Electrolyte and Blood Pressure最新文献

{"title":"Esophageal Artery Pseudoaneurysm and Takayasu Arteritis in a Patient with Autosomal Dominant Polycystic Kidney Disease.","authors":"Hyunsuk Kim, Yeonsil Yu, Kwang Eon Shim, Jin Eop Kim, Junga Koh, Jong-Woo Yoon, Curie Ahn, Yun Kyu Oh","doi":"10.5049/EBP.2018.16.1.11","DOIUrl":"https://doi.org/10.5049/EBP.2018.16.1.11","url":null,"abstract":"A 47-year-old female previously diagnosed with ADPKD visited the hospital due to sudden pain in her upper abdomen and back. Esophagogastroduodenoscopy, contrast-enhanced abdominal computed tomography (CT), and CT angiography identified an esophageal artery pseudoaneurysm and hematoma in the esophagus. Urgent angiography and embolization were performed. After the procedure, CT angiography and positron emission tomography were performed due to differences in blood pressure between the arms. The patient was also found to have Takayasu arteritis and subsequently received outpatient follow-up care. The possible mechanisms that cause vascular abnormalities in ADPKD patients include damaged vascular integrity due to abnormal polycystin expression caused by PKD mutations and connective tissue abnormalities. Further research is needed to confirm these mechanisms, and ADPKD patients should be assessed for vascular abnormalities.","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"16 1","pages":"11-14"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2018.16.1.11","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36345407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Different Expression Patterns of HSP22, a Late Embryogenesis Abundant-like Protein, in Hypertrophic H9C2 Cells Induced by NaCl and Angiotensin II.","authors":"Jae Hwi Sung,&nbsp;Ahran Song,&nbsp;Taegun Park,&nbsp;Eunyoung Kim,&nbsp;Seunggwan Lee","doi":"10.5049/EBP.2018.16.1.1","DOIUrl":"https://doi.org/10.5049/EBP.2018.16.1.1","url":null,"abstract":"<p><strong>Background: </strong>High-NaCl diet is a contributing factor for cardiac hypertrophy. The role of HSP22 as a protective protein during cardiac hypertrophy due to hypernatremia is unclear. Accordingly, this study aimed to establish a cellular hypernatremic H9C2 model and to compare the expression of HSP22 in Ca²⁺ homeostasis between a high-NaCl and angiotensin II-induced hypertrophic cellular H9C2 model.</p><p><strong>Methods: </strong>Real-time PCR was performed to compare the mRNA expression. Flow cytometry and confocal microscopy were used to analyze the cells.</p><p><strong>Results: </strong>The addition of 30 mM NaCl for 48 h was the most effective condition for the induction of hypertrophic H9C2 cells (termed the <i>in vitro</i> hypernatremic model). Cardiac cellular hypertrophy was induced with 30 mM NaCl and 1 µM angiotensin II for 48 h, without causing abnormal morphological changes or cytotoxicity of the culture conditions. HSP22 contains a similar domain to that found in the consensus sequences of the late embryogenesis abundant protein group 3 from <i>Artemia</i>. The expression of HSP22 gradually decreased in the <i>in vitro</i> hypernatremic model. In contrast to the <i>in vitro</i> hypernatremic model, HSP22 increased after exposure to angiotensin II for 48 h. Intracellular Ca²⁺ decreased in the angiotensin II model and further decreased in the <i>in vitro</i> hypernatremic model. Impaired intracellular Ca²⁺ homeostasis was more evident in the <i>in vitro</i> hypernatremic model.</p><p><strong>Conclusion: </strong>The results showed that NaCl significantly decreased HSP22. Decreased HSP22, due to the hypernatremic condition, affected the Ca²⁺ homeostasis in the H9C2 cells. Therefore, hypernatremia induces cellular hypertrophy via impaired Ca²⁺ homeostasis. The additional mechanisms of HSP22 need to be explored further.</p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"16 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2018.16.1.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36345406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Associated with Mediastinal Schwannoma.","authors":"Shin Han Song,&nbsp;Gyeong Ah Sim,&nbsp;Seon Ha Baek,&nbsp;Jang Won Seo,&nbsp;Jung Weon Shim,&nbsp;Ja Ryong Koo","doi":"10.5049/EBP.2017.15.2.42","DOIUrl":"https://doi.org/10.5049/EBP.2017.15.2.42","url":null,"abstract":"<p><p>Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common cause of euvolemic hypo-osmotic hyponatremia. There are several etiologies of SIADH including neuroendocrine tumor, pulmonary disease, infection, trauma, and medications. Here, we report a case of SIADH associated with a schwannoma involving the mediastinum in a 75-year-old woman who presented with nausea, vomiting, and general weakness. Laboratory testing showed hypo-osmolar hyponatremia, with a serum sodium level of 102mmol/L, serum osmolality of 221mOsm/kg, urine osmolality of 382mOsm/kg, urine sodium of 55 mmol/L, and plasma antidiuretic hormone (ADH) of 4.40 pg/mL. Chest computed tomography identified a 1.5-cm-sized solid enhancing nodule in the right lower paratracheal area. A biopsy specimen was obtained by video-assisted thoracoscopic surgery, which was diagnosed on pathology as a schwannoma. The hyponatremia was completely resolved after schwannoma resection and plasma ADH level decreased from 4.40 pg/mL to 0.86 pg/mL. This case highlights the importance of suspecting and identifying the underlying cause of SIADH when faced with refractory or recurrent hyponatremia, and that on possibility is mediastinal schwannoma.</p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"15 2","pages":"42-46"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2017.15.2.42","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35792866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"25-hydroxyvitamin D Levels was not Associated with Blood Pressure and Arterial Stiffness in Patients with Chronic Kidney Disease.","authors":"Kyung Mi Park,&nbsp;Hak Hoon Jun,&nbsp;Jinkun Bae,&nbsp;Yu Bum Choi,&nbsp;Dong Ho Yang,&nbsp;Hye Yun Jeong,&nbsp;Mi Jung Lee,&nbsp;So-Young Lee","doi":"10.5049/EBP.2017.15.2.27","DOIUrl":"https://doi.org/10.5049/EBP.2017.15.2.27","url":null,"abstract":"<p><strong>Background: </strong>We investigated the effect of vitamin D deficiency on cardiovascular risk profiles in an Asian population with chronic kidney disease (CKD).</p><p><strong>Methods: </strong>A total of 210 participants (62 non-dialysis CKD patients and 148 hemodialysis [HD] patients) were enrolled between December 2009 and February 2010. Vitamin D deficiency was determined using the serum 25-hydroxyvitamin D [25(OH)D] concentration. Blood pressure and arterial stiffness were measured. Subjects were divided into groups according to 25(OH)D concentration based on a cut-off of 13.5 ng/mL in non-dialysis CKD patients and 11.3 ng/mL in HD patients.</p><p><strong>Results: </strong>The mean age was 61.7±12.3 years in non-dialysis CKD patients and 57.0±12.7 years in HD patients. In the non-dialysis CKD group, mean estimated glomerular filtration rate (eGFR) was 29.7±15.4 mL/min/1.73 m². Mean 25(OH)D concentration was 13.6±7.8 ng/mL in non-dialysis CKD patients and 11.3±6.7 ng/mL in HD patients. More than half of the subjects had vitamin D deficiency (67.6% in non-dialysis CKD patients and 80.4% in HD patients). There were no significant differences in systolic blood pressure, pulse pressure, and arterial stiffness between higher and lower 25(OH)D groups among non-dialysis CKD and HD patients. Multivariate analysis revealed that female sex (odds ratio [OR]: 5.890; 95% confidence interval [CI]: 2.597-13.387; p<0.001) and presence of diabetes (OR: 2.434; 95% CI: 1.103-5.370; p=0.028) were significantly associated with lower serum 25(OH)D levels in HD patients.</p><p><strong>Conclusion: </strong>The prevalence of vitamin D deficiency was high in both nondialysis CKD patients and HD patients. Serum 25(OH)D concentration was not a significant factor associated with blood pressure and arterial stiffness among non-dialysis CKD and HD patients.</p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"15 2","pages":"27-36"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2017.15.2.27","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35792865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Edematous Hyponatremia Treated with Tolvaptan in a Patient with Amyotrophic Lateral Sclerosis.","authors":"Gheun-Ho Kim","doi":"10.5049/EBP.2017.15.2.37","DOIUrl":"https://doi.org/10.5049/EBP.2017.15.2.37","url":null,"abstract":"<p><p>Amyotrophic lateral sclerosis (ALS) patients rarely present with either syndrome of inappropriate antidiuretic hormone secretion or generalized edema. Tolvaptan is a selective vasopressin V2 receptor antagonist that produces effective aquaresis, and its use in ALS patients has not been previously reported. A 50-year-old male ALS patient was admitted because of both generalized edema and dilutional hyponatremia. These manifestations were refractory to conventional diuretics and fluid therapy, but a very brisk diuresis was induced by tolvaptan administration. Edema and hyponatremia were also improved, and the patient was able to be discharged without tolvaptan. In this case report, we postulate how edema and dilutional hyponatremia developed in the patient, and discuss the mechanism of tolvaptan in treating hypervolemic hyponatremia. Further experience is necessary to evaluate the usefulness of tolvaptan in patients with neurological disorders.</p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"15 2","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2017.15.2.37","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35792864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Ethylene Glycol intoxication with Acute Renal Injury: Successful Recovery by Fomepizole and Renal Replacement Therapy.","authors":"Chang Hun Song,&nbsp;Hong Jin Bae,&nbsp;Young Rok Ham,&nbsp;Ki Ryang Na,&nbsp;Kang Wook Lee,&nbsp;Dae Eun Choi","doi":"10.5049/EBP.2017.15.2.47","DOIUrl":"https://doi.org/10.5049/EBP.2017.15.2.47","url":null,"abstract":"<p><p>Ethylene glycol is a widely used and readily available substance. Ethylene glycol ingestion does not cause direct toxicity; however, its metabolites are highly toxic and can be fatal even in trace amounts. Poisoning is best diagnosed through inquiry, but as an impaired state of consciousness is observed in most cases, poisoning must be suspected when a significantly elevated osmolar gap or high anion gap metabolic acidosis is found in blood tests. Hemodialysis and alcohol dehydrogenase inhibitors such as ethanol and fomepizole are a part of the basic treatment, and timely diagnosis and treatment are crucial because any delays can lead to death. However, there are few reported cases in Korea, and no report on the use of fomepizole. Herein, we report a case of acute renal failure caused by ethylene glycol poisoning that was treated with fomepizole and hemodialysis and present a literature review.</p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"15 2","pages":"47-51"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2017.15.2.47","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35792868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central Diabetes Insipidus Linked to Rathke's Cleft Cyst, Polyuria in a 17-year-old Girl.","authors":"Ha Yeon Kim,&nbsp;Seung Jin Lee,&nbsp;Eun Hui Bae,&nbsp;Seong Kwon Ma,&nbsp;Soo Wan Kim","doi":"10.5049/EBP.2017.15.1.23","DOIUrl":"https://doi.org/10.5049/EBP.2017.15.1.23","url":null,"abstract":"<p><p>A 17-year-old girl presented with polyuria (7 L/day) and polydipsia for one year. Initial urine osmolality was 113mOsm/kg H₂O. Following 6 h of fluid restriction, serum plasma osmolality reached 300mOsm/kg H₂O, whereas urine osmolality was 108mOsm/kg H₂O. Urine osmolality was increased by 427% from 108 to 557mOsm/kg after vasopressin challenge. The patient was diagnosed with central diabetes insipidus, possibly derived from the atypical occupation of a Rathke's cleft cyst at the pituitary stalk following magnetic resonance imaging with enhancement. She was discharged with desmopressin nasal spray (10 µg); urine output was maintained at 2-3 L/day, and urine osmolality was >300 mOsm/kg. Additional pituitary image studies and evaluation of hypopituitarism should be included in the differential diagnosis of patients with central diabetes insipidus.</p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"15 1","pages":"23-25"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2017.15.1.23","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35519439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Case of Posterior Reversible Encephalopathy Syndrome in a Patient with Anti-glomerular Basement Membrane Antibody Glomerulonephritis: A Case Report and Review of the Literature.","authors":"Boram Cha,&nbsp;Dae Young Kim,&nbsp;Hyunil Jang,&nbsp;Seun Deuk Hwang,&nbsp;Huck Jei Choi,&nbsp;Moon-Jae Kim","doi":"10.5049/EBP.2017.15.1.12","DOIUrl":"https://doi.org/10.5049/EBP.2017.15.1.12","url":null,"abstract":"<p><p>Posterior reversible encephalopathy syndrome (PRES) is characterized by a clinical and radiological entity with the sudden onset of seizures, headache, altered consciousness, and visual disturbances in patients with the findings of reversible vasogenic subcortical edema without infarction. Hypertension, renal disease, and autoimmune disease are co-morbid conditions of PRES. Nevertheless, there have only been a few case reports of PRES in a patient with anti-glomerular basement membrane antibody glomerulonephritis (anti-GBM GN). This paper presents the possible first Korean case of a 36-year-old woman with the striking features of PRES. She presented with a sudden onset of visual blindness, headache, and seizure. The brain MRI images revealed hyperintense lesions in both the occipital and parietal lobes, which suggested vasogenic edema. Three months before this presentation, she was diagnosed with anti-GBM GN. Since then, she underwent immunosuppression with cyclophosphamide and steroid, and hemodialysis for renal failure with a treatment of anti-GBM GN.</p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"15 1","pages":"12-16"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2017.15.1.12","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35519436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal Tubular Acidosis in Patients with Primary Sjögren's Syndrome.","authors":"Su Woong Jung,&nbsp;Eun Ji Park,&nbsp;Jin Sug Kim,&nbsp;Tae Won Lee,&nbsp;Chun Gyoo Ihm,&nbsp;Sang Ho Lee,&nbsp;Ju-Young Moon,&nbsp;Yang Gyun Kim,&nbsp;Kyung Hwan Jeong","doi":"10.5049/EBP.2017.15.1.17","DOIUrl":"https://doi.org/10.5049/EBP.2017.15.1.17","url":null,"abstract":"<p><p>Primary Sjögren's syndrome (pSS) is characterized by lymphocytic infiltration of the exocrine glands resulting in decreased saliva and tear production. It uncommonly involves the kidneys in various forms, including tubulointerstitial nephritis, renal tubular acidosis, Fanconi syndrome, and rarely glomerulonephritis. Its clinical symptoms include muscle weakness, periodic paralysis, and bone pain due to metabolic acidosis and electrolyte imbalance. Herein, we describe the cases of two women with pSS whose presenting symptoms involve the kidneys. They had hypokalemia and normal anion gap metabolic acidosis due to distal renal tubular acidosis and positive anti-SS-A and anti-SS-B autoantibodies. Since one of them experienced femoral fracture due to osteomalacia secondary to renal tubular acidosis, an earlier diagnosis of pSS is important in preventing serious complications.</p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"15 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2017.15.1.17","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35519438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D and Hypertension.","authors":"Hye Yun Jeong,&nbsp;Kyung Mi Park,&nbsp;Mi Jung Lee,&nbsp;Dong Ho Yang,&nbsp;Sang Hoon Kim,&nbsp;So-Young Lee","doi":"10.5049/EBP.2017.15.1.1","DOIUrl":"https://doi.org/10.5049/EBP.2017.15.1.1","url":null,"abstract":"<p><p>Vitamin D has the pleiotropic effects in multiple organ systems, and vitamin D deficiency was suggested to be associated with high blood pressure according to previous reports. Several interventional studies have examined the effect of vitamin D supplementation on high blood pressure patients, but the results have been inconsistent. In this article, we examined the literature that have proposed a mechanism involving vitamin D in the regulation of blood pressure and review previous observational and interventional studies that have shown the relationship between vitamin D and hypertension among various populations.</p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"15 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2017.15.1.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35519437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}