Food Chemistry Molecular Sciences最新文献

{"title":"Tetracycline residue alters the nutritional quality and bioactive composition of soybean sprouts: Evidence from transcriptomic and rhizosphere microbiota analyses","authors":"Ting Cai ,&nbsp;Jie Yao ,&nbsp;Hongmei Jiang ,&nbsp;Jie Zou ,&nbsp;Ting Xia ,&nbsp;Xinyue Mou ,&nbsp;Shan Zhang ,&nbsp;Xiao Tan ,&nbsp;Jie Tang ,&nbsp;Wenliang Xiang","doi":"10.1016/j.fochms.2025.100345","DOIUrl":"10.1016/j.fochms.2025.100345","url":null,"abstract":"<div><div>Antibiotic residues in edible crops have become an increasing food safety concern, yet their impacts on crop nutritional quality and bioactive composition remain poorly understood. Here, we investigated the effects of tetracycline, a widely used antibiotic in soil–vegetable systems, on the growth and nutritional quality and bioactive composition of soybean sprouts. Results showed tetracycline exposure significantly inhibited sprout growth and nutrient accumulation in a dose-dependent manner, with high concentrations reducing vitamin C, total flavonoids, and coumestrol contents by approximately 50 %, 30 %, and 43 %, respectively. Transcriptomic analysis revealed that these related declines were associated with disruptions in carbon, amino acid, and lipid metabolism, as well as in flavonoid and coumestrol biosynthesis pathways. In parallel, rhizosphere microbiota analysis showed that tetracycline reshaped microbial community structure by reducing nitrogen-cycling-related taxa (<em>Dokdonella</em>, <em>Acidibacter</em>) and enriching resistant genera (<em>Acinetobacter)</em>, which were significantly correlated with changes in sprout nutritional quality and bioactive composition. Together, these results demonstrate that tetracycline residues drive substantial losses of nutritional and bioactive composition in edible crops through coordinated metabolic and microbiome-mediated mechanisms, revealing an underappreciated pathway by which antibiotic contamination threatens crop nutritional value and food quality.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"12 ","pages":"Article 100345"},"PeriodicalIF":4.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lychee peel extract and chitosan synergistically delay mango ripening: Molecular insights","authors":"Zhiwei Wu ,&nbsp;Qinghua Qiao ,&nbsp;Zhen Wang ,&nbsp;Tiancui Shang ,&nbsp;Shifang Wu ,&nbsp;PengPeng He ,&nbsp;Zhisheng Lin ,&nbsp;Zhenxin Ren","doi":"10.1016/j.fochms.2026.100355","DOIUrl":"10.1016/j.fochms.2026.100355","url":null,"abstract":"<div><div>Although lychee peel extract (LPE) is rich in bioactive compounds, its potential for postharvest fruit preservation remains unexplored. We hypothesised that LPE would act synergistically with chitosan (CH) to delay mango ripening by simultaneously modulating cell wall integrity, pigment metabolism, and hormone signaling pathways. Here, we demonstrate that chitosan combined with lychee peel extract (CHL) delays mango ripening through a multi-targeted mechanism. Specifically, CHL outperformed chitosan alone by significantly suppressing peel yellowing, maintaining fruit firmness, and reducing decay over 12 days of storage. Integrated transcriptomic and metabolomic analyses revealed that LPE reprogrammed ripening-associated pathways by (1) upregulating cell wall remodeling genes (CSLE1, XTH23) to stabilize pectin architecture, (2) retaining chlorophyll via suppressed CRTISO and PSY (carotenoid synthesis) and enhanced CHLP (chlorophyll biosynthesis), and (3) decoupling sugar-acid dynamics through γ-aminobutyric acid (GABA) and succinic acid accumulation. Notably, LPE attenuated ethylene-auxin- abscisic acid (ABA) crosstalk by downregulating ripening-specific transcription factors (ERF003, bZIPs) while activating stress-responsive WRKYs. These findings establish LPE as a sustainable alternative to synthetic preservatives, leveraging agricultural byproducts for eco-friendly fruit preservation.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"12 ","pages":"Article 100355"},"PeriodicalIF":4.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNAs from colostrum and mature cow milk: High-throughput sequencing and functional enrichment","authors":"Abdelmoneim H. Ali ,&nbsp;Zain Najjar ,&nbsp;Shao-Quan Liu ,&nbsp;Mutamed Ayyash","doi":"10.1016/j.fochms.2025.100337","DOIUrl":"10.1016/j.fochms.2025.100337","url":null,"abstract":"<div><div>As vital regulators of newborn development, milk-derived microRNAs (miRNAs) have gained increasing attention recently. However, the variation in miRNAs profile among colostrum and mature milk remains unclear. We hypothesized that miRNAs content of colostrum and mature cow milk differs significantly, reflecting stage-specific biological functions related to immune priming and metabolic adaptation. Herein, high-throughput small RNA sequencing was performed to compare miRNAs profile in colostrum and mature cow milk. A total of 353 and 390 miRNA precursors were respectively detected in colostrum and mature milk, with diverse expression profiles. Colostrum displayed higher quantities of immune-related miRNAs, such as <em>let-7</em>, <em>miR-21</em>, and <em>miR-146</em>, whereas mature milk was enriched in metabolic regulation-related miRNAs, such as <em>miR-29b</em>, <em>miR-210</em>, and <em>miR-378</em>. Differential expression analysis showed 159 miRNAs substantially upregulated in colostrum and 38 in mature milk. Functional enrichment and pathway analysis revealed that mature milk miRNAs were associated with energy metabolism and tissues remodeling, while colostrum miRNAs were involved in early immune signaling and developmental activities. These findings support our hypothesis that miRNA expression patterns are temporally controlled across lactation and may serve as molecular indicators of milk functionality. This knowledge could be leveraged to enhance newborn nutrition strategies and design functional dairy products enriched with stage-specific miRNAs.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"12 ","pages":"Article 100337"},"PeriodicalIF":4.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145711810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated genomic, transcriptomic, and metabolomic profile analysis reveals molecular mechanism underlying meat quality traits in Chinese Kangle chickens","authors":"Qin He ,&nbsp;Liang Xiong ,&nbsp;Shuting Fang ,&nbsp;Yan Chen ,&nbsp;Jinge Ma ,&nbsp;Zhangfeng Wang ,&nbsp;Yanping Wu ,&nbsp;Jiguo Xu ,&nbsp;Xinwei Xiong","doi":"10.1016/j.fochms.2025.100350","DOIUrl":"10.1016/j.fochms.2025.100350","url":null,"abstract":"<div><div>The local Chinese Kangle chicken breed has plump muscles, tender-tasting meat, and strong disease resistance. We aimed to identify muscle metabolites and associated regulatory genes that determine Kangle chicken muscle quality and flavor by elucidating the as yet unknown underlying molecular regulatory mechanism through omics-based analyses. Phenotype analysis and genome-wide association study (GWAS) showed that intramuscular fat (IMF) exhibited a high coefficient of variation and identified two SNPs that reached genome-wide significance levels (<em>P</em> &lt; 1.23 × 10⁻⁶), with QTLs affecting IMF located on chromosomes 1, 2, 4, and 7. Transcriptome analysis screened 201 differential expression genes between chickens with high and low IMF content. Among these, the expression level of the FYVE-type zinc finger containing (<em>PIKFYVE</em>) gene located in the significant QTL region was significantly downregulated in the High-IMF group, which was validated by qRT-PCR. Metabolomics identified 17 intergroup differential metabolites, and the High-IMF group was significantly enriched in vitamin B6 metabolism and glycine, serine, and threonine metabolism. Differentially expressed gene and metabolite analyses in breast muscles and pathway enrichment and co-occurring network analyses showed that <em>PIKFYVE</em> impacted IMF. Its expression significantly and negatively correlated with most lipid metabolites. This study is the first to establish <em>PIKFYVE</em> as the primary regulatory gene of IMF in Kangle chickens. It provides crucial and valuable practical insights into genetically breeding high-quality meat chicken breeds.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"12 ","pages":"Article 100350"},"PeriodicalIF":4.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Tiroler Bergkäse PDO cheese: A multimethodological approach","authors":"Hannah Innerbichler ,&nbsp;Alexander Trockenbacher ,&nbsp;Alexander Höller ,&nbsp;Sabine Scholl-Bürgi ,&nbsp;Lorenzo Del Vecchio ,&nbsp;Martina Cirlini ,&nbsp;Jürgen König ,&nbsp;Katrin Bach","doi":"10.1016/j.fochms.2025.100336","DOIUrl":"10.1016/j.fochms.2025.100336","url":null,"abstract":"<div><div>Tiroler Bergkäse PDO is a traditional Austrian hard cheese from Tyrol, a product of great regional significance. This study aimed to describe Tiroler Bergkäse PDO by comparing it with Bergkäse without PDO from Tyrol and a Stilfser type cheese from South Tyrol. To account for variability, three cheese wheels from three production days were analyzed for each cheese. Multimethodological characterization included quantitative Polymerase Chain Reaction, Ion Exchange Chromatography, and Headspace-Solid Phase Microextraction/Gas Chromatography-Mass Spectrometry. The characterization Tiroler Bergkäse PDO should impart potentially unique features. Multivariate analysis of the bacterial composition, free amino acid content, and volatile fraction revealed differences between all cheeses (α = 0.05). A triangle test confirmed significant differences, with more pronounced differences between the Bergkäse type cheeses and the Stilfser type cheese. The Stilfser type showed distinct differences in bacterial composition, amino acid content, and volatile profile, making it less similar to the Bergkäse type cheeses. Multivariate analysis also revealed differences between the PDO and non-PDO Bergkäse which is characterized by high levels of L. <em>delbrueckii</em> due to its starter culture, and a high free amino acid content from longer ripening, alongside elevated levels of hexanal and acetoin. In contrast, Bergkäse without PDO shows high levels of 2,3-butanediol and 2-nonanone, alongside high levels of L. <em>mesenteroides</em>, <em>L. lactis</em> subsp. <em>lactis</em>, and L. <em>lactis</em> subsp. <em>cremoris</em>. It was possible to distinguish between Tiroler Bergkäse PDO from non-PDO cheeses by microbial, amino acid, and volatile profiles and support the use of advanced methods to characterize regional foods.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"12 ","pages":"Article 100336"},"PeriodicalIF":4.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic and biochemical insights into LOX pathway aroma biosynthesis during ripening of Ziziphus jujuba Mill. cv. Li","authors":"Lina Wang ,&nbsp;Qiaoling Liu ,&nbsp;Chuan Chen ,&nbsp;Rongfa Guan ,&nbsp;Peilong Sun","doi":"10.1016/j.fochms.2025.100347","DOIUrl":"10.1016/j.fochms.2025.100347","url":null,"abstract":"<div><div>Aroma is a critical determinant of fruit quality, largely synthesized through the lipoxygenase (LOX) pathway. We hypothesized that the dynamic regulation of the LOX pathway during jujube fruit ripening governs the distinct evolution of its key aroma compounds. This study used HS-SPME coupled with GC–MS to profile aroma compounds in jujube during ripening. Semi-quantitative analysis revealed hexanal (1160–1870 μg/kg) and (E)-2-hexenal (1470–3180 μg/kg) as the most abundant aldehydes, followed by benzaldehyde and (E)-2-pentenal. Odor activity value (OAV) analysis identified hexanal, (<em>E</em>)-2-hexenal, and (<em>E</em>)-2-nonenal as the key aroma compounds. LOX enzyme activity increased from 277 U/g to 711 U/g during ripening, while ADH and AAT activities showed fluctuating trends. Transcriptome analysis revealed 12 candidate transcripts involved in aroma synthesis, with multivariate statistical analysis demonstrating coordinated changes in gene expression associated with volatile accumulation. Our findings verify the hypothesis that LOX pathway regulation drives aroma evolution during jujube ripening and provide a genetic foundation for targeted quality improvement in jujube fruits.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"12 ","pages":"Article 100347"},"PeriodicalIF":4.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of 1-MCP treatment combined with polyethylene film bag packaging on the quality of ‘Shannong Su’ pears during storage","authors":"Xukai Hou ,&nbsp;Rui Zhang ,&nbsp;Xinmeng Zhou ,&nbsp;Lu Li ,&nbsp;Sumin Qi ,&nbsp;Nan Wang ,&nbsp;Zongying Zhang ,&nbsp;Xuesen Chen","doi":"10.1016/j.fochms.2026.100358","DOIUrl":"10.1016/j.fochms.2026.100358","url":null,"abstract":"<div><div>Postharvest loss constitutes a critical issue during the storage period of pears. Based on previous studies, both 1-methylcyclopropene (1-MCP) treatment and modified atmosphere packaging (MAP) can delay fruit senescence and softening. To investigate whether the combination of these treatments achieves a superior storage effect, ‘Shannong Su’ pears were treated with 1 μL/L 1-MCP for 24 h, then packaged in sealed or perforated film bags or left unpackaged, and stored at 4.00 ± 0.50 °C for 120 days. Firmness, ethylene release, quality indicators, gene expression, and metabolite profiles were analyzed. Results showed that 1-MCP inhibited ethylene production and the expression of <em>PbACS1/2</em> and <em>PbACO1</em>. The combined treatment (1-MCP + sealed film bag) achieved the lowest expression levels of nine key cell wall-degrading enzyme genes (<em>PbXTH1/28</em>, <em>PbPL8/18</em>, <em>PbCGR3</em>, <em>PbPG</em>, <em>Pbα/β-GAL</em>, <em>Pbβ-GLU</em>) and maintained higher firmness, antioxidant capacity, total sugar, protopectin, and cellulose content. Metabolomic analysis revealed that 1-MCP treatment altered the biosynthesis of plant secondary metabolites and fatty acids, suggesting it may influence the anabolic metabolism of defensive compounds and lipids in plants. Film bag packaging affected antioxidant stress responses, nitrogen metabolism, specific amino acid derivative metabolism, and cofactor biosynthesis, indicating that sealed film packaging may induce oxidative stress responses and activate specific defensive or protective metabolic pathways. In conclusion, the combined treatment preserves pear quality through synergistic inhibition of ethylene synthesis, suppression of cell wall-degrading genes, and modulation of metabolic pathways. This cost-effective method can reduce postharvest losses in ‘Shannong Su’ pears and guide the storage of other similar climacteric fruits.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"12 ","pages":"Article 100358"},"PeriodicalIF":4.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative transcriptome analysis reveals the coordinated regulation of the miR-34c-5p/AASS axis in chicken skeletal muscle development and intramuscular fat deposition","authors":"Ke Zhang ,&nbsp;Zhenzhen Gu ,&nbsp;Shuohan Li ,&nbsp;Xi Cheng ,&nbsp;Yang Wang ,&nbsp;Hongyu Wei ,&nbsp;Zhimin Cheng ,&nbsp;Yihao Zhi ,&nbsp;Mohammed Kamal Challioui ,&nbsp;Yulong Guo ,&nbsp;Hong Li ,&nbsp;Zhuanjian Li ,&nbsp;Yadong Tian ,&nbsp;Xiangtao Kang ,&nbsp;Xiaojun Liu ,&nbsp;Weihua Tian","doi":"10.1016/j.fochms.2025.100339","DOIUrl":"10.1016/j.fochms.2025.100339","url":null,"abstract":"<div><div>Skeletal muscles (SM) development and intramuscular fat (IMF) accumulation are critical determinants of meat quality and yield in chickens. While numerous myogenesis- or adipogenesis-related regulators have been identified in chickens, the coordinated regulation of both SM development and IMF accumulation remains poorly studied. MicroRNAs (miRNAs) have increasingly been implicated in myogenesis or adipogenesis by post-transcriptional regulating target gene expression; however, evidence on their coordinated regulation of both SM development and IMF accumulation in chickens is lacking. In this study, time-series transcriptomes for miRNA and mRNA expression were generated from breast muscle tissues of commercial Arbor Acres (AA) broilers across different developmental stages. Weighted gene co-expression network analysis and differential expression analysis revealed ten miRNAs as key regulators of chicken IMF deposition and SM development. Notably, miR-34c-5p simultaneously modulates the proliferation of both chicken primary myoblasts (CPMs) and chicken intramuscular preadipocytes (CIPs), and CPMs myogenic differentiation and CIPs adipogenic differentiation. Mechanistically, miR-34c-5p suppresses <em>AASS</em> gene expression by directly binding to its 3′-untranslated region (3’UTR), thereby coordinately regulating chicken myogenesis and adipogenesis. Collectively, these findings revealed the synchronous regulation of miR-34c-5p in IMF deposition and SM development by silencing its target <em>AASS</em> gene in chickens. These insights enhance our understanding of the regulatory mechanisms underlying IMF deposition and SM development and potential possible genetic targets to improve meat yield and quality in chickens.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"12 ","pages":"Article 100339"},"PeriodicalIF":4.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomics and 4D-DIA proteomic analysis reveal differences in meat quality between Sichuan white rabbits and New Zealand white rabbits","authors":"Liangde Kuang ,&nbsp;Yunduan Wang ,&nbsp;Min Lei ,&nbsp;Xueer Mu ,&nbsp;Lin Huang ,&nbsp;Bin Wang ,&nbsp;Jingwei He ,&nbsp;Rui Yang ,&nbsp;Rongxia Li ,&nbsp;Congyan Li ,&nbsp;Wei Fu","doi":"10.1016/j.fochms.2025.100340","DOIUrl":"10.1016/j.fochms.2025.100340","url":null,"abstract":"<div><div>Understanding the molecular basis of rabbit meat quality is essential for genetic improvement. We compared Sichuan White (S) and New Zealand White (N) rabbits using carcass phenotyping (<em>n</em> = 20), longissimus dorsi transcriptomics (<em>n</em> = 3), and 4D-DIA proteomics (<em>n</em> = 3). Differentially expressed genes (DEGs) were identified using |log₂FoldChange| ≥ 0.3693 and p &lt; 0.05, and differentially expressed proteins (DEPs) were determined using fold change ≥ 1.3 or ≤ 0.7692 and <em>p</em> &lt; 0.05. S rabbits exhibited lower drip loss and shear force but higher intramuscular fat (IMF) content, despite N rabbits displaying greater carcass yield. Integrated omics analysis revealed 848 differentially expressed genes and 140 differentially expressed proteins. The IMF accumulation in S rabbits was driven by upregulated lipid biosynthesis and suppressed fatty acid oxidation. Enrichment of oxidative phosphorylation and thermogenesis indicated enhanced mitochondrial coupling and redox balance, supporting water-holding capacity. Upregulation of ECM-related integrin β-subunits was correlated with improved tenderness. Sixty-eight KEGG pathways were co-enriched across omics layers, highlighting the interplay of lipid metabolism, mitochondrial function and ECM remodeling. Integrated transcriptomic and proteomic analyses revealed that upregulated lipid biosynthesis, suppressed fatty acid oxidation, and enhanced ECM–receptor signaling jointly contribute to superior meat quality in S rabbits. These findings provide candidate molecular targets for improving native rabbit meat quality and offer a foundation for future marker-assisted selection after validation in independent populations.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"12 ","pages":"Article 100340"},"PeriodicalIF":4.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyphenols in food and food wastes: Extraction, isolation, and health applications","authors":"Malthe Fredsgaard ,&nbsp;Andre Fussy ,&nbsp;Gowri Købke Nybo ,&nbsp;Jutta Papenbrock ,&nbsp;Laura Sini Sofia Hulkko ,&nbsp;Mina Dadjoo ,&nbsp;Tanmay Chaturvedi ,&nbsp;Mette Hedegaard Thomsen","doi":"10.1016/j.fochms.2025.100351","DOIUrl":"10.1016/j.fochms.2025.100351","url":null,"abstract":"<div><div>Despite decades of polyphenol research, an integrated perspective on their biosynthesis, advanced extraction methods from food wastes, and potential as versatile inhibitors of pathogenic proteins and enzymes, particularly incorporating modified drug-likeness criteria, remains elusive. This integrative review compares and analyzes data on emerging polyphenol extraction and processing methods from various sources, including fruits, vegetables, berries, food production byproducts, and terrestrial sources of biomass. The drug-likeness of the reviewed polyphenols was assessed via a modified Lipinski's rule of five, and their interactions with proteins and enzymes in pathogenic pathways were investigated. The hypothesis is that polyphenols derived from food wastes exhibit high versatility as potential ligands with promising inhibitory effects that mitigate cascading disease effects in the human body. Therefore, the inhibition of proteins and enzymes involved in a wide range of diseases, including cancers, inflammatory diseases, diabetes and obesity, cardiovascular diseases, and mental and neurological disorders, was explored. Furthermore, the multifaceted nature of food and food waste-derived polyphenols was emphasized, highlighting their potential as extractable compounds with broad health-related applications. These novel insights enable targeted valorization of food wastes for personalized nutraceuticals, promote sustainable bioprocessing, and pave the way for clinical translation.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"12 ","pages":"Article 100351"},"PeriodicalIF":4.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}