Baseline High Blood Pressure is Associated with Clinico-Pathologic Findings and Later Renal Progression in Chronic Glomerulonephritis.

Pub Date : 2019-12-01 Epub Date: 2019-12-31 DOI:10.5049/EBP.2019.17.2.54
Ji Yung Lee, Hyung-Seok Ihm, Jin Sug Kim, Hyeon Seok Hwang, Kyung Hwan Jeong, Chun-Gyoo Ihm
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引用次数: 2

Abstract

Background: Several factors had been suggested to contribute to the development of hypertension in chronic glomerulonephritis (GN). This study was conducted to find the association of baseline blood pressure (BP) with pathophysiologic findings and later renal progression in chronic GN.

Methods: Clinico-pathological findings including serum creatinine (Cr), proteinuria, pathological findings, and urinary Na excretion were analyzed in a total of 233 patients with IgA nephropathy from The Kyung-Hee Cohort of GN. Glomerular surface area (GSA) was measured by imaging analysis and urine angiotensinogen (AGT) concentrations by human ELISA kits.

Results: Systolic BP was ≥130mmHg in 124 patients (53%). Systolic BP was negatively correlated with follow-up eGFR (r=-0.32, p<0.0001) and positively serum uric acid concentrations, while it had no significant relationships with initial serum Cr and eGFR. As compared with patients with systolic BP<130 mmHg, those with ≥130 mmHg were older and showed higher serum Cr, proteinuria, 24 hr urinary Na excretion, mean GSA, and T-I fibrosis, lower follow-up eGFR, and steeper decline in slope of eGFR. The results in patients with normal serum Cr concentrations were comparable to those in whole group. Systolic BP was positively correlated with age, baseline and follow-up proteinuria, serum uric acid concentrations and IgM deposit and negatively with follow-up eGFR. In subgroup analysis, systolic BP was also positively correlated with mean GSA and urinary AGT concentrations.

Conclusion: This study showed that baseline systolic BP is related to urinary Na excretion, glomerulomegaly, T-I fibrosis and later renal progression in patients with IgA nephropathy.

Abstract Image

Abstract Image

Abstract Image

基线高血压与慢性肾小球肾炎的临床病理表现和后期肾脏进展有关。
背景:一些因素被认为有助于慢性肾小球肾炎(GN)高血压的发展。本研究旨在发现基线血压(BP)与慢性肾小球肾病的病理生理表现和后期肾脏进展之间的关系。方法:分析来自The ky庆熙队列的233例IgA肾病患者的临床病理表现,包括血清肌酐(Cr)、蛋白尿、病理表现和尿钠排泄。成像法测定肾小球表面积(GSA), ELISA法测定尿血管紧张素原(AGT)浓度。结果:收缩压≥130mmHg 124例(53%)。收缩压与随访eGFR呈负相关(r=-0.32, p)。结论:本研究显示基线收缩压与IgA肾病患者尿钠排泄、肾小球肿大、T-I纤维化及后期肾脏进展有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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