medical Literature Analysis and Retrieval System (PubMeb), in the Latin American and Caribbean Literature in Health Sciences (LILACS), and in the Scientific Electronic Electronic Library Online (SciELO), for articles published in the last ten years. Randomized clinical trials, with a cross-sectional design, which compared the MN frequency in the oral mucosa of adult smokers and non-smokers, were selected. Results: A total of 52 articles were identified, four of them were removed due to duplicity. From the remaining 48 studies, after reading their titles and abstracts, 14 remained, which had their full texts read. Finally, eight articles remained for the qualitative analysis. Discussion and conclusion: Individuals who use tobacco present genotoxic and cytotoxic damages that interfere in the mitosis process, which leads to MN formation. The hypothesis of smoking as the cause of this genetic alteration is corroborated by the authors when comparing the data obtained in their studies between risk groups and control groups.","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71116454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Meningiomas e microambiente tumoral: expressão de PD-L1 e interferon gama no prognóstico 脑膜瘤与肿瘤微环境:PD-L1和干扰素γ在预后中的表达

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200028

Gunter Gerson, Paulo-Goberlânio-de Barros Silva, C. Soares, Gabriel Chagas, A. R. Rangel, A. A. Rodrigues, C. Nogueira, Fabio Tavora

引用次数: 0

Manifestações da deglutição em pacientes com câncer de orofaringe submetidos à terapia conservadora: revisão sistemática 保守治疗口咽癌患者吞咽表现:系统综述

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200046

J. N. Gois, Susana Barbosa, Felipe Rodrigues de Matos, C. H. César, L. Paranhos

引用次数: 1

Thrombogram: case report of pseudothrombocytopenia 血栓造影:假性血小板减少症1例

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200005

B. Costa, M. C. Vellés, M. Viana, Ana Pereira, S. Rocha, Liliana P. Rocha, V. Moreira

引用次数: 1

Disseminated and cutaneous cryptococcosis by C. neoformans VNI in an immunocompetent patient 免疫功能正常患者由新生隐球菌VNI引起的播散性和皮肤隐球菌病

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200017

F. C. A. Maranhão, Douglas L. H. Fonseca, Graciella S. A. Santos, L. A. Fonseca, E. J. Santos, D. W. Silva

引用次数: 2

Oral lichen planus with cutaneous manifestations: case report with emphasis on dental diagnostic criteria 有皮肤表现的口腔扁平苔藓:病例报告，强调牙科诊断标准

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200030

R. Rodrigues, J. Pinheiro, G. G. Silva, C. Barboza, R. B. Leite

{"title":"Oral lichen planus with cutaneous manifestations: case report with emphasis on dental diagnostic criteria","authors":"R. Rodrigues, J. Pinheiro, G. G. Silva, C. Barboza, R. B. Leite","doi":"10.5935/1676-2444.20200030","DOIUrl":"https://doi.org/10.5935/1676-2444.20200030","url":null,"abstract":"Lichen planus is a chronic inflammatory disease involving the skin and mucosa, which often affects the oral cavity. The objective of this study is to report a case of oral lichen planus (OLP) with cutaneous manifestations and to discuss the clinical, histopathological aspects and the established treatment. A 61-years-old female white patient was referred for evaluation of white lesions in the oral mucosa. In the intraoral examination, multiple white lesions with striated appearance were observed in the jugal mucosa, tongue and border. The extraoral examination revealed scaly lesions on the arm, white spots on the legs, and nail dystrophy on feet. Based on biopsy of the oral lesions and the histopathological analysis, the diagnosis of OLP was confirmed. The patient underwent treatment with clobetasol propionate topical cream (0.5 mg), and was instructed to apply it to affected area, once or twice a day for four weeks. In the clinical follow-up after one month and 15 days, the improvement of the lesions could be analyzed. As OLP is a disease with an etiopathogenesis that is still poorly recognized, several factors may enable the development of this condition. Therefore, the dentist’s clinical view is essential for the most effective treatment.","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71116685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute lymphocytic leukemia associated with toxoplasmosis: case report 急性淋巴细胞白血病合并弓形虫病1例报告

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200033

S. Machado, L. R. Oliveira, Beatriz M. Scalassara, Karina G. Faria, Lara E. F. O. Almeida

引用次数: 0