Felicia Li Ling Ong MBBS, MRCP , Darryl Kai Xian Chin , Yiming Zhu , Choon Chiat Oh MBBS, MRCP, MSc
{"title":"Oncolytic viral therapy for nonmelanoma skin cancer and cutaneous lymphoma – A systematic review","authors":"Felicia Li Ling Ong MBBS, MRCP , Darryl Kai Xian Chin , Yiming Zhu , Choon Chiat Oh MBBS, MRCP, MSc","doi":"10.1016/j.jdin.2024.11.010","DOIUrl":"10.1016/j.jdin.2024.11.010","url":null,"abstract":"<div><div>The rising incidence and consequent health care burden of nonmelanoma skin cancers, including cutaneous lymphomas, are a growing cause for concern. Oncolytic viruses (OVs) are emerging immunotherapies with limited literature on their use. We conducted a systematic review to evaluate their role in nonmelanoma skin cancer and cutaneous lymphoma treatment (CRD42024526854). We identified 11 published studies involving a total of 20 patients (squamous cell carcinoma <em>n</em> = 3, Merkel cell carcinoma <em>n</em> = 7, cutaneous T cell lymphoma <em>n</em> = 9, basal cell carcinoma <em>n</em> = 1). OVs used include Talimogene laherparepvec (73%, <em>n</em> = 8), measles virus (9%, <em>n</em> = 1), vesicular stomatitis virus (9%, <em>n</em> = 1), and adenovirus (9%, <em>n</em> = 1). Complete response occurred in 67% (<em>n</em> = 2) of squamous cell carcinoma cases, 85% (<em>n</em> = 6) of Merkel cell carcinoma cases, and 11% (<em>n</em> = 1) of cutaneous T cell lymphoma cases. The most common adverse event was fever or flu-like symptoms (<em>n</em> = 5, 25%). Fourteen unpublished clinical trials investigating regimes such as OV monotherapy (43%, <em>n</em> = 6), combination therapy with existing immunotherapy (21%, <em>n</em> = 3), and comparing OV combination versus monotherapy (29%, <em>n</em> = 4) or versus immune checkpoint inhibitor alone (7%, <em>n</em> = 1). Overall, heterogeneity of existing studies significantly limits generalizability of results. Further research is needed to reveal the potential role of OVs in the future of nonmelanoma skin cancer and cutaneous lymphoma treatment.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"20 ","pages":"Pages 4-20"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryan S.Q. Geng MSc , Katherine A. Buhler BHSc , May Y. Choi MD, MPH , David Croitoru MD, MSc , Elena Pope MD, MSc , Marvin J. Fritzler MD, PhD , Cathryn Sibbald MD
{"title":"Serum Th1, Th2, Th17, and innate immune system biomarkers are elevated in pediatric alopecia areata with and without concurrent atopic dermatitis: A cross-sectional study","authors":"Ryan S.Q. Geng MSc , Katherine A. Buhler BHSc , May Y. Choi MD, MPH , David Croitoru MD, MSc , Elena Pope MD, MSc , Marvin J. Fritzler MD, PhD , Cathryn Sibbald MD","doi":"10.1016/j.jdin.2024.09.008","DOIUrl":"10.1016/j.jdin.2024.09.008","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"18 ","pages":"Pages 128-130"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brandon R. Block BA, Camille M. Powers BS, Annie Chang MS, Caroline Campbell MD, Austin J. Piontkowski BS, Jeremy Orloff BA, Melissa A. Levoska MD, Ahuva Cices MD, Justine Fenner MD, Jordan Talia MD, Jonas A. Adalsteinsson MD, PhD, Jonathan Ungar MD, Nicholas Gulati MD, PhD
{"title":"Diagnostic performance of generative pretrained transformer -4 with vision technology versus board-certified dermatologists: A comparative analysis using dermoscopic and clinical images","authors":"Brandon R. Block BA, Camille M. Powers BS, Annie Chang MS, Caroline Campbell MD, Austin J. Piontkowski BS, Jeremy Orloff BA, Melissa A. Levoska MD, Ahuva Cices MD, Justine Fenner MD, Jordan Talia MD, Jonas A. Adalsteinsson MD, PhD, Jonathan Ungar MD, Nicholas Gulati MD, PhD","doi":"10.1016/j.jdin.2024.10.006","DOIUrl":"10.1016/j.jdin.2024.10.006","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"18 ","pages":"Pages 142-144"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11713480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariano Alba MS , Nora Rudd BS , Adam Zakaria MD, MAS , Aileen Y. Chang MD , Erin H. Amerson MD
{"title":"Hidradenitis suppurativa is associated with cardiometabolic comorbidities in a racially and ethnically diverse safety net population: A cross-sectional analysis","authors":"Mariano Alba MS , Nora Rudd BS , Adam Zakaria MD, MAS , Aileen Y. Chang MD , Erin H. Amerson MD","doi":"10.1016/j.jdin.2024.10.003","DOIUrl":"10.1016/j.jdin.2024.10.003","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"18 ","pages":"Pages 131-133"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}