Electrolyte and Blood Pressure最新文献_第4页

Osmotic Demyelination Syndrome Associated with Hypernatremia Caused by Lactulose Enema in a Patient with Chronic Alcoholism. 慢性酒精中毒患者乳果糖灌肠引起的高钠血症与渗透性脱髓鞘综合征相关

Electrolyte and Blood Pressure Pub Date : 2021-06-01 Epub Date: 2021-06-30 DOI: 10.5049/EBP.2021.19.1.15

Jeong Ho Lee, Chang Seong Kim, Eun Hui Bae, Soo Wan Kim, Seong Kwon Ma

{"title":"Osmotic Demyelination Syndrome Associated with Hypernatremia Caused by Lactulose Enema in a Patient with Chronic Alcoholism.","authors":"Jeong Ho Lee, Chang Seong Kim, Eun Hui Bae, Soo Wan Kim, Seong Kwon Ma","doi":"10.5049/EBP.2021.19.1.15","DOIUrl":"https://doi.org/10.5049/EBP.2021.19.1.15","url":null,"abstract":"A 44-year-old man with chronic alcoholism presented with seizure and loss of consciousness. He was diagnosed with alcoholic hepatic encephalopathy, and his neurologic symptoms recovered after lactulose enema treatment. His initial serum sodium level was 141mEq/L. However, his mental state became confused after treatment with lactulose enema for five days, and his serum sodium level increased to 178mEq/L. After five days of gradual correction of serum sodium level from 178mEq/L to 140mEq/L, the patient's mental state recovered, but motor weakness in both limbs remained. Therefore, magnetic resonance imaging of the brain was performed. T2-weighted brain images showed bilateral symmetrical hyperintensities in the central pons, basal ganglia, thalami, hippocampi and unci, which were consistent with central pontine and extrapontine myelinolysis. We report a rare case of osmotic demyelination syndrome that occurred as a result of a rapid increase from a normal sodium level to hypernatremia caused by lactulose enema administered to treat alcoholic hepatic encephalopathy.","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"19 1","pages":"15-18"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/65/ebp-19-15.PMC8267071.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39206882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hypertension and Electrolyte Disorders in Patients with COVID-19. COVID-19患者高血压和电解质紊乱

Electrolyte and Blood Pressure Pub Date : 2020-12-01 Epub Date: 2020-12-28 DOI: 10.5049/EBP.2020.18.2.23

Jeong-Hoon Lim, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho

{"title":"Hypertension and Electrolyte Disorders in Patients with COVID-19.","authors":"Jeong-Hoon Lim, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho","doi":"10.5049/EBP.2020.18.2.23","DOIUrl":"https://doi.org/10.5049/EBP.2020.18.2.23","url":null,"abstract":"The worldwide coronavirus disease 2019 (COVID-19) pandemic is still in progress, but much remains unknown about the disease. In this article, we review the association of hypertension or the renin-angiotensin system (RAS) with COVID-19 and the correlation between electrolyte disorders and disease severity. Underlying hypertension is likely to be associated with severe or critical COVID-19, but the relationship is not clear owing to confounding factors. Angiotensin-converting enzyme 2 (ACE2) plays an important role in the non-classical RAS pathway and binds to a receptor binding domain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The RAS blockade is known to increase ACE2 levels, but controversy remains regarding the effect of RAS blockade therapy in the course of COVID-19. Some reports have indicated a protective effect of RAS blockade on COVID-19, whereas others have reported an association of RAS blockade therapy with the occurrence of severe complications such as acute kidney injury and admission to the intensive care unit. Electrolyte disorders are not uncommon in patients with COVID-19, and severe COVID-19 has frequently shown hypokalemia, hyponatremia, and hypocalcemia. Electrolyte imbalances are caused by alteration of RAS, gastrointestinal loss, effects of proinflammatory cytokines, and renal tubular dysfunction by the invasion of SARS-CoV-2.","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"18 2","pages":"23-30"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5c/ed/ebp-18-23.PMC7781764.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38790774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Cisplatin-induced Atrioventricular Block Requiring a Pacemaker: Two Case Reports and a Literature Review. 需要起搏器的顺铂诱导房室传导阻滞:两例报告和文献综述。

Electrolyte and Blood Pressure Pub Date : 2020-12-01 Epub Date: 2020-12-28 DOI: 10.5049/EBP.2020.18.2.49

Hyun-Jin Bang, Ho Young Lee, Hyeon-Jong Kim, Namsik Yoon, Ik-Joo Chung, Woo Kyun Bae

{"title":"Cisplatin-induced Atrioventricular Block Requiring a Pacemaker: Two Case Reports and a Literature Review.","authors":"Hyun-Jin Bang, Ho Young Lee, Hyeon-Jong Kim, Namsik Yoon, Ik-Joo Chung, Woo Kyun Bae","doi":"10.5049/EBP.2020.18.2.49","DOIUrl":"https://doi.org/10.5049/EBP.2020.18.2.49","url":null,"abstract":"Chemotherapeutic drugs can cause cardiac toxicities such as cardiomyopathy, arrhythmia, and cardiovascular disease. The well-known side effects of cisplatin are nephrotoxicity, nausea, vomiting, and electrolyte imbalance. Cardiotoxicity induced by cisplatin is rare, and its pathophysiology is unknown. Here, we present two cases of complete and high-degree atrioventricular (AV) block that occurred during cisplatin-based chemotherapy and required pacemaker placement. A 64-year-old woman and a 75-year-old man, who had no underlying heart disease, developed dyspnea without chest pain and bradycardia during cisplatin-based chemotherapy. However, there were no significant differences in their serum electrolyte levels, cardiac enzyme levels, and echocardiography results before and after drug administration. The ECGs were confirmed with complete AV block and high-degree AV block, which requiring pacemaker placement. We assume that cisplatin directly caused the complete, high-degree AV block, which required a pacemaker placement in our cases. In such cases, a cumulative dose of cisplatin over 240 mg/m2 is a risk factor for early symptoms of AV block. If patients complain of dyspnea without chest pain during cisplatin-based chemotherapy, arrhythmic complications should be considered. This information may be helpful for clinicians treating patients with cisplatin chemotherapy.","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"18 2","pages":"49-52"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a5/06/ebp-18-49.PMC7781763.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39125545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Hyponatremia Associated with Pulmonary Arterial Hypertension: Syndrome of Inappropriate Antidiuresis Versus Right Heart Failure. 低钠血症与肺动脉高压相关:不适当的抗利尿综合征与右心衰。

Electrolyte and Blood Pressure Pub Date : 2020-12-01 Epub Date: 2020-12-28 DOI: 10.5049/EBP.2020.18.2.40

Juyeon Kang, Dae Hyun Lim, Gheun-Ho Kim

引用次数: 1

Liver Infarction and Venous Thromboembolism after Tamoxifen Use in an ADPKD Patient with Encapsulating Peritoneal Sclerosis: A Case Report. 他莫昔芬用于ADPKD伴包裹性腹膜硬化患者后肝梗死和静脉血栓栓塞1例报告。

Electrolyte and Blood Pressure Pub Date : 2020-12-01 Epub Date: 2020-12-28 DOI: 10.5049/EBP.2020.18.2.44

Kyoung Min Kwak, Gwang Ho Choi, Kwang Eon Shim, Ho Yong Jin, Seok Hyung Kim, Jong Woo Yoon, Hyunsuk Kim

{"title":"Liver Infarction and Venous Thromboembolism after Tamoxifen Use in an ADPKD Patient with Encapsulating Peritoneal Sclerosis: A Case Report.","authors":"Kyoung Min Kwak, Gwang Ho Choi, Kwang Eon Shim, Ho Yong Jin, Seok Hyung Kim, Jong Woo Yoon, Hyunsuk Kim","doi":"10.5049/EBP.2020.18.2.44","DOIUrl":"https://doi.org/10.5049/EBP.2020.18.2.44","url":null,"abstract":"Encapsulating peritoneal sclerosis (EPS) is a potentially fatal complication after long-term peritoneal dialysis, and tamoxifen can be used for its prevention and treatment. However, tamoxifen is known to increase the risk of venous thromboembolism. A 49-year-old woman was admitted with sudden abdominal pain. The patient had received peritoneal dialysis for 20 years and switched to hemodialysis after the diagnosis of EPS. Tamoxifen (10mg) and prednisolone (20mg) had been administered for 8 months. On computed tomography, the left hepatic lobe was hardly illuminated, leading to a diagnosis of liver infarction. A month later, she was re-admitted due to abdominal pain and extensive deep vein thrombosis of the leg. The administration of tamoxifen was stopped and prednisolone was reduced to 10mg. As her malnutrition progressed, she succumbed to death of gram negative sepsis. The patient was concluded to have liver infarction and extensive venous thrombosis as a side effect of tamoxifen.","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"18 2","pages":"44-48"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c5/fd/ebp-18-44.PMC7781765.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39125544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Association of Proteinuria with Urinary Concentration Defect in Puromycin Aminonucleoside Nephrosis. 嘌呤霉素氨基核苷肾病患者尿浓度缺陷与蛋白尿的关系。

Electrolyte and Blood Pressure Pub Date : 2020-12-01 Epub Date: 2020-12-28 DOI: 10.5049/EBP.2020.18.2.31

Chor Ho Jo, Sua Kim, Gheun-Ho Kim

{"title":"Association of Proteinuria with Urinary Concentration Defect in Puromycin Aminonucleoside Nephrosis.","authors":"Chor Ho Jo, Sua Kim, Gheun-Ho Kim","doi":"10.5049/EBP.2020.18.2.31","DOIUrl":"https://doi.org/10.5049/EBP.2020.18.2.31","url":null,"abstract":"Background: Puromycin aminonucleoside (PA) can induce nephrotic syndrome in rats, and proteinuria is an important mediator of tubulointerstitial injury in glomerulopathy. We assumed that glomerular proteinuria may affect tubular function, such as urinary concentration, and investigated whether a urinary concentration defect is associated with proteinuria in puromycin aminonucleoside nephrosis (PAN). We also investigated the defect response to enalapril.Methods: Glomerular proteinuria was induced by a single intraperitoneal injection of PA (150mg/kg BW) in male Sprague-Dawley rats. In a half of these rats, enalapril (35mg/kg BW) was administered daily in a food mixture for two weeks. After the animal experiment, kidneys were harvested for immunoblot analysis and histopathologic examination.Results: Compared with the control group, PA-treated rats had severe proteinuria, polyuria, and a lower urine osmolality. PA treatment induced remarkable tubulointerstitial injury and significant reductions in protein abundances of aquaporin-1 and Na-K-2Cl co-transporter type 2 (NKCC2). Proteinuria significantly correlated with osteopontin expression in the kidney and inversely correlated with renal expression of aquaporin-1, aquaporin-2, and NKCC2. The degree of tubulointerstitial injury significantly correlated with proteinuria, urine output, and osteopontin expression and inversely correlated with urine osmolality and renal expression of aquaporin-1, aquaporin-2, and NKCC2. No significant differences in parameters were found between PA-treated rats with and without enalapril.Conclusion: In PAN, glomerular proteinuria was associated with tubulointerstitial injury and water diuresis. Downregulation of aquaporin-1 and NKCC2 can impair countercurrent multiplication and cause a urinary concentration defect in PAN.","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"18 2","pages":"31-39"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1a/fe/ebp-18-31.PMC7781767.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38790775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Recurrent Severe Hyponatremia in a Patient with Sjögren's Syndrome. Sjögren综合征患者复发性严重低钠血症

Electrolyte and Blood Pressure Pub Date : 2020-06-01 Epub Date: 2020-06-18 DOI: 10.5049/EBP.2020.18.1.19

Hyung Duk Kim, Jennifer Lee, Byung Ha Chung, Chul Woo Yang, Yong-Soo Kim, Cheol Whee Park

引用次数: 3

Extremely Severe Hypernatremia Caused by Wrong Belief in a Patient with Cervical Cancer. 错误信念致宫颈癌患者极重度高钠血症1例。

Electrolyte and Blood Pressure Pub Date : 2020-06-01 Epub Date: 2020-06-18 DOI: 10.5049/EBP.2020.18.1.16

Myeong Su Park, Hyuk Jin Park, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim, Minah Kim

引用次数: 1

Urinary Concentration Defect and Renal Glycosuria in Cyclosporine-treated Rats. 环孢素治疗大鼠尿浓度缺损与肾糖尿症。

Electrolyte and Blood Pressure Pub Date : 2020-06-01 Epub Date: 2020-06-18 DOI: 10.5049/EBP.2020.18.1.1

Jun Han Lee, Su A Kim, Chor Ho Jo, Chang Hwa Lee, Gheun-Ho Kim

{"title":"Urinary Concentration Defect and Renal Glycosuria in Cyclosporine-treated Rats.","authors":"Jun Han Lee, Su A Kim, Chor Ho Jo, Chang Hwa Lee, Gheun-Ho Kim","doi":"10.5049/EBP.2020.18.1.1","DOIUrl":"https://doi.org/10.5049/EBP.2020.18.1.1","url":null,"abstract":"Background: Urinary concentration impairment is a major feature of cyclosporine nephrotoxicity.Methods: We explored two possible mechanisms that may underlie cyclosporine-induced polyuria; water, and/or osmotic diuresis. Cyclosporine was subcutaneously injected to normal salt-fed Sprague-Dawley rats at a daily dose of 25mg/kg for 2 weeks (Experiment I) and 7.5mg/kg for 6 weeks (Experiment II).Results: In Experiment I, cyclosporine treatment caused an increase in urine volume (2.7±0.5 vs. 10.3±1.13mL/d/100 g BW, p<0.001) and a decrease in urine osmolality (2,831±554 vs. 1,379±478mOsm/kg H2O, p<0.05). Aquaporin-2 (AQP2) protein expression decreased in cyclosporine-treated rat kidneys (cortex, 78±8%, p<0.05; medulla, 80±1%, p<0.05). Experiment II also showed that urine volume was increased by cyclosporine treatment (4.97±0.66 vs. 9.65±1.76mL/d/100 g BW, p<0.05). Whereas urine osmolality was not affected, urinary excretion of osmoles was increased (7.5±0.4 vs. 14.9±1.4mosmoles/d/100 g BW, p<0.005). Notably, urinary excretion of glucose increased in cyclosporine-treated rats (7±1 vs. 10,932±2,462 mg/d/100 g BW, p<0.005) without a significant elevation in plasma glucose. In both Experiment I and II, GLUT2 protein expression in the renal cortex was decreased by cyclosporine treatment (Experiment I, 55±6%, p<0.005; Experiment II, 88±3%, p<0.05).Conclusion: Both water diuresis and osmotic diuresis are induced by cyclosporine nephrotoxicity. AQP2 and GLUT2 downregulation may underlie water and osmotic diuresis, respectively.","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"18 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/41/7b/ebp-18-1.PMC7327388.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38144512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Voriconazole-induced Severe Hyperkalemia Precipitated by Multiple Drug Interactions. 伏立康唑引起的多种药物相互作用导致的严重高钾血症。

Electrolyte and Blood Pressure Pub Date : 2020-06-01 Epub Date: 2020-06-18 DOI: 10.5049/EBP.2020.18.1.10

Jae Young Choi, Seong Geun Cho, Ki-Seok Jang, Gheun-Ho Kim

{"title":"Voriconazole-induced Severe Hyperkalemia Precipitated by Multiple Drug Interactions.","authors":"Jae Young Choi, Seong Geun Cho, Ki-Seok Jang, Gheun-Ho Kim","doi":"10.5049/EBP.2020.18.1.10","DOIUrl":"https://doi.org/10.5049/EBP.2020.18.1.10","url":null,"abstract":"Voriconazole, a triazole antifungal agent used to treat serious fungal infections, has a pharmacokinetic characteristic of undergoing hepatic metabolism by the cytochrome P450 system. Few cases of hyperkalemia have been reported, which presented only when the serum voriconazole level was exceptionally elevated by drug-drug interactions. Additionally, azole antifungals may interfere with the biosynthesis of adrenal steroids and therefore can predispose patients to aldosterone deficiency. However, it is unclear whether voriconazole itself can induce hypoaldosteronism or hyperkalemia. Here, we report a case of voriconazole-induced hyperkalemia in a patient administered concurrent medications to treat comorbidities. Voriconazole was orally administered for pulmonary aspergillosis, and three episodes of severe hyperkalemia recurred, which improved with emergency treatment. In the first episode, renin-angiotensin-aldosterone system inhibitors were associated. We found that dronedarone might have increased the voriconazole level in the second episode. At that time, severe hypercalcemia was concurrent, which improved with acute hemodialysis and eliminating dronedarone. Finally, severe hyperkalemia recurred without concurrent medications known to interact with voriconazole. Upon switching from voriconazole to itraconazole, the hyperkalemia was resolved. Drug level monitoring is necessary when voriconazole is used. Genetic susceptibility, such as through CYP2C19 polymorphism, may be investigated for patients with adverse reactions to voriconazole.","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"18 1","pages":"10-15"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/28/ebp-18-10.PMC7327389.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38144411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6