Journal of Fatima Jinnah Medical University最新文献

{"title":"Short term outcome of treatment with percutaneous cross Kirschner wires in paediatric distal humeral metaphyseal diaphyseal junction fractures","authors":"S. Qureshi, Irfan Ahmad, F. Masood, J. Raza, R. Nadeem, Aliza Nadeem, D. Chaudhary, M. Taqi","doi":"10.37018/saqi4789","DOIUrl":"https://doi.org/10.37018/saqi4789","url":null,"abstract":"Background: Soft tissue sarcomas (STS) are malignant tumours arising from mesenchymal tissue, comprising <1% of all the tumours of the human body and represent the second most common type of solid tumours in children and adolescents. Surgical resection is considered the mainstay of treatment, supported by multimodal therapies including chemotherapy and radiotherapy. Resource-limited countries, like Pakistan, face additional challenges due to inadequate resources. This study presents the experience of management of soft tissue sarcomas presenting to a tertiary care hospital in Central Lahore. Patients and Methods: This was an observational study conducted in Surgical Unit I of Sir Ganga Ram Hospital Lahore from January 2017 till June 2022. American Joint Committee on Cancer (AJCC) staging system and Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC) resection classification was applied. Surgical treatment including R0, R1 and R2 resections were carried out. SPSS 23 version was used for statistical analysis of collected data. Results: A total of 36 patients; 24 male (66.7%) and 12 females (33.3%) were included. Anatomical site involvement was observed as 23 (63.8%) limb sarcomas and 13 (36.1%) trunk sarcomas. Out of 36 patients, 20 (55.6%) patients were staged as stage II, 11 (30.5%) patients as stage III and 5 (13.9%) as stage I. Total 17 (47.2%) patients underwent wide excision, 13 (36.1%) patients underwent limited excision, 4 (11.1%) patients underwent compartmental excision and 2 (5.6%) patients underwent palliative excision.  Conclusion: Thigh was the commonest site of involvement in extremity sarcomas. Retroperitoneal sarcomas were most frequent among trunk tumours. Leiomyosarcoma was the most common histopathological diagnosis followed by malignant peripheral nerve sheath tumours. Most of the patients presented with stage II disease. Keywords: Soft Tissue Sarcoma, Presentation, Resection, Histology, Outcome","PeriodicalId":349972,"journal":{"name":"Journal of Fatima Jinnah Medical University","volume":"133 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124128455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hyperglycemic and dyslipidemic effects of L-arginine in streptozotocin-induced diabetic rats","authors":"Novera Sohail Bajwa, Muhammad Waqar Aslam Khan, Noaman Ishaq, Q. Haider, Sumetha Yaseen, A. Zafar","doi":"10.37018/nsbm.0901","DOIUrl":"https://doi.org/10.37018/nsbm.0901","url":null,"abstract":"Background: Diabetes is a serious disease which is posing a great risk to the overall health care all around the globe. Major factor in its systemic adverse effects is the enhancement of lipolysis by prolonged hyperglycaemia ultimately leading to dyslipidemia. This dyslipidemia is a big risk feature for all cardiovascular diseases related to most of the diabetic patients. L arginine blessed with antioxidant properties can play a substantial role in the prevention, and management of diabetes and related complications. The study was aimed at finding the novel uses of L-Arginine in diabetes. \u0000Subject and method: 15 adult Sprague Dawley rats , only female (to avoid pregnancy) weighing 250+ 50 g were used in this study which were divided equally (five rats each) into three groups randomly after ensuring that their lipid profiles and blood sugar were normal. After keeping one group as Normal Control Group (NC), the remaining two groups were made quasi-analogue Type II diabetic model through administration of Streptozotocin (35 mg/kg) in a single dose intra-peritoneal (IP). After lapse of 48 hours, all the rats of two groups had shown blood sugar levels over 300 mg/dl and therefore were taken as diabetic. One of the two diabetic groups was taken as “Positive Control” with DM rats (DM), while the other was taken as treatment group DM+L-ARG Group”.  \u0000Results: With regards to fasting blood sugar (BSF), total cholesterol (T-Chol), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL), Group III (DM+L-ARG) showed significant improvement with the p-value of less than 0.001. \u0000Conclusion: After conducting this experimental animal work, we are able to conclude that in Streptozotocin induced diabetic model, the novel use of antioxidant L-Arginine with good safety profile and minimal adverse effects also has significant anti-hyperglycemic and anti-lipidemic activity.","PeriodicalId":349972,"journal":{"name":"Journal of Fatima Jinnah Medical University","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128590939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of effect of prophylactic administration of ondansetron and placebo on prevention of post induction hypotension in elderly patients undergoing surgery in general anesthesia","authors":"Lala Rukh Bangash, Aqsa Akhter, Madiha Zafar, Arsalan Zaki, Marium Waheed, A. Anwar","doi":"10.37018/aalr.8618","DOIUrl":"https://doi.org/10.37018/aalr.8618","url":null,"abstract":"Background: Post-induction hypotension is a frequently encountered complication seen particularly in elderly population. Hypotension, by impairing vital organ perfusion, increases the morbidity and mortality of the patients. prophylactic use of ondansetron in preventing hypotension after induction of general anaesthesia in elderly patients , hence getting the benefit of preventing both hypotension and postoperative nausea and vomiting by the use of a single drug. \u0000Subjects and method: This randomized controlled clinical trial was carried out in the operation theaters of general surgery, Mayo Hospital, Lahore, from 09-09-2017 to 09-09-2018. A total of 80 patients who were to undergo general anaesthesia for elective general surgical procedures were recruited for this study. After taking informed consent, the patients were randomly divided into two groups. Patients in group A received ondansetron and those in group B received placebo prior to the induction of anaesthesia. Efficacy was labeled in terms of absence of hypotension i.e. a drop in mean arterial pressure of no more than 25% of baseline at 1, 3, 5, 9 and 11 minutes after induction of anaesthesia. The data was recorded on a predesigned proforma. Statistical analysis was done using SPSS version 21. \u0000Results: Both groups were comparable in terms of age, gender, ASA status, BMI and weight. Efficacy was seen in 19 (47.50%) cases managed by ondansetron vs. 10 (25%) in placebo group (p = 0.03). There was significant difference of efficacy in patients with age between 60 to 70 years where 63.63% patients in the Group A effectively maintained their blood pressure (p=0.02). Patients having age 70 years or above did not show statistically significant difference. History of hypertension made no impact on the efficacy of ondansetron for maintaining blood pressure after induction (p=0.53) \u0000Keywords:                 \u0000      Ondansetron, Efficacy, Hypotension","PeriodicalId":349972,"journal":{"name":"Journal of Fatima Jinnah Medical University","volume":"530 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123073855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Covid-19 vaccination affect menstruation pattern?","authors":"S. Anwar, Sajjad Ahmad, Hamzulla Khan, Kausar Inayatullah","doi":"10.37018/sasa.0901","DOIUrl":"https://doi.org/10.37018/sasa.0901","url":null,"abstract":"Background: As Millions of people are receiving COVID-19 vaccine around the world, a number of side effects are being reported. Menstrual cycle disturbance is also a side effect reported by hundreds of women on social media. The objective of this study was to assess the association of menstrual abnormalities with COVID-19 vaccination. \u0000Subjects and methods: This descriptive cross sectional study was conducted in Obstetrics and Gynecology OPD of Mufti Mehmood Hospital D.I. Khan from March 2021 to June 2021. The health care workers who received Sinopharm COVID-19 vaccine and consented were included. Data was collected about change in menstrual cycle pattern after COVID-19 vaccination. \u0000Results: A total of 80 subjects were included in the study with mean age of 32.6 +7.89 years. There were 36 (45.0%) doctors, 33 nurses (41.25%), 6 (7.5%) paramedics and 5 (6.25%) medical students. According to their marital status, 51 (63.75%) were married and 29 (36.25%) were unmarried. Out of 80 subjects, 16 (20%) reported disturbance in menstrual cycle pattern, 13 (81.2%) after first dose and 3 (18.75%) after both first and second dose. Among these 9 (56.25%) reported heavy menstrual bleeding, 4 (25%) had prolonged bleeding days while 3 (18.75%) had irregular bleeding pattern. \u0000Conclusion: Menstrual cycle disturbance is a reported side effect of COVID-19 vaccination. It is more commonly reported after first dose and heavy menstrual bleedings is the most common pattern followed by prolonged/irregular bleeding.","PeriodicalId":349972,"journal":{"name":"Journal of Fatima Jinnah Medical University","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124140021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic features and outcomes in critically ill mechanically ventilated COVID-19 patients with respiratory failure in a resource limited ICU setting – Report from a tertiary care center in Karachi","authors":"Mehak Hanif, K. Sumalani, Zarkesh Shaikh, Vishal Mandhan, Shahbaz Haider","doi":"10.37018/mhkk.2868","DOIUrl":"https://doi.org/10.37018/mhkk.2868","url":null,"abstract":"Background: Studies done on severe COVID-19 have revealed a wide heterogeneity in intensive care clinical outcomes across various countries. We aimed to identify the demographic features and outcomes of mechanically ventilated COVID-19 patients with respiratory failure in Pakistan in resource limited settings. \u0000Methods: This was a cross-sectional study conducted at the COVID-19 Intensive care unit (ICU) of Jinnah postgraduate medical center in Karachi, Pakistan. 86 patients who received mechanical ventilation in a period of five months from 1/2/2021 till 30/6/2021 were included in the study. Patient demographic characteristics, comorbidities, clinical manifestations of COVID-19 infection, laboratory values at the time of presentation (hemoglobin, Neutrophil lymphocyte ratio, platelets, glomerular filtration rate, C-reactive protein, D-dimers, Ferritin, liver function tests and electrolytes) and mode and duration of ventilation, final outcome (survivor vs. non-survivor) and cause of death in non-survivors were recorded. \u0000Results: 86 patients, who required mechanical ventilation because of severe respiratory distress not alleviated by non-invasive methods of ventilation, were included in the study. 66.3% (n=57) were males and 33.7% (n=29) were females. Mean age was 59 (SD 12). The most common comorbidities were diabetes mellitus and hypertension 44.2% (n=38) each. Only 3 (3.4%) of mechanically ventilated patients were extubated and 1 patient was eventually discharged home on room air. The mortality rate was 98.8% and only one patient survived. The most common causes of death were respiratory failure (86%, n=74), renal failure (48.8%, n=42) and sepsis (18.6%, n=16). \u0000Conclusion: Mortality in COVID-19 patients who require mechanical ventilation is very high in resource limited settings because of the lack of essential medications, specialized teams and established protocols of ICU management and is not related to the demographic characteristics and comorbidities of patients and severity of disease at presentation. \u0000Keywords: \u0000       COVID-19, Intensive Care Unit, Mechanical Ventilation, Mortality","PeriodicalId":349972,"journal":{"name":"Journal of Fatima Jinnah Medical University","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127173451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of soft tissue sarcomas: Experience of surgery at a tertiary care referral hospital in Central Lahore","authors":"A. Nazir, Muhammad Rashid Naveed, Ghazala Bano, Azka Sohail","doi":"10.37018/anmr.0901","DOIUrl":"https://doi.org/10.37018/anmr.0901","url":null,"abstract":"Background: Soft tissue sarcomas (STS) are malignant tumours arising from mesenchymal tissue, comprising <1% of all the tumours of the human body and represent the second most common type of solid tumours in children and adolescents. Surgical resection is considered the mainstay of treatment, supported by multimodal therapies including chemotherapy and radiotherapy. Resource-limited countries, like Pakistan, face additional challenges due to inadequate resources. This study presents the experience of management of soft tissue sarcomas presenting to a tertiary care hospital in Central Lahore. \u0000Patients and methods: This was an observational study conducted in Surgical Unit I of Sir Ganga Ram Hospital Lahore from January 2017 till June 2022. American Joint Committee on Cancer (AJCC) staging system and Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC) resection classification was applied. Surgical treatment including R0, R1 and R2 resections were carried out. SPSS 23 version was used for statistical analysis of collected data. \u0000Results: A total of 36 patients; 24 male (66.7%) and 12 females (33.3%) were included. Anatomical site involvement was observed as 23 (63.8%) limb sarcomas and 13 (36.1%) trunk sarcomas. Out of 36 patients, 20 (55.6%) patients were staged as stage II, 11 (30.5%) patients as stage III and 5 (13.9%) as stage I. Total 17 (47.2%) patients underwent wide excision, 13 (36.1%) patients underwent limited excision, 4 (11.1%) patients underwent compartmental excision and 2 (5.6%) patients underwent palliative excision. Recurrence was observed in 8 patients for which palliative 2 (5.6%), limited 3 (8.3%) or potentially curative resection 3 (8.3%) was performed. \u0000Conclusion: Thigh was the commonest site of involvement in extremity sarcomas. Retroperitoneal sarcomas were most frequent among trunk tumours. Leiomyosarcoma was the most common histopathological diagnosis followed by malignant peripheral nerve sheath tumours. Most of the patients presented with stage II disease. Resectional surgery, whether curative or palliative, was found to be the management modality of choice. Rhabdomyosarcoma most frequently recurred within 6 months of potentially curative surgery (R1), most likely due to compromised initial resection.","PeriodicalId":349972,"journal":{"name":"Journal of Fatima Jinnah Medical University","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117121778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poliomyelitis in Pakistan: Evolving challenges and way forward","authors":"Taskeen Zahra","doi":"10.37018/taza.0901","DOIUrl":"https://doi.org/10.37018/taza.0901","url":null,"abstract":"Poliomyelitis, an acute paralytic illness, affects children under the age of five. It is brought on by the Polio Virus (PV), a single-stranded RNA virus that comes in three serotypes (type 1, 2, and 3) which is transmitted by feco-oral route.1,2 Since 1988, there has been a 99.9% decrease in polio cases worldwide because of the World Health Organization's Global Polio Eradication initiative.1 This initiative has played a vital role in eradication of the disease. Pakistan is one of the 2 nations where polio remains as an endemic disease even at the end of 2022, the other being Afghanistan.2 \u0000          In 2021, Pakistan reported just 1 case of polio linked to the Wild Poliovirus type 1 (WPV1) against 14 cases from April 1 through July 31, 2022.2 Eleven instances of polio have been reported in the Northwestern Waziristan in 2022, clearly illustrating the loopholes in national policies to completely eradicate the disease despite its goal to immunize 12.6 million children by 2022.2 The goal of the Global Polio Eradication Initiative's (GPEI) current 5-year strategic plan is to interrupt WPV1 transmission by 2023.3 \u0000                According to WHO and UNICEF estimates, in Pakistan approximately 83% of infants received three doses of the Oral Poliovirus Vaccine (OPV) and one dose of Inactivated Poliovirus Vaccine (IPV) in 2021. While none of the districts in Baluchistan, Khyber Pakhtunkhwa, and Sindh attained 80% vaccine coverage, 86% districts in Punjab province had >3 dose OPV coverage.4","PeriodicalId":349972,"journal":{"name":"Journal of Fatima Jinnah Medical University","volume":"559 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121173340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical expression of HER2 and MUC1 in breast carcinoma and its correlation with histological grades","authors":"Sidra Ghazanfer, R. Jaffar, H. Mahmood","doi":"10.37018/sgrj.0901","DOIUrl":"https://doi.org/10.37018/sgrj.0901","url":null,"abstract":"Background: Mucin 1 (MUC1) is overexpressed in almost 90% of CA breast cases and is usually associated with poor prognosis. On the other hand, HER2 is profoundly expressed in breast carcinoma and is also linked with increased disease recurrence, tumor invasion and poor prognosis. Thus, this study was designed to assess the expression of MUC1 and HER2 against the histological grades of breast carcinoma in our population. \u0000Materials and methods: It was a cross sectional analytical study conducted at Post Graduate Medical Institute/General Surgery Departments of Lahore General Hospital (LGH), Lahore. Duration of study was 12 month from 27-3-2018 to 30-3-2019. Total 60 newly diagnosed cases of CA breast were included in the study. Immunohistochemistry technique was used and MUC1 and HER2 markers were applied to check the probable association between the two markers and the histological grades of cancer. \u0000Results: A total of 60 cases were included in the study, out of which 96.7% (n=58) were invasive ductal carcinoma, while 3.3% (n=2) were Invasive lobular carcinoma. Among the total, 60% (n=36) were found positive for MUC1 (moderate/strong) and 40% (n=24) were found negative (negative/weak). Regarding HER2, 26.7% (n=16) were strong positive, 20% (n=12) were at the borderline/equivocal and 53.3% (n=32) were found negative for HER 2. \u0000Conclusion: Statistically significant association was found between MUC1 and HER2 against the histological grades of breast cancer patients (p <0.05). \u0000 ","PeriodicalId":349972,"journal":{"name":"Journal of Fatima Jinnah Medical University","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123665349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of amnion versus calcium alginate as split-thickness skin graft donor site dressing: A randomised controlled trial","authors":"Roeya -E-Rasul, B. Akram, Z. Abidin, F. A. Khalid, Sheraz Raza, K. Khalid","doi":"10.37018/ouan1021","DOIUrl":"https://doi.org/10.37018/ouan1021","url":null,"abstract":"Background: Split-thickness skin graft (STSG) covers patient’s primary wound, but, at the expense of a donor-wound which heals by secondary intention. This study evaluated the efficacy of amnion and calcium alginate dressings at STSG donor sites in terms of healing duration, patient comfort and incidence of infection. \u0000Patients and methods: An open label randomised control trial was conducted during October 2018 to May 2019. Total 60 patients, aged 20-45 years, were randomly allocated to two equal groups. Amnion was applied to 30 donor sites in Group A and calcium alginate in 30 donor sites in Group B. Patients were phone-called on 1st, 3rd and 7th post-operative days and donor site pain scored using numerical rating scale. Donor site was opened on 10th postoperative day and signs of infection assessed. Lastly, the day on which donor site healed, revealing an epithelialized wound, was noted. \u0000Results: Group A included 30 patients (11 females, 19 males) having mean age of 31.23 years and Group B included 30 patients (12 females, 11 males) having mean age of 31.30 years. Average pain scores on 1st, 3rd and 7th post-operative days were 7.6, 6.6 and 4.4 in Group A and it was 8.2, 6.5 and 4.4 in Group B. Two cases of amnion, 4 of calcium alginate got infected. Average healing duration was 11 days in Group A; and it was 14 days in Group B (p-value = 0.000). \u0000Conclusion: Amnion shows quicker healing and better pain control than calcium alginate.","PeriodicalId":349972,"journal":{"name":"Journal of Fatima Jinnah Medical University","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124601996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with low birthweight among newborns delivered at term in a tertiary care hospital in Lahore","authors":"Taskeen Zahra, Uzair Mumtaz, Nayyer Riffat, F. Mushtaq, Muhammad Hussain Cheema, T. Mahmud","doi":"10.37018/mxdd8087","DOIUrl":"https://doi.org/10.37018/mxdd8087","url":null,"abstract":"Background: Low birth weight (LBW) is an important risk factor that contributes to mortality of 15-20% of newborn globally. This case-control study was conducted to determine factors associated with low birth weight among new-born delivered at term in obstetrical and gynecological wards of the hospital. \u0000Patients and methods: Mothers of 150 low birth weight babies born at term were taken as cases and 150 normal weight babies born at same day, were taken as controls. Mothers were interviewed on using a semi-structured and pretested questionnaire. The data was analyzed on SPSS Version 22.0. A p-value <0.05 was considered statistically significant. \u0000Results: Illiterate mothers had 2.332 odds of having low birth weight babies (0.03, 95% CI = 1.3317 to 4.152). Mothers from low socio-economic status had 3.54 odds of delivering LBW (p-value = 0.000, 95% CI = 2.184 to 5.94). The odds of having low birth weight babies was 4.004 times high in the mothers exposed to passive smoking (p-value = 0.000, 95% CI = 2.477 to 6.474). Hemoglobin value less than 10 gm/dl was found to be significantly associated with odd of having LBW 3.003 in anemic mothers versus non anemic mothers (p-value = 0.0027, 95% CI = 1.279 to 3.227). Mother with parity <3 had 0.0933 odds of having low birth weight babies. Mothers having adequate antenatal care had 0.394 odds of having low birth weight babies. \u0000Conclusion: Illiteracy, low socio-economic status, employment, anemia, tobacco smoke exposure and inadequate antenatal care were significantly associated with LBW.","PeriodicalId":349972,"journal":{"name":"Journal of Fatima Jinnah Medical University","volume":"210 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128164073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}