JAAD International最新文献

{"title":"Epidemiologic trends in cutaneous squamous cell carcinoma from 2011 to 2021 at All Africa Leprosy, Tuberculosis, and Rehabilitation Training Center (ALERT) in Addis Ababa, Ethiopia","authors":"Tizita Yosef MD ,&nbsp;Wondwossen Ergete MD ,&nbsp;Rishab R. Revankar BS ,&nbsp;Heli A. Patel BS ,&nbsp;Tsegaye Hailu Kumsa MSc ,&nbsp;Vishal A. Patel MD ,&nbsp;Selfu Girma MSc ,&nbsp;Benjamin K. Stoff MD, MA","doi":"10.1016/j.jdin.2024.07.014","DOIUrl":"10.1016/j.jdin.2024.07.014","url":null,"abstract":"<div><h3>Background</h3><div>Cutaneous squamous cell carcinoma (cSCC) is the most common keratinocyte carcinoma in dark-skinned ethnic groups. Available studies are primarily focused on white populations, with fewer data available for black Africans, including Ethiopians. Therefore, less priority may be given to treatment and prevention in this population.</div></div><div><h3>Objective</h3><div>To determine the prevalence and risk factors of cSCC among patients presenting to All Africa Leprosy, Tuberculosis, and Rehabilitation Training Center , Addis Ababa, Ethiopia.</div></div><div><h3>Methods</h3><div>A literature review was performed to determine existing knowledge. A retrospective descriptive cross-sectional study was then conducted based on stored data of confirmed cases of cSCC from 2011 to 2021 at ALERT. Demographics, other parameters related to cSCC (size, anatomic location, degree of differentiation, metastasis, and recurrence), and potential risk factors including scars, burns, HIV status, xeroderma pigmentosum, and leprosy were collected and entered on a prepared data extraction sheet and analyzed using SPSS version 25 manufactured by IBM.</div></div><div><h3>Results</h3><div>Among 15,075 total pathologic samples reviewed, 3.8% (<em>n</em> = 570) were reported histopathologically as invasive cSCC (<em>n</em> = 437), keratoacanthoma, or (squamous cell carcinoma in-situ (Bowen disease). 50.3% (<em>n</em> = 287) occurred in female, and the mean age of affected patients was 50.1 years (SD 17.2). Nearly 70% were reported after &gt;1 year of symptoms, including morphologic change, ulceration, and nonhealing wound. HIV status was not universally screened but was positive in 9.8% (46/437). Cases were commonly found to occur on the lower extremities (X² = 2.7196, Pr = 0.099) and &gt;4 cm in size (46.3%). Among 274 cases with adequate histologic description, 82.5% (<em>n</em> = 226) were well-differentiated. Loco-regional metastases comprised 6.0% (<em>n</em> = 34) and 46.7% (<em>n</em> = 266) had ulceration.</div></div><div><h3>Conclusion</h3><div>The biologic significance of ulceration in this population is unclear. Ulceration may indicate chronic wounds or Marjolin’s ulcers. High rates of metastasis call for a better understanding of risk factors, preventive measures, and early diagnosis. This model of research may serve as a foundation for future nationwide investigations through the Federal Ministry of Health of Ethiopia’s Disease Prevention and Control Directorate.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 99-103"},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpersonal and communication skills development in dermatology residency: Results of a single-institution needs assessment","authors":"Elizabeth E. Bailey MD, MPH ,&nbsp;Bryan K. Dang BSN, RN, PHN ,&nbsp;Luqman Mushila Hodgkinson MD, PhD, MS ,&nbsp;Rachel Schwartz PhD ,&nbsp;Merisa Kline MHA ,&nbsp;Barbette Weimer-Elder PhD ,&nbsp;Kristin M. Nord MD","doi":"10.1016/j.jdin.2024.07.011","DOIUrl":"10.1016/j.jdin.2024.07.011","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 178-180"},"PeriodicalIF":0.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of psychiatric comorbidities and treatment initiation in African American pediatric patients with vitiligo: A retrospective, single-center, case-control study","authors":"Emily Strouphauer BSA ,&nbsp;Sana Suhail BS ,&nbsp;Carly Mulinda BA ,&nbsp;Promise Ufomadu BSA ,&nbsp;Nicole Nyamongo BS ,&nbsp;Grace Lee MD ,&nbsp;Soo Jung Kim MD, PhD","doi":"10.1016/j.jdin.2024.07.012","DOIUrl":"10.1016/j.jdin.2024.07.012","url":null,"abstract":"<div><h3>Background</h3><div>Vitiligo may impact psychosocial development, especially among African American pediatric patients, given heightened visibility and increasing rates of anxiety and depression in this subpopulation.</div></div><div><h3>Objective</h3><div>Evaluate psychiatric comorbidities and treatment initiation in African American pediatric patients.</div></div><div><h3>Methods</h3><div>A total of 327 African American pediatric patients with vitiligo were each matched to 3 patients without vitiligo by age, race, and sex in this case-control study. Prevalence of psychiatric conditions and subsequent initiation of pharmacotherapy and/or psychotherapy were analyzed.</div></div><div><h3>Results</h3><div>Compared to controls, pediatric African American patients with vitiligo were significantly more likely to be diagnosed with depression (<em>P</em> &lt; .001) disruptive behavior disorders (<em>P</em> &lt; .001), eating disorders (<em>P</em> = .013), generalized anxiety disorder (<em>P</em> &lt; .001), substance abuse (<em>P</em> = .011), and suicidal ideation (<em>P</em> = .005). Patients with depression, disruptive behavior disorders, and eating disorders had higher initiation rates (76.5%, 82.1%, and 100%, respectively) for psychiatric treatment compared to those with generalized anxiety disorder and substance abuse (55.3% and 61.5%). Nearly 15% of patients did not initiate treatment for suicidal ideation.</div></div><div><h3>Limitations</h3><div>This retrospective study has a limited sample size in a single institution and does not explore psychiatric treatment efficacy.</div></div><div><h3>Conclusions</h3><div>Better understanding of associated psychological comorbidities and impacts on African American children of vitiligo may improve quality of life and dermatologic outcomes for these individuals.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 104-110"},"PeriodicalIF":0.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of interleukin-17 and interleukin-23 inhibitors in the development, progression, and recurrence of cancer: A systematic review","authors":"Marie Vangilbergen MD ,&nbsp;Aline Stockman MD ,&nbsp;Axelle Van De Velde MD ,&nbsp;Maria Garmyn MD, PhD ,&nbsp;Kevin Punie MD, PhD ,&nbsp;Tom Hillary MD, PhD","doi":"10.1016/j.jdin.2024.06.006","DOIUrl":"10.1016/j.jdin.2024.06.006","url":null,"abstract":"<div><h3>Background</h3><div>Biologicals targeting interleukin (IL)-17 and IL-23 improve quality of life in psoriasis and other chronic autoimmune disorders with a favorable safety profile. However, current guidelines do not recommend their use in patients with recent oncologic history due to limited evidence.</div></div><div><h3>Objective</h3><div>To understand the impact of IL-17 and IL-23 inhibitors on cancer development, progression, and recurrence by systematically reviewing available literature.</div></div><div><h3>Methods</h3><div>We conducted a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.</div></div><div><h3>Results</h3><div>Most studies investigating the use of IL-23 and IL-17 blockers did not find a higher incidence of cancer compared to the general population. One study observed no relapse in patients with a history of cancer.</div></div><div><h3>Limitations</h3><div>The systematic review is limited due to variations in study designs and outcomes, making it difficult to achieve a comprehensive synthesis and comparison between studies. Furthermore, small sample sizes were notable.</div></div><div><h3>Conclusion</h3><div>Preclinical studies suggest that treating psoriasis with IL-17 or IL-23 blockers is safe, also in patients witch active cancer or a history of it. Pharmacovigilance data show no increased malignancy rate in patients treated with these treatment modalities. However, data on relapse in patients with a history or active malignancy are limited.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 71-79"},"PeriodicalIF":0.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Use of an elastic-scattering spectroscopy and artificial intelligence device in the assessment of lesions suggestive of skin cancer: A comparative effectiveness study”","authors":"Tai-Lin (Irene) Lee MD ,&nbsp;Joe K. Tung MD, MBA","doi":"10.1016/j.jdin.2024.06.005","DOIUrl":"10.1016/j.jdin.2024.06.005","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 122-123"},"PeriodicalIF":0.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitiligo may be associated with an increased genetic risk of cardiovascular disease: A Mendelian randomization study","authors":"Austin J. Piontkowski BS,&nbsp;Celina Dubin MD,&nbsp;Ross O’Hagan MD,&nbsp;Jeremy Orloff BA,&nbsp;Camille M. Powers BS,&nbsp;Nicholas Gulati MD, PhD","doi":"10.1016/j.jdin.2024.07.010","DOIUrl":"10.1016/j.jdin.2024.07.010","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 21-23"},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666328724001081/pdfft?md5=14a8aad85dd82ff1bb68ae19ef112ed3&pid=1-s2.0-S2666328724001081-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To vaccinate or not to vaccinate patients undergoing biologic treatment in dengue-endemic countries?","authors":"María Julia Cura MD,&nbsp;Luis Daniel Mazzuoccolo MD","doi":"10.1016/j.jdin.2024.07.009","DOIUrl":"10.1016/j.jdin.2024.07.009","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 19-20"},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266632872400107X/pdfft?md5=8ce783247e89713f75e8621b44457162&pid=1-s2.0-S266632872400107X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraffin sections may be useful in Mohs micrographic surgery for nonmelanoma skin cancer in select patients","authors":"Ryan T. Ladd MD ,&nbsp;Taylor Viggiano MD ,&nbsp;Sarah E.B. Smith MD ,&nbsp;Skye Buckner-Petty MPH ,&nbsp;Yul W. Yang MD, PhD ,&nbsp;Shari A. Ochoa MD","doi":"10.1016/j.jdin.2024.07.005","DOIUrl":"10.1016/j.jdin.2024.07.005","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 27-28"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mayo Clinic experience: Once daily dosing of isotretinoin for acne","authors":"Hasina Maredia MD ,&nbsp;Megha Tollefson MD ,&nbsp;Aaron Keehr RN ,&nbsp;Julio C. Sartori-Valinotti MD","doi":"10.1016/j.jdin.2024.07.008","DOIUrl":"10.1016/j.jdin.2024.07.008","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 82-83"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142415957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The frequency of lichenoid features in mucous membrane pemphigoid: A retrospective review of the histopathology","authors":"Sarah G. McAlpine BS ,&nbsp;Paul B. Googe MD ,&nbsp;Donna A. Culton MD, PhD","doi":"10.1016/j.jdin.2024.07.007","DOIUrl":"10.1016/j.jdin.2024.07.007","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"17 ","pages":"Pages 17-18"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666328724001032/pdfft?md5=9b8fa73ba653d42e76d276ec97313313&pid=1-s2.0-S2666328724001032-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142096653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}