JAAD International最新文献

{"title":"The intersection of melanoma survival and social determinants of health in the United States: A systematic review","authors":"McKenzie E. Maloney BS ,&nbsp;Caleb Bacak BS ,&nbsp;Kellen Tjioe DDS, MSc, PhD ,&nbsp;Loretta S. Davis MD ,&nbsp;E. Andrew Balas MD, PhD ,&nbsp;Gagan Agrawal MS, PhD ,&nbsp;Jorge E. Cortes MD ,&nbsp;Marisol Miranda-Galvis DDS, MS, PhD","doi":"10.1016/j.jdin.2024.07.006","DOIUrl":"10.1016/j.jdin.2024.07.006","url":null,"abstract":"<div><h3>Background</h3><div>Despite recent improvements in melanoma survival rates, persistent inequalities pose barriers to care for some patients.</div></div><div><h3>Objective</h3><div>To assess the influence of social determinants of health (SDoH) on melanoma treatment outcomes.</div></div><div><h3>Methods</h3><div>A systematic review (Prospective Register of Systematic Reviews CRD42022346854) of manuscripts that examined the association between SDoH and melanoma treatment-related outcomes in the United States was conducted using 5 databases.</div></div><div><h3>Results</h3><div>The analysis encompassed data from 12 retrospective manuscripts. The SDoH domains most frequently investigated were health care access and quality (<em>n</em> = 6 manuscripts, 50%) and economic stability (<em>n</em> = 7, 58.3%). Other domains included social and community context (<em>n</em> = 5, 41.7%) and education access (<em>n</em> = 3, 25%). These findings revealed significant correlations between poor melanoma survival and low levels of economic stability, limited education, government health insurance, and being uninsured and unmarried.</div></div><div><h3>Limitations</h3><div>Many SDoH were not analyzed at the patient level. SDoH are vast categories, but manuscripts usually analyze one aspect of a particular category.</div></div><div><h3>Conclusions</h3><div>These results highlight the need for physicians to recognize the substantial impact of SDoH on melanoma outcomes and to adopt more comprehensive strategies focused on patient-centered care. Integrating social support mechanisms into clinical practice emerges as a key mechanism to promote equitable and effective interventions.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 126-138"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life in primary cutaneous B-cell lymphoma following local radiotherapy","authors":"Alice Heger MS,&nbsp;Khaled Elsayad PhD,&nbsp;Christian Kandler MD,&nbsp;Jan Siats MD,&nbsp;Michael Oertel MD,&nbsp;Christopher Kittel MD,&nbsp;Hans Theodor Eich PhD","doi":"10.1016/j.jdin.2024.07.002","DOIUrl":"10.1016/j.jdin.2024.07.002","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 53-54"},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social vulnerabilities in head-neck melanoma care: A retrospective cohort study in the United States","authors":"Lillian McCampbell BS ,&nbsp;David Jun Fei-Zhang BA ,&nbsp;Daniel Chelius MD ,&nbsp;Ling-Lun Bob Hsia MD ,&nbsp;Robert Dellavalle MD, PhD, MSPH ,&nbsp;Jill D’Souza MD ,&nbsp;David Bentrem MD ,&nbsp;Jeffrey Wayne MD ,&nbsp;Jeffrey Rastatter MD ,&nbsp;Anthony Sheyn MD","doi":"10.1016/j.jdin.2024.05.011","DOIUrl":"10.1016/j.jdin.2024.05.011","url":null,"abstract":"<div><h3>Background</h3><div>Studies addressing social determinants of health (SDH) in head-neck melanomas (HNM) have only assessed socioeconomic factor impact but not a wider scope of SDH.</div></div><div><h3>Objective</h3><div>Utilizing the Social Vulnerability Index (SVI), to assess the influence of specific SDH and their quantifiable associations with HNM management disparities across the varied community contexts in the United States.</div></div><div><h3>Methods</h3><div>This retrospective cohort study analyzed adults diagnosed with HNM from 1975 to 2017 from the Surveillance, Epidemiology, and End Results Program database.</div></div><div><h3>Results</h3><div>A total of 374,138 HNM in adults from 1975 to 2017 were assessed for disparities affiliated with increasing overall vulnerability/SVI scores and SDH themes. For several melanoma subtypes, higher social vulnerability significantly decreased odds (lowest for amelanotic, odds ratio 0.74; 95% confidence interval, 0.63-0.86) for indicated surgery, increased odds of indicated radiation (highest for epithelioid cell, 1.44; 1.08-1.96), and advanced staging on first presentation (highest for acral lentiginous, 1.13; 1.01-1.27). Household composition, followed by socioeconomic status and minority-language status contributed significantly to the overall trend.</div></div><div><h3>Limitations</h3><div>Limitations include unknown cause of death and SVI score calculation based on county of residency.</div></div><div><h3>Conclusions</h3><div>This investigation highlights significant detrimental trends in HNM management with overall social vulnerability while showcasing the quantifiable associations of specific SDH themes on HNM-disparities.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 37-47"},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related progression of androgenetic alopecia: Statistical analysis of 5372 Japanese men","authors":"Hiroshi Fujimaki MD, PhD ,&nbsp;Masayuki Yanagisawa MD, PhD ,&nbsp;Toshihiro Yoshitake MD, PhD ,&nbsp;Akio Sato MD, PhD","doi":"10.1016/j.jdin.2024.07.003","DOIUrl":"10.1016/j.jdin.2024.07.003","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 84-85"},"PeriodicalIF":0.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142415886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axillary extramammary Paget disease in a patient with a history of Birt-Hogg-Dubé syndrome","authors":"Melissa M. Rames MD ,&nbsp;Eucabeth Asamoah MD ,&nbsp;Rebecca Danhof MD, MPH ,&nbsp;Addison Demer MD","doi":"10.1016/j.jdin.2024.06.001","DOIUrl":"10.1016/j.jdin.2024.06.001","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 4-5"},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666328724000890/pdfft?md5=13ddddf473ae3e3bed41941571b04e0b&pid=1-s2.0-S2666328724000890-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141853272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary cutaneous melanoma of the breast skin: Incidence, characteristics, and management","authors":"Alexander S. Hines MD,&nbsp;Elliott H. Campbell MD,&nbsp;Jacob P. Reinhart MD,&nbsp;Olivia M. Crum MD,&nbsp;Sydney L. Proffer MD,&nbsp;Jerry D. Brewer MD,&nbsp;Lawrence E. Gibson MD,&nbsp;Addison M. Demer MD","doi":"10.1016/j.jdin.2024.06.003","DOIUrl":"10.1016/j.jdin.2024.06.003","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 15-16"},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666328724000956/pdfft?md5=043eb819c008c3649ff06aac58730ccb&pid=1-s2.0-S2666328724000956-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141839625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why do pressure injuries still occur? A multicenter qualitative study of nurses and caregivers","authors":"Wilson Sim MBBS ,&nbsp;Tan Hwei Sian Clara Michelle MBBS ,&nbsp;Nur Qasrina Binte Iskandar Lim BSc ,&nbsp;Veronica Loh MN, BSc ,&nbsp;Cheryl Wan Xuan Chua MBBS ,&nbsp;Jason Er BSN, MSN ,&nbsp;Joyce Er MN, BSc ,&nbsp;Phillip Phan PhD ,&nbsp;Ellie C.E. Choi MBBS, MRCP","doi":"10.1016/j.jdin.2024.05.006","DOIUrl":"10.1016/j.jdin.2024.05.006","url":null,"abstract":"<div><h3>Background</h3><div>The frequent occurrence of pressure injuries despite their preventability raises important questions about our understanding of the barriers to care. This study explores the lived experience of nurses and caregivers in Singapore to establish a conceptual framework for better understanding of pressure injuries arising in the community.</div></div><div><h3>Methods</h3><div>A multicenter qualitative study was conducted utilizing semistructured interviews and focused group discussions of nurses and caregivers of patients with pressure injuries. Data were collected with a narrative inquiry approach and analyzed with grounded theory. An iterative cycle of interviewing, coding, discussion, and reflection was conducted until theoretical saturation.</div></div><div><h3>Results</h3><div>Ten inpatient nurses and 10 caregivers from the community were recruited. Analysis identified cognitive (awareness and caregiver training), emotional (motivation and empowerment), resource (human and infrastructural), and biomedical factors which collectively impacted the effectiveness of prevention. Additionally, constructs of learning and sustainability of caregiving played a crucial role in long term prevention.</div></div><div><h3>Limitation</h3><div>The derived framework requires further validation with quantitative data and may not be generalizable to other cultural and economic populations.</div></div><div><h3>Conclusion</h3><div>Multiple constructs have been identified to have a synergistic effect in prevention. Targeted measures should be implemented by healthcare institutions to better equip caregivers in prevention.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 29-36"},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141853114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and tolerability of tirbanibulin ointment 1% treatment on 100 cm2 of the face or scalp in patients with actinic keratosis: A phase 3 study","authors":"Neal Bhatia MD ,&nbsp;Edward Lain MD ,&nbsp;Abel Jarell MD ,&nbsp;Janet DuBois MD ,&nbsp;Maria Luisa Tamarit MD ,&nbsp;Meritxell Falques MSc ,&nbsp;Vera Kiyasova MD, PhD ,&nbsp;Laura Padullés PhD ,&nbsp;Raquel Otero PhD ,&nbsp;Andrew Blauvelt MD, MBA","doi":"10.1016/j.jdin.2024.07.001","DOIUrl":"10.1016/j.jdin.2024.07.001","url":null,"abstract":"<div><h3>Background</h3><p>Tirbanibulin is approved for actinic keratosis (AK) field treatment up to 25 cm². However, AK often affects larger areas; thus, AK treatments for larger fields are needed.</p></div><div><h3>Objective</h3><p>Evaluate the safety and tolerability of tirbanibulin when applied to a field of approximately 100 cm².</p></div><div><h3>Methods</h3><p>Phase 3, multicenter, open-label, single-arm study among adult patients having a treatment field on the face or balding scalp of approximately 100 cm² with 4-12 AKs. Patients received tirbanibulin to cover the treatment field once daily (5 consecutive days). Safety was assessed by evaluating treatment emergent adverse events and tolerability by composite score of 6 local tolerability signs (LTS).</p></div><div><h3>Results</h3><p>A total of 105 patients were included. The most common LTS were erythema (96.1%) and flaking/scaling (84.4%), being mostly mild-to-moderate severity, and resolved/returned to or close to baseline by Day 29. The only severe LTS were erythema (5.8%) and flaking/scaling (8.7%). Most frequent treatment emergent adverse events were application site pruritus (10.5%) and application site pain (8.6%). Mean total number of AKs decreased from 7.7 AKs at baseline to 1.8 AKs at Day 57. Mean percent of change (reduction) from baseline in lesion count was 77.8% at Day 57.</p></div><div><h3>Limitations</h3><p>No control group. No long-term follow-up.</p></div><div><h3>Conclusion</h3><p>Safety and tolerability profiles in patients treated with tirbanibulin up to 100 cm² were consistent with those previously reported over smaller field. Tirbanibulin could be used on a larger field (&gt;25 cm²).</p></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 6-14"},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666328724000981/pdfft?md5=2164185d053fc4490864f07352159211&pid=1-s2.0-S2666328724000981-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141845131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and outcomes of Merkel cell carcinoma related to Merkel cell polyomavirus status in Iceland in 1981-2023","authors":"Maria Vygovska MD ,&nbsp;David Hoyt BS ,&nbsp;Ashley M. Snyder PhD, MPH ,&nbsp;Thorarinn Jonmundsson MSc ,&nbsp;Ashley Khouri BS ,&nbsp;Dev Ram Sahni MD, MHA ,&nbsp;Jonathan Ungar MD ,&nbsp;Jesse M. Lewin MD ,&nbsp;Nicholas Gulati MD, PhD ,&nbsp;Robert G. Phelps MD ,&nbsp;Vikram N. Sahni MD ,&nbsp;Jane M. Grant-Kels MD ,&nbsp;Helgi Sigurdsson MD ,&nbsp;Jon Gunnlaugur Jonasson MD ,&nbsp;Jonas A. Adalsteinsson MD, PhD","doi":"10.1016/j.jdin.2024.06.004","DOIUrl":"10.1016/j.jdin.2024.06.004","url":null,"abstract":"<div><h3>Background</h3><div>Impact of Merkel cell polyomavirus (MCPyV) associated Merkel cell carcinoma (MCC) has not been assessed in the Icelandic population, nor in a whole population elsewhere.</div></div><div><h3>Objectives</h3><div>The primary objective was to assess trends in the incidence of MCC in Iceland and the association with MCPyV. Secondary objectives aimed to analyze MCC outcomes.</div></div><div><h3>Methods</h3><div>In this retrospective cohort study, patients diagnosed with MCC between 1981 and 2021 were identified from the Icelandic Cancer Registry. Patients were separated into 2 groups based on MCPyV immunochemistry staining. Age-standardized incidence was calculated and Joinpoint analysis was used to assess incidence trends. A Cox proportional hazards model was used to assess survival differences between the 2 groups.</div></div><div><h3>Results</h3><div>Overall incidence of MCC increased from 0.015 to 0.26 per 100,000 persons, though the incidence of MCPyV positive cases recently decreased while negative cases increased. MCPyV negative tumors were associated with sun exposure (<em>P</em> &lt; .01), a history of keratinocyte carcinoma, smaller tumor size, and lower overall survival.</div></div><div><h3>Limitations</h3><div>Even with population-level data, comprehensively investigating associations with MCC is difficult due to its rarity.</div></div><div><h3>Conclusion</h3><div>MCPyV negative MCC tumors were associated with lower survival despite smaller tumor size. Thus, MCPyV status could be an important prognostic biomarker.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 192-199"},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141710778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the influence of medications with antagonistic effects on low-dose oral minoxidil in patients with alopecia: A retrospective study","authors":"Deesha Desai BS ,&nbsp;Ambika Nohria BA ,&nbsp;Michelle Sikora BS ,&nbsp;Michael Buontempo BS ,&nbsp;Jerry Shapiro MD ,&nbsp;Avrom S. Caplan MD ,&nbsp;Michael Garshick MD ,&nbsp;Kristen I. Lo Sicco MD","doi":"10.1016/j.jdin.2024.05.010","DOIUrl":"10.1016/j.jdin.2024.05.010","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 1-3"},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666328724000968/pdfft?md5=de1157e0631063dbf60181f8744db89e&pid=1-s2.0-S2666328724000968-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141704859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}