Journal of Chromatography A最新文献

{"title":"MOF-199/graphene aerogel-derived porous carbon as solid-phase microextraction coating for the highly sensitive determination of phthalate acid esters in condiments","authors":"Yaming Sun ,&nbsp;Shiqi Chai ,&nbsp;Junnan Li ,&nbsp;Chenchen Song ,&nbsp;Hailiang Zhao ,&nbsp;Lijun He ,&nbsp;Dongmei Liu","doi":"10.1016/j.chroma.2026.466749","DOIUrl":"10.1016/j.chroma.2026.466749","url":null,"abstract":"<div><div>Phthalate acid esters (PAEs) are ubiquitous pollutants in food, necessitating accurate detection to ensure food quality and safety. Herein, a novel MOF-199/graphene aerogel composite-derived porous carbon material (MGC) was successfully fabricated and applied as a solid-phase microextraction (SPME) coating for the efficient extraction and enrichment of trace PAEs from condiment. The MGC coating exhibits high enrichment capacity for PAEs, attributed to its hydrophobic carbon skeleton and abundant mesoporous structure. A sensitive analytical method based on headspace SPME coupled with gas chromatography-flame ionization detection was established using the MGC coated fiber. The method achieved a good linear response, low limits of detection (0.005–0.1 μg L⁻¹), satisfactory recoveries (71.9 %-122.6 %). The intra-fiber relative standard deviations are between 0.1 % and 7.9 %, and those for inter-fiber are from 4.8 % to 11.2 %. The successful determination of PAEs in soy sauce and monosodium glutamate confirms the feasibility and practicality of the method. This work offers a novel analytical method with exceptional sensitivity and reliability, while also expanding the application of porous carbon in SPME.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1770 ","pages":"Article 466749"},"PeriodicalIF":4.0,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-throughput and green UPCC-MS/MS assay for simultaneous quantification of 20 oligomers of PEG1K coupled with ammonium adduct and post-column infusion strategies to enhance sensitivity","authors":"Yue Deng ,&nbsp;Shuang Feng ,&nbsp;Xiaoyan Zhang ,&nbsp;Jiarui Zhang ,&nbsp;Jiale Liu ,&nbsp;Xinyue Zhou ,&nbsp;Shimeng Fu ,&nbsp;Yong Zhang ,&nbsp;Lei Yin ,&nbsp;Meiyun Shi","doi":"10.1016/j.chroma.2026.466726","DOIUrl":"10.1016/j.chroma.2026.466726","url":null,"abstract":"<div><div>This study presents an innovative analytical approach utilizing ultra-performance convergence chromatography tandem mass spectrometry (UPCC-MS/MS) for the systematic separation and quantification of 20 oligomers (<em>n</em> = 9–28) of polyethylene glycol 1000 (PEG1K) in rat urine. A key innovation involves the use of ammonium adducts ( [M+NH₄]⁺ and [M + 2NH₄]²⁺) as precursor ions, significantly enhancing sensitivity and selectivity, particularly for higher oligomers (<em>n</em> &gt; 21), where doubly charged species predominated. Coupled with a post-column compensation strategy, ionization efficiency was improved by 1–10-fold. Chromatographic separation was achieved under isocratic conditions using a green mobile phase based on supercritical CO₂ with a methanol–formic acid co-solvent, enabling efficient baseline resolution within a short runtime while minimizing organic solvent consumption. The method was validated per FDA guidelines, demonstrating excellent linearity, precision, and accuracy. Its applicability was confirmed through excretion kinetics studies in rats tail vein injection of PEG1K, revealing rapid renal clearance with 23% of the dose excreted within 4 h and cumulative excretion reaching 64% at 48 h. Green analytical chemistry metric assessments (BAGI and GEMAM) highlighted the method's superior environmental profile. This work establishes a sensitive, efficient, and sustainable platform for polymer pharmacokinetic research.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1770 ","pages":"Article 466726"},"PeriodicalIF":4.0,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular dynamics simulations of mixed-mode chromatography: Generation and solvation of a silica-based, reversed-phase/anion-exchange stationary phase","authors":"Daniel Frerichs ,&nbsp;Alexandra Höltzel ,&nbsp;Andreas Steinhoff ,&nbsp;Fabrice Gritti ,&nbsp;Kevin D. Wyndham ,&nbsp;Thomas H. Walter ,&nbsp;Ulrich Tallarek","doi":"10.1016/j.chroma.2026.466746","DOIUrl":"10.1016/j.chroma.2026.466746","url":null,"abstract":"<div><div>As a first step towards predicting retention for mixed-mode liquid chromatography (MMLC) separations of small, hydrophilic, ionizable analytes, we created a slit-pore model of a silica-based, endcapped, reversed-phase/anion-exchange (RP/AEX) stationary phase and performed molecular dynamics simulations of its solvation by a water‒acetonitrile (W‒ACN) mobile phase under conditions where the AEX function is neutral or charged. In the latter case, sodium and chloride ions were added as co-ions and counterions, respectively, to the 60/40 (v/v) W/ACN mobile phase. The silica surface functionalization, which modeled existing column technology, yielded a unique surface topology, where bonded-phase islands formed by octadecylsilyl chains around a central tertiary alkylamine group are interspersed with hydroxylated silica patches that are exposed to the mobile phase. The two MMLC systems were analyzed regarding the solvent density, structure, and orientation with respect to the density distribution of hydrophobic and hydrophilic bonded-phase elements (alkyl groups and nitrogen atoms, respectively) at different distances from the silica surface. Effects originating from the surface functionalization were captured by comparison with a conventional RPLC stationary phase, whereas effects originating from the presence of charge were quantified by comparing the two simulated MMLC systems (neutral vs. charged surface). The analysis of ion density distributions and ion contact profiles, in particular, suggested that the surface topology of the MMLC stationary phase shields the AEX function from contact with hydrophilic counterions and favors the accumulation of analyte compounds with both hydrophobic and hydrophilic structural elements.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1770 ","pages":"Article 466746"},"PeriodicalIF":4.0,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive evaluation of reversed-phase and hydrophilic interaction liquid chromatography – mass spectrometry for analysis of gangliosides","authors":"Miroslav Lísa ,&nbsp;Roman Hájek","doi":"10.1016/j.chroma.2026.466731","DOIUrl":"10.1016/j.chroma.2026.466731","url":null,"abstract":"<div><div>Gangliosides are biologically significant molecules with essential physiological roles in the organism. They are increasingly studied as biomarkers for disease diagnosis and progression. Due to their extreme structural diversity and typically low abundance in biological samples, efficient and sensitive liquid chromatography–mass spectrometry (LC-MS) methods are required for their analysis. In this study, we present a comprehensive comparison of the performance of two widely used LC-MS approaches: reversed-phase (RP) and hydrophilic interaction liquid chromatography (HILIC). Both methods were independently optimized following an identical protocol, with a focus on chromatographic performance and MS response. Notably, salt concentration had a pronounced impact on ganglioside retention, peak shape, isomer separation, and MS signal intensity in both chromatographic modes. In HILIC, adjusting the initial gradient composition and profile enabled effective separation of gangliosides from highly abundant matrix lipids. The RP method demonstrated superior ganglioside signal intensity and a 3.5-fold reduction in analysis time. Both approaches allowed the separation of gangliosides based on the number of sialic acid and saccharide residues. Additionally, the RP method enabled separation according to ceramide composition. We established rules for RP separation based on the number of carbon atoms in the ceramide moiety, which can be used to predict ganglioside retention times. Based on our findings, each method offers distinct advantages for specific analytical goals. The HILIC approach is better suited for untargeted ganglioside profiling using accurate <em>m/z</em> and interclass separation, while the RP method is ideal for sensitive, high-throughput targeted analysis in complex biological matrices.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1770 ","pages":"Article 466731"},"PeriodicalIF":4.0,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of portable atmospheric-pressure solids analysis probe–quadrupole mass spectrometry and UPLC−MS for the rapid screening of illicit substances in human urine","authors":"Doreen N.B Chandra Siri ,&nbsp;Si Ling Ng ,&nbsp;Ngee Sing Chong ,&nbsp;Philip J. Marriott ,&nbsp;Yong Foo Wong","doi":"10.1016/j.chroma.2026.466720","DOIUrl":"10.1016/j.chroma.2026.466720","url":null,"abstract":"<div><div>Atmospheric-pressure solids analysis probe (ASAP) is an ambient pressure ionisation mass spectrometry technique that allows the direct analysis of liquids and solids, with or without sample preparation, producing rapid, efficient, and real-time results. In this study, portable ASAP−quadrupole mass spectrometry (ASAP−QMS) method in positive ion mode was demonstrated for the rapid analysis of 9 drugs of abuse (amphetamine, methamphetamine, oxycodone, methadone, morphine, 3,4-methylenedioxymethamphetamine, ketamine, 6-monoacetylmorphine, and cocaine), fortified in water and urine samples, with analysis time of ∼30 s. Initially, a direct analysis approach without sample preparation was applied to fortified water and urine samples. However, significant urine matrix effects were observed, leading to ion suppression and detector saturation. A simple solid-phase extraction (SPE) procedure was then applied to reduce matrix effects arising from the urine samples. The influence of cone voltages on the fragmentation and abundance of molecular ions for the illicit compounds was evaluated. The analytes exhibited limits of detection in the range of 0.3 – 2 µg mL^-1, which were considerably higher than the UPLC−ESIMS (0.05 – 0.1 µg mL^-1) method. Drug compounds identification was performed via MS spectrum matching against an in-house database. Comparative assessment with UPLC−ESI linear ion trap MS using United Nations Office on Drugs and Crime International Collaborative Exercises urine samples showed detection accuracies of 43% for ASAP−QMS and 100% for the UPLC−MS method. The lower accuracy of ASAP−QMS was attributed to the poor spectral library matching (similarity scores &lt; 850) in complex urine matrices, particularly for low-concentration drug compounds. Nevertheless, portable ASAP−QMS (with SPE) achieved a higher greenness assessment score (0.54) compared to UPLC−MS (0.37), highlighting its potential as a rapid and environmentally friendly drug screening approach.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1770 ","pages":"Article 466720"},"PeriodicalIF":4.0,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Box-Behnken optimized salting-out assisted liquid-liquid extraction coupled with LC-MS/MS for sustainable amisulpride quantification in human plasma","authors":"Ahmed Serag ,&nbsp;Manal E. Alosaimi ,&nbsp;Maram H Abduljabbar ,&nbsp;Adnan Alharbi ,&nbsp;Faisal Alsenani ,&nbsp;Farooq M. Almutairi ,&nbsp;Muneef M. Aldhafeeri ,&nbsp;Atiah H. Almalki","doi":"10.1016/j.chroma.2026.466727","DOIUrl":"10.1016/j.chroma.2026.466727","url":null,"abstract":"<div><div>A sustainable salting-out assisted liquid-liquid extraction coupled with liquid chromatography-tandem mass spectrometry (SALLE-LC-MS/MS) method was developed and validated for amisulpride quantification in human plasma according to ICH M10 guidelines. Box-Behnken experimental design systematically optimized SALLE parameters through evaluation of sample pH (5.0–10.0), acetonitrile volume (500–1500 μL), salt concentration (2.0–6.0 mol/L), and centrifugation time (3.0–10.0 min). The developed polynomial model demonstrated strong predictive capability with subsequent numerical optimization identifying optimal conditions of pH 8.5, acetonitrile 1200 μL, ammonium acetate 4.5 mol/L, and 3-minute centrifugation. These conditions achieved 97.6% extraction recovery for amisulpride with minimal deviation from predicted values. Following optimization, chromatographic separation was achieved using a C18 column with isocratic elution (acetonitrile:water with 0.1% formic acid, 70:30 v/v) and 4-minute analysis time, with multiple reaction monitoring employing transitions <em>m/z</em>370.1→242.1 for amisulpride and <em>m/z</em>376.2→165.1 for haloperidol internal standard. Comprehensive validation subsequently demonstrated linearity across 2–1500 ng/mL with acceptable accuracy, precision, and stability under clinical storage conditions. Matrix effects ranged from 88–105% with low variability, while extraction recovery exceeded 98% across all quality control levels. Clinical application in healthy volunteers (<em>n</em> = 5) following 200 mg oral amisulpride administration successfully characterized key pharmacokinetic parameters including C_max (506 ng/mL), t_max (3.8 h), and t_1/2 (13.3 h) over 48 h. Finally, multi-metric sustainability assessment using CaFRI (75/100), BAGI (77.5/100), and RGB12 (83.1/100 whiteness) frameworks confirmed achievement of white analytical chemistry through balanced analytical performance, environmental friendliness, and practical implementation feasibility. The method offers significant advantages including minimal waste generation, reduced solvent consumption, and enhanced throughput while maintaining regulatory compliance for amisulpride therapeutic drug monitoring applications.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1770 ","pages":"Article 466727"},"PeriodicalIF":4.0,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase-separation mode in HPLC: Theoretical prediction and experimental evaluation of elution times","authors":"Yoshiki Hiramatsu ,&nbsp;Takeshi Iharada ,&nbsp;Kazuhiko Tsukagoshi","doi":"10.1016/j.chroma.2026.466734","DOIUrl":"10.1016/j.chroma.2026.466734","url":null,"abstract":"<div><div>A novel high-performance liquid chromatography (HPLC) approach, termed the phase-separation mode, was developed by employing a phase-separation multiphase flow (PSMF) as the mobile phase. Unlike conventional modes, this system exploits two coexisting liquid phases that generate distinct liquid–liquid interfaces in packed columns. In this study, we established a theoretical framework for predicting analyte elution times in the phase-separation mode and validated them experimentally. A theoretical equation was derived on the basis of the proposed separation mechanism, incorporating capacity factors between the stationary and mobile phases as well as between the two mobile phases, in addition to their respective hold-up times. The model was applied using an octadecylsilyl (ODS)-modified silica column and biphasic water/acetonitrile/ethyl acetate mixtures as eluents, with naphthalene derivatives serving as analytes. The calculated elution times showed good agreement with experimental values in most solvent systems. Some deviations were observed when the minor phase might behave as a non-continuous liquid domain near the particle surface. These deviations were not simple errors but provided supplementary mechanistic insights we discussed. The present work establishes a mechanistic and theoretical basis for the design and evaluation of chromatographic separations in the phase-separation mode using PSMF.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1770 ","pages":"Article 466734"},"PeriodicalIF":4.0,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-friendly sugarcane bagasse-based biochar alginate beads as green sorbents for rapid and highly efficient benzoylurea insecticides extraction in tea samples","authors":"Kittiya Sakhaem ,&nbsp;Sujittra Aintharaprasert ,&nbsp;Dararat Saenkam ,&nbsp;Phatchara Rattanaphonsaen ,&nbsp;Wannipha Khiaophong ,&nbsp;Yanawath Santaladchaiyakit ,&nbsp;Jitlada Vichapong","doi":"10.1016/j.chroma.2026.466701","DOIUrl":"10.1016/j.chroma.2026.466701","url":null,"abstract":"<div><div>In this work, an environmentally method was proposed for the trace determination of benzoylureas by high performance liquid chromatography system after micro-solid phase extraction method. Sugarcane bagasse-based biochar alginate beads as were employed as sorbent material. The synthesized material was characterized. The univariate optimization approach was performed to determine optimum conditions for both preparation of sugarcane bead adsorbents and micro-solid phase extraction procedure. Under optimal conditions, the limit of detection was found to be in the range of 1.0 – 2.0 μg L^–1 and the linearity was obtained between 3.0 and 400 μg L^–1 with coefficient of determination greater than 0.99. The applicability of the investigated method was evaluated with recovery studies by spiking experiments in tea samples. The acceptable recovery results between 72.1 and 121.1 % by applying matrix matching calibration showed that the proposed analytical approach is feasible for the determination of benzoylurea insecticides in tea matrices.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1769 ","pages":"Article 466701"},"PeriodicalIF":4.0,"publicationDate":"2026-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145964714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an arrow solid-phase microextraction GC–MS/MS method for the determination of 69 odorants in water","authors":"FeiFei Dai ,&nbsp;Ruoyu Zhang ,&nbsp;Dandan Nie ,&nbsp;Shuqing Ma ,&nbsp;Yurong Qin","doi":"10.1016/j.chroma.2026.466703","DOIUrl":"10.1016/j.chroma.2026.466703","url":null,"abstract":"<div><div>A quantitative method for determining 69 odorants in water was developed using arrow-type headspace solid-phase microextraction (SPME) coupled with gas chromatography-tandem mass spectrometry (GC–MS/MS). Key extraction parameters, including extraction and desorption temperatures and times, NaCl addition, fiber type, and rotation speed, were systematically optimized. Under the optimized conditions, target compounds were efficiently enriched, separated on a polar chromatographic column, detected in selected reaction monitoring (SRM) mode, and quantified using external calibration. The method demonstrated high sensitivity, with limits of detection (LODs) ranging from 0.015 to 75 ng/L, and 55 compounds exhibiting LODs below 10 ng/L. All analytes showed excellent linearity (R² &gt; 0.995) within their respective ranges. Precision was satisfactory, with relative standard deviations (RSDs) between 1.10 % and 17.85 %, including 59 compounds with RSDs &lt;10 %. Average recoveries at three spiking levels ranged from 80 % to 120 %. This automated and environmentally friendly method offers high sensitivity and accuracy, meeting the analytical requirements for complex odorants in water.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1769 ","pages":"Article 466703"},"PeriodicalIF":4.0,"publicationDate":"2026-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145964651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyetheretherketone (PEEK)-based open tubular ion chromatography for perchlorate detection","authors":"Jiafeng Pang ,&nbsp;Zihan Zeng ,&nbsp;Hui Zeng ,&nbsp;Min Zhang ,&nbsp;Weixiong Huang","doi":"10.1016/j.chroma.2026.466700","DOIUrl":"10.1016/j.chroma.2026.466700","url":null,"abstract":"<div><div>Open tubular ion chromatography (OTIC) offers a lightweight, low-pressure and efficient platform for on-site ion analysis. Polyetheretherketone (PEEK) is an attractive column substrate because of its mechanical strength, chemical resistance and thermal stability, yet conventional sulfuric-acid sulfonation limits ion-exchange capacity and requires long preparation times. Here, a mixed methanesulfonic and sulfuric acid reagent followed by acetone rinsing was used to streamline the sulfonation process, producing a roughened inner surface with higher functional group density. The optimized 25 μm i.d. PEEK capillaries achieved a cation-exchange capacity of 2.5 ± 0.1 peq/mm², roughly eight times higher than that from single-acid treatment. The latex-coated columns had an anion-exchange capacity of 20.0 ± 0.8 peq/mm² and enabled baseline separation of perchlorate within 5 min using 6 mM sodium salicylate as the eluent. When integrated with a nonsuppressed OTIC system and electromembrane extraction, the method exhibited high reproducibility (RSD &lt; 3%), a quantitation limit of 0.2 μM, and recoveries of 87.6–114.9% in environmental samples, confirming its reliability and sensitivity for perchlorate analysis.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1769 ","pages":"Article 466700"},"PeriodicalIF":4.0,"publicationDate":"2026-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145973878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}