JAAD International最新文献_第7页

Combination secukinumab and surgical intervention for moderate-to-severe hidradenitis suppurativa: A retrospective cohort study 联合secukinumab和手术干预治疗中重度化脓性汗腺炎：一项回顾性队列研究

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-10-02 DOI: 10.1016/j.jdin.2025.08.014

Qiuyun Xu MD , Yifan Xie MD , Zhuo Chen MD , Fang Fang MD , Shuyi Shen MD , Songyu Wang MD , Chengbei Bao MD , Ying Zou PhD , Dan Deng PhD , Chao Ji MD, PhD , Ting Gong PhD

引用次数: 0

The brain-skin connection: A narrative review of neuroendocrine and immune pathways 脑-皮肤连接：神经内分泌和免疫途径的叙述性回顾

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-10-28 DOI: 10.1016/j.jdin.2025.10.008

Chang Chuen Tan , Krystal Valerie Soh , Eugene Wang , Ellie Ci-En Choi MBBS, MMed, MRCP, MCI

{"title":"The brain-skin connection: A narrative review of neuroendocrine and immune pathways","authors":"Chang Chuen Tan , Krystal Valerie Soh , Eugene Wang , Ellie Ci-En Choi MBBS, MMed, MRCP, MCI","doi":"10.1016/j.jdin.2025.10.008","DOIUrl":"10.1016/j.jdin.2025.10.008","url":null,"abstract":"<div><h3>Background</h3><div>Stress is a well-established trigger for many skin diseases; yet its biological mechanisms are poorly understood.</div></div><div><h3>Objective</h3><div>To synthesize current evidence on brain-skin pathways, emphasizing key mediators and feedback loops that explain how stress exacerbates skin disease and vice versa.</div></div><div><h3>Methods</h3><div>A comprehensive search through August 25, 2025, using terms related to brain-skin communication, psychodermatology, and stress-related pathophysiology included both in-vivo and in-vitro animal and human studies.</div></div><div><h3>Results</h3><div>159 articles were included and synthesized. Key findings highlight a bidirectional brain-skin axis involving the brain and pituitary, adrenal glands, peripheral nerves and skin. Stress triggers the brain and pituitary to release corticotropin-releasing hormone and adrenocorticotropic hormone; adrenal glands to secrete cortisol, catecholamines and androgens; and peripheral nerves to release neuropeptides such as Substance P and calcitonin gene-related peptide. These are implicated in skin inflammation while skin-derived mediators (cytokines, chemokines, neurotrophins) may disrupt and cross the blood-brain barrier, amplifying neuroinflammation, and psychiatric symptoms. Together, these form a self-sustaining feedback perpetuating both dermatologic and psychological disease.</div></div><div><h3>Limitations</h3><div>Much of the mechanistic understanding is derived from animal models; high-quality human data remain limited.</div></div><div><h3>Conclusion</h3><div>Understanding the brain-skin axis identifies therapeutic targets and guides future research on stress-related skin disease.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 112-123"},"PeriodicalIF":5.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rosacea prevalence, severity, and phenotype by race, ethnicity, and gender: A cross-sectional study of a diverse patient cohort within a primary care population 酒渣鼻的患病率、严重程度和表型与种族、民族和性别有关：一项对初级保健人群中不同患者队列的横断面研究

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-11-27 DOI: 10.1016/j.jdin.2025.11.016

Alexander R. Gomez-Lara BA, BS , Adam Zakaria MD, MAS , Maria Elena Sanchez-Anguiano BS , Erin H. Amerson MD

引用次数: 0

Atopic dermatitis beyond the skin: Characterizing skin pain in the “Scars of Life” study 皮肤以外的特应性皮炎：“生命的伤疤”研究中皮肤疼痛的特征

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-10-14 DOI: 10.1016/j.jdin.2025.09.018

Jonathan I. Silverberg MD, PhD , Roberto Takaoka MD , Jerry Tan MD, FRCPC , Thomas Luger MD , Chaoying Gu MD, PhD , Roni Dodiuk-Gad MD , Flavia Pretti Aslanian MD, PhD , Cita Rosita Sigit Prakoeswa MD , Bruno Halioua MD , Ann’Laure Demessant Flavigny PhD , Caroline Le Floc’h PhD , Nabil Kerrouche PhD , Stéphanie Merhand PE , Wendy Smith Begolka PE , África Luca de Tena Smith PE , Shulamit Burstein PE , Delphine Kerob MD , Charles Taieb MD, PhD , Charbel Skayem MD , Therdpong Tempark MD , Laurent Misery MD, PhD (Pr)

引用次数: 0

Relative survival analysis of Merkel cell carcinoma across intersectional demographics using the Surveillance, Epidemiology, and End Results (SEER) database 使用监测、流行病学和最终结果（SEER）数据库对默克尔细胞癌进行交叉人口统计学的相对生存分析

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-11-03 DOI: 10.1016/j.jdin.2025.10.015

Benjamin D. Hu BS , Brandon R. Block BA , Grace Rabinowitz BA , Raphaella Lambert BA , Andrew Zhu MSc , Hannah Verma BA , Jón Gunnlaugur Jónasson MD , Bardur Sigurgeirsson MD, PhD , Shane Meehan MD , Jonathan Ungar MD , Jesse M. Lewin MD , Nicholas Gulati MD, PhD , Jonas A. Adalsteinsson MD, PhD

引用次数: 0

Supporting evidence and recommendations for the management of patients with systemic-eligible atopic dermatitis: A Canadian consensus document 对全身性特应性皮炎患者管理的支持证据和建议：加拿大共识文件

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-09-26 DOI: 10.1016/j.jdin.2025.06.009

Kerri Purdy MD , Melinda Gooderham MD , Mohannad Abu-Hilal MD , April Armstrong MD , Rachel Asiniwasis MD , Gurbir Dhadwal MD , Carolyn Jack MD , Perla Lansang MD , Fiona Lovegrove MD , Julien Ringuet MD , Shanna Spring MD

{"title":"Supporting evidence and recommendations for the management of patients with systemic-eligible atopic dermatitis: A Canadian consensus document","authors":"Kerri Purdy MD , Melinda Gooderham MD , Mohannad Abu-Hilal MD , April Armstrong MD , Rachel Asiniwasis MD , Gurbir Dhadwal MD , Carolyn Jack MD , Perla Lansang MD , Fiona Lovegrove MD , Julien Ringuet MD , Shanna Spring MD","doi":"10.1016/j.jdin.2025.06.009","DOIUrl":"10.1016/j.jdin.2025.06.009","url":null,"abstract":"<div><h3>Background</h3><div>Atopic dermatitis is a chronic, relapsing, and remitting inflammatory skin disease. Multiple systemic therapeutic options are available to treat atopic dermatitis.</div></div><div><h3>Objective</h3><div>To provide evidence-based recommendations on the use of systemic therapies for atopic dermatitis in Canada that consider the nuances of the Canadian healthcare system and provide guidance for populations of clinical interest.</div></div><div><h3>Methods</h3><div>A panel of 14 experts, including 11 dermatologists from Canada and 3 from the United States, reviewed available literature on systemic therapies for atopic dermatitis. The published evidence, along with clinical expertise and opinion, was used to draft a concise set of statements to guide healthcare providers in Canada on systemic treatment of atopic dermatitis.</div></div><div><h3>Results</h3><div>During 3 rounds of virtual meetings with all 14 experts voting in all meetings, a total of 29 statements reached the 75% agreement required for consensus.</div></div><div><h3>Limitations</h3><div>The consensus statements are based on expert opinions and consensus in the absence of evidence-based clinical research for patient outcomes. The statements represent considerations for patient management and not specific guidelines for patient treatment.</div></div><div><h3>Conclusion</h3><div>The recommendations and statements provided serve to guide Canadian healthcare providers on the practical aspects of managing systemic-eligible patients with atopic dermatitis.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 31-49"},"PeriodicalIF":5.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between out-of-pocket costs and treatment patterns in psoriasis and psoriatic arthritis: A claims-based cohort study 银屑病和银屑病关节炎的自付费用与治疗模式之间的关系：一项基于索赔的队列研究

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-12-04 DOI: 10.1016/j.jdin.2025.11.020

Alyssa M. Roberts BS , Charlotte Jeong BS , Peichi Chou BA , Elaine J. Ma BA , Abigail Katz BA , Matthew J. Yan BS, BA , Nicole Johnsen BS , Yvonne Nong MD , April W. Armstrong MD, MPH

引用次数: 0

Differential response to Janus kinase inhibitors in refractory livedoid vasculopathy: Biomarker-guided therapy may improve clinical response 难治性类活体血管病变对Janus激酶抑制剂的差异反应：生物标志物引导疗法可能改善临床反应

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-12-10 DOI: 10.1016/j.jdin.2025.11.024

Guoqun Yu MBBS , Jinjin Zhu MD , Yuan Zhang MBBS , Fan Yang MBBS , Jing Yang MD , Juan Tao MD, PhD

引用次数: 0

Predicting outcomes of port-wine stains treated with hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT): An observational study using multimodal deep learning 血卟啉单甲基醚光动力疗法（HMME-PDT）治疗波特酒斑的预后预测：一项使用多模态深度学习的观察性研究

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-11-21 DOI: 10.1016/j.jdin.2025.11.009

Jinjin Zhu MD , Chunhui Xie PhD , Yan Li MD , Xue Wang MD , Ziqiong Cheng MD , Yunqi Li PhD , Juan Tao MD, PhD

引用次数: 0

Global, regional, and national burden of alopecia areata from 1990 to 2021: An analysis from the Global Burden of Disease Study 2021 1990年至2021年斑秃的全球、地区和国家负担：来自2021年全球疾病负担研究的分析

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-12-17 DOI: 10.1016/j.jdin.2025.11.027

Dezhao Bi MMed , Songmao Hua MMed , Yunyao Hu MMed , Jinrui Zhang MMed , Haolong Ran MMed , Lei Han MMed , Jin Tong Tey MMed , Shun Guo MD

引用次数: 0