Nigerian Journal of Physiological Sciences最新文献

{"title":"ABSTRACTS OF THE PROCEEDINGS OF THE XLth ANNUAL SCIENTIFIC CONFERENCE OF THE PHYSIOLOGICAL SOCIETY OF NIGERIA : 7-11 February, 2023, University of Ibadan, Ibadan, Oyo State, Nigeria","authors":"Admin Admin","doi":"10.54548/njps.v38i1.17","DOIUrl":"https://doi.org/10.54548/njps.v38i1.17","url":null,"abstract":"Proceedings of the 40th Scientific conference of the Physiological Society of Nigeria hosted by the Department of Physiology, College of medicine, Uiversity of Ibadan. Ibadan, Nigeria","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139367368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detrimental Effects of Saccharum officinarum Juice on Reproductive Functions of Female Wistar Rats","authors":"Eunice Ogunwole, Jane Essien Ebong, Lazarus Abraham Audu","doi":"10.54548/njps.v38i1.15","DOIUrl":"https://doi.org/10.54548/njps.v38i1.15","url":null,"abstract":"Changing dietary compositions have contributed to the growing epidemic of metabolic diseases with serious impacts on several aspects of health, including reproductive health. Saccharum officinarum juice has a natural sweetness that makes the general populace relinquish its use as a sweet course and well-known raw material for the production of refined sugar. Studies have reported adverse effects of this juice on male reproductive functions, but there is a paucity of information on females. This study investigated the effects of fresh Saccharum officinarum juice on the reproductive functions of female Wistar rats. A sugarcane press juicer was used to extract Saccharum officinarum juice. Twenty female Wistar rats (180-200 g) grouped into four (n = 5) received 1.0 mL/kg/day distilled water (control), and 1.0, 3.2, and 10.0 mL/kg/day of fresh Saccharum officinarum juice once daily for 21 days by gavage. Serum follicle-stimulating hormone, luteinizing hormone, and estrogen levels were measured using enzyme-linked immunosorbent assay (ELIZA). The estrous cycle was assessed using the Marcondes principle and histology of the ovary and uterus were assessed by microscopy. Data were analyzed using the Analysis of variance at a significance of p < 0.05. Saccharum officinarum juice caused an increase in the body weight and serum levels of follicle-stimulating hormone and luteinizing hormone. It altered the estrous cycle by increasing the frequency of occurrence of the proestrus phase but reduced that of the metestrus phase. The juice altered the cytoarchitecture of the ovaries via vacuolations and cysts within the ovarian stroma, while the uterine section showed distorted endometrial lining and glands. Saccharum officinarum juice inflamed the ovaries and distorted the estrous cycle and uterine endometrial lining. Saccharum officinarum juice consumption may possess deleterious effects on the reproductive functions of female Wistar rats.&#x0D; &#x0D; Keywords: Saccharum officinarum juice, Ovary, Uterus, Estrous cycle, Infertility.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium and Omega-3 Fatty Acids Ameliorate Highly Active Anti-Retroviral Therapy (HAART)-induced Reproductive Impairment in Male Wistar Rats","authors":"Ekpe Aribo","doi":"10.54548/njps.v38i1.6","DOIUrl":"https://doi.org/10.54548/njps.v38i1.6","url":null,"abstract":"Highly active anti-retroviral therapy (HAART) is currently the main stay in the treatment of Human Immunodeficiency Virus (HIV) disease. This treatment regimen typically combines three or more antiretroviral drugs and like most drug combinations or polypharmacy, has side effects including those on reproductive function which could place HIV patients on HAART under double risk in terms of reproductive function. Part of tissue damage following HAART administration is blamed on oxidative stress. We therefore sought to explore effects of Omega 3 and Selenium, two common antioxidants on HAART-induced male reproductive impairment in a non-HIV animal model. Sixteen male adult Wistar rats weighing 120g to 250g used for the study were grouped into 4 groups of four rats each (control, HAART-only, HAART + Omega 3 and HAART + Selenium groups). Duration of daily administration was six weeks. Results showed no significant changes in pH of epidydimal semen among the groups. Sperm count and viability were significantly reduced in HAART-only compared with control (p<0.05) but increased in HAART + Omega 3 and HAART + Selenium groups compared with HAART-only group (p< 0.05). Sperm motility was significantly reduced in HAART-only compared with control group (p< 0.05). A significantly higher percentage of total sperm defects was observed in HAART-only group compared with control (p <0.05) but significantly lower in the HAART + Selenium compared with HAART-only groups (p<0.05). Serum testosterone was significantly reduced in HAART-only compared with control groups (p<0.05) but significantly increased in HAART + Omega 3 and HAART + Selenium groups compared with HAART- only group (p<0.05). Serum concentration of luteinizing and follicle stimulating hormones were not significantly different among the groups. Testicular concentration of malondialdehyde was significantly increased in HAART-only compared with control (p<0.05) but significantly reduced in HAART + Omega 3 and HAART + Selenium groups compared with HAART-only group (p<0.05 in each). Testicular glutathione peroxidase activity was significantly reduced in HAART-only and HAART + Selenium groups compared with control (p< 0.05), but significantly higher in HAART + Omega 3 and HAART + Selenium compared with HAART-only groups (p<0.05 each). Testicular superoxide dismutase activity was significantly lower in the HAART-only and HAART + Selenium compared with control (p<0.05) but significantly higher in HAART + Omega 3 and HAART + Selenium compared with HAART-only groups (p<0.05 each). Level of tumour necrosis factor – alpha in testes was significantly higher in HAART-only (p<0.05) but lower in the HAART + Selenium (p<0.05) groups compared with control. Tumor necrosis factor–alpha was however significantly reduced in HAART + Omega 3 and HAART + Selenium groups compared with HAART-only (p<0.05 each) groups. Interleukin-6 levels were significantly increased in all HAART-administered groups compared with control (p<0.05 eac","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucuna pruriens seed repeals the hypothalamic-pituitary-testicular axis disruption following carbamazepine treatment in male Wistar rats","authors":"Opeyemi Osuntokun, Gbola Olayiwola, Taiwo Adekemi Abayomi, Alimat Toyin Lawal, Opeyemi Samson Adeleke, Abiodun Oladele Ayoka","doi":"10.54548/njps.v38i1.16","DOIUrl":"https://doi.org/10.54548/njps.v38i1.16","url":null,"abstract":"This study examined the potential effects of Mucuna pruriens (MP) seed powder on the disruptions of the hypothalamic-pituitary-testicular axis caused by the carbamazepine (CBZ) treatment in male Wistar rats. A total of 35 male Wistar rats were randomized into 5 groups (n=7). The animal in group 1 received normal saline (0.2 ml) orally, while groups 2-5 received carbamazepine (CBZ) 25 mg/kg per oral. Groups 1, and 2 were fed with standard rats’ chow, while groups 3-5 rats were supplied with a diet containing MP seed powder at 2.25 g, 1.5 g, and 0.75 g respectively. The serum level of male reproductive hormones, estradiol, seminal profiles, and histoarchitecture of the hypothalamus, pituitary, and testis was delineated. Descriptive and inferential statistics were used to analyze the result. There was a marked decrease in the testicular weight, follicle-stimulating hormone, testosterone concentration, and normal sperm cells in the CBZ, and CBZ + MP (2.25 mg/kg) treatment groups. There was a marked increase in the testicular tissue lipid peroxidation in the CBZ, and CBZ + MP (g) treated rats in addition to various morphological alterations in the hypothalamus, pituitary, and testis. These anomalies were receded in the CBZ + MP (1.5 g), and CBZ + MP (0.75 g) treatment groups. Consumption of MP (1.5 g, and 0.75 g) may alleviate the injurious effects of CBZ treatment on the hypothalamic-pituitary-testicular functions.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Human Placental Lactogen Assays in Ultrasound Evaluated Pregnancy-Induced Hypertension: A Marker of Placental Function in Pregnancy","authors":"Samuel Efanga, O.A. Akintomide, A.T. Udofia, O.A. Okon, H.C. Okpara","doi":"10.54548/njps.v38i1.2","DOIUrl":"https://doi.org/10.54548/njps.v38i1.2","url":null,"abstract":"Human placental lactogen (HPL) is a pregnancy-related hormone produced by the placenta. The overall functions of serum HPL impacts the developing fetus and placenta. The objective of this study was to determine the relationship between maternal serum concentration of HPL and sonographic fetal growth parameters in pregnancy induced hypertension as a marker of placental function. This prospective cross-sectional study was conducted over a 9-month period in the University of Calabar Teaching Hospital, Calabar, Nigeria that involved 100 women with pregnancy induced hypertension. An obstetric ultrasound scan was done on all the subjects and their blood was collected for HPL evaluation using Enzyme-linked Immunosorbent Assay (ELISA). SPSS version 20 was used to analyze the data. Maternal serum HPL had a significant positive correlation with PLA (P=0.000), estimated gestational age (P=0.000), estimated fetal weight (P=0.000) and amniotic fluid index AFI (P=0.000) and a significant negative correlation with proteinuria (P=0.047), fetal heart rate (P=0.032) and HC/AC (P=0.000). It is concluded that maternal serum HPL concentration increases as pregnancy advances and causes a significant increase in placental thickness, fetal weight and amniotic fluid volume, however, its reduction is significantly associated with the onset of pre-eclampsia, fetal distress and asymmetrical intra-uterine growth restriction. Thus, the evaluation of maternal serum HPL concentration is a reliable marker of placental function in the second half of pregnancy","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological, Biochemical and Molecular Docking Evaluation of the Anti-inflammatory Effects of Methanolic Extract of Bridelia ferruginea stem bark on Acetic acid-induced Ulcerative Colitis in Rats","authors":"Omolaso Blessing Oluwagbamila, Adeoti Adeniran, Kayode Adeniran, Alfred Abioye, Esther Nathaniel-Ukwa","doi":"10.54548/njps.v38i1.12","DOIUrl":"https://doi.org/10.54548/njps.v38i1.12","url":null,"abstract":"Ulcerative colitis (UC) is a chronic disorder that involves inflammation. This study was carried out to examine the anti-inflammatory effect of the methanol extract of Brideliaferrugineastem barkinAcetic acid-induced ulcerative colitis inmaleWistarrats. Twenty-four rats were randomly divided into 6 groups of 4 animals each, colitis was thereafter induced by intrarectal administration of4% (v/v)Aceticacidin all except group 1, which received distilled water. For post-colitis induction treatment group 2 received distilled water, groups 3, 4 and 5 were orally administeredthe extract at doses of 100mg/kg, 200mg/kg and 400mg/kg, respectively while group 6 received sulfasalazine 500mg/kg orally.Post colitis induction, treatment lasted for 7 days and at the end of the experiment, colon samples were collected for estimation of antioxidant, inflammatory and histological parameters. Molecular docking study was also carried out to gain more insights about the promising anti-inflammatory compounds earlier identified in the extract.Results revealed that the extract significantly (p<0.05) attenuated the increased MDA, nitrite,TNF-α and IL-6 levels. Activities of SOD, CAT, MPO and GSH levelswere also, significantly (p<0.05) increased. Furthermore, molecular docking study revealed that α-amyrin may have contributed significantly to the anti-inflammatory activity of the extract because of its remarkable binding affinity for IL-6, iNOS, IL1-β,TNF-α and COX-2 relative to prednisolone and celecoxib. This study suggests that the extract attenuated acetic acid-induced colitis via antioxidative and anti-inflammatory mechanisms.&#x0D; .","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of standardized Eucalyptus globulus leaf extract on brain oxidative stress and aberrant neurochemistry of fructose-streptozotocin-induced diabetic rats","authors":"A. C. Akinmoladun, Bidemi Sikirat Jiddah Kazeem, Morenikejimi Bello, M. Tolulope Olaleye","doi":"10.54548/njps.v38i1.10","DOIUrl":"https://doi.org/10.54548/njps.v38i1.10","url":null,"abstract":"The neuro-pharmacological effect of Eucalyptus globulus ethanol leaf extract in fructose-streptozotocin-induced diabetic rats was evaluated in this study. The phytochemical analysis of the extract was carried out using HPLC-DAD. Diabetes was induced in rats with 10% fructose in drinking water and a single intraperitoneal injection of 40 mg/kg streptozotocin (STZ). Diabetic animals were orally treated with 100-400 mg/kg of the extract for 21 days with glibenclamide as the reference drug. Blood and brain tissue were processed for the determination of serum electrolyte levels, hematological indices, and biochemical estimations. Ergosterol, pinitol, catechin, quercetin, robinetinidol, and other polyphenols were identified in the extract. Diabetic animals showed decreased serum potassium and sodium ion levels and decreased hematocrit, hemoglobin, red blood cells, white blood cells and lymphocytes but increased neutrophils. The brains of animals in the untreated diabetic group with increased blood glucose level showed oxidative stress (increased level of MDA and myeloperoxidase but decreased level of reduced glutathione and superoxide dismutase) and disturbed neurochemistry (increased level of acetylcholinesterase and monoamine oxidase but decreased level of Na+K+ATPase, tyrosine hydroxylase and dopamine). Administration of the Eucalyptus globulus leaf extract remarkably ameliorated the observed hyperglycemia, electrolyte, and hematological imbalances in animals. In addition, the administration of the extract attenuated the brain redox imbalance, and neurochemical disturbances in the rats. These results show that Eucalyptus globulus leaves contain antioxidant and neurotransmitter modulating phytochemicals with the potential to be developed as therapeutic agents for the management of diabetic cerebrovascular problems and related complications.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Therapeutic Effect of Single/Combined Administration of Saxagliptin, Metformin and Intranasal Insulin on Dexamethasone Induced Insulin Resistance in Albino Wistar Rat Model","authors":"Jephtah Oche, Olufunke Olorundare, Saheed Afolabi, Mary Ologe, Anoka Njan, Olatunde Akanbi","doi":"10.54548/njps.v38i1.7","DOIUrl":"https://doi.org/10.54548/njps.v38i1.7","url":null,"abstract":"Glucocorticoids have therapeutic benefits in the management of several inflammatory and immunological disorders. Despite these medicinal effects, they have the drawback of causing metabolic disorders such as hyperglycemia, insulin resistance etc., which is known to be a key indicator of metabolic syndrome. Metabolic syndrome is a major predisposing factor to type 2 diabetes mellitus and cardiomyopathy. This study was designed to compare and evaluate the effects of saxagliptin, metformin and intranasal insulin (when used singly or in combination) on dexamethasone induced insulin resistance. Fifty-six female rats were randomly assigned into eight groups. Group 1 represented the control; Group 2 was administered with dexamethasone (1mg/kg) (untreated); Group 3 received dexamethasone + intranasal insulin (2IU); Group 4 received dexamethasone + intranasal insulin + metformin (40mg/kg); Group 5; received dexamethasone + intranasal + saxagliptin (8mg/kg); Group 6 received dexamethasone + metformin (40mg/kg); Group 7 received dexamethasone + saxagliptin (8mg/kg); Group 8 received dexamethasone + saxagliptin(8mg/kg) + metformin(40mg/kg). Treatments were given for one week. At the end of the study, blood samples were collected for biochemical assays and pancreas excised for histological examination. Dexamethasone (1mg/kg) induced hyperglycemia, hyperinsulinemia, dyslipidemia, impaired glucose tolerance and disrupted the structural integrity of the pancreas. Treatment with saxagliptin, metformin and their combination significantly decreased blood glucose level, decreased LDL Level and improved glucose tolerance. The selected hypoglycemic agents used in present study ameliorate the dexamethasone induced hyperglycemia and insulin resistance of which the combination of metformin with saxagliptin showed greater efficacy.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictability of Metabolic Risk factors from hand and foot anthropometry in Hausa ethnic population of Kano, Nigeria","authors":"Asuku A. Yusuf","doi":"10.54548/njps.v38i1.1","DOIUrl":"https://doi.org/10.54548/njps.v38i1.1","url":null,"abstract":"articular ethnic/racial group. Adiposity measures are employed to screen MRF by clinicians. The ratio of the second to fourth digit of the hand (2D:4D) has been shown to be a tight correlate of MRF. Attempts to predict MRF from hand anthropometry is relatively a new idea. The present study aims to predict MRF from digit and body anthropometry. The study recruited 266 males and 199 females of Hausa origin. Systematic random sampling was employed. Anthropometric measurements and blood pressure were obtained using standard techniques. Regression analysis was used to predict MRF, SPSS version 20 was used for statistical analyses and P < 0.05 was set as level of significance. MRF (serum glucose, total cholesterol, lipoprotein cholesterol, and blood pressure (BP) were predictable from 2D:4D and body anthropometric measures. Waist-to-hip ratio (WHR) was the most consistent MRF predictor. In males, WHR alone predicted TC (R2 = 0.67 and P<0.0001), HDL-C (R2 =0.68 and P <0.0001), LDL-C (R2 = 0.67 and P < 0.001) and diastolic blood pressure (DBP) [R2 =0.43 and P <0.001)]. The right 2D:4D contributed slightly to the prediction of SBP and FBG increasing the R2 value to 0.62from 0.6 for FBG and from 0.6 to 0.64 for SBPKeywords: Body anthropometry, Digit anthropometry, Metabolic risk, Predictability","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calculated Nutritional Indices in Symptomatic Hospitalized Nigerian Covid-19 Patients","authors":"J.A. Akinwumi, Victor F Edem, Olatunbosun Ganiyu Arinola","doi":"10.54548/njps.v38i1.4","DOIUrl":"https://doi.org/10.54548/njps.v38i1.4","url":null,"abstract":"Multifaceted approaches are needed to control the ongoing COVID-19 pandemic, therefore assessing the patients’ nutritional status is desirable to justify the suggestion of biochemical nutritional markers or nutritional indices in the prognosis of COVID-19. This longitudinal study determined biochemical nutritional markers (albumin, prealbumin and total cholesterol) and nutritional indices [Controlling Nutritional Status (CONUT) score and Prognostic Nutritional Index (PNI)] in symptomatic hospitalized COVID-19 patients compared with control. These parameters were related to age, sex and days of admission of the patients. Plasma obtained were analyzed for biochemical nutritional markers and indices calculated. Data were analyzed using the Statistical Package for Social Sciences (SPSS Inc., USA) version 20.0. The mean prealbumin (PAB) and total cholesterol (TC) levels were significantly lower in COVID-19 patients compared to control (P<0.05). PNI classified 90% of COVID-19 patients as well-nourished while CONUT score classified 75.6% of COVID-19 patients as mildly malnourished. In COVID-19 patients at discharge, the mean level of TC was significantly increased compared with COVID-19 patients at admission. The mean albumin level in patients with ≤10days of admission was significantly lower when compared to those with those having >10days of admission. There were no significant differences in the PNI and CONUT scores of the participants in relation to age, gender and days of admission. This study concluded that Severe Acute Respiratory Syndrome Coronavirus 2 (SAR-COV 2) infection affects certain biochemical nutritional biomarkers and that PNI and CONUT could be use as cheap, reliable and affordable nutritional prognostic tools in the management of COVID-19 patients","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}