Dingwu Qu , Yurong Wang , Lubo Cao , Qiangchuan Hou , Zhongjun Liu , Ji'an Zhong , Zhuang Guo
{"title":"Combined microbiome and metabolome analysis of Dacha and Ercha fermented grains of Fen-flavor Baijiu","authors":"Dingwu Qu , Yurong Wang , Lubo Cao , Qiangchuan Hou , Zhongjun Liu , Ji'an Zhong , Zhuang Guo","doi":"10.1016/j.fochms.2025.100298","DOIUrl":"10.1016/j.fochms.2025.100298","url":null,"abstract":"<div><div>Fen-flavor Baijiu is produced via two fermentation rounds (Dacha and Ercha), and quality is shaped by microbes in fermented grains. We hypothesized that the two rounds select distinct lactic acid bacteria (LAB) consortia with different metabolic potentials that associate with stage-specific metabolites and flavor compounds. We profiled 24 fermented-grain samples using shotgun metagenomics and untargeted metabolomics. Ercha showed lower alpha-diversity and a composition distinct from Dacha. <em>Lactobacillus acetotolerans</em> dominated Dacha, whereas <em>Acetilactobacillus jinshanensis</em> dominated Ercha. We detected 225 differential metabolites; 12 involved in flavonoid biosynthesis were higher in Dacha, while pyrimidine metabolism was more prominent in Ercha. Several LAB species—including L. <em>acetotolerans</em>, <em>Lentilactobacillus hilgardii</em>, <em>Lactobacillus amylovorus</em>, and <em>Lactobacillus amylolyticus</em>—showed positive correlations with these flavonoids. Genes encoding L-lactate dehydrogenase and acetate kinase were mainly carried by L. <em>acetotolerans</em> and associated with acetic acid and ethyl acetate in fermented grains. These outcomes supported our hypothesis and suggested actionable levers for production: stage-targeted monitoring of marker taxa/genes and rational starter design to steer flavor formation in Fen-flavor Baijiu.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"11 ","pages":"Article 100298"},"PeriodicalIF":4.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hong Xu , Xueting Bi , Junjie Xing , Mengqian Guo , Haoran Zhang , Xuejie Zhang , Wei Li , Bingfu Lei
{"title":"Regulatory role of calcium sulfide in ripening delay of postharvest bananas","authors":"Hong Xu , Xueting Bi , Junjie Xing , Mengqian Guo , Haoran Zhang , Xuejie Zhang , Wei Li , Bingfu Lei","doi":"10.1016/j.fochms.2025.100297","DOIUrl":"10.1016/j.fochms.2025.100297","url":null,"abstract":"<div><div>Hydrogen sulfide (H₂S) has been demonstrated to delay ripening and senescence in various fruits, offering great capability for postharvest preservation. However, existing application methods face several limitations, such as unstable release, difficulty in dosage control, and safety concerns, and its regulatory mechanisms in fruit systems remain unclear. In this study, calcium sulfide (CaS) was used as a slow-release H₂S donor that gradually releases H₂S through reactions with airborne moisture and carbon dioxide to treat bananas. CaS treatment significantly downregulated key ethylene biosynthetic genes and corresponding enzymes (ACO and ACS), thereby reducing ethylene production. The expression of starch-degrading and cell wall-modifying genes was also suppressed, delaying starch breakdown and cell wall disassembly. Enzyme assays and transcriptomic analyses confirmed that CaS delays banana ripening through coordinated regulation at both transcriptional and biochemical levels. As a result, CaS treatment effectively extended shelf life and maintained fruit quality of bananas. These findings reveal the potential of CaS as a novel H₂S-releasing agent for postharvest preservation.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"11 ","pages":"Article 100297"},"PeriodicalIF":4.7,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haijie Huang , Li Zhao , Weijian Huang , Xuejie Feng , Fuchu Hu , Ya Zhao , Huiliang Li , Yunlu Peng , Yuhan Wang , Zhongrun Zhang , Yijun Liu
{"title":"Deciphering the metabolic patterns of cashew apple ripening process: A comprehensive non-targeted metabolomics analysis","authors":"Haijie Huang , Li Zhao , Weijian Huang , Xuejie Feng , Fuchu Hu , Ya Zhao , Huiliang Li , Yunlu Peng , Yuhan Wang , Zhongrun Zhang , Yijun Liu","doi":"10.1016/j.fochms.2025.100296","DOIUrl":"10.1016/j.fochms.2025.100296","url":null,"abstract":"<div><div>Metabolite changes during the ripening process of cashew apples are crucial for their quality development. A total of 2379 metabolites were isolated and identified from fresh cashew apples at four different ripening stages using UHPLC-MS. Metabolite set enrichment analysis (MSEA) revealed that the differential metabolites in CA2_vs_CA1, CA3_vs_CA2, and CA4_vs_CA3 comparisons were mainly enriched in amino acids and peptides, steroids, pyrimidines, and fatty acids and conjugates, etc. Volcano plot analysis identified 631, 384, and 392 upregulated metabolites, and 625, 923, and 392 downregulated metabolites in CA2_vs_CA1, CA3_vs_CA2, and CA4_vs_CA3 comparisons, respectively. KEGG pathway enrichment analysis demonstrated that these differential metabolites were primarily involved in aminoacyl-tRNA biosynthesis, purine metabolism, and glycine, etc. Notably, the differential metabolites in CA4_vs_CA3 showed the highest enrichment in <span>d</span>-glutamine and D-glutamate metabolism, as well as phenylalanine. The metabolic profile of cashew apples revealed stage-specific patterns during ripening, offering key insights for optimizing harvest, storage, and processing.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"11 ","pages":"Article 100296"},"PeriodicalIF":4.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Proteomic changes associated with health benefit properties in fresh and preserved mustard greens","authors":"Charanya Saekampang , Vipawan Pimpak , Poowadol Promwat , Pongsakorn Kruaweangmol , Narumon Phaonakrop , Sittiruk Roytrakul , Ulaiwan Withayagiat , Paiboon Tunsagool","doi":"10.1016/j.fochms.2025.100295","DOIUrl":"10.1016/j.fochms.2025.100295","url":null,"abstract":"<div><h3>Background</h3><div>Mustard greens are gaining global popularity, but preservation methods like salting and pickling raise specific concerns related to high sodium content and microbial safety. This study conducted a proteomics analysis to identify health-beneficial proteins in mustard greens.</div></div><div><h3>Objective</h3><div>To explore protein profiles associated with health benefits in fresh and preserved mustard greens.</div></div><div><h3>Methods</h3><div>Shotgun proteomics combined with LC-MS/MS was applied to identify proteins, followed by statistical analysis using Welch's <em>t</em>-test with Benjamini–Hochberg false discovery rate correction. Unique proteins were visualized with a Venn diagram, annotated using the Gene Ontology (GO) database, and mapped to functional categories with Sankey diagrams. In silico validation of protein stability and gastrointestinal digestion was performed to assess the release of bioactive peptides.</div></div><div><h3>Results</h3><div>A total of 118 high-confidence proteins were identified, including 27 unique to fresh, 23 to salted, and 22 to pickled mustard greens. Unique proteins in fresh mustard greens were associated with carbohydrate, amino acid, and nucleotide metabolism. Pickled mustard greens had proteins linked to carbohydrate, lipid, glycerol, vitamin, and cofactor metabolism, while salted mustard greens had proteins involved in amino acid, nucleotide, lipid, and glycerol metabolism. In silico digestion revealed that approximately 19–20 % of peptide fragments contained bioactive motifs, predominantly angiotensin-converting enzyme (ACE) and dipeptidyl peptidase-IV (DPP-IV) inhibitory sequences.</div></div><div><h3>Conclusion</h3><div>Preserved mustard greens contain unique proteins associated with health benefits based on GO annotations, distinguishing their protein profiles from fresh mustard greens. This study provides insights into their functional properties, addressing concerns related to their consumption.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"11 ","pages":"Article 100295"},"PeriodicalIF":4.7,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144911971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative analysis of curcuminoid content, antioxidant capacity, and target-specific molecular docking of turmeric extracts sourced from Thailand","authors":"Shisanupong Anukanon , Komgrit Saeng-ngoen , Yawanart Ngamnon , Ngamnetr Rapan , Weerasak Seelarat , Pannraphat Takolpuckdee , Nisa Pakvilai , Yaiprae Chatree","doi":"10.1016/j.fochms.2025.100291","DOIUrl":"10.1016/j.fochms.2025.100291","url":null,"abstract":"<div><div>Curcuminoids are the active compounds richest in turmeric rhizomes (<em>Curcuma longa</em> L.), comprising curcumin I, demethoxycurcumin (curcumin II), and bisdemethoxycurcumin (curcumin III). This study hypothesized that particular curcumin derivatives could mitigate oxidative stress and inflammation response by targeting specific inflammatory mediators. Therefore, this study aimed to quantify the concentrations of these curcuminoid forms in local turmeric extracts from Thailand. Subsequently, the study analyzed their <em>in vitro</em> antioxidant properties, alongside molecular docking and dynamics simulations targeting key oxidative stress- and inflammation-related proteins. Samples were collected from three representative cultivated areas in Thailand: the eastern, southern, and northern regions. The ethanolic extracts from all samples exhibited relatively high total curcuminoid content (eastern: 15.1 %, southern: 25.9 %, and northern: 31.6 % <em>w</em>/w in extract), as determined by high-performance liquid chromatography. Curcumin I emerged as the predominant variant, followed closely by curcumin II and III. The ethanolic extracts from the three cultural areas demonstrated significant antioxidant activity, as assessed by ORAC, FRAP, and DPPH assays. Among the three curcuminoids, curcumin III exhibited the strongest predicted binding affinities in molecular docking studies toward antioxidant and anti-inflammatory targets, including 5-LOX, NRF2, IKK1, NF-κB, and NOX4. Molecular dynamics simulations corroborated these findings, revealing that curcumin III formed the most stable complexes, particularly with IKK1, as indicated by low RMSD values (2–3 Å), and high hydrogen bond occupancy. Thus, curcumin III exhibits potential <em>in silico</em> inhibition of inflammatory mediators, supporting its promise as a natural compound for antioxidant and anti-inflammatory nutraceutical development.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"11 ","pages":"Article 100291"},"PeriodicalIF":4.7,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144911849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genetic and chemical analysis of olive oil produced by Greek olive cultivars: Linking genetic profiles with fatty acid composition and phenolic stability","authors":"Annia Tsolakou , Kostas Ioannidis , Sofia Lymperopoulou , Panagiotis Diamantakos , Georgios Kostelenos , Eleni Melliou , Prokopios Magiatis","doi":"10.1016/j.fochms.2025.100292","DOIUrl":"10.1016/j.fochms.2025.100292","url":null,"abstract":"<div><div>This pilot study explores the relationship between the genetic profiles of olive cultivars and monounsaturated fatty acid (MUFA) content of their oils, with emphasis on oxidative stability and phenolic integrity. Our working hypothesis was that cultivar-specific genetic variation in MUFA content, directly affects the oxidative stability of key phenolics, particularly oleocanthal and oleacein. To examine the association between genetic clustering and oleic acid content, eighty Greek olive cultivars cultivated under controlled nursery conditions were genotyped using eleven genomic simple sequence repeat (SSR) markers, and their fatty acid composition was determined by <sup>1</sup>H NMR. Phenolic stability was tested using oils with contrasting MUFA levels. Genetic analysis identified three clusters. Chemical cluster analysis, by dividing cultivars into three MUFA classes, revealed significant differences among divisions. Linking genetic and lipid profile groups highlighted notable overlap. This study reveals a clear experimental association between MUFA abundance in the olive matrix and its capacity to preserve phenolic integrity. By confirming the role of MUFA content in phenolic stability, our results provide a baseline reference for early-stage cultivar selection and for future breeding programs targeting enhanced olive oil quality.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"11 ","pages":"Article 100292"},"PeriodicalIF":4.7,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Omics landscapes in molecular mechanisms with Amomum tsaoko as an example","authors":"Dengke Fu , Yuanzhong Wang , Jinyu Zhang","doi":"10.1016/j.fochms.2025.100294","DOIUrl":"10.1016/j.fochms.2025.100294","url":null,"abstract":"<div><div>To improve the quality and efficiency of cultivating <em>Amomum tsaoko</em> (AT), a non-model plant, it is crucial to understand the intrinsic molecular mechanisms underlying its growth. This review summarizes the significance of multi-omics in the study of plant molecular mechanisms and illustrates how multi-omics technology can solve the practical problems of non-model plants using AT as an example. In this review, we argue that nonlinear dimensionality reduction is more suitable for data organization in multi-omics because it is compatible with the nonlinear relationship between the components of systems biology. Subsequently, researchers have verified the strong vitality of multi-omics from three perspectives: the natural communication, breeding, and shade tolerance mechanisms of AT. Finally, we summarized some of the current commonly used plant genome databases and analyzed their utility for such research. We believe that our study makes a significant contribution to the literature because this review summarizes the multi-omics research process in detail, from data processing to application to the use of public databases, and illustrates the potential for the application of multi-omics with the example of a non-model plant, AT.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"11 ","pages":"Article 100294"},"PeriodicalIF":4.7,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144911950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiajia Wang , Jiayu Liao , Kaisen Zhao , Na Shen , Yulin Xu , Jie Wang , Xianbo Jia , Wenqiang Sun , Songjia Lai
{"title":"Integrated multi-omics reveals potential regulatory mechanisms of meat quality","authors":"Jiajia Wang , Jiayu Liao , Kaisen Zhao , Na Shen , Yulin Xu , Jie Wang , Xianbo Jia , Wenqiang Sun , Songjia Lai","doi":"10.1016/j.fochms.2025.100293","DOIUrl":"10.1016/j.fochms.2025.100293","url":null,"abstract":"<div><div>We hypothesized that the differences in meat quality stem from breed-specific regulation of muscle metabolic pathways. To explore the molecular mechanisms underlying meat quality differences between Liangshan cattle and Simmental crossbred cattle, we conducted metabolomic and transcriptomic analyses of the <em>longissimus dorsi</em>. Metabolomics revealed that Liangshan cattle exhibited higher <span>l</span>-carnitine levels, which may contribute to enhanced energy metabolism and improved meat quality, as well as a more favorable fatty acid composition. Integrated transcriptomic and metabolomic analysis suggested potential regulatory mechanisms: <em>FASN</em> may enhance fat deposition and tenderness by promoting butanoyl-CoA biosynthesis. Additionally, <em>ALDOC</em>, <em>PFKL</em>, <em>PGAM1</em>, and <em>SDS</em> may modulate citrulline metabolic flux, thereby influencing protein synthesis and promoting lipogenesis. These findings support our hypothesis by clarifying how coordinated gene–metabolite interactions influence meat quality. A potential regulatory model for the genetic-metabolic interaction of beef quality was established, providing a candidate framework for molecular breeding targeting beef quality traits.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"11 ","pages":"Article 100293"},"PeriodicalIF":4.7,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haoran Shen , Hong Quan , Yixi Cai , Yazhou Lu , Peiyao Yu , Xiaozhong Lan , Xinbo Guo
{"title":"The potential regulation mechanism of lily extracts responds to AAPH induced oxidative stress in zebrafish","authors":"Haoran Shen , Hong Quan , Yixi Cai , Yazhou Lu , Peiyao Yu , Xiaozhong Lan , Xinbo Guo","doi":"10.1016/j.fochms.2025.100290","DOIUrl":"10.1016/j.fochms.2025.100290","url":null,"abstract":"<div><div>This study investigated the antioxidant capacity and molecular mechanisms of lily bulb polyphenols using zebrafish (<em>Danio rerio</em>) embryos subjected to AAPH-induced oxidative stress. Two extraction methods—cold (CE) and hot (HE) water extraction—were compared. HE exhibited significantly higher total phenolic content (31 ± 4 %, <em>p</em> < 0.05) and polyphenol abundance (9.8 ± 0.6-fold increase, <em>p</em> < 0.05), particularly regaloside A and <em>p-</em>coumaric acid, than CE. Heat-assisted extraction of lily bulbs liberated more polyphenols (both in terms of content and variety), which translated into measurably greater antioxidant protection in vivo. In vivo assays revealed that both extracts improved embryo survival, restored SOD activity, and reduced ROS accumulation, lipid peroxidation, and cell death, with HE demonstrating superior efficacy. Mechanistically, regaloside A and <em>p-</em>coumaric acid reversed AAPH-induced dysregulation of key oxidative stress-related genes. Specifically, they downregulated <em>keap1a</em>, <em>rela</em>, <em>erk2</em>, and <em>p38</em> expression while restoring <em>nrf2</em>, <em>sod1</em>, and <em>sod2</em> levels, indicating modulation of Nrf2, NF-κB, and MAPK pathways. The data support the hypothesis that heating increases polyphenol yield and that lily polyphenols exert antioxidant effects via the stated pathways. These findings provide a mechanistic basis for developing lily-based antioxidant ingredients for functional foods.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"11 ","pages":"Article 100290"},"PeriodicalIF":4.7,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144911969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Targeted metabolomic and transcriptomic reveal the regulatory network of ultrasound on polyphenol biosynthesis in tender coconut flesh during storage","authors":"Cheng Fang , Xie Huang , Yanpei Huang , Ming Zhang , Haiming Chen , Weijun Chen , Qiuping Zhong , Jianfei Pei , Ying Lv , Rongrong He , Wenxue Chen","doi":"10.1016/j.fochms.2025.100289","DOIUrl":"10.1016/j.fochms.2025.100289","url":null,"abstract":"<div><div>Coconut flesh, the solid endosperm, of coconut, which is rich in fat, protein and polyphenols. To investigate the impact of ultrasound treatment on the biosynthesis of polyphenols in tender coconut flesh during storage, the targeted metabolomic and transcriptomic analyses were employed. A total of 36 phenolic compounds were identified, of which catechin, epicatechin, gossypol and vanillic acid were the most abundant ones in ‘Hainan Tall’ coconut flesh. Ultrasound treatment maintained the levels of syringic acid, catechin and epicatechin, while suppressing the expression of most associated genes. Correlation analysis revealed that, downregulation expressions of <em>FLS</em>, <em>4CL2</em>, <em>F3′5′H</em>, <em>CHS2</em> and <em>CHS3</em> decreased kaempferol, isoliquiritigenin and luteoloside content but increased catechin content. Furthermore, downregulation of <em>CSE</em>, <em>DFR</em> and <em>CHI</em> reduced contents of luteolin, whereas downregulation of <em>LAR</em> and <em>ANS</em> elevated the contents of catechin and epicatechin. Unraveling the effect of ultrasound on phenolic biosynthesis in the tender coconut flesh at metabolite and transcript levels provides technical and theoretical support for the high-value development and utilization of Hainan coconut resources.</div></div>","PeriodicalId":34477,"journal":{"name":"Food Chemistry Molecular Sciences","volume":"11 ","pages":"Article 100289"},"PeriodicalIF":4.7,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}