Endocrine and Metabolic Science最新文献

{"title":"A comparative study between metformin and insulin on biochemical variables in diabetic patients","authors":"Maha Elttayef Jasim ,&nbsp;Noor Essam Abdul-Razzaq","doi":"10.1016/j.endmts.2024.100206","DOIUrl":"10.1016/j.endmts.2024.100206","url":null,"abstract":"<div><div>Diabetes mellitus is a chronic metabolic disorder characterized by high blood sugar levels due to inadequate insulin production or inefficient use of insulin by the body's cells. It poses significant health risks, including cardiovascular disease and kidney damage, affecting millions worldwide. Management involves careful monitoring of blood glucose levels, lifestyle modifications, and sometimes insulin therapy to maintain optimal health.so Metformin is a widely prescribed oral medication used to manage type 2 diabetes by improving insulin sensitivity.</div><div>The study was conducted in the period from February to March 2023, where a blood sample was collected from males aged from 30 to 50 years. The samples were divided into 15 healthy people as control, 12 samples with diabetes type 2, 12 samples with diabetes type 2 who are treated with metformin, and 12 samples with diabetes type 2 who are treated with insulin injections. The samples were separated in a centrifuge at 4000 rpm, then divided to 10 fractions and stored in the freezer until biochemical tests were performed for the study.</div><div>The results showed A significant increase at Glucose and HbA1C in all groups compared with control. So total cholesterol and low density lipoprotein decrease in diabetic and treatment with insulin injections compared all groups, triglycerides and very low density lipoprotein increase in all diabetic groups compared with control. Alanin trans aminase showed decrease value in diabetic group and treatment with insulin injections compared with all groups but aspartate trans aminase showed result opposite.</div></div><div><h3>Aim of study</h3><div>Since diabetes is a chronic disease, it is necessary to know the effects of the most famous treatments taken by diabetics, which are metformin and insulin, on the lipid profile and liver and kidney functions.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100206"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of thyroid dysfunction among pregnant women in the horn of Africa: A systematic review and Meta-analysis","authors":"Marye Nigatie ,&nbsp;Getinet Kumie ,&nbsp;Abdu Jemal ,&nbsp;Solomon Gedfie ,&nbsp;Woldeteklehaymanot Kassahun ,&nbsp;Muluken Gashaw ,&nbsp;Agenagnew Ashagre ,&nbsp;Tadesse Misganaw ,&nbsp;Wagaw Abebe ,&nbsp;Ermias Getachew ,&nbsp;Selamyhun Tadesse ,&nbsp;Zelalem Dejazmach ,&nbsp;Sisay Ayana ,&nbsp;Yalewayker Gashaw ,&nbsp;Zelalem Asmare ,&nbsp;Assefa Sisay ,&nbsp;Atitegeb Abera ,&nbsp;Biruk Beletew Abate ,&nbsp;Melese Abate Reta","doi":"10.1016/j.endmts.2024.100200","DOIUrl":"10.1016/j.endmts.2024.100200","url":null,"abstract":"<div><h3>Background</h3><div>Thyroid dysfunction ranks among the most prevalent endocrine disorders. This disorder during pregnancy has been linked to adverse effects on both the mother and the baby. However, there is a scarcity of data and inconsistent documentation regarding thyroid issues in pregnant women in low-income nations.</div></div><div><h3>Objective</h3><div>The aim of this systematic review and meta-analysis was to determine the general prevalence of thyroid disorders in pregnant women.</div></div><div><h3>Methods</h3><div>To identify relevant studies, a comprehensive search was conducted across Scopus, PubMed, Science Direct databases, and Google Scholar and repository registers from January 1, 2000 to December 31, 2023. Ten pertinent publications were chosen for the final meta-analysis. Relevant data was extracted using Microsoft Excel and analyzed using STATA software version 17, employing a random-effect model. Sensitivity analysis was conducted to evaluate each study's impact on the outcome, and Egger's test was utilized to detect publication bias. A trim-and-fill analysis was executed to adjust for bias in the effect estimate. Heterogeneity across studies was assessed using Cochran's Q statistic and I² statistics. Subgroup analysis was carried by study design, country and publication year.</div></div><div><h3>Results</h3><div>In this systematic review and meta-analysis, the prevalence of thyroid dysfunction among 2538 pregnant women was 12.0 % (95 % CI: 8.00 %–17.00 %). To account for the significant heterogeneity observed, a random effect model was utilized. Specifically, the prevalence of hypothyroidism in pregnant women was determined to be 10.00 % (95 % CI: 4.00–16.00 %) with a high level of heterogeneity (I² = 94.27 %, <em>p</em> &lt; 0.001). Notably, the sensitivity analysis conducted did not reveal any substantial impact on the overall pooled prevalence of thyroid dysfunction.</div></div><div><h3>Conclusion</h3><div>The meta-analysis revealed a significantly higher rate of thyroid disorders among pregnant women compared to global estimates. To assess the effects of treating thyroid conditions on pregnancy outcomes and inform clinical decisions, it is recommended to implement cost-effective thyroid-stimulating hormone screening during pregnancy.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100200"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet activation and inflammation in transgender women using hormone therapy","authors":"Lieve Mees van Zijverden ,&nbsp;Moya Henriëtte Schutte ,&nbsp;Marieke Tebbens ,&nbsp;Milou Cecilia Madsen ,&nbsp;Jeske Joanna Katarina van Diemen ,&nbsp;Chantal Maria Wiepjes ,&nbsp;Martin den Heijer ,&nbsp;Abel Thijs","doi":"10.1016/j.endmts.2024.100201","DOIUrl":"10.1016/j.endmts.2024.100201","url":null,"abstract":"<div><h3>Objective</h3><div>The pathophysiological process behind the increased risk of cardiovascular disease (CVD) in transgender women remains to be elucidated. This exploratory study aimed to investigate whether changes in platelet activation and inflammation after the start of feminizing gender-affirming hormone therapy (GAHT) could be a contributing mechanism.</div></div><div><h3>Design</h3><div>Longitudinal cohort study.</div></div><div><h3>Methods</h3><div>Venous blood was collected from 17 transgender women at 0, 12 and 52 weeks after GAHT initiation, consisting of estradiol and testosterone suppression. Platelet activation markers plasma thromboxane B2, Closure Time, CD63, CD62p, platelet-leukocyte complexes and immature platelet fraction were measured. CRP and 11 cytokines were measured as inflammation markers.</div></div><div><h3>Results</h3><div>CD63, CD62p and platelet-leukocyte complexes tended to increase after 12 weeks of GAHT. After 52 weeks, all platelet activation markers showed anti-aggregatory changes. Eight out twelve inflammation markers exhibited a decreasing tendency at week 12. Equivalently, after 52 weeks, eight inflammation markers tended to decrease, seven of which had also exhibited a decrease at week 12.</div></div><div><h3>Conclusions</h3><div>The collective findings suggest that platelet activation fluctuates during feminizing GAHT, exhibiting an initial increase followed by a decrease. Additionally, inflammation markers tend to decrease. Within the scope of this study, we could not identify GAHT induced platelet activation as a definite contributing factor in the increased risk of CVD in transgender women. Studies with larger numbers of participants and longer follow-up duration are needed to further investigate the effect of feminizing gender-affirming hormone therapy on platelet activation and inflammation.</div></div><div><h3>Trial registration</h3><div>EudraCT #2017-003072-31.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100201"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute and prolonged ketosis lower serum IGF-I levels in human subjects","authors":"Mads Svart ,&nbsp;Alisa D. Kjaergaard ,&nbsp;Thien Vinh Luong ,&nbsp;Lars C. Gormsen ,&nbsp;Niels Møller ,&nbsp;Jens Otto L. Jørgensen ,&nbsp;Esben Søndergaard","doi":"10.1016/j.endmts.2024.100207","DOIUrl":"10.1016/j.endmts.2024.100207","url":null,"abstract":"<div><h3>Objective</h3><div>Metabolic health and longevity are influenced by numerous factors including the growth hormone (GH) – insulin-like growth factor I (IGF<img>I) axis and ketone bodies (KB). However, data on the impact of KB exposure on GH and IGF-I levels are few.</div></div><div><h3>Design and patients</h3><div>To investigate the effect of acute and chronic KB exposure on GH and IGF-I levels in human subjects. GH and IGF-I levels were measured in three human studies: i) After a single oral ingestion of KB (36.5 g of Na-D/L-βOHB) vs. placebo in six healthy individuals; ii): after a three-week isocaloric ketogenic diet (KD) compared to a standard diet (SD) in 11 overweight individuals; and iii) in a genetic predisposition study using the specific genetic variants in the SCOT gene (rs7712274 and rs7728482), which is associated with ketonuria.</div></div><div><h3>Results</h3><div>A single oral KB ingestion significantly lowered serum IGF-I with 33 ng/ml (KB ingestion) vs 15 ng/ml (placebo), <em>P</em> = 0.01. Ketogenic diet significantly lowered serum IGF-I levels 111 ng/ml (KD) vs 125 ng/ml (SD), P = 0.01 in combination with a two-fold increase in serum GH 0.9 ng/ml to 1.8 ng/ml (KD) compared to 0.9 ng/ml to 0.4 ng/ml (SD), <em>P</em> = 0.03. Individuals with genetic predisposition to ketonuria had lower levels of IGF-I (β = −0.0068, SE = 0.0029, <em>P</em> = 0.02).</div></div><div><h3>Conclusions</h3><div>KB exposure is associated with reduced serum IGF-I levels in the presence of non-suppressed or elevated GH levels. This observation points to a suppressive effect of KB on hepatic IGF-I production. The association between genetic predisposition to ketonuria and increased body size is unexpected and deserves further investigations.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100207"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and temporal trends of anemia in patients with thyroid disease: 1999–2018 NHANES","authors":"Juan Liu,&nbsp;Xin Wang,&nbsp;Liping Huang,&nbsp;Yanqiu Li,&nbsp;Mingliang Chen","doi":"10.1016/j.endmts.2024.100198","DOIUrl":"10.1016/j.endmts.2024.100198","url":null,"abstract":"<div><h3>Background</h3><div>Anemia and thyroid disease, both prevalent health conditions, often co-occur and may be easily overlooked, collectively imposing a significant burden on society. This study specifically investigated the prevalence and temporal trends of anemia among individuals with thyroid disease in the US population, shedding light on a critical intersection in public health.</div></div><div><h3>Methods</h3><div>Utilizing National Health and Nutrition Examination data from 10 survey cycles (1999<strong>–</strong>2018), this study included participants aged 20<strong>–</strong>85 years who self-reported a diagnosis of thyroid disease. Anemia was defined with a cutoff of 12 g/dL for women and 13 g/dL for men. The chi-square test compared prevalence across different categories and survey cycles. Data analysis employed R 4.3.2, with <em>P</em> &lt; 0.05 considered statistically significant.</div></div><div><h3>Results</h3><div>The median hemoglobin level among all individuals with thyroid disease was 13.6 g/dL. The overall prevalence of anemia among the US thyroid disease patients was 12.00 % (95 % CI: 10.96–13.09). A noteworthy upward trend in the prevalence of anemia among thyroid disease patients occurred during 1999<strong>–</strong>2008 (9.58 %, 95 % CI: 8.14<strong>–</strong>11.18) and 2009<strong>–</strong>2018 (13.68 %, 95 % CI: 12.26<strong>–</strong>15.21). Anemia incidence in individuals with thyroid disease was higher in females (9.05 %, 95 % CI: 8.14<strong>–</strong>10.02), the elderly population (7.98 %, 95 % CI: 7.12<strong>–</strong>8.91), individuals living alone (5.96 %, 95 % CI: 5.21<strong>–</strong>6.77), those with high body mass index (5.38 %, 95 % CI: 4.67<strong>–</strong>6.17), and non-Hispanic Whites (5.33 %, 95 % CI: 4.62<strong>–</strong>6.11).</div></div><div><h3>Conclusions</h3><div>The prevalence of anemia in the US population with thyroid disease was 12 %, indicating an increase over the past few decades.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100198"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term diabetic hyperglycaemia modifies social behaviour in rats","authors":"Justine Renaud ,&nbsp;Alexandre Clouet ,&nbsp;Giulia Costa ,&nbsp;Jimmy Beaulieu ,&nbsp;Domenico Sergi ,&nbsp;Maria-Grazia Martinoli","doi":"10.1016/j.endmts.2024.100197","DOIUrl":"10.1016/j.endmts.2024.100197","url":null,"abstract":"<div><div>Diabetes is a known risk factor for cognitive decline and mood disorders. However, the effects of long-term diabetic hyperglycaemia on the various dimensions of social behaviours, such as play or aggression, remains to be fully elucidated. In this study, we evaluated the social behaviour in a nicotinamide-streptozotocin rat model of long-term diabetic hyperglycaemia, in the absence of glucose-lowering treatments. Five months following induction of hyperglycaemia, we scored affiliative/exploratory or aggressive social interactions between pairs of unacquainted rats in a neutral arena. Our results demonstrate alterations in the behaviour of long-term diabetic rats faced with social novelties. Specifically, diabetic hyperglycaemic rats engaged in hyper-sociable and hyper-aggressive encounters. Interestingly, social interactivity was not associated with the degree of hyperglycaemia in affiliative/exploratory or in aggressive social interactions, in our long-term diabetic rat model. Altogether, our data suggest a lack of social appropriateness in long-term diabetic hyperglycaemic rats which is independent of the degree of hyperglycaemia. These findings support the importance of a tight glycaemic control in the management of diabetes at every stage of the disease and enlighten the importance of impaired glycaemic control as a novel metabolic player impacting the neural networks of social behaviours.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100197"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium nanoparticles from Corchorus olitorius corrects polycystic ovarian syndrome by inhibition of hormonal imbalance, aromatase and cellular inflammation via hypothalamic-ovarian axis in female rat","authors":"T.E. Akintola ,&nbsp;J.K. Akintunde ,&nbsp;O.E. Eteng ,&nbsp;F.C. Thomas ,&nbsp;J.T. Adeleke","doi":"10.1016/j.endmts.2024.100202","DOIUrl":"10.1016/j.endmts.2024.100202","url":null,"abstract":"<div><h3>Purpose</h3><div>Women of fertile age are affected by an endocrine disorder called polycystic ovarian syndrome (PCOS) and is typified by polycystic ovaries, hyperandrogenism, and irregular menstruation. Because of their ability to pass through cellular barriers, nanodrugs have recently been recommended as a treatment for a number of disorders. Thus, the purpose of this study was to evaluate the efficacy of synthetized selenium nanoparticles from <em>Corchorus olitorius</em> leaves (CO-SeNPs) against hypertension coexisting with PCOS.</div></div><div><h3>Methods</h3><div>There were nine groups consisting of Control, Letrozole, L-NAME, Letrozole + L-NAME, Letrozole + CO-SeNPs, L-NAME + CO-SeNPs, Letrozole + L-NAME + CO-SeNPs, Letrozole + metformin, CO-SeNPs only. Letrozole and L-NAME were used to induce hypertension and PCOS for 21 and 14 days, respectively. The estrus cycle was monitored and animals were sacrificed after 35 days.</div></div><div><h3>Result</h3><div>The findings demonstrated that while letrozole and L-NAME decreased estrogen and progesterone levels, they significantly increased luteinizing hormone, follicle stimulating hormone, testosterone, aromatase, and 17β-hydroxysteroid dehydrogenase levels. Furthermore, in the hypothalamus, ovary, and uterine of rats with hypertensive PCOS, there was a substantial rise in tumor necrosis factor-α and monocyte chemoattractant protein-1, but a significant drop in Nrf-2.</div></div><div><h3>Conclusion</h3><div>By lowering neuroendocrine hormones and steroidogenic enzymes, CO-SeNPs therapy reduced hypertension and PCOS.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100202"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiologic pattern and factors associated with adverse outcomes of diabetic ketoacidosis in medical intensive care units of a tertiary care centre in India","authors":"Shubhadeep Paul ,&nbsp;Sourav Debnath ,&nbsp;Anurag Kumar Singh ,&nbsp;Shivang Mishra ,&nbsp;Sumit Rajotiya ,&nbsp;Mahaveer Singh ,&nbsp;Rahul Parashar ,&nbsp;Pusparghya Pal ,&nbsp;Sachin Kumar","doi":"10.1016/j.endmts.2024.100204","DOIUrl":"10.1016/j.endmts.2024.100204","url":null,"abstract":"<div><h3>Aim</h3><div>Diabetic ketoacidosis (DKA) is a dreadful complication of diabetes mellitus characterized by a biochemical triad of hyperglycemia, ketosis, and metabolic acidosis. The clinic-epidemiologic pattern and outcomes of DKA in the Indian subcontinent are largely unexplored, yet understanding them is crucial for optimizing management strategies.</div></div><div><h3>Methods</h3><div>A total of 138 patients admitted with a DKA diagnosis were reviewed retrospectively over two years. Patient demographics, clinical history, laboratory findings, precipitating factors, and intensive care management were extracted from case files. Clinical outcomes were classified as either discharge or death. Data analysis was performed using SPSSv29.</div></div><div><h3>Results</h3><div>The mean age of the patients was 41.54 (16) years; 77 (55.79 %) were female, 56.52 % had type 1, 23.19 % had type 2, and 20.29 % had pancreatic diabetes. Non-compliance with infection (21.02 %), and pancreatitis (21.01 %) were common DKA triggers. Severity was assessed by pH, anion gap, and bicarbonate levels. The overall mortality rate was 11.59 %. Factors significantly associated with mortality included age &gt;60 years, &gt;3 previous DKA episodes, hypokalaemia, elevated serum creatinine, and altered sensorium.</div></div><div><h3>Conclusion</h3><div>These findings emphasize the importance of demographics and risk factors in assessing DKA mortality risk, aiding early identification and targeted interventions for high-risk patients.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100204"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increase of serum vitamin D levels in the COVID-19 pandemic: Report of a Mexican reference clinical laboratory","authors":"García-Alcalá Héctor ,&nbsp;Minutti-Zanella Claudia ,&nbsp;Orta-Flores Verónica ,&nbsp;López-Martínez Briceida","doi":"10.1016/j.endmts.2024.100199","DOIUrl":"10.1016/j.endmts.2024.100199","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic prompted health professionals to look for prevention and treatment options to improve outcomes. Vitamin D3 (VitD) is a sun dependent, immunomodulatory hormone that was widely used approaching COVID-19 because of previous experience with other RTIs. Its use was recommended in clinical practice guidelines and mainstream media, motivating supplement consumption. This increased the demand for serum VitD determinations, as well as the progressive increase of serum VitD levels.</div></div><div><h3>Objective</h3><div>Study the change in mean VitD serum levels in the population of one reference clinical laboratory before and during pandemic years.</div></div><div><h3>Methods</h3><div>We analyzed 65,481 results (78% female, mean age of 53.47 (M = 55, IQR = 25)).</div></div><div><h3>Results</h3><div>The median Vitamin D level was higher in all seasons in the pandemic years compared to previous years: spring 24 ng/dL (IQR 13.7) vs 25.4 ng/dL (IQR 17), summer 23.5 ng/dL (IQR 13.4) vs 24.2 ng/dL (IQR 16.3), autumn 23.7 ng/dL (IQR 14.3) vs 27 ng/dL (IQR 18.7), winter 22.4 ng/dL (IQR 14.9) vs 23.4 ng/dL (IQR 17.8).</div></div><div><h3>Conclusions</h3><div>The increase in serum VitD during the pandemic years is probably due to the recommendations of its use in guidelines of clinical practice. Although up to date the CDC and NIH have deemed there is not enough information in favor or against VitD use, epidemiology studies should be done to observe the impact of widespread VitD use in COVID-19 and other illnesses.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100199"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with quality of life and functional capacity in patients with diabetic foot in the Dominican Republic","authors":"Berniza Calderón ,&nbsp;Manuel Soto ,&nbsp;Alba Beltré","doi":"10.1016/j.endmts.2024.100203","DOIUrl":"10.1016/j.endmts.2024.100203","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the quality of life (QoL) and physical functioning of patients with diabetic foot (DF) and their associated factors.</div></div><div><h3>Methods</h3><div>120 participants with DF were recruited in 5 diabetic foot clinics in Dominican Republic. QoL and physical function were measured with the SF-36 and FAAM questionnaires respectively. Multiple linear regression models were used to determine the factors associated with each of the SF-36 and FAAM dimensions.</div></div><div><h3>Results</h3><div>The median scores for the SF-36's dimensions were: physical functioning 30 (Interquartile range [IQR]: 40), role limitations due to physical health 0 (IQR: 25), role limitations due to emotional problems 100 (IQR: 100), vitality 55 (IQR: 30), mental health 55 (IQR: 24), social functioning 50 (IQR: 50), bodily pain 45 (IQR: 47.5), general health 50 (IQR: 30). Median scores for the FAAM's activities of daily living and sports dimensions were 39.3 (IQR: 25.7) and 28.6 (IQR: 28.6) respectively. After multiple linear regression analysis, factors associated with lower SF-36 scores were advanced Wagner grade, smoking, unemployment, female sex, time to treatment, comorbidities and microvascular complications. Factors associated to lower FAAM scores were Wagner grade and living alone.</div></div><div><h3>Conclusion</h3><div>Patients with DF have poor QoL and physical function, with Wagner grade being the main associated factor. Attention should be given to prevention and opportune treatment. Studies that evaluate the impact of preventive and chronic disease management programs for DF are needed.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100203"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}