Suchasna pediatriia Ukrayina最新文献

{"title":"Value of vascular cell adhesion molecule-1 and CC16 protein in bronchiolitis in young children","authors":"N.I. Tokarchuk, A.A. Overchuk","doi":"10.15574/sp.2023.133.47","DOIUrl":"https://doi.org/10.15574/sp.2023.133.47","url":null,"abstract":"Given the severity of the course of bronchiolitis in young children, especially with a burdened allergic history, the search for biomarkers for early diagnosis and prognosis of the disease is urgent. Purpose - to substantiate the expediency of determining the levels of VCAM-1 and CC16 in blood serum in bronchiolitis in young children. Material and methods. The main group consisted of 34 children with bronchiolitis without a serious allergic history. The comparison group included 33 children who suffered from bronchiolitis and had a severe allergic history. The control group consisted of 25 conditionally healthy children. The clinical and laboratory examination consisted in determining the levels of VCAM-1 and CC16 in blood serum using the immunoenzymatic method. Results. The level of VCAM-1 in blood serum was established (55.5±1.12 ng/ml) in the children of the main group, while in the children of the comparison group the average value (164.9±1.1 ng/ml) of this indicator was 3 times higher, (AOR=3; 95% CI: 1.48-6.12; p<0.05). In children of the control group, the average level of VCAM-1 in blood serum was (41.6±1.32 ng/ml). Analysis of the average level of CC16 protein in blood serum revealed its significant increase in children of the main group (41.2±1.24 ng/ml) compared to the indicator of children with bronchiolitis with a severe allergic history (22.8±1.64 ng/ml ml), (AOR=1.6; 95% CI: 0.8-3.2; p<0.05). In children of the control group, the average value of the CC16 protein was within the reference values (16.2±2.43 ng/ml). Conclusions. In young children with bronchiolitis, it is advisable to determine the level of CC16 and VCAM-1 protein in blood serum. It was found that the level of SS16 protein in blood serum was significantly lower in children with a severe allergic history compared to children without a severe allergic history. On the other hand, regarding the level of VCAM-1 in blood serum, its value was significantly increased in the majority of children with severe allergic history. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135469725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of COVID-19 in teenagers. Clinical cases","authors":"N.V. Drutsul-Melnyk, L.A. Ivanova, I.B. Horbatiuk, A.O. Shkilniuk","doi":"10.15574/sp.2023.133.52","DOIUrl":"https://doi.org/10.15574/sp.2023.133.52","url":null,"abstract":"Coronavirus infection in childhood is a common disease and has a number of features of the clinical course. There remain quite a lot of problems related to the variety of clinical symptoms, the severity of the course and treatment tactics in different age categories. Purpose - to study the epidemiological and clinical features of the coronavirus disease COVID-19 in adolescents compared to the younger age group in order to predict the severity of the course and determine treatment tactics. Materials and methods. A single-center retrospective open cohort study of 188 patients under the age of 18 hospitalized in the infectious disease department of the Chernivtsi Regional Children’s Clinical Hospital with a confirmed respiratory infection caused by SARS-CоV-2 was conducted. This cohort of patients is divided into 2 clinical groups. The Group I consisted of children aged 12 to 18 years (43 children), the Group II included children aged 0 to 11 years (145 patients). Results. Epidemiologically, extrafamilial sources of infection prevail in adolescence in the range of 44.2% (n=19), which is explained by greater social activity compared to children from birth to 11 years of age. For the 1st observation group, symptoms of damage to the lower respiratory tract are more characteristic, in particular, cough 81.4% (n=23), shortness of breath 51.1% (n=22), hypoxemia 14.2% (n=6) and symptoms of associated with intoxication syndrome (general weakness, asthenia 97.6% (n=42), decreased appetite, refusal to eat 74.4% (n=32), myalgia 11.6% (n=5), headache 14,2% (n=6)). The severity of the course of the coronavirus infection in adolescence is due to the dominance of lower respiratory tract lesions with the development of pneumonia in 58.2% (n=25) of cases, which required longer and more intensive treatment. Conclusions. The share of adolescents hospitalized due to COVID-19 was 22.9% (n=43), among them with a severe degree of impairment of the general condition - 16.4% (n=7), which is due to the predominance of damage to the lower respiratory tract with the development of pneumonia in 58.2% (n=25) of cases. This cohort of patients is characterized by a longer intoxication syndrome, the epidemiological role of family contacts with regard to COVID-19 decreases, and the value of unidentified non-familial sources of infection increases - 44.2% (n=19). The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of parents or their guardians was obtained for conducting research. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135470608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematopoietic stem cell transplantation in patient with DOCK8 deficiency: Ukrainian experience","authors":"A.M. Hilfanova, D.V. Zabara, O.V. Lysytsya, A.V. Volkova","doi":"10.15574/sp.2023.133.97","DOIUrl":"https://doi.org/10.15574/sp.2023.133.97","url":null,"abstract":"Dedicator of Cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency that exemplifies the broad clinical features of primary immunodeficiencies (PIDs), extending beyond recurrent infections including atopy, autoimmunity, and cancer. Purpose - to describe the natural course of hyper-IgE syndrome (HIES) disease in an 8-year-old boy and his path to diagnosis, as well as our first local history of conservative treatment for 6 months. In particular, we describe the effectiveness of omalizumab, and the application of allogeneic hematopoietic stem cell transplantation with follow-up. Clinical case. The 8-year-old boy presented with severe eczema and an involvement of the whole surface of the body. Infectious syndrome manifested from the age of 4 months in a form of recurrent respiratory infections. Over the next few years, the child suffered from life-threatening infections with high serum IgE (&gt;3000 IU/ml). The examination revealed a cushingoid constitution, flat-valgus feet, and dysmorphic features. Therefore, HIES was suspected. Genetic studies have confirmed the diagnosis by detecting a pathogenic homozygous mutation in the DOCK8 gene (Deletion Exons 2-46). We decided to use a humanized monoclonal anti-IgE antibody (off-label) to control the skin syndrome rather than systemic steroids. A significant improvement in skin condition, a decrease in eosinophils, and IgE were observed. Allogeneic stem cell transplantation of hematopoietic cells (HSCT) derived from peripheral blood of an human leukocyte antigen (HLA) - identical sibling donor was performed. The donor had a pathogenic mutation identical to the recipient in the DOCK8 gene but in a heterozygous state. Our data and treatment approach may be clinically useful as a diagnostic and treatment approach to HIES. The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135469719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gram-positive microbiota as potential factors of healthcare-associated infections in children and adults","authors":"O.P. Korniychuk, I.V. Tymchuk, N.M. Ferents, Y.T. Konechnyi","doi":"10.15574/sp.2023.133.58","DOIUrl":"https://doi.org/10.15574/sp.2023.133.58","url":null,"abstract":"In the Lviv region, cases of healthcare-associated infections (HAIs) in children occur, but are practically not registered. For the period 2019-2021, not a single case was registered. Purpose - to identify and compare the species composition of potential HAIs pathogens in children and adults in Lviv hospitals. Materials and methods. Material for the study was collected from children from various biological niches who were undergoing inpatient treatment in Lviv hospitals. Identification was carried out using MIKRO-LA-TEST kits manufactured by Erba Lachema. Antibiotic susceptibility was determined according to EUCAST recommendations. Results. Among the isolated gram-positive microbiota that meets the criteria of HAIs, enterococci were most often detected in adults (30,8%), among children (from 0 to 17 years) - in 35,4% of cases. Staphylococcus epidermidis was detected in 21,5% from children's patients, as the causative agent of the purulent-septic process, while in adults – 27,2%. A significant part of S. aureus cultures (63,6%) isolated from children was resistant to amoxicillin (among adults - 56,5%), ceftazidime (54,5%) and cefuroxime (45,4%). Among adult patients, the percentage of isolated resistant strains to ceftriaxone (65,2%), cefotaxime (52,2%), cefepime (87,0%) was significantly higher compared to such indicators in children – 9,1%, 18,2% and 36,4%. The antibiotic ceftizoxime, widely used in recent years in the treatment of children, was not effective in 45,5% of cases. Conclusions. Despite the low level of registration of HAIs in children, this problem exists. The number of resistant strains is increasing. The sensitivity of strains to antibiotics isolated in children and adults differs significantly, so general recommendations may not be effective. The role of the clinical microbiologist and epidemiologist is extremely important for effective infection control and quality empiric antibiotic therapy in individual healthcare settings. The research was carried out in accordance with the standarts of bioethics, approved by the ethics committee of the Danylo Halytskyi LNMU. The informed consent of the child's parents and the patient was obtained for the description of the clinical case. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135469726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment the impact of the torus tubarius correction by power-assisted technique on the equipressor eustachian tube function","authors":"K.V. Liakh, A.L. Kosakovskyi, Ya.V. Shkorbotun","doi":"10.15574/sp.2023.133.80","DOIUrl":"https://doi.org/10.15574/sp.2023.133.80","url":null,"abstract":"Purpose of the research is to evaluate the impact of the torus tubarius correction by microdebrider technique on the eustachian tube function in children without middle ear pathology. Materials and methods. 115 children aged 3 to 12 years participated in the study. All children underwent endoscopic modified microdebridement adenotomy for the first time, which, in the case of tubal hypertrophy (we analyzed the frequency of this phenomenon), was combined with its correction by the microdebridement method. For the next stage of the research, we selected 19 children, who had preoperative intratympanic pressure monitoring results more than -100 daPa and who hadn’t concomitant tonsil hypertrophy (19 children). Control measurement was done on days 1 and 8-10 after the intervention. Depending on the presence/absence of concomitant hypertrophy of the torus tubarius, patients were divided into the main (11 patients) and control (8 patients) groups. The analysis was carried out using the STATISTICA program. Results. 36 patients were diagnosed with torus tubarius hypertrophy. When comparing intratympanic pressure on the 1st day after the intervention in patients of the main and control groups, a significant difference in values was found (-144.37±41.09/-95.00±27.90 daPa). On day 8-10, the intratympanic pressure data in patients of both groups did not differ from each other (-39.15±14.85 daPa in the main and -33.87±19.57 daPa in the control groups) and preoperative values in both groups. Conclusions. Hypertrophy of the torus tubarius is noted in 31.3% of patients with primary adenotomy. The microdebrider technique method of torus tubarius correction is safe in view of the equipressor function of the auditory tube. The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of parents or their guardians was obtained for conducting research. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135470783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The von Willebrand factor as a marker of partially controlled asthma severity in children","authors":"N.I. Makieieva, V.V. Andrushchenko","doi":"10.15574/sp.2023.133.31","DOIUrl":"https://doi.org/10.15574/sp.2023.133.31","url":null,"abstract":"Asthma is one of the most common chronic non-communicable diseases among adults and children. Recent studies have paid special attention to endothelial dysfunction in the mechanism of development and progression of asthma, on the one hand, and the occurrence of long-term consequences of endothelial damage, on the other hand. Endothelial dysfunction in the modern sense is not only a pathology of the vascular wall but also a deep, complexly organized system of disorders and compensatory and adaptive reactions that originates at the molecular genetic level. Purpose - to improve the knowledge of assessing the levels of von Willebrand factor (VWF) as a marker of endothelial dysfunction in the blood of children with partially controlled asthma. Materials and methods. 94 children participated in the study. Patients were divided into 4 groups: the Group 1 - children with mild persistent asthma (n=59), the Group 2 - moderately severe persistent asthma (n=10), the Group 3 - severe persistent asthma (n=12), and the Group 4 - control group (n=13). The study of VWF was carried out by a standard enzyme-linked immunosorbent assay (ELISA) using the Human VWF ELISA Kit. Data were analyzed using Statsoft Statistica version 8 (Tulsa, OK) and MedCalc statistical software version 17.2. Results. It was found that children with asthma had significantly increased levels of VWF in the blood serum compared to the control group. The highest levels of serum VWF were found in patients with severe asthma. Conclusions. Elevated levels of VWF indicate the presence of endothelial dysfunction. Increased levels of VWF depending on the severity of asthma indicate more severe endothelial damage in children with severe asthma. The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of parents or their guardians was obtained for conducting research. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135469722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness of future parents about vaccination","authors":"A.M. Pugach, A.V. Bondarenko","doi":"10.15574/sp.2023.133.85","DOIUrl":"https://doi.org/10.15574/sp.2023.133.85","url":null,"abstract":"Purpose - to assess the intentions of students of different universities to vaccinate their future children and the factors that influence their decision. Materials and methods. A Google form with 20 questions was developed. The data were obtained from an online survey conducted among students who have not yet had children. The questions concerned the attitude to immunoprophylaxis, as well as information about the age, gender and occupation of the respondents (of particular interest are those who have or are obtaining a medical education). Results. A total of 145 students took part in the survey, including 79.5% from healthcare and 20.5% from non-healthcare sectors. The majority of those who took part in the survey were female, aged 18 to 30. According to the data, after giving birth to children, 77.2% of respondents expressed a desire to invest in disease prevention and enjoy a full life, while almost 8% consider it appropriate to treat diseases that have already occurred, and more than 14% are undecided about medical tactics. In general, 81% have a positive attitude towards vaccination; 16% have a reservation, more than 2% are undecided, and almost 1% have a negative attitude. According to the attitude towards vaccination of their future children, five distinct parental groups were identified among the respondents: “unquestioning acceptors” - 57% of respondents indicated that they intend to vaccinate their future children with all vaccines available in Ukraine, 43.9% - “cautious acceptors” - will choose only mandatory vaccinations; 8.8% are undecided and slightly less than 2% are “refusers” from all vaccines. The first place among the main reasons for refusing to vaccinate children is the fear of adverse reactions and post-vaccination complications; the second place is distrust of the manufacturer and the third is caution because of so-called contraindications. The survey also found that when determining contraindications to vaccinating an unborn child, respondents would most likely listen to the opinion of the following specialists: pediatrician - 87.7%; immunologist - 56.1%; family doctor - 46.5%. Conclusions. The level of awareness of vaccination among young people is generally satisfactory. There is no difference between doctors and non-physicians. To maximize protection of children from vaccine-preventable infections, pediatricians should effectively counsel parents on the benefits of vaccines and the risks of delaying or refusing vaccination. To increase understanding and benefit of vaccines among the general population and reduce vaccine hesitation/refusal, vaccine education should begin as part of a healthy lifestyle and disease prevention program long before university and continue after medical and non-medical training. Basic knowledge about vaccines should be included in the curriculum of not only medical but also non-medical universities. The research was carried out in accordance with the principles of the Helsinki Declaration. The","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135469720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for placenta previa among pregnant women of Kyiv, Ukraine: a retrospective cohort study","authors":"V.O. Berestovyi, O.V. Zelinska, N.V. Gerevich, D.O. Govsieiev","doi":"10.15574/sp.2023.133.65","DOIUrl":"https://doi.org/10.15574/sp.2023.133.65","url":null,"abstract":"Placenta previa is a significant obstetric problem with elevated morbidity and mortality rates for both mother and fetus. The risks associated with placenta previa underscore the necessity for comprehensive treatment and timely intervention to mitigate adverse outcomes. Purpose - to conduct a retrospective analysis of the impact of obstetric-gynecological factors on the prediction of placenta previa occurrence and its influence on perinatal outcomes. Materials and methods. A retrospective cohort study was conducted on cases of placenta previa between 2018 and 2022. The study included 22491 deliveries, of which 65 (0.29%) cases were registered as placenta previa. Data from delivery records of 374 patients without placenta previa were used for comparison. The following variables were evaluated for all patients: maternal age, characteristics of the menstrual cycle, gravidity, parity, history of cesarean sections, gestational age at delivery, method of delivery, blood loss during delivery, length of postpartum hospitalization, birth weight, gender of the newborn, Apgar scores at 1 and 5 minutes. Gynecological intervention histories, including curettage/hysteroscopy, laparoscopy, and cervical treatment, as well as obstetric pathologies, such as cesarean section, ectopic pregnancy, instrumental abortions, missed pregnancies, and assisted reproductive technologies in the last pregnancy, were examined. Results. Multifactorial analysis revealed four significant risk factors. The risk of placenta previa was found to increase with advanced maternal age (p<0.001), OR=1.14 (95% CI 1.07-1.20), and the presence of previous cesarean sections (p<0.001), OR=5.51 (95% CI 2.73-11.1), while a history of previous deliveries reduced the risk (p<0.001), OR=0.24 (95% CI 0.15-0.40). Instrumental abortions increased the risk of placenta previa (p=0.001), OR=2.14 (95% CI 1.20-3.81). Newborns in the placenta previa group had lower Apgar scores at 1 and 5 minutes and lower birth weight. Conclusions. The obtained results emphasize the importance of considering risk factors in assessing placenta previa occurrence during antenatal monitoring and can contribute to improving obstetric and perinatal care for women. However, the morphological and functional basis of placenta previa remains unknown and requires further study. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of participating institution. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135469721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seizures in a teenager as a manifestation of 22q11.2 deletion syndrome","authors":"O.R. Boyarchuk, L.A. Volianska","doi":"10.15574/sp.2023.133.110","DOIUrl":"https://doi.org/10.15574/sp.2023.133.110","url":null,"abstract":"22q11.2 deletion syndrome (DiGeorge syndrome) is one of the most common chromosomal abnormalities, which is characterized by multiplicity and variability of damage to various organs and systems: cardiovascular, immune, nervous, endocrine, skeletal. Purpose - to increase doctors' awareness regarding the diagnosis of 22q11.2 deletion syndrome in patients with seizure disorder based on a clinical case analysis. Here we report a clinical case of DiGeorge syndrome (22q11.2 deletion syndrome) in a boy with seizures diagnosed at the age of 14 years by genetic testing because of suspected epileptic encephalopathy. Diagnosed hypofunction of the parathyroid gland and hypocalcemia are obviously the cause of seizures and required a change in treatment. Despite the presence of T- and B-lymphopenia, the boy did not have a frequent infectious syndrome. The absence of defining signs of the 22q11.2 deletion syndrome at an early age, namely the absence of data for a congenital heart defect, pronounced facial dysmorphias, frequent infections, did not give an opportunity to suspect this syndrome at an early age. Taking into account the prevalence, multiplicity and variability of the lesion and the varying degree of severity of clinical manifestations in 22q11.2 deletion syndrome, patients with this syndrome can be found in the practice of every doctor. With seizures in combination with developmental disorders, it is necessary to rule out 22q11.2 deletion syndrome at any age. Wider awareness of the dysmorphic and clinical manifestations of this syndrome will allow better diagnosis of this disease, which requires a multidisciplinary approach to management. The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135469723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnesium’s role in a healthy person’s body, in the course and rehabilitation after infectious respiratory pathology and COVID-19 (literature information, own data)","authors":"Yu. Marushko, T. Hyshchak, O. Dmytryshyn, B. Dmytryshyn, M. Myka","doi":"10.15574/sp.2023.133.90","DOIUrl":"https://doi.org/10.15574/sp.2023.133.90","url":null,"abstract":"Magnesium is a macroelement that plays an important role in the regulation of many physiological processes. In the case of insufficient intake of magnesium, which does not meet the needs of the child's body, its deficiency develops. Clinical manifestations of magnesium deficiency are nonspecific and may be similar to symptoms of various diseases, including asthenic syndrome. In turn, asthenic syndrome is common in children who have suffered infectious diseases, COVID-19, influenza, and other acute respiratory infectious pathology. In such children, excessive anxiety, rapid fatigue, sudden mood changes, sleep disorders, and emotional lability can be detected. Given that the leading role in ensuring the proper functioning of most of the body's enzyme systems, tissue respiration, energy exchange, and synthetic processes belongs to magnesium, it is assumed that the development of the described symptoms may be related to its deficiency. Purpose - to summarize literature data on the role of magnesium in the body of a healthy person, the peculiarities of its metabolism, its importance in the course and rehabilitation after respiratory infectious pathology and COVID-19, signs of deficiency, and methods of its correction; evaluate the results of own research. Materials and methods. General clinical (analysis of anamnesis data), laboratory (determination of magnesium level in blood serum), statistical, bibliographic, and information-analytic research methods were used. 60 children aged 9 to 18 took part in the study, among them 35 children who had COVID-19 (the first group) and 25 children who did not have COVID-19 (the second group). Results. It was established that the average value of magnesium level in blood serum in children of the first group was lower than in children of the second group (p=0.005). Individual analysis showed that 31.4% of patients in the first group, who had a term of 4-5 months after COVID-19, noted the presence of post-COVID-19 symptoms, such as excessive fatigue, headache, muscle weakness, impaired sleep, appetite, which coincides with the data of the literature. Conclusions. The data of our study may indicate the effect of transferred COVID-19 on the level of magnesium in the blood serum, which may be one of the reasons for its deficiency and, accordingly, the development of post-COVID-19 symptoms in children. It is advisable to carry out laboratory determination of the magnesium level in children who had acute respiratory infectious pathology, including COVID-19, to establish the causes of the development of individual symptoms that aggravate the general well-being, prevent the development of magnesium deficiency and find additional ways of rehabilitation after respiratory infectious pathology and COVID-19. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135470606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}