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Current Research in Complementary & Alternative Medicine最新文献

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Unravelling the Therapeutic Potential of Gambogic Acid: Deciphering Its Molecular Mechanism of Action and Emerging Role as an Anticancer Xanthone 揭示藤黄酸的治疗潜力:破译其分子作用机制和作为抗癌山酮的新作用
Current Research in Complementary & Alternative Medicine Pub Date : 2023-06-09 DOI: 10.29011/25772201.100083
Kapil Dangi, Karishma Niveria, I. Singh, A. Verma
{"title":"Unravelling the Therapeutic Potential of Gambogic Acid: Deciphering Its Molecular Mechanism of Action and Emerging Role as an Anticancer Xanthone","authors":"Kapil Dangi, Karishma Niveria, I. Singh, A. Verma","doi":"10.29011/25772201.100083","DOIUrl":"https://doi.org/10.29011/25772201.100083","url":null,"abstract":"Use of current anticancer therapies such as chemo-radiotherapy (CRT), biologics and immunotherapies are severely limited due to side-effects and systemic toxicity. Cancer metastasis, drug resistance, and recurrence of cancer are other important considerations to evolve targeted therapies. This highlights the urgent clinical need to explore natural compounds that are bioactive, biosafe and unquestionably efficient as immune-modulators for cancer prevention and anti-cancer therapy. Natural compounds are extremely successful in clinics as they have unique structures and complexity. Gambogic acid (GA), a plant derived caged-xanthone molecule extracted from Garcinia hanburyi tree as a dry resin that has emerged as a miracle molecule that exhibits multifarious biological activities against various cancers making it attractive for clinical applications. Since the molecular targets are still unclear, this review focuses on the therapeutic efficacy and its associated mechanistic interactions with its recognized targets involving anti-angiogenesis, anti-metastasis, synergistic effects and chemo-sensitization.","PeriodicalId":350008,"journal":{"name":"Current Research in Complementary & Alternative Medicine","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134138606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case Report on Alpha-gal Syndrome α -gal综合征1例报告
Current Research in Complementary & Alternative Medicine Pub Date : 2023-05-19 DOI: 10.29011/2577-2201.100078
A. Ahmady, K. Yashi, J. Virk, Kiani Roudabeh, Taral K. Parikh, Samriddh Chaudhari, Leah Treffeisen
{"title":"A Case Report on Alpha-gal Syndrome","authors":"A. Ahmady, K. Yashi, J. Virk, Kiani Roudabeh, Taral K. Parikh, Samriddh Chaudhari, Leah Treffeisen","doi":"10.29011/2577-2201.100078","DOIUrl":"https://doi.org/10.29011/2577-2201.100078","url":null,"abstract":"The alpha-Gal syndrome (AGS) is a relatively newly recognized food allergy in which patients develop sensitization to meat after being bitten by specific tick species. AGS causes a delayed IgE mediated allergic reaction after consumption of meat and sometimes-dairy products and currently it is treated by avoiding consumption of allergens. Here we present a patient who has been living with AGS for about 20 years","PeriodicalId":350008,"journal":{"name":"Current Research in Complementary & Alternative Medicine","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133725604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Indian Delicacy Nimbu Achar: Your Lemony Pathway to Brain Health 印度美食Nimbu Achar:你的柠檬通往大脑健康之路
Current Research in Complementary & Alternative Medicine Pub Date : 2023-05-15 DOI: 10.29011/2577-2201.100079
Sharadendu Bali
{"title":"The Indian Delicacy Nimbu Achar: Your Lemony Pathway to Brain Health","authors":"Sharadendu Bali","doi":"10.29011/2577-2201.100079","DOIUrl":"https://doi.org/10.29011/2577-2201.100079","url":null,"abstract":"Lemon pickle has been made and consumed in India since times immemorial. Though the pickle is made in many different ways, using different ingredients, the basic pickle contains very few ingredients. These include lemons, red chillies, carom seeds and salt. All these ingredients have been found to have numerous health benefits, including promotive effects on the brain. These beneficial actions include anti-inflammatory, anti-oxidant, anti-dementia, anti-anxiety and anti-depressive effects. Several human studies have also ascertained that regular consumption of lemons and other citrus fruits improves cognition, mood and sleep patterns. Besides the direct effect of the lemon phytochemicals on the brain, lemon peel has also been found to boost the gut-brain axis via prebiotic effects","PeriodicalId":350008,"journal":{"name":"Current Research in Complementary & Alternative Medicine","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122152887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Honouring Old Age Ritual Celebration in Newar Culture and Medicine Wheel in Anishinaabe Culture: Exploring an Indigenous Cross-Cultural Aging Wellness as an Alternative Medicine and Healing Approach 在Newar文化和Anishinaabe文化中纪念老年仪式庆祝活动:探索土著跨文化老年健康作为替代医学和治疗方法
Current Research in Complementary & Alternative Medicine Pub Date : 2023-05-15 DOI: 10.29011/2577-2201.100077
Hom Lal Shrestha, Lucy Shrestha, Art Petahtegoose
{"title":"Honouring Old Age Ritual Celebration in Newar Culture and Medicine Wheel in Anishinaabe Culture: Exploring an Indigenous Cross-Cultural Aging Wellness as an Alternative Medicine and Healing Approach","authors":"Hom Lal Shrestha, Lucy Shrestha, Art Petahtegoose","doi":"10.29011/2577-2201.100077","DOIUrl":"https://doi.org/10.29011/2577-2201.100077","url":null,"abstract":"This article depicts a personal narrative and experience based on the observation and exposure of an ancient Newar tradition of honouring ageing and wellness in the native land of Nepal. Furthermore, this paper illuminates a shared pedagogy of holistic ageing-wellness physically, mentally, spiritually, and emotionally in both Newar and Anishinaabe cultures. In Newar culture, a ritualistic ceremony honours old age called “Bura Janko.” It recognizes the foundation of intergenerational relationships that respect the spirituality and wisdom of the Elder. By examining the 5,000-year-old Bura Janko traditions in Nepal in conjunction with ancient Anishinaabe tradition Medicine Wheel teachings and ceremonies among First Nations Anishinaabe communities in Northern Ontario, we hope to","PeriodicalId":350008,"journal":{"name":"Current Research in Complementary & Alternative Medicine","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130059517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Part 2: Cinnamon Extract Decreases Size and Lipid Volume In 3T3-L1 Preadipocytes Grown in Three-Dimensional Agarose Culture 第二部分:肉桂提取物降低三维琼脂糖培养3T3-L1前脂肪细胞的大小和脂质体积
Current Research in Complementary & Alternative Medicine Pub Date : 2023-05-09 DOI: 10.29011/2577-2201.100076
A. Aulthouse, Ellen Freeh, Sabrina Newstead, Kayla Baxendell, Sean Mild, Amy L Stockert
{"title":"Part 2: Cinnamon Extract Decreases Size and Lipid Volume In 3T3-L1 Preadipocytes Grown in Three-Dimensional Agarose Culture","authors":"A. Aulthouse, Ellen Freeh, Sabrina Newstead, Kayla Baxendell, Sean Mild, Amy L Stockert","doi":"10.29011/2577-2201.100076","DOIUrl":"https://doi.org/10.29011/2577-2201.100076","url":null,"abstract":"In part 1 of the study, the 3D agarose model was presented for its use in 3T3-L1 cells. Growth in 3D agarose allowed 3T3-L1 preadipocytes to differentiate spontaneously without the chemical induction that is used to induce differentiation in monolayer cultures. Part 2 utilizes the previously published 3D agarose culture model to examine the effects of cinnamon extract on the 3T3-L1 cells. Here we report that the morphological changes associated with the 3D agarose cultured 3T3-L1 cells are not altered by the presence of cinnamon extract at the concentration tested. The treated cells remained round with accumulated lipid, as visualized with oil red O staining. However, a significant reduction in median cell size was noted in cultures treated with cinnamon extract. Differentiation was confirmed at all time points by both oil red O staining and immunohistochemistry detection of a known marker of differentiation, PPARγ. Results demonstrate that the decreased size of the cinnamon treated cells is associated with a decreased lipid volume, but only in cells grown in the 3D agarose culture. The same trend was not observed in monolayer treated cells. Modified monolayer experiments, designed to explore the effects of cell rounding on lipase activity, suggest that lipase activity is suppressed when rounded cells are treated with cinnamon extract, an observation that is not replicated in cinnamon treated flat cells. Extrapolation of this data suggests a possible use for cinnamon that could lead to reduced lipid volume storage in adipose cells, although additional studies should be conducted to determine safety and extraneous reactions possible by cinnamon.","PeriodicalId":350008,"journal":{"name":"Current Research in Complementary & Alternative Medicine","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116555153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Shakuyakukanzoto on The Exacerbation of Peripheral Neuropathic Pain and The Decreased Grip Strength in Mice Treated with Paclitaxel 尺骨丸对紫杉醇治疗小鼠周围神经性疼痛加重及握力下降的影响
Current Research in Complementary & Alternative Medicine Pub Date : 2023-05-05 DOI: 10.29011/2577-2201.100075
T. Andoh, Shin Fukatsu
{"title":"Effects of Shakuyakukanzoto on The Exacerbation of Peripheral Neuropathic Pain and The Decreased Grip Strength in Mice Treated with Paclitaxel","authors":"T. Andoh, Shin Fukatsu","doi":"10.29011/2577-2201.100075","DOIUrl":"https://doi.org/10.29011/2577-2201.100075","url":null,"abstract":"of","PeriodicalId":350008,"journal":{"name":"Current Research in Complementary & Alternative Medicine","volume":"128 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128189134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Evaluation of Symptom Qualification using Serial and Parallel Diagnostics 使用串行和并行诊断对症状定性的诊断评价
Current Research in Complementary & Alternative Medicine Pub Date : 2023-04-27 DOI: 10.29011/2577-2201.100074
{"title":"Diagnostic Evaluation of Symptom Qualification using Serial and Parallel Diagnostics","authors":"","doi":"10.29011/2577-2201.100074","DOIUrl":"https://doi.org/10.29011/2577-2201.100074","url":null,"abstract":"Diagnoses play a pivotal role in medical care. They consolidate information, enable clear communication, and serve as the basis for scientific research. The medical field is vast, with thousands of symptoms indicating various medical conditions. Additionally, the diagnostic process for infectious diseases is relatively clear and based on the identification of a certain set of symptoms. Symptoms with a common cause form a pattern that aids in the diagnosis. Retrospectively, in the medical school environment, replicating the success of treating infectious diseases in situations of metabolic disease cases has been attempted. However, the model for infectious diseases does not match that for metabolic diseases. Thus, we argue that, in addition to a serialpattern identification approach, using a parallel approach to symptom identification, even after the diagnosis has been made, should be considered. Herein, we distinguish between serial and parallel diagnostic methods, with the aim of enhancing the interface between regular and integrated medicine. The distinction in qualitative symptom evaluation between the different branches of medicine forms the basis of integrated medicine.","PeriodicalId":350008,"journal":{"name":"Current Research in Complementary & Alternative Medicine","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128137755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Novel All Natural Plant Based Ointment Formulation on Diaper Rash Severity in Infants: A Clinical Trial 新型全天然植物软膏配方对婴儿尿布疹严重程度的影响:一项临床试验
Current Research in Complementary & Alternative Medicine Pub Date : 2023-03-13 DOI: 10.29011/2577-2201.100072
Trupti Patel, Shilpa Dhar, Vidya Jain, Tejas Vyas, Arohi Bapna, Virendra Narkhede, Rutu Bhimani, Parth Joshi, Simran Sethi, Govindarajan Raghavan
{"title":"Effects of Novel All Natural Plant Based Ointment Formulation on Diaper Rash Severity in Infants: A Clinical Trial","authors":"Trupti Patel, Shilpa Dhar, Vidya Jain, Tejas Vyas, Arohi Bapna, Virendra Narkhede, Rutu Bhimani, Parth Joshi, Simran Sethi, Govindarajan Raghavan","doi":"10.29011/2577-2201.100072","DOIUrl":"https://doi.org/10.29011/2577-2201.100072","url":null,"abstract":") Effects of Novel All Natural Plant Based Ointment Formulation on Diaper Rash Severity in Infants: A Clinical Trial. Curr Res Cmpl","PeriodicalId":350008,"journal":{"name":"Current Research in Complementary & Alternative Medicine","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116322943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects and Mechanisms of Traditional Chinese Medicine and Related Active Constituents Treating Gout 中药及相关活性成分治疗痛风的作用及机制
Current Research in Complementary & Alternative Medicine Pub Date : 2023-02-22 DOI: 10.29011/2577-2201.100070
Hao Wen, Le Yang, Ruicheng Liu, Guang-li Yan, Hui Sun, Ling Kong, Ye Sun, Ying Han, Qiqi Zhao, Shuyu Kang, Xi-jun Wang
{"title":"Effects and Mechanisms of Traditional Chinese Medicine and Related Active Constituents Treating Gout","authors":"Hao Wen, Le Yang, Ruicheng Liu, Guang-li Yan, Hui Sun, Ling Kong, Ye Sun, Ying Han, Qiqi Zhao, Shuyu Kang, Xi-jun Wang","doi":"10.29011/2577-2201.100070","DOIUrl":"https://doi.org/10.29011/2577-2201.100070","url":null,"abstract":") Effects and Mechanisms of Traditional Chinese Medicine and Related Active Constituents Treating Gout","PeriodicalId":350008,"journal":{"name":"Current Research in Complementary & Alternative Medicine","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132626706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Efficacy of Pankajakasthuri Orthoherb Tablets in Managing Various Signs and Symptoms Associated with Patients Diagnosed with Osteoarthritis: Open Clinical Trial 骨关节炎片治疗骨关节炎患者各种体征和症状的临床疗效:开放临床试验
Current Research in Complementary & Alternative Medicine Pub Date : 2022-12-23 DOI: 10.29011/2577-2201.100067
Hareendran Nair, Sreejith Satheesan, G. Sreekumar, Arun Pratap, Shan Sasidharan
{"title":"Clinical Efficacy of Pankajakasthuri Orthoherb Tablets in Managing Various Signs and Symptoms Associated with Patients Diagnosed with Osteoarthritis: Open Clinical Trial","authors":"Hareendran Nair, Sreejith Satheesan, G. Sreekumar, Arun Pratap, Shan Sasidharan","doi":"10.29011/2577-2201.100067","DOIUrl":"https://doi.org/10.29011/2577-2201.100067","url":null,"abstract":") Clinical Efficacy of Pankajakasthuri Orthoherb Tablets in Managing Various Signs and Symptoms Associated with Patients Diagnosed with Osteoarthritis: Open Clinical Trial.","PeriodicalId":350008,"journal":{"name":"Current Research in Complementary & Alternative Medicine","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132285095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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