Suchasna pediatriia Ukrayina最新文献

{"title":"Post-traumatic stress disorder in children: early recognition and coordination of medical care in the conditions of war","authors":"S.O. Mokia-Serbina, N.I. Zabolotnia, M.I. Mavropulo","doi":"10.15574/sp.2023.132.91","DOIUrl":"https://doi.org/10.15574/sp.2023.132.91","url":null,"abstract":"At the current stage, when military operations continue and there is possible development of various manifestations of psychotraumatic stress disorders in children, the acuteness and urgency of solving the problem determines the need for early recognition of the symptoms of post-traumatic stress disorder, due to its frequency and high risk and indicators of negative consequences. Purpose - to improve the quality of life of children in wartime conditions by early recognition of symptoms of the risk of developing post-traumatic stress disorder and increasing the awareness of primary care physicians about this condition and coordination of medical and psychological care. Materials and methods. Practical guidelines on the early recognition of symptoms of the risk of developing post-traumatic stress disorder in children are presented in the national Adapted clinical guideline based on evidence (2016), Unified clinical protocol (primary, secondary (specialized) and tertiary highly specialized medical care) (2019), as well as the guidelines of the National Institute for Health and Clinical Improvement of Great Britain (NICE, 2018) and information from PubMed databases, UpTo Date. For determining these recommendations the new version of the International Classification of Diseases (ICD-11) was taken into account. Results. An analysis of clinical guidelines and scientific literature related to the study of post-traumatic stress disorder in children, in particular, its early recognition by primary care physicians, was carried out. The question of the peculiarities of the clinical course of psychotraumatic disorders depending on the time of their appearance after a traumatic event and the age of children is highlighted. In the context of the time that has passed since the traumatic event and the age of the children, a screening program for the early recognition of symptoms of the risk of developing post-traumatic stress disorder, which require immediate response by primary care workers, is presented. Special attention was paid to children from war zones, geographically remote regions, displaced persons, refugees. Conclusions. Early conducting of a short screening assessment of the risk of developing post-traumatic stress disorder in children, a timely decision on the provision of medical and psychological assistance, will contribute to the improvement of their quality of life in wartime conditions. No conflict or interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135895942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exhaled phospholipids as a prognostic factor of pulmonary complications in children with acute lymphoblastic leukemia","authors":"N. Makieieva, V. Koval, T. Gorbach","doi":"10.15574/sp.2023.132.44","DOIUrl":"https://doi.org/10.15574/sp.2023.132.44","url":null,"abstract":"Introduction. Pulmonary complications are common in children with acute lymphoblastic leukemia (ALL). The assessment of phospholipids (PL) in the exhaled breath condensate can provide more information about pathological processes in the lungs in children with ALL. Purpose - to assess the level of PL in the exhaled breath condensate (EBC) in children with ALL and its prognostic value. Materials and methods. 40 children with ALL aged 6-17 years were examined. 1st group included newly diagnosed children with ALL (n=18). 2nd group involved ALL survivors, who had completed the total course of chemotherapy (n=22). The control (С) group consisted of 15 healthy children. The levels of PL in the EBC were investigated by spectrophotometric thin-layer chromatography using an SPh 46 spectrophotometer. Results. The frequency of pulmonary complication was 82.5% during chemotherapy protocols and 18.4% in ALL survivals. The statistically significant increase in the level of phospholipids in 1st (150.75 (137.62; 158.45) mmol/l) and 2nd (130.12 (120.59; 138.34) mmol/l) ALL groups compared with the group C (54.80 (48.30; 60.80) mmol/l) has been detected (p1-C=0.0000; p2-C=0.0000). Children of the 1st group had significantly higher levels of PL in the EBC than children of the 2nd group (p1-2=0.002911). PL level in EBC collected during induction phase of chemotherapy >132.15 mmol/l can be prognostic for the development of acute pulmonary complications (Sensitivity 93.75%; Specificity 100%). PL level in EBC collected after a complete course of chemotherapy >133.28 mmol/l can be predictive for persistent pulmonary complications (Sensitivity 100.00%; Specificity 83.33%). Conclusions. PL level in EBC can be prognostic for the development of pulmonary complications, both during chemotherapy and in long-term remission after completed chemotherapy course. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43942062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effectiveness of the magnesium-potassium complex in correcting the health status of children who have suffered from COVID-19","authors":"Y. Marushko, O.A. Dmytryshyn","doi":"10.15574/sp.2023.132.7","DOIUrl":"https://doi.org/10.15574/sp.2023.132.7","url":null,"abstract":"The health status of children and adolescents after an acute episode of COVID-19, namely the post-acute and long-term consequences of SARS-CoV-2, is an urgent medical problem. The pathogenesis of the development of the post-covid state has not yet been fully studied and includes various links, including a violation of the constancy of the levels of various macroelements in biological tissues and blood. Since the leading role in ensuring the proper functioning of energy and synthetic processes in the body belongs to magnesium, it is assumed that the development of post-covid state may be associated with hypomagnesemia. Purpose - to evaluate the level of magnesium in the blood serum of children who have suffered from COVID-19, to analyze their state of health, level of tolerance to physical exertion, and quality of life; to optimize approaches to the correction of detected violations, by prescribing a magnesium-potassium complex, and to evaluate its effectiveness. Materials and methods. 75 children aged 6 to 18 took part in the study. Among them, 60 children with a confirmed diagnosis of COVID-19 in the anamnesis and a period after COVID-19 more than 12 weeks and 15 somatically healthy children of the same age did not suffer from COVID-19 (control group). Children with COVID-19 were divided into a main group (35 children who had reduced serum magnesium levels) and a control group (25 children with normal magnesium levels). The research was conducted in two stages. In the first stage, the health status of children who suffered from COVID-19 was analyzed. The second stage of the study involved the appointment of PANCICOR magnesium-potassium complex to children of the main group and the evaluation of the effectiveness of its use on the 60th day of treatment. General clinical (analysis of anamnesis data, Rufier test results, questionnaire), laboratory (determination of magnesium level in blood serum), instrumental (cycle ergometry), and statistical research methods were used. Results. Magnesium deficiency is a common disorder of macronutrient homeostasis in children who have experienced COVID-19. Post- covid syndrome was detected in 28.3% of children. At the same time, the proportion of post-covid state detection was higher in the group of children with magnesium deficiency compared to the group of children with normal serum magnesium levels. The level of tolerance to physical exertion and indicators of quality of life in children who suffered from COVID-19 are significantly lower (p<0.05) compared to children in the control group who did not suffer from COVID-19. The analysis of the parameters of the health status of children on the 60th day of taking the magnesium-potassium complex PANCICOR showed a positive effect of the drug on the characteristics of the state of health that were studied. In particular, on the 30th day of treatment, no child noted the manifestations of the post-covid condition. Indicators of the quality of life and tolerance to phy","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42918554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhinogenic orbital complications of acute rhinosinusitis in children","authors":"Y. Havrylenko, V. Syniachenko, M.A. Biletska, I. Ruban","doi":"10.15574/sp.2023.132.80","DOIUrl":"https://doi.org/10.15574/sp.2023.132.80","url":null,"abstract":"Purpose - to determine the frequency and prevalence of rhinogenic orbital complications (RОC) in children with acute rhinosinusitis (ARS) depending on their gender and age, with an analysis of the treatment performed in the pediatric ENT department. Materials and methods. A retrospective analysis of 61 patients with ROС at АRS in children who were treated in the otorhinolaryngology department of the City Children’s Hospital No. 1 in Kyiv from 2016 to 2020 was conducted. The diagnosis was established on the basis of the anamnesis, general clinical examination, endoscopic examination and radiological methods of diagnosis (X-rays or CT of paranasal sinuses). All patients received complex treatment with a parenteral antibiotic and were examined by related specialists: an ophthalmologist, a pediatrician, a neurologist or a neurosurgeon as needed. Results. The average age of the patients was 5 years and 2 months. There were 34 (55.7%) boys, 27 (44.3%) girls. In 38 (62.3%) sick children, reactive swelling of the eyelids of the right eye was diagnosed, in 22 (36.1%) reactive swelling of the eyelids of the left eye, in one (1.6%) case, periostitis of the right orbit was diagnosed. All patients with ROС on the background of АRS received parenteral antibacterial therapy with one or two drugs, among which ceftriaxone was prescribed in 98.3%, metrogyl in 41%, macrolide in 21.3%, and amoxicillin in 1.6% of cases. 3 (5%) patients underwent surgical treatment - puncture and drainage of the maxillary sinus, 2 (3.7%) sick children underwent frontotomy with sinus drainage. Complex conservative treatment without surgical intervention was effective in 56 (91.3%) patients. The average length of hospital stay was 7.7 days. Conclusions. In children with АRS, ROС occurs most often at the age of 3 to 7 years (49.2%) and manifests itself in the form of reactive swelling of the eyelids of the right eye in 62.3% and in 36.3% of the left eye. Timely antibiotic therapy in patients with АRS of children with ROС makes it possible to effectively treat this pathology without the use of surgical methods. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42049934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of immunological indicators in children with behavioral disorders due to perinatal cerebrovascular lesions","authors":"S. Boltivets, T. Gonchar, L. Uralova, O. Gonchar, Yuliya Chelyadyn","doi":"10.15574/sp.2023.132.67","DOIUrl":"https://doi.org/10.15574/sp.2023.132.67","url":null,"abstract":"Purpose - a comprehensive study of the immune system of patients with deviant behavior due to perinatal pathology. Materials and methods. The sample consisted of 43 boys aged 7 to 15 years with a history of perinatal hemorrhagic and hypoxic-ischemic cerebrovascular injuries, which later provoked various forms of non-psychotic deviant behavior. To check the results, a control group consisting of 43 mentally and physically healthy children and adolescents was selected. The main group, which showed persistent deviant behavior, was prescribed a drug whose active substance is dalargin, a peptide compound whose structure includes 6 amino acid residues. Clinical-amnestic, clinical-psychopathological, neurosonography was used to diagnose perinatal cerebrovascular injuries in newborns (in history) with subsequent use of computed tomography (CT) and magnetic resonance imaging (MRI) methods, statistical data processing was carried out using «SPSS 16.0» and «Excel» programs from the «Microsoft Office 2003» package. Results. The study of T- and so-called T-active lymphocytes of the peripheral blood showed that before treatment, a significant decrease in the content of these cells was observed in children (to 4.26±0.80% and 22.42±0.69% against 65.81±1.66% 44.42±1.25% in the control group, p>0.05). Proliferative activity changes significantly in response to T- and B-mitogens. Proliferative activity recovered completely (25.56±3.26% and 59.72±2.19% vs. 57.23±1.51% in the control group). Conclusions. Children and adolescents with pronounced deviant behavior of residual organic genesis, resistant to traditional therapy, are characterized by significant changes in the immune status caused by dysimmunoglobulinemia, imbalance of the lymphocyte subpopulation, suppression of the functional activity of these populations on mitogens, which indicates secondary immunodeficiency. The therapeutic effectiveness of the dalargin-peptide compound is determined by its function as an immunocorrector in treatment-resistant behavioral disorders. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43156881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotype-associated prognosis of mono-organ and poly-organ atopic marching phenotypes in children","authors":"V. Dytiatkovskyi","doi":"10.15574/sp.2023.132.16","DOIUrl":"https://doi.org/10.15574/sp.2023.132.16","url":null,"abstract":"Purpose - to research the influence of the single nucleotide variants (SNV) as of thymic stromal lymphopoietin genes (rs11466749 TSLP), orsomucoid-1-like protein 3 (rs7216389 ORMDL3) and human nuclear glucocorticoid receptor type 3 subfamily C member 1 gene (rs 10052957 h-GR/NR3C1) on the risk of developing AM phenotypes «AD», «AD+AR/ARC», «AD+AR/ARC+BA». Materials and methods. 127 children in the main and 105 in the control group aged from 3 to 18 were recruited into the study. All patients underwent the oral cavity mucosa swab, the material of which was subjected genotyping by the means of real-time polymerase chain reaction for SNV variants rs11466749 TSLP, rs7216389 ORMDL3 and rs 10052957 h-GR/NR3C1. For statistical processing the Pearson’s ꭕ2 criteria, Fisher’s exact test, Student’s test was used; the results were considered significant at p<0.05, trending to significance - at p=0.05-0.1. Results. The impact of the studied SNV on the risk of the poly-organ phenotype «AD+AR/ARC» development correlated to the mono-organ ««AD»: G/G rs11466749 TSLP: rs=0.173, OR=5.85 (p=0.08); C/T rs7216389 ORMDL3: rs=0.227, OR=0.36 (p<0.05), T/T rs7216389 ORMDL3: rs=0.227, OR=2.79 (p<0.05); A/G rs 10052957 h-GR/NR3C1: rs=0.215, OR=0.40 (p<0.05), G/G rs 10052957 h-GR/NR3C1: rs=0.263, OR=2.97 (p<0.01). The impact of the studied SNV on the development of the full poly-organ AM phenotype «AD+AR/ARC+BA» correlated to the mono-organ «AD»: A/A rs11466749 TSLP: rs=0.207, OR=2.71 (p=0.09), A/G rs11466749 TSLP: rs=0.310, OR=0.17 (p<0.01), G/G rs11466749 TSLP: rs=0.213, OR=7.43 (p=0.09). Conclusions. Different SNV variants of rs11466749 TSLP, rs7216389 ORMDL3, rs 10052957 h-GR/NR3C1 have both inducing and protective impact on the development of mono-organ and poly-organ AM phenotypes in children. The risk of the mono-organ phenotype «AD» developing into the poly-organ «AD+AR/ARC» is directly associated and significantly increased in carriers of the genotypes T/T rs7216389 ORMDL3 and G/G rs 10052957 h-GR/NR3C1, trending to significance - within G/G rs11466749 TSLP. The bespoke risk is significantly reduced in carriers of C/T rs7216389 ORMDL3 and A/G rs 10052957 h-GR/NR3C1 genotypes. The risk of developing a full poly-organ AM phenotype «AD+AR/ARC+BA» from mono-organ «AD» is significantly reduced in carriers of the A/G rs11466749 TSLP genotype, and is with trend to significance increased within homozygous A/A and G/G rs11466749 TSLP genotypes. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patients and children’s parents was obtained for conducting the studies. No conflict of interests was declared by the author.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48028669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crohn’s disease in children. Clinical case","authors":"V. Dudnyk, V. Furman, O. Kutsak, V. Pasik","doi":"10.15574/sp.2023.132.111","DOIUrl":"https://doi.org/10.15574/sp.2023.132.111","url":null,"abstract":"Crohn’s disease (CD) is a chronic relapsing disease characterized by transmural granulomatous-ulcerative inflammation affecting some or all parts of the gastrointestinal tract. Purpose - to acquaint practicing doctors with the features of the manifestations, differential diagnosis and course of CD in children. The features of the differential diagnosis and clinical course of CD are given. The basic diagnostic value of complaints, anamnesis, clinical picture, laboratory and instrumental methods of research, histological study of a biopsy of the cecum and appendix is highlighted. Microscopic examination of the cecum biopsy revealed the presence of a corrugated surface of the mucous membrane of the large intestine with focally slightly disturbed histoarchitectonics: crypts of various sizes and shapes, some with an unevenly expanded lumen. The cellular composition of the crypts is represented by colonocytes and goblet cells with reduced mucus formation, the presence of single crypt abscesses. Own plate with foci of fibrosis, unevenly infiltrated with lymphocytes, plasma cells, segmented nuclear neutrophils, eosinophils, basal plasmacytosis is noted. The muscle plate is slightly thickened, with uneven full blood vessels, infiltrated with lymphocytes, plasma cells, segmented neutrophils, with the presence of single lymphoid follicles (“incomplete granulomas”). The morphological picture may correspond to CD (taking into account endoscopic, clinical, anamnestic and other data). The research was carried out in accordance with the principles of the Declaration of Helsinki. Informed consent of the child’s parents was obtained for the research. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46695390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of adaptative and compensatory capabilities of girls with disorders of menstrual function","authors":"V. Dynnik, О. Dynnik, O.G. Verchoshanova, H. Havenko","doi":"10.15574/sp.2023.132.56","DOIUrl":"https://doi.org/10.15574/sp.2023.132.56","url":null,"abstract":"The duration and regularity of the menstrual cycle are influenced by many factors, including psychosocial stress, which can lead to activation of the hypothalamic-pituitary-adrenal system. Purpose - to assess the levels of stress hormones cortisol, insulin (IRI), prolactin, and the cortisol/insulin (K/In) index in adolescent girls with menstrual disorders. Materials and methods. 177 adolescent girls aged 12–17 years with menstrual disorders were examined (87 with abnormal uterine bleeding (АUB), 90 - with oligomenorrhea (OM)). The comparison group consisted of 57 girls of the same age with normal menstrual cycles examined in the early follicular phase. The level of cortisol, insulin, prolactin (PRL) was measured in blood serum on an empty stomach using the immunoenzyme method to determine the level of organism’s adaptive capabilities. All hormones were defined according to the instructions for the kits. The ratio of K/In was calculated. Results. In girls with menstrual disorders, three types of reaction from the adrenal glands were found, which were expressed in increased levels of cortisol above 75 and 90 percentile, a decrease (below 10 percentile) and its fluctuations within physiological values. At cortisol values above the 90 percentile, the average level of glucose, IRI, and HOMA in teenage girls with OM did not differ from the normative values, and in patients with AUB these indicators were significantly higher than in adolescents with OM. The K/In ratio in girls with OM by 1.8 times exceeded the similar indicator of adolescents with AUB (p<0.04) and was slightly higher than in the comparison group, which indicates a satisfactory reaction of stress tolerance. With AUB, this coefficient decreased, which may indicate exhaustion of the body’s adaptive capabilities. The same situation was observed when cortisol increased above the 75 percentile. When the cortisol level was within physiological values, the content of glucose and IRI also did not go beyond the limits of normative fluctuations. The stress ratio (K/In) had no significant difference depending on the type of violations and was significantly reduced. The absence of changes in the content of cortisol and IRI in the blood serum in response to the onset of menstrual disorders may indicate a certain instability in the development of the body's protective reactions in teenage girls with menstrual disorders. Conclusions. The revealed changes in the content of cortisol, insulin, K/In and PRL as markers of a non-specific stress reaction in the structure of the adaptive response in disorders of menstrual function carry additional information about impaired adaptation to stress and the state of compensatory capabilities of the girl's body, expand the understanding of pathogenetic mechanisms these disorders and can be used both in the assessment of the state of adaptation and in the development of appropriate preventive strategies. The research was carried out in accordance with the principles ","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48791814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Course features and functional condition of pancreas in adolescents with gastroesophageal reflux disease","authors":"І.S. Lembryk, О.V. Zhyliak, А. Stefanyshyn, О.О. Tsytsiura, І.V. Slimkevych","doi":"10.15574/sp.2023.132.28","DOIUrl":"https://doi.org/10.15574/sp.2023.132.28","url":null,"abstract":"Chronic acid-dependent diseases and, in particular, gastroesophageal reflux disease (GERD), are urgent problems in pediatric gastroenterology. However, the clinical features and functional state of the pancreas in adolescents with reflux disease remain not fully understood. Purpose - to investigate the main parameters of quality of life, clinical features, and functional state of the pancreas in adolescents with GERD. Materials and methods. We examined 100 inpatients aged 13-17 years who were hospitalised in the period between 2016 and 2022. The diagnosis was verified according to modern protocols of diagnosis and treatment, and the results were statistically processed using the Statistica for Microsoft 7.0 software package. Results. Of the children we examined, 80.0% had endoscopically positive (non-erosive form) GERD, with 50.0% having concomitant functional pancreatic disorders. The most significant changes in blood amylase were noted in patients with comorbidity (120.5±0.1 g/(hr×L) and 33±0.3 g/(hr×L), p<0.05) and in patients with the erosive form of GERD (98.1±0.2 g/(hr×L) and 25±0.1 g/(hr×L), p<0.05). Serum lipase levels were also more pronounced in patients with comorbid GERD (70±0.1 U/L and 35±0.2 U/L, χ2=32, p<0.0001). In these teenagers, there was a violation of the quality of life according to the main parameters: heartburn, regurgitation, sleep disorders (the sum of points on three scales was 14.95±0.36 (95% confidence interval: 14.85-15.05) in combination with the appearance of pathology. 11.25±0.65 (95% confidence interval: 11.02-11.48) points - in patients with an isolated course of the disease, erosive form (р˂0.001). Conclusions. The clinical features of GERD in combination with functional pancreatic disorders include severe abdominal pain localized in the pyloric duodenal zone and left hypochondrium. In adolescents with comorbid GERD, the levels of organ-specific enzymes were more often increased compared to the control group. Quality of life was significantly changed in them too. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41450940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional dyspepsia in children (literature review)","authors":"T. Kravchenko, G. Kopiyka, V. V. Zaretska","doi":"10.15574/sp.2023.132.85","DOIUrl":"https://doi.org/10.15574/sp.2023.132.85","url":null,"abstract":"Functional digestive disorders account for a significant proportion of gastrointestinal diseases in children. In recent years, we have seen the growth of functional dyspepsia in children, which is an urgent problem for both children's gastroenterologists and pediatricians. Purpose - to conduct a systematic review of the literature on etiopathogenesis, clinical manifestations, laboratory and instrumental studies, as well as methods of treatment and prevention of functional dyspepsia in children. The scientific literature is analyzed and the data on the complex etiopathogenesis of functional dyspepsia, the multifaceted pathogenetic links, the role of psychoneurological factors are presented. The modern classification of functional dyspepsia in children is given. It should be noted that, despite the widespread prevalence of this pathology, doctors sometimes face significant difficulties at the stage of diagnosis. «Symptoms of anxiety», in the presence of which the diagnosis of functional dyspepsia becomes impossible. According to domestic and international studies, the treatment of functional dyspepsia should be comprehensive, include dietary recommendations, recommendations on regime and lifestyle, and drug therapy. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47689574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}