Suchasna pediatriia Ukrayina最新文献

{"title":"The state of oral hygiene, periodontal tissues and assessment of fine motor skills of hands in children with cerebral palsy","authors":"N. Gevkaliuk","doi":"10.15574/sp.2023.132.73","DOIUrl":"https://doi.org/10.15574/sp.2023.132.73","url":null,"abstract":"Children with cerebral palsy often face difficulties in controlling their own movements and coordinating muscle activities, making even simple tasks such as individual oral hygiene challenging to perform. Purpose - to assess the index of individual oral hygiene and periodontal tissue condition, development of fine motor skills in children with cerebral palsy to determine the quality of tooth brushing. Materials and methods. The study included 34 children aged 8-12 years with cerebral palsy. The oral hygiene status was determined clinically and using the Fedorov-Volodkina oral hygiene index. The periodontal tissue condition was assessed using the PMA index, the bleeding index by Muhlleman, and the periodontal index. The level of fine motor skills development was assessed using the Motor Giftedness Scale by N.I. Ozeretskyi and special techniques with tasks of different content. Results. The indicators of the level of development and individual components of motor functions, including fine motor skills of the hands in children with cerebral palsy according to the Motor Giftedness Scale by N.I. Ozeretskyi, were 6.67±1.16 points, and 3.12±1.10 and 2.10±0.03 points according to special techniques with tasks of different content. The assessment of oral hygiene using the Fedorov-Volodkina index showed that only 8.82% of cases were rated as «good» «satisfactory» in 26.47% of cases, and «unsatisfactory» in 64.71% of cases. The qualitative assessment of the oral hygiene index showed an average score of 2.5±0.02 points. The PMA index in children with cerebral palsy was 41.67%, bleeding index was 1.47±0.01, and periodontal index was 1.21±0.09. Conclusions. The results of the study showed that due to the impaired development of fine motor skills of the hands in children with cerebral palsy, mechanical cleaning of teeth from dental plaque is complicated, which negatively affects oral hygiene and periodontal tissue condition. The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent from the children’s parents was obtained for the research. No conflict of interests was declared by the author.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44444660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and genetic characteristics of young children with epileptic encephalopathies and their role in the development of autism spectrum disorders","authors":"L.G. Kyrylova, O.O. Miroshnikov, V.M. Badyuk, O.O. Dolenko","doi":"10.15574/sp.2023.132.34","DOIUrl":"https://doi.org/10.15574/sp.2023.132.34","url":null,"abstract":"Purpose - to analyze the clinical and genetic characteristics of young children with developmental and epileptic encephalopathies and to determine their role in the formation of autism spectrum disorders (ASD). Materials and methods. The study included 58 children aged 0-3 years with the onset of epileptic seizures in the first year of life, clinical manifestations of developmental and epileptic encephalopathies with genetic etiology. The examination included assessment of neurological status, collection of anamnesis, assessment of semiology and determination of seizure type, assessment of development and screening for ASD at the age of 18 and 24 months, night sleep electroencephalography (video EEG), brain magnetic resonance imaging (MRI), screening for pathogenic variants by whole-exome sequencing or examination of relevant gene panels. Pathogenic variants of 33 different genes were found in the examined children. Pathogenic variants of genes responsible for the function of ion channels (41.3%), intracellular signaling systems (17.2%), organelles and intracellular membranes (12.1%) were most frequently found. 44.8% of children had symptoms of ASD at the age of 18 months, and 68.9% of children at the age of 24 months. The predominant types of epileptic seizures were myoclonic (37.9%) and focal clonic (34.4%). According to video EEG monitoring, interictal focal (39.6%) and multifocal (22.4%) epileptiform changes dominated in the examined children. According to MRI, structural changes of the brain were found in 86.2% of children. Conclusions. It is shown that children with a history of myoclonic seizures (RR=1.264) and infantile spasms (RR=1.44) have a high risk of developing ASD at 24 months. It has been established that there is a positive relationship between the presence in the child of mutations in the genes responsible for the functioning of ion channels (RR=1.32), as well as for the functioning of synapses, neurotransmitters and receptors (RR=1.5) and the development of ASD in 24 months. The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Bioethics and Deontology Commission. Informed consent of the children’s parents was obtained for the research. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":"124 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135895943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical case of manifestation of primary immunodeficiency diagnosed before as Burkitt’s lymphoma","authors":"O. Urbas, Z. Vovk, O. A. Holodnykh, U.I. Alekseieva, A.L. Ivanenko","doi":"10.15574/sp.2023.132.104","DOIUrl":"https://doi.org/10.15574/sp.2023.132.104","url":null,"abstract":"Lymphoma is a group of neoplastic diseases characterized by the clonal proliferation of lymphoid cells, manifested by the response of various stages of differentiation of normal B-lymphocytes, less often T-lymphocytes or natural killer cells. The etiology of most lymphomas is unknown. Some of the proven causal-consequence factors are: viral infections and immunodeficiency conditions. Purpose - to draw the attention of non-immunologists to the peculiarities of detecting the primary immunodeficiency (PID) states and the problem of their late diagnosis based on the data of a clinical case. Clinical case. A clinical observation of severe non-genetically differentiated PID is given. Screening signs of PID in the form of recurrent infectious respiratory tract syndrome and frequent long-term use of antibacterial drugs are highlighted, which should alert doctors to clinical and immunological markers of primary immunodeficiency. The presence of Burkitt's lymphoma in the boy also does not exclude the possibility of the manifestation of an immunodeficiency state, both secondary to the drug treatment of lymphoma, and primary, which can manifest itself in puberty. Common variable immunodeficiency is one of those PIDs that \"starts\" with Burkitt's lymphoma. Conclusions. The problem of low detection of probable PID in children in Ukraine is urgent. Primary care physicians are the first to be able to partially solve this problem by examining the infectious history and laboratory screening tests. There is incomplete awareness of related medical specialties regarding the signs of PID in lymphoproliferative syndrome in children. This clinical case demonstrates signs of PID at an early age. Low detection is also associated with poor capacity and quality and/or lack of immunological laboratory testing, particularly in public facilities. The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the of the child’s parents was obtained for the research No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44699068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical case of alopecia totalis in pediatric practice","authors":"O. Stroi, Т.А. Кyian, N. Balatska, L. Levadna, G.E. Kozynkevych","doi":"10.15574/sp.2023.132.99","DOIUrl":"https://doi.org/10.15574/sp.2023.132.99","url":null,"abstract":"Alopecia (baldness) is a pathological hair loss. A chronic relapsing course leads to a violation of the emotional sphere of the child, worsens the quality of life. Alopecia is considered autoimmune, since it is characterized by hair loss due to lymphocytic infiltration around the hair follicles. It can be secondary as a result of infectious and inflammatory processes. Purpose - is to conduct own clinical observation of a child with total alopecia to increase the awareness of doctors about this pathology in children. Clinical case. The article presents a clinical case of total alopecia in an 11-year-old child. It is known from the anamnesis that in 9 months the child began to lose hair on his head, at 2 years old - eyebrows and eyelashes, at 3 years old he was diagnosed with total alopecia. The patient had a complex clinical and laboratory examination with the involvement of a multidisciplinary team, since alopecia can occur under the mask of autoimmune diseases and immunodeficiencies. Total alopecia, atopic dermatitis, changes in immunological status in the anamnesis, cases of early mortality among family members, as well as a history of alopecia areata in the father gave us reason to suspect a genetic disease in the patient, including autoimmune polyendocrinopathy candidiasis-ectodermal dystophia (APECED syndrome) with mutation in the AIRE gene. Conclusions. For verification the diagnosis and choose a treatment strategy, the patient needs an additional examination: sequencing of the relevant locus of the AIRE gene to detect mutations characteristic of APECED syndrome, as well as a serological test to detect the titer of antibodies to Candida and a puncture biopsy of the scalp. Considering the above, the prognosis for recovery is unfavorable. The research was carried out in accordance with the principles of the Declaration of Helsinki. Informed consent of parents was obtained for the study. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46904737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Picky eating children at pediatrician’s appointment","authors":"V. Bobrova, L. Kot, L.A. Luhova","doi":"10.15574/sp.2023.131.93","DOIUrl":"https://doi.org/10.15574/sp.2023.131.93","url":null,"abstract":"The review article provides data from modern approaches to diagnosis and correction of behavioral eating disorders, that tend to occur in preschool children. Purpose - to consider the algorithm of pediatrician’s actions in the case of preschool children eating difficulties; to point out the main ways to prevent from development of child’s health negative consequences. Basic principles of eating behaviour disturbances were analyzed. The main factors, that affect the establishment of child eating behaviour are pregnant woman nutrition, influence of genetic factors and breastfeeding in early childhood. Malnutrition and loss of appetite among the preschool children with a lack of timely detection and due correction lead to negative consequences for children’s health and development, associated with chronic nutriet deficiency. Pediatrician algorithm of actions to manage preschool children eating difficulties includes the estimation of physical development, excluding of internal organs pathology, central nervous system and neuropsychiatric disease. Nutritional anamnesis should comprise information about child’s nutrition from the moment of birth: composition and method of feeding, age of complementary food introduction, food tolerance and manifestation of unusual eating behaviour at this time. Conclusions. When parents visit a pediatrician with complaints about difficulties in feeding a preschool child, it is necessary to calmly and thoroughly analyze the child’s behaviour, general physical condition and eating habits, and, based on this, determine the possible reasons why the child has no appetite. This will determine what to do with the “starving” child, and whether it is need to do anything at all. The main rules that will help to form healthy eating behaviour in children are the formation of healthy eating habits and the development of healthy lifestyle skills in the child’s family, a full and varied diet, nutrition, regular exercise and outdoor walks. Treatment should be comprehensive and focus primarily on the psychological side of the problem, with nutritional correction as needed. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45106272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difficulties in diagnosing Kimerly’s anomaly (own clinical observation)","authors":"D. Khapchenkova, S. Dubyna, S.S. Skorobogach, V. Husiev","doi":"10.15574/sp.2023.131.121","DOIUrl":"https://doi.org/10.15574/sp.2023.131.121","url":null,"abstract":"Kimmerle’s anomaly is characterized by the presence of a bony arch of congenital or secondary origin in the structure of the first cervical vertebrae, which restricts the movement of the vertebral artery and causes its compression. This pathology belongs to craniovertebral malformations - congenital anatomical defects of the structure of the junction of the skull with the first cervical vertebra. Kimerly’s anomaly is diagnosed in approximately 12-30% of the population, causing vertebral artery syndrome, which is the cause of chronic ischemia in the posterior parts of the brain. Purpose - to describe the clinical case of Kimmerle’s anomaly in a teenager as an example of a long diagnostic search for this pathology. Clinical case. A 9-year-old girl complained of frequent headaches accompanied by vomiting. Similar conditions occurred every 3-4 weeks. Gastroenterological and neurological factors were not detected. The conditions were relieved by sleep, and drug therapy was not effective. During puberty, such attacks became less frequent and later disappeared. At the age of 16, the girl began to complain of neck pain, recurrent migraines, sharp «shooting» pain in the ear, accompanied by a buzzing sound, ringing, later joined by syncopal states, gait instability, and facial muscle weakness. An X-ray of the craniovertebral junction revealed Kimmerle’s anomaly. The patient’s condition improved with the use of the Shantz collar and constant physical therapy and neuroprotective therapy. Conclusions. Kimmerle’s anomaly can be asymptomatic and incidental, but in younger patients with a combination of neuro-otolaryngological symptoms and drop attacks, this pathology should be excluded. When taking anamnesis, attention should be paid to the chronology and conditions of symptom onset, as well as the patient’s medical history. The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44796736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response of autonomic nervous system in children with mitral valve prolapse to physical exercises","authors":"I.O. Mitiuriaieva-Korniiko, O. Kuleshov, K. Pivtorak, Y. Medrazhevska, L. Fik","doi":"10.15574/sp.2023.131.46","DOIUrl":"https://doi.org/10.15574/sp.2023.131.46","url":null,"abstract":"The problem of cardiovascular diseases diagnosing is topical. The prevalence of mitral valve prolapse (MVP) has been increasing over the past decades, which requires a differentiated study to prevent its complications in children. Purpose - to explore the reaction of the autonomic nervous system to physical exercises in children with MVP, taking into account the mitral regurgitation (MR). Materials and methods. 44 children with MVP were examined and divided into two groups considering MR aged from 13 to 17 years old. The Group 1 consisted from 20 (45.5%) children with MVP without MR, the Group 2 - 24 (54.5%) children with MVP without MR. It were studied the influence of physical activity on the state of vegetative homeostasis in these children. The estimation of autonomic system state and heart rhythm variability parameters, including spectral and frequency analyses were conducted by cardiointervalography. Estimation of these parameters was performed after physical exercises and compared with primary results. Results. Increasing of VLf (Very low frequency) and Lf (Low frequency) data parameters on 32.7% and 65.6% in children with MVP without MR was noted which shows the prevalence of sympathetic part of autonomic nervous system (ANS), while in children with MR - on 40.5% and 85%, respectively, that is 7.8 and 19.5% more than in children without MR. This can be associated with increased sympathicotonia against the background of the MR presence. Among the parameters which describe the parasympathetic part of the ANS, there was an increase in Hf (High frequency) by 67.0% in children without MR, when it appears, this parameter decreases by 9,1% - we observe an increase in relative sympathicotonia. Increase of sympathetic tonus was also noted in Lf/Hf elevation by 3.8% (without MR) and by 28% (with MR). The analysis of heart rate variability (HRV) time parameters expectedly had changes within reducing of SDNN (Standard deviation of the NN (R-R) intervals) by almost half (p<0.05) in children of both subgroups and the increase of rMSSD (root mean square of successive R-R interval differences) by 23.2% in children without MR (р<0.05), and with the appearance of MR decrease of this parameter by 24.3% was noted. Therefore, in children with MVP, with the appearance of MR, changes in the parameters that characterize the state of ANS with sympathicotonia increasing and parasympathicotonia weakening. Conclusions. In children with MVP, against the background of physical exertion, there is an increase in changes in the balance of the ANS, regardless to the presence or absence of MR. In children with MVP, against the background of MR, the influence of the sympathetic division of the ANS increases almost twice after physical exertion. These children should be under the close supervision of pediatricians, pediatric cardiologists and family doctors. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was app","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47733018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crohn’s disease in young children. Difficult path to diagnosis","authors":"O. Shadrin, V. P. Misnyk, T. Marushko, R. V. Mostovenko","doi":"10.15574/sp.2023.131.111","DOIUrl":"https://doi.org/10.15574/sp.2023.131.111","url":null,"abstract":"Inflammatory bowel diseases (IBD) is a group of chronic diseases characterized by destructive non-specific immune inflammation of the intestinal wall. The main forms include Crohn's disease and ulcerative colitis. Currently, Crohn's disease is one of the most urgent problems of children's gastroenterology, which is due to the annual increase in morbidity, \"rejuvenation\" of the pathological process, difficulties of diagnosis treatment, and high risk in developing of complications. IBDs with very early onset of manifestation have an atypical or erased clinical picture, which makes timely diagnosis in this age group of patients much more difficult. Purpose - to describe own clinical observation of a case of Crohn's disease with a very early onset. Clinical case. Was presented an observation of a patient of 2 years and 7 months old with Crohn’s disease the feature of which was a severe course with pronounced lesion of the gastrointestinal tract. The results of clinical data, laboratory, instrumental and histological methods of research, the complex stages of diagnosing of Crohn’s disease, as well as the issues of the patient’s treatment were discussed. The peculiarity of the described case was the early onset of the disease, continuously relapsing course, frequent acute respiratory diseases accompanied with diarrheal syndrome, absence of some specific complaints and changes in biochemical and immunological tests, corticosteroid dependence and severe extraintestinal manifestations of Crohn’s disease (anemia of a mixed nature). The diagnosis of Crohn’s disease was made at the age of 1year and 9 months (1 year and 4 months after the appearance of the first symptoms), which was confirmed a year later after a repeat examination. Late diagnosis was caused by the variety of clinical manifestations, absence of clear symptoms of the disease at the first stages of observation. The research was carried out in accordance with the principles of the Declaration of Helsinki, informed consent of the child's parents was obtained for the research. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47467640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychiatric disorders in children with congenital heart defects","authors":"V. Martyniuk, N. Rudenko, H. Fedushka","doi":"10.15574/sp.2023.131.74","DOIUrl":"https://doi.org/10.15574/sp.2023.131.74","url":null,"abstract":"The article is devoted to the actual problem of children’s neurology, children’s cardiology and children’s cardiac surgery - namely, the features of neuropsychological development (NPD) in children with congenital heart defects (CHD). Purpose - to review modern research on the diagnosis of NPD in children with CHD, which is a necessary condition for optimizing patient care and developing a rehabilitation plan. The topicality of the topic is due to the lack of research on the early diagnosis of the violation of the NPD of this category of children. Consider features of development and damage to the brain in children with congenital heart defects. The relationship between the action of various epigenetic factors and pathophysiological factors that influence neuropsychological development in children with CHD is highlighted. Features of diagnosis of NPD in children with CHD using neuromonitoring, scales and tests (near-infrared spectroscopy, electroencephalography, magnetic resonance imaging, ultrasound, Bailey scales, Peabody scale) are shown. Conclusions. The relationship between the type of heart defect and the features of the child’s NPD has been determined. The adverse effect of cyanotic heart defects on the child’s neurodevelopment has been confirmed. Early diagnosis of CHD, including prenatal, and timely surgical correction at an early age significantly improve the results of surgical treatment and exert a positive influence on further NPD. The emphasis is on continuing the search for early diagnostic markers in order to optimize the treatment of NPD in children with CHD, as well as the development of effective rehabilitation methods for this category of children. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45777820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of oral diseases in children with epidermolysis bullosa: a case report and literature review","authors":"V. Ivanchyshyn, A. Kuzyk, U. O. Stadnyk, M. Kuzyk","doi":"10.15574/sp.2023.131.126","DOIUrl":"https://doi.org/10.15574/sp.2023.131.126","url":null,"abstract":"Today, more than 300 million people worldwide suffer from one or more rare diseases. Epidermolysis bullosa (EB) is a heterogeneous group of hereditary diseases characterized by a genetic predisposition to a hypersensitive body reaction to minor skin damage, characterized by the formation of blisters and erosions on the skin and mucous membranes, followed by scarring. It is one of the most severe hereditary dermatoses. In EB, pathological conditions also occur in the oral cavity. Thus, patients with EB require a special “atraumatic” approach to medical procedures, hygienic care, professional oral hygiene, etc. Purpose - to systematize clinical recommendations for oral care for patients with BE on the basis of a clinical case. Clinical case. We present a clinical case of a patient with a dystrophic EB and a diagnosis of acute chronic granulating periodontitis. Examination of the oral cavity revealed microstomia, multiple caries, erosions and ulcers on the oral mucosa, signs of chronic catarrhal gingivitis, as well as dentoalveolar anomalies. After achieving a satisfactory degree of mouth opening using a set of exercises for the maxillofacial muscles, treatment of the acute chronic granulating periodontitis of the tooth 23 was performed. As a result of the clinical observation and analysis of the literature, we systematized practical recommendations aimed at facilitating the treatment of oral diseases in patients with EB. Conclusions. Treatment of oral diseases in patients with EB is primarily aimed at preventing pain and preventing secondary infection of affected areas. Treatment of dental caries contributes to the correct position of the tongue, improved swallowing and phonetics, as well as to improvement in nutritional status and aesthetic appearance. Oral hygiene reduces the risk of injury to the oral and pharyngeal mucosa. In the treatment of patients with EB, it is important to use a multidisciplinary approach with the involvement of specialists of different specialties. Implementation of simple but effective recommendations made by pediatric dentists will increase the effectiveness of prevention of oral diseases in these children. The study was conducted in accordance with the principles of the Declaration of Helsinki. Informed consent of parents and child was obtained for the study. No conflict of interests was declared by the authors.","PeriodicalId":34724,"journal":{"name":"Suchasna pediatriia Ukrayina","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47376298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}