Endocrine and Metabolic Science最新文献

{"title":"Clinical significance of uric acid, blood pressure anticipating proteinuria worsening in pregnant women of advanced age","authors":"Hang Thi Thu Ho ,&nbsp;Thuan Hoa Nguyen ,&nbsp;Ha Hong Nguyen ,&nbsp;Sam Phan Hai Nguyen ,&nbsp;Kien Trung Nguyen","doi":"10.1016/j.endmts.2025.100273","DOIUrl":"10.1016/j.endmts.2025.100273","url":null,"abstract":"<div><h3>Background</h3><div>Women of advanced maternal age are considered a high-risk obstetric population. Increases in serum uric acid levels, body mass index, and blood pressure have been associated with a higher likelihood of developing proteinuria. However, data on the predictive value of these factors for proteinuria progression specifically in this population remain limited.</div></div><div><h3>Objectives</h3><div>To determine the optimal cutoff values of serum uric acid, body mass index, systolic blood pressure, and diastolic blood pressure in predicting the progression of proteinuria in pregnant women of advanced maternal age.</div></div><div><h3>Materials and methods</h3><div>This was a cross-sectional descriptive study with longitudinal follow-up conducted among pregnant women who attended the Obstetrics Department of Vinh Long General Hospital from November 2022 to October 2023. Advanced maternal age was defined as maternal age of 35 years or older. Proteinuria was considered elevated when the 24-h urinary protein level reached ≥300 mg after the 20th week of gestation.</div></div><div><h3>Results</h3><div>A total of 100 pregnant women were enrolled, with a mean age of 38.6 ± 4.7 years. The proportions of active smoking and alcohol consumption were 18.0 % and 20.0 %, respectively. Overweight and obesity (OR = 6.06; 95 % CI: 1.97–18.59), smoking (OR = 3.89; 95 % CI: 1.30–11.59), and alcohol use (OR = 3.14; 95 % CI: 1.08–9.11) were significantly associated with the development of proteinuria. A pre-pregnancy body mass index (BMI) cut-off of 22.5 kg/m² showed the highest predictive value for proteinuria progression, with an area under the ROC curve (AUC) of 0.89 (95 % CI: 0.81–0.98), sensitivity of 86.2 %, and specificity of 92.3 %. Serum uric acid (AUC = 0.88), systolic blood pressure (AUC = 0.81), and diastolic blood pressure (AUC = 0.80) also demonstrated strong predictive performance.</div></div><div><h3>Conclusion</h3><div>Overweight/obesity, smoking, and alcohol consumption were identified as risk factors for increased proteinuria. In addition, pre-pregnancy BMI, serum uric acid levels, systolic blood pressure, and diastolic blood pressure all demonstrated strong predictive value for proteinuria progression in pregnant women of advanced maternal age.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100273"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 diabetes mellitus and hyperglycemia among hospitalized COVID-19 patients: A single center study from Lebanon","authors":"Mohamad Fleifel ,&nbsp;Amal Al Zoghbi ,&nbsp;Jana Tabaja ,&nbsp;Andrew El Alam ,&nbsp;Khaled Abi Farraj ,&nbsp;Randa Al Zaatari ,&nbsp;Yara Skaff ,&nbsp;Rami Tabbikha ,&nbsp;Kamar Eid ,&nbsp;Rana Attieh ,&nbsp;Soha Bayda ,&nbsp;Wassim Assaad ,&nbsp;Dana El Masri ,&nbsp;Ali Al Dailaty ,&nbsp;Naya Fadel ,&nbsp;Nesrine Abi Saad ,&nbsp;Omar El Tarras ,&nbsp;Georges Namnoum ,&nbsp;Pascale Salameh ,&nbsp;Rola Husni-Samaha ,&nbsp;Jocelyn Eid Fares","doi":"10.1016/j.endmts.2025.100280","DOIUrl":"10.1016/j.endmts.2025.100280","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;The residual effects of coronavirus (CoV) disease 2019 (COVID-19) remains to this day as modern research continues to further investigate the disease. COVID-19 patients with diabetes mellitus (DM) seem to have a poorer prognosis overall. Lebanon's DM prevalence has been previously well described in the literature, and some studies have documented some of COVID-19's drastic morbidity and mortality in type 2 DM (T2DM) patients. As per our literature review, there has not been any study in Lebanon, which exclusively describes the state of T2DM and hyperglycemia among COVID-19 adult inpatients.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Aim&lt;/h3&gt;&lt;div&gt;To describe T2DM and hyperglycemia in relation to selected patients' clinical characteristics, paraclinical data, and mortality outcomes of COVID-19 pneumonia among patients admitted to the Lebanese American University Medical Center-Rizk Hospital (LAUMC-RH), a large tertiary care medical center in Beirut, Lebanon.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methodology&lt;/h3&gt;&lt;div&gt;This was an observational retrospective study of COVID-19 patients admitted to LAUMC-RH over a near course of 8 months. The eligible subjects were hospitalized adult (≥18 years old) male and nonpregnant female patients with COVID-19 pneumonia. The total eligible sample was 484 patients. All analyses were evaluated at 0.05 significance level. Cross tabulation of the results was done along with odds ratio when applicable. Cross tabulation of the results was done along with odds ratio when applicable. Multivariate analysis, survival analysis, and cox regression were also performed.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Among the admitted COVID-19 patients, 33.7 % had T2DM and 9.2 % of the DM patients had previously undiagnosed T2DM. Approximately 4.5 % of the COVID-19 patients had documented hypoglycemia, and 55 % had hyperglycemia. Comparing T2DM to non-T2DM patients, approximately 48.2 % of hypertension (HTN), 52.6 % of dyslipidemia (DL), and 58.9 % of coronary artery disease (CAD) COVID-19 patients had T2DM (&lt;em&gt;p&lt;/em&gt;-values &lt;0.05). Around 69.6 % of patients who remained between 5 and 10 days in the intensive care unit (ICU) had T2DM (p-value &lt;0.05). 36.8 % of the deceased inpatients had T2DM; however, the result was statistically insignificant. 55.3 % and 68.2 % of the patients with hyperglycemia and hypoglycemia, respectively, had T2DM (&lt;em&gt;p&lt;/em&gt;-values &lt;0.05). Hyperglycemic emergencies occurred mostly in patients with T2DM (p-value &lt;0.05), with intravenous (IV) insulin drip being used in 77.1 % among T2DM patients (&lt;em&gt;p&lt;/em&gt;-value &lt;0.05). The mean glycated haemoglobin (HbA1c) for T2DM patients alone was 8.12 ± 1.68 %. Approximately 94.7 % of patients who had in-hospital hyperglycemia where on steroids (p-value &lt;0.05). Patients with HTN, DL, CAD, overweight, and obesity all had T2DM and in-hospital hyperglycemia (&lt;em&gt;p&lt;/em&gt;-values &lt;0.05). Patients on home sulfonylureas (SU) or metformin were more likely to survive post hosp","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100280"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyles according to disease duration in patients with diabetes and hypertension","authors":"Joan A. Loayza-Castro ,&nbsp;Lupita Ana Maria Valladolid-Sandoval ,&nbsp;Luisa Erika Milagros Vásquez Romero ,&nbsp;Fiorella E. Zuzunaga-Montoya ,&nbsp;Jhonatan Roberto Astucuri Hidalgo ,&nbsp;Víctor Juan Vera-Ponce","doi":"10.1016/j.endmts.2025.100259","DOIUrl":"10.1016/j.endmts.2025.100259","url":null,"abstract":"<div><h3>Introduction</h3><div>In patients with hypertension (HTN) and diabetes mellitus (DM), lifestyles should be optimal to avoid long-term complications. However, it is sometimes unclear whether the disease duration factor could contribute to their improvement.</div></div><div><h3>Objective</h3><div>1) To analyze the trend of lifestyles in patients with DM or HTN; 2) to determine the association of lifestyles according to the time since diagnosis in these patients.</div></div><div><h3>Materials and methods</h3><div>Analytical cross-sectional study based on Peru's Demographic and Family Health Survey between 2014 and 2023. Lifestyles were: smoking status, alcohol consumption, and fruit/vegetable consumption. The time since diagnosis variable was dichotomized (&lt; 2 years versus ≥2 years).</div></div><div><h3>Results</h3><div>Lifestyle trends between the established years showed a fluctuating pattern, with a significant interruption in 2020, followed by a return to pre-2020 variations, except for a decrease in smokers in subjects with HTN. On the other hand, no significant association was found between any of the three lifestyles and the time since diagnosis of HTN or DM2.</div></div><div><h3>Conclusion</h3><div>The trends found in lifestyles have not resulted in a sustained decrease in bad habits or a constant improvement in healthy lifestyles, except for smokers in patients with HTN, but rather a general state without substantial changes has been maintained. In turn, the disease duration does not seem to be a determining factor for changes in the lifestyles of patients with DM or HTN.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100259"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral vascular disease and its associated factors among diabetic patients on follow-up at Ras Desta Damtew Memorial Hospital, Addis Ababa, Ethiopia","authors":"Zerihun Chala Deme ,&nbsp;Getchew Fekadu Feda ,&nbsp;Dereje Tsegaye ,&nbsp;Agumasie Semahegn","doi":"10.1016/j.endmts.2025.100271","DOIUrl":"10.1016/j.endmts.2025.100271","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to assess the prevalence of peripheral vascular disorders and associated factors among diabetic patients on follow-up at Ras Desta Damtew Memorial Hospital, Ethiopia.</div></div><div><h3>Methods</h3><div>An institutional-based cross-sectional study was conducted among 275 randomly selected Diabetes Mellitus patients attending follow-up at Ras Desta Damtew Memorial Hospital, Addis Ababa, Ethiopia, from July to August 2024. Data were collected using structured questionnaires, ankle-brachial index, and Edinburgh Claudication Questionnaire, IPAQ-SF. Data were entered into Epi-data version 4.6 and exported to SPSS version 25 for analysis. Bi-variable and multivariable binary logistic regression analyses were conducted to determine associations between dependent and independent variables. Adjusted odds ratios with 95 % confidence intervals were reported, and statistical significance was considered at <em>p</em> ≤ 0.05.</div></div><div><h3>Results</h3><div>The study found that 12 % (95 % CI: 8.15 %–15.85 %) of diabetic patients developed peripheral vascular disorders. Significant associations were found with smoking (AOR: 5.59; 3.42–8.63), alcohol use (AOR: 4.09; 2.56–7.74), hypertension (AOR: 3.55; 1.69–6.25), and physical inactivity (AOR: 3.80; 1.56–9.47).</div></div><div><h3>Conclusions</h3><div>Over one in ten diabetic patients developed peripheral vascular disease. Key associated factors include smoking, alcohol use, hypertension, and physical inactivity. Interventions targeting these risk factors are necessary to reduce related complications in diabetic patients.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100271"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144813854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between HbA1c levels and thickness of carotid intima media in prediabetic and diabetic patients","authors":"Murat Ay ,&nbsp;Alper Sari","doi":"10.1016/j.endmts.2025.100283","DOIUrl":"10.1016/j.endmts.2025.100283","url":null,"abstract":"<div><h3>Objective</h3><div>In this study, it was shown that cardiovascular risk can be reduced by controlling risk factors, and this can be achieved by measuring the carotid intima-media thickness (CIMT) and performing follow-up. An increase in atherosclerosis and cardiovascular risk factors is seen in the prediabetic stage, and CIMT measurement may help in preventing complications before developing diabetes and inflammatory processes.</div></div><div><h3>Method</h3><div>Total 89 patients and 40 healthy controls were analyzed to determine the relationship between their mean HbA1c levels, laboratory data, and CIMT in patients with identified chronic diseases.</div></div><div><h3>Results</h3><div>No significant correlation was noted between the mean HbA1c and right and left CIMT in patients with diabetes mellitus. In the prediabetic patient group, the a weak positive and significant correlation was found between mean HbA1c and bilateral CIMT analysis.</div></div><div><h3>Conclusion</h3><div>In conclusion, the risk of atherosclerosis and cardiovascular complications is increased in the prediabetic stage and non-invasive evaluation with treatment and follow-up may prevent complications, especially cardiovascular ones, in the diabetic stage.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100283"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on thyroid nodules: Characteristics and clinical management","authors":"Elisa Lepore ,&nbsp;Laura Rizza ,&nbsp;Francesca Rota ,&nbsp;Roberto Baldelli","doi":"10.1016/j.endmts.2025.100255","DOIUrl":"10.1016/j.endmts.2025.100255","url":null,"abstract":"<div><div>Thyroid nodules (TNs) represent a highly widespread condition, usually destined to a positive outcome. Nevertheless, making a correct diagnosis is crucially important to ensure an appropriate and tailored strategy of follow up or treatment. Several different techniques allow to gradually characterize TNs by performing cytological and compositional analysis. In addition, collecting data of common risk factors together with recognized features - including microcalcifications, uneven margins, taller-than-wide form - may contribute to indicate a suspected malignancy. By combining all these information and proceeding step by step in the patients' investigation to achieve a diagnosis, physicians can optimize the diagnostic process thus differentiating the small percentage of patients that need surgical intervention, without impacting on those patients with benign TNs. This may result helpful for improving the management of patients with TNs. Instead, in cases of benign TNs that no need neither surgical nor pharmacological treatments, dietary supplementations based on micronutrients involved in thyroid physiology, as iodine or myo-Inositol (myo-Ins), represent a useful tool. Even though evidence from literature sustains a correlation between iodine deficiency and TN occurrence, there are very few studies regarding a possible correlation between myo-Ins deficiency and presence of TNs. Therefore, further investigations aimed to correlate myo-Ins levels with the cytological severity of TNs may add new insights on this topic and improve the diagnostic process that aims to tailored therapies for these patients.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100255"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of primary pseudohypoaldosteronism accompanied by respiratory distress syndrome","authors":"Aikaterini Salavoura,&nbsp;Christina Kanaka,&nbsp;Evaggelia Lykopoulou,&nbsp;Despina Lazopoulou","doi":"10.1016/j.endmts.2025.100276","DOIUrl":"10.1016/j.endmts.2025.100276","url":null,"abstract":"<div><div>There is reported a case of a 5-month-old boy diagnosed with Type I pseudohypoaldosteronism which is a rare salt-losing disease caused by resistance of the target organs to aldosterone.</div><div>Diagnosis was based on clinical presentation with frequent admissions from a young age due recurrent episodes of vomiting and wheezing as well as relevant electrolyte disturbances. It is interesting that during hospitalizations, the baby showed recurrent episodes of wheezing not responding to b-agonists and corticosteroids and depended on daily oxygen supplementation. Molecular investigation of the ENac gene was normal.</div><div>The systemic form of type I pseudoaldosteronism involves pulmonary dysfunction in addition to increased levels of aldosterone.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100276"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145361540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The constrained disorder principle: A novel framework for understanding glycemic variability and optimizing diabetes management","authors":"Orly Agmon ,&nbsp;Tal Sigawi ,&nbsp;Yaron Ilan","doi":"10.1016/j.endmts.2025.100262","DOIUrl":"10.1016/j.endmts.2025.100262","url":null,"abstract":"<div><div>Traditional diabetes management primarily focuses on controlling average glucose levels, typically assessed through HbA1c. However, emerging research highlights the significance of glucose fluctuations in influencing diabetes outcomes. Glycemic variability (GV) and glucose complexity are crucial yet often overlooked aspects of glucose regulation. This review introduces the Constrained Disorder Principle (CDP), a novel framework suggesting that biological systems function optimally within a controlled range of variability. Excessive and insufficient glucose fluctuations can be harmful, indicating a J-shaped relationship between GV and health outcomes. The CDP shifts the focus of diabetes management from simply minimizing GV to defining an optimal range that aligns with physiological glucose regulation. This approach enables more precise treatment targets. The CDP emphasizes the potential of variability-based treatment strategies, incorporating controlled fluctuations into therapy. These strategies aim to enhance adaptive responses, improve treatment efficacy, and reduce the development of resistance. By redefining the role of GV in diabetes care, the CDP may offer a transformative perspective that paves the way for more personalized, dynamic, and effective management strategies.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100262"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mineralocorticoid receptor antagonists reduce inflammatory signaling independent of myofiber mineralocorticoid receptor","authors":"Jeovanna Lowe ,&nbsp;Arden B. Piepho ,&nbsp;Chetan K. Gomatam ,&nbsp;Peyton Debell ,&nbsp;Megan N. Ballinger ,&nbsp;Jill A. Rafael-Fortney","doi":"10.1016/j.endmts.2025.100266","DOIUrl":"10.1016/j.endmts.2025.100266","url":null,"abstract":"<div><div>Chronic inflammation is a feature of Duchenne muscular dystrophy (DMD), a degenerative striated muscle disease. Mineralocorticoid receptor (MR) antagonists (MRAs) have demonstrated clinical benefit on later onset DMD cardiomyopathy, and preclinical studies in mouse models have demonstrated efficacy on multiple steps of skeletal muscle pathology. MRA treatment of the <em>mdx</em> mouse model reduces pro-inflammatory gene expression from skeletal muscle myeloid immune cells and represses muscle cytokine signaling and fibrosis. Myofiber-specific knockout of MR in <em>mdx</em> mice improves muscle force and reduces fibrosis, but inflammation in this model had not been investigated. In this study we investigated muscle inflammation at the cellular level using flow cytometry and at the protein signaling level using an unbiased cytokine assay. Numbers and proportions of myeloid cells were the same in <em>mdx</em> mice and those lacking myofiber MR, similar to the absence of cell type differences previously observed with either MRA treatment or myeloid MR knockout. MRA treatment, but not myofiber MR deletion alone, led to reductions in numerous cytokines and chemokines also previously observed in <em>mdx</em> mice. These data suggest that the beneficial reduction of inflammatory signaling from MRAs is largely independent of myofiber MR and occurs through another mechanism.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100266"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The status of thyroid disorders among patients with type 2 diabetes mellitus in Guilan province, Iran","authors":"Maryam Yaseri ,&nbsp;Haniyeh Sadat Fayazi ,&nbsp;Fatemeh Mahdi ,&nbsp;Faezeh Motevali ,&nbsp;Seyedeh Sahereh Mortazavi Khatibani","doi":"10.1016/j.endmts.2025.100267","DOIUrl":"10.1016/j.endmts.2025.100267","url":null,"abstract":"<div><h3>Aims</h3><div>This study aimed to investigate the prevalence of thyroid disorders and their associated risk factors in patients with type 2 diabetes mellitus.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted among 223 patients with type 2 diabetes mellitus (T2DM). Patients were categorized into two groups based on the presence or absence of thyroid disorders. Demographic, clinical, and laboratory data were collected, and risk factors associated with thyroid disorders were evaluated by comparing diabetic patients with and without thyroid dysfunction. Statistical analysis was performed using SPSS version 22, with the level of significance set at <em>P</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>The mean age of patients was 54.24 ± 9.73 years, and 72.6 % (<em>n</em> = 162) were female. The prevalence of thyroid disorders among patients with T2DM was 61.9 %, with hypothyroidism being the most common (45.7 %). Cardiovascular disease was the most frequent diabetes-related complication (43.9 %), while nephropathy had the lowest prevalence (40.8 %). Neuropathy, nephropathy, and cardiovascular disease were significantly more frequent in patients with thyroid disorders compared to those without (<em>P</em> &lt; 0.05). A family history of thyroid disease was present in 40.4 % of patients, and 17.0 % were positive for anti-thyroid peroxidase antibodies. Thyroid disorders were more prevalent in females (67.9 %) compared to males (45.9 %) (<em>P</em> = 0.003). Female gender and a positive family history were significant risk factors for developing thyroid disorders (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This study demonstrated that female gender and a positive family history of thyroid disease are significant predictors of thyroid dysfunction in patients with T2DM. These findings underscore the need for routine screening for thyroid disorders in this patient population.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100267"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}