Medycyna wieku rozwojowego最新文献

{"title":"Body weight and quality of life among adolescents in krakow.","authors":"Agnieszka Magiera, E. Sochacka-Tatara, A. Sowa, R. Jacek, A. Pac","doi":"10.34763/devperiodmed.20182202.160170","DOIUrl":"https://doi.org/10.34763/devperiodmed.20182202.160170","url":null,"abstract":"AIM\u0000The aim of this study was to assess the relationship between body weight and the quality of life among adolescents in Krakow, Poland.\u0000\u0000\u0000MATERIAL AND METHODS\u0000The study comprised 1291 pupils - 632 girls and 659 boys from 17 Krakow middle schools. Their quality of life (QoL) was assessed by means of the Polish version of the KIDSCREEN-27 questionnaire. Five dimensions of QoL were analyzed as low, average and high QoL according to Polish cut-off points. The body mass index (BMI) of the adolescents was classified as underweight, normal weight, or excessive weight according to Polish growth charts.\u0000\u0000\u0000RESULTS\u0000Low QoL was observed significantly more often in girls than in boys. Excessive weight among both girls and boys was found to be a risk factor for low QoL in the \"Physical Well-being\" dimension as compared to normal weight adolescents. Additionally, boys with excessive weight had a two-fold higher risk of low QoL in the \"Social Support & Peers\" dimension (OR=2.00; 95 %CI:1.14-3.50). Underweight was associated with higher risk of low QoL in the \"Physical Well-being\", \"Autonomy & Parents\", and \"Social Support & Peers\" dimensions, but only among boys.\u0000\u0000\u0000CONCLUSIONS\u0000Both, underweight and excessive weight were associated with low QoL. Excessive weight in youth was linked mainly with lower physical well-being. Underweight was a predictor of low QoL only among boys in the dimensions related to physical health, as well as relations with family and peers.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"22 2 1","pages":"160-170"},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69886331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the release of exogenous nitric oxide on the responses of the pregnant human myometrium to oxytocin.","authors":"B. Modzelewska, T. Kleszczewski, A. Kostrzewska","doi":"10.34763/devperiodmed.20182204.301307","DOIUrl":"https://doi.org/10.34763/devperiodmed.20182204.301307","url":null,"abstract":"Currently there is insufficient evidence to support the routine administration of nitric oxide donors in the treatment of threatened preterm labor. An understanding of the role that nitric oxide plays in the management of threatened preterm labor may lead to more effective treatment and prevention. This is why the aim of our study was to examine the involvement of exogenous nitric oxide release in regulating responses of the human pregnant myometrium to oxytocin. Biopsies of human myometrial tissue during pregnancy were obtained from 8 pregnant women, aged 21-35 years. The responses of the specimens to oxytocin in the absence and presence of a DETA/NO were recorded under isometric conditions. Preincubation with exogenous nitric oxide significantly (p<0.001) attenuated the contractile response of the uterine strips to oxytocin in concentrations higher than 10 -8 mol/L. The inhibition of nitric oxide synthesis alone or in combination with DETA/NO incubation did not significantly change the oxytocin contractile effect in the concentration-response curve. Moreover, there was no significant variation in the mean value for log EC 50 for oxytocin between the group with oxytocin alone and other groups. We present evidence in support of the hypothesis that continuous nitric oxide supply to the human pregnant myometrium environment attenuates its response to oxytocin but only when endogenous production of nitric oxide is not impaired.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"22 4 1","pages":"301-307"},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69886594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent highlights of research on androgen receptors in women.","authors":"Kamil Zaręba, Iwona Sidorkiewicz","doi":"10.34763/devperiodmed.20172101.0712","DOIUrl":"https://doi.org/10.34763/devperiodmed.20172101.0712","url":null,"abstract":"In this brief review we present an outline of the current state of research on examples of hyperandrogenism that can be strongly associated with diverse modifications in the androgen signaling pathway. We discuss the most prominent clinical features of androgen excess and correlate them with studies on androgen receptor (AR) alterations. For the first time we summarize the confirmed localizations of all known AR receptors in women. The knowledge of ARs may be the basis for AR-targeted therapies of androgenic disorders in women, including malignancy, as it has recently been demonstrated for triple-negative breast cancer. Moreover, we summarize the structure and characterization of key AR splice variants, which could be involved in the androgenization in women.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"21 1 1","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69885873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiology and symptoms of renal colic in children - A case report.","authors":"M. Rakowska, K. Królikowska, K. Jobs, Małgorzata Placzyńska, B. Kalicki","doi":"10.34763/devperiodmed.20182203.265269","DOIUrl":"https://doi.org/10.34763/devperiodmed.20182203.265269","url":null,"abstract":"Urolithiasis is a disease characterized by the presence of stones in the kidney or urinary tract. It is often detected accidentally during an ultrasound or an abdominal x-ray performed for other reasons. However, the first symptom of kidney stone disease can be severe pain called renal colic. Pain caused by a colic attack is characterized by sudden onset. In half of the cases it is associated with nausea or vomiting and can lead to hypotension and fainting. The exact location and radiation of the pain depends on the location of the stone in the urinary tract. The first most commonly performed study is abdominal ultrasound with estimation of the deposit size and evaluation of urinary tract obstruction. Alternative or complementary studies are: an abdominal x-ray where radiopaque deposits can be shown, or unenhanced helical computed tomography of the abdomen. The severity of pain depends on the individual pain threshold and on the change in hydrostatic pressure in the part of the urinary system above the obstruction. Prolonged deposition of the stone in one place causes the activation of autoregulatory mechanisms to lower the pressure of the upper urinary tract, which limits the pain. The basic treatment for renal colic is analgetic therapy. The most commonly used drugs are NSAIDs and opiates. Another important component of renal colic treatment are medications that facilitate urinary stone passage by reducing oedema or limiting urethral contractions, such as: calcium channel blockers, alpha blockers, phosphodiesterase inhibitors. Intensive hydration is not currently recommended. Patients who are unlikely to spontaneously excrete the stone are eligible for minimally invasive treatment. The risk of urolithiasis recurring is high, reaching up to 40% in 5 years and up to 50% in 10 years. However, it can be reduced by proper prevention. The paper describes the pathophysiology of pain in renal colic, the treatment methods, and the case of a boy with recurrent renal colic.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"22 3 1","pages":"265-269"},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69886590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcifying Epithelial Odontogenic Tumour. Review of the literature and own experience.","authors":"Tomasz Piskadło, R. Brodowski, M. Książek, Paweł Pakla, Mateusz Dymek, Piotr Haberko, J. Frańczak, W. Stopyra, B. Lewandowski","doi":"10.34763/devperiodmed.20192301.3438","DOIUrl":"https://doi.org/10.34763/devperiodmed.20192301.3438","url":null,"abstract":"The present paper discusses the case of a patient who was surgically treated for a rare calcifying epithelia/ odontogenic tumour (Pindborg tumour) at the Department of Maxillofacia/ Surgery, F. Chopin Clinical Voivodeship Hospital in Rzeszow. Ca/cifying Epithelia/ Odontogenic Tumour (CEOT) is a benign odontogenic tumour arising from the remnants of the dental lamina epithelium. The first three cases of this tumour were recognized by the Danish patho/ogist J.J. Pindborg in 1955. Since then Ca/cifying Epithelia/ Odontogenic Tumour has been commonly referred to as the Pindborg tumour. This type of neop/asm is relatively rare, since it occurs in approximately 0.4% of all odontogenic tumour cases. Due to a fairly common tendency of recurrence, estimated to be approximately 14% of all cases, the preferred o choice of treatment is radical surgical procedure and postoperative follow-up. Appropriate clinical and histopatho/ogical diagnosis is very important before applying the most suitable surgical treatment. Based on the case reviewed and the available literature, we can confirm the suitability of the therapeutic procedure course aligned with contemporary views, guidelines and established standards.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"23 1 1","pages":"34-38"},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69886913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Polish version of the short scale measuring health literacy in adolescence.","authors":"J. Mazur, A. Małkowska-Szkutnik, L. Paakkari, O. Paakkari, D. Zawadzka","doi":"10.34763/devperiodmed.20192303.190197","DOIUrl":"https://doi.org/10.34763/devperiodmed.20192303.190197","url":null,"abstract":"BACKGROUND\u0000Recent years saw the development of international tools for measuring health competencies understood as health literacy (HL). One of them is the short index Health Literacy for School-Aged Children (HLSAC) implemented by the members of the Health Behaviour in School-aged Children (HBSC) network. So far, when researching the properties of this instrument, less attention has been devoted to the correlation of HLSAC with other tools related to health.\u0000\u0000\u0000THE AIM\u0000of the paper is to present selected psychometric features of the HLSAC index in a sample of Polish pupils, supplemented by the preliminary analysis of its association with the health locus of control.\u0000\u0000\u0000MATERIAL AND METHODS\u0000The information collected relates to 630 junior secondary school students surveyed in Poland in 2016 as part of the HLSAC questionnaire pilot study. The Multidimensional Health Locus of Control (MHLC) scale by K. Wallston was used as the additional module for Poland. It differentiates among three dimensions of health control: internal, external - dependent on other people, and external - dependent on random factors. It was checked which HLC dimension correlates most strongly with HL.\u0000\u0000\u0000RESULTS\u0000It was demonstrated that the HLSAC scale consisting of 10 questions has a very good reliability in the Polish version (Cronbach alfa = 0.851) and a one-factor structure. Confirmatory factor analysis supported a unidimensional model (RMSEA = 0.082; CFI=0.922; TLI=0.877). The HLSAC most strongly correlates with the internal health locus of control (r=0.376; p<0.001), slightly less with the influence of other people (r=0.153; p<0.001), while the correlation with the random factor health locus of control is insignificant (p=0.947). It was found that there is a weak, however significant, positive correlation between family affluence and HLSAC (p=0.041).\u0000\u0000\u0000CONCLUSIONS\u0000The analyses conducted demonstrated that the Polish version of HLSAC has good psychometric features. The relatively higher correlation between HLSAC and internal rather than external health locus of control was confirmed. The practical effect of the pilot study was to develop an improved version of the HLSAC scale, which has been recommended for the mainstream HBSC 2018 survey.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"23 3 1","pages":"190-197"},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69887422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progressive familial intrahepatic cholestasis type 3].","authors":"Patryk Lipiński, I. Jankowska","doi":"10.32388/wc72tw","DOIUrl":"https://doi.org/10.32388/wc72tw","url":null,"abstract":"Progressive familial intrahepatic cholestasis is caused by mutations in the ABCB4 gene and belongs to the family of familial intrahepatic cholestais disorders inherited in an autosomal recessive pattern. To date, about 200 patients with various hepatobiliary disorders associated with ABCB4 gene mutations have been described in the literature. The aim of this manuscript was to describe the pathogenesis, clinical presentation, diagnostic process and treatment of progressive familial intrahepatic cholestais type 3, based on the literature review.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"22 4 1","pages":"385-389"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49640542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of the Technique of Surfactant Administration (LISA vs INSURE) on the Outcomes of Respiratory Distress Syndrome Treatment in Preterm Infants","authors":"Urszula Kaniewska, E. Gulczyńska","doi":"10.34763/devperiodmed.20192303.163171","DOIUrl":"https://doi.org/10.34763/devperiodmed.20192303.163171","url":null,"abstract":"Abstract Intratracheal administration of exogenous surfactant is a well-established therapy for respiratory distress syndrome in preterm infants. The two preferred methods for respiratory support in neonates that contribute to limiting the risk of lung damage associated with mechanical ventilation include nCPAP and non-invasive ventilation. The increasing popularity of surfactant administration techniques is due to the fact they reduce the time of mechanical ventilation until this medication is administered. In some cases a short period of mechanical ventilation follows (INSURE: INtubation-SURfactant-Extubation). There are also methods that make it possible to completely avoid intubation and help maintain spontaneous breathing during surfactant administration (LISA: Less Invasive Surfactant Administration, MIST: Minimal Invasive Surfactant Therapy). Aim To analyze treatment outcomes in preterm infants who suffer from respiratory distress syndrome and require exogenous surfactant administration depending on the technique used: LISA vs INSURE. Material and methods The present retrospective analysis included 129 infants born at a gestational age of between 24 and 33 weeks who were hospitalized in the Neonatology Department in the years 2014-2016, were administered surfactant and remained on non-invasive ventilation. All the subjects received only proractant alfa. Both study groups: LISA (n=83) and INSURE (n=46) were analyzed in terms of respiratory distress treatment outcomes and the presence of complications of prematurity. Results There were no significant differences in patient characteristics between the two study groups (LISA vs INSURE: mean birth body weight was 1210g vs 1275 g, respectively; mean gestational age at birth was 30 weeks vs 29 6/7 weeks, respectively). The comparison of respiratory support method and FiO2 concentration within the first 72 hours after surfactant administration showed no significant differences between the groups. Similarly, respiratory outcomes did not significantly differ between the LISA and INSURE groups and were: the need for intubation ☒ 42.2% vs 32.6%, p=0.201, duration of mechanical ventilation – median days 0 vs 0, p=0.377, duration of nCPAP – median days 5 vs 5, p=0.379, duration of oxygen supplementation – median days 1 vs 1, p=0.555, and the incidence of bronchopulmonary dysplasia – 28.9% vs 23.9%, p=0.506. Also, the incidence of complications was similar in both study groups. Conclusions Our retrospective analysis of preliminary outcomes of surfactant administration involving the use of the LISA technique showed no statistically significant differences as compared with the INSURE method. The randomized, prospective study that is currently being conducted at our Neonatology Department and includes biochemical markers of lung damage, will bring more objective data on the safety and effectiveness of both surfactant administration techniques (LISA vs INSURE).","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"23 1","pages":"163 - 171"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45771521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis, Classification and Management of Ankyloglossia Including Its Influence on Breastfeeding","authors":"D. Brzęcka, M. Garbacz, Marcin Micał, B. Zych, B. Lewandowski","doi":"10.34763/devperiodmed.20192301.7985","DOIUrl":"https://doi.org/10.34763/devperiodmed.20192301.7985","url":null,"abstract":"Abstract Ankyloglossia is defined as a congenital malformation that alters lingua/ mobility and function. ft is listed as one of the possib/e reasons behind problems with breastfeeding. Due to current WHO recommendations that encourage mothers to breastfeed exclusively up to 6 months of age, quick recognition of any obstacles in the suction mechanism and determining the possible reasons for problems should be a priority. A review of the literature was conducted concerning the diagnosis of ankyloglossia, possible methods of treatment and their efficacy in improving breastfeeding quality. The authors of the research cited claim that any surgica/ intervention should be performed only in cases of symptomatic ankylog/ossia interfering with sucking mechanisms. The most frequent surgical procedure performed in newborns with symptomatic ankyloglossia is frenulotomy. ft is a simple procedure with a low risk of complications. The literature gives a great number of studies confirming both the short and long-term efficacy of tongue-tie release in improving breastfeeding quality with emphasis on decreasing mothers' discomfort, nipple pain and trauma.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"23 1","pages":"79 - 85"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44735163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[25 years of work: The Interdisciplinary Team for Fetal Malformation at the Institute of Mother and Child in Warsaw - from counselling to clinical ethics].","authors":"Magdalena Rutkowska, Sławomir Szczepaniak, Tomasz Mikołaj Maciejewski, Renata Jaczyńska, Ewa Helwich, Marzanna Reśko-Zachara","doi":"10.34763/devperiodmed.20192304.246252","DOIUrl":"10.34763/devperiodmed.20192304.246252","url":null,"abstract":"<p><p>Perinatology is a dynamically developing field of medicine. The progress of technology in recent decades has made it possible to recognize birth defects very early, including those which are lethal or genetically determined. In many clinical situations, it is no longer possible to work alone to reach a definitive diagnosis, plan treatment or predict the clinical course of the affected fetus/newborn. There is a need for teamwork, which ensures the proper, early care starting in the fetal period, not only in the delivery room or NICU. This paper discusses the ethical foundations of creating interdisciplinary teams, taking as an example the Interdisciplinary Team for Fetal Malformation at the Institute of Mother and Child in Warsaw, which has been active for 25 years, and presents how it works in practice. On the basis of the clinical cases that are examined, practical guidelines were formulated for both the work of medical teams and the way parents are informed about the clinical situation of their child and about sharing the care after the birth of the child. A document was also proposed with information on prenatal diagnosis, decisions made by the interdisciplinary team regarding the mother and child, as well as the conclusions resulting from discussions with parents.</p>","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"23 4","pages":"246-252"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37521329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}