JAAD International最新文献_第3页

Phenotypic characterization of neurofibromatosis type 1 in a large Chinese cohort: A cross-sectional study 中国一大队列中1型神经纤维瘤病的表型特征：一项横断面研究

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-10-16 DOI: 10.1016/j.jdin.2025.09.020

Zhichao Wang MD , Xing Hu MD, PhD , Haoyang Mo MD , Minxue Shen PhD , Carlos G. Romo MD, PhD , Katya Vera BA , Zhixiong Liu MD, PhD , Qingfeng Li MD, PhD , Chuntao Li MD, PhD , Kavita Y. Sarin MD, PhD

{"title":"Phenotypic characterization of neurofibromatosis type 1 in a large Chinese cohort: A cross-sectional study","authors":"Zhichao Wang MD , Xing Hu MD, PhD , Haoyang Mo MD , Minxue Shen PhD , Carlos G. Romo MD, PhD , Katya Vera BA , Zhixiong Liu MD, PhD , Qingfeng Li MD, PhD , Chuntao Li MD, PhD , Kavita Y. Sarin MD, PhD","doi":"10.1016/j.jdin.2025.09.020","DOIUrl":"10.1016/j.jdin.2025.09.020","url":null,"abstract":"<div><h3>Background</h3><div>Neurofibromatosis type 1 (NF1) is a multisystemic genetic disorder characterized by <em>NF1</em> gene mutations. The well-described manifestations of NF1 are primarily derived from European populations.</div></div><div><h3>Objective</h3><div>To evaluate the phenotypic characteristics of Chinese patients with NF1.</div></div><div><h3>Methods</h3><div>This cross-sectional, multicenter study involved patients with NF1 from Chinese and U.S. populations. Clinical data were obtained from NF1 clinics and patient-reported outcome assessments.</div></div><div><h3>Findings</h3><div>1313 patients with Chinese NF1 were included. We found that Chinese patients were diagnosed later in life and exhibited a lower prevalence of spinal neurofibromas and fractures but a higher rate of malignant peripheral nerve sheath tumors as compared to U.S. patients. Four distinct NF1 subtypes were identified: severe neural, cutaneous, hereditary, and mild. Significant correlations were observed between freckles and cutaneous neurofibromas and between bone lesions and pseudarthrosis. Cutaneous manifestations were correlated with systemic manifestations, and the risk of developing plexiform neurofibromas was inversely proportional to the number of cutaneous neurofibromas and freckles.</div></div><div><h3>Limitations</h3><div>The use of self-report data may introduce subjectivity and recall bias.</div></div><div><h3>Conclusion</h3><div>This study provides the first comprehensive analysis of clinical phenotypes in Chinese patients with NF1. The identification of distinct NF1 subtypes, phenotypic correlations, and ethnic differences supports more personalized management strategies for NF1 patients.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 181-190"},"PeriodicalIF":5.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo molecular skin fluorescence imaging for noninvasive assessment of atypical nevi and melanoma: A validation trial 活体分子皮肤荧光成像非典型痣和黑色素瘤的无创评估：一项验证试验

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-11-26 DOI: 10.1016/j.jdin.2025.11.010

Douglas Grossman MD, PhD , Elizabeth Berry MD , Justin M. Ko MD , Raja Sivamani MD , Serena Mraz MD , Sunil S. Dhawan MD , Kevin Manbeck MS , Amit Shachaf PhD , Shamika Majmudar MS , Catherine Shachaf PhD , Sancy Leachman MD, PhD

{"title":"In vivo molecular skin fluorescence imaging for noninvasive assessment of atypical nevi and melanoma: A validation trial","authors":"Douglas Grossman MD, PhD , Elizabeth Berry MD , Justin M. Ko MD , Raja Sivamani MD , Serena Mraz MD , Sunil S. Dhawan MD , Kevin Manbeck MS , Amit Shachaf PhD , Shamika Majmudar MS , Catherine Shachaf PhD , Sancy Leachman MD, PhD","doi":"10.1016/j.jdin.2025.11.010","DOIUrl":"10.1016/j.jdin.2025.11.010","url":null,"abstract":"<div><h3>Background</h3><div>Current visual assessments and assistive technologies for melanoma detection primarily focus on detecting morphological changes, often requiring invasive biopsies for confirmation.</div></div><div><h3>Objective</h3><div>To determine the efficacy of skin fluorescent imaging (SFI), a novel noninvasive technology for detection of αvβ3 integrin in the tumor microenvironment, for discrimination of benign from malignant melanocytic lesions.</div></div><div><h3>Methods</h3><div>A prospective validation trial evaluated 240 clinically suspicious cutaneous pigmented lesions prior to biopsy in 6 academic and community dermatology clinics in California, Utah, and Oregon.</div></div><div><h3>Results</h3><div>The distribution of lesions included 99 (41%) lesions without dysplasia, 59 (25%) nevi with low-grade dysplasia, 51 (21%) nevi with high-grade dysplasia, 20 (8.3%) melanoma in situ, and 11 invasive melanomas (4.6%). SFI cutoff scores of 5 and 7 demonstrated sensitivities of 93% and 87% and specificities of 77% and 91%, respectively, for discrimination of lesions with no or low-grade dysplasia from those with high-grade dysplasia or melanomas. The area under the receiver operating characteristic curve was 0.907 (95% CI 0.864-0.951, <em>P</em> <.0001).</div></div><div><h3>Limitations</h3><div>This was a single-arm trial.</div></div><div><h3>Conclusions</h3><div>SFI demonstrated high sensitivity and specificity for discriminating low-risk from high-risk lesions, representing a promising approach to enhance evaluation of clinically concerning pigmented lesions and reduce unnecessary biopsies.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 279-286"},"PeriodicalIF":5.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonkeratinocyte skin cancer in survivors of childhood, adolescent, and young adult cancer with and without radiotherapy 有无放疗的儿童、青少年和青年癌症幸存者的非角化细胞皮肤癌

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-10-14 DOI: 10.1016/j.jdin.2025.09.019

Yuming Sun PhD , Zehao Luo MD , Furong Zeng PhD , Guangtong Deng PhD

引用次数: 0

Impact of sleep disturbance on mental health in schoolchildren with atopic dermatitis: A population-based study 睡眠障碍对小学生特应性皮炎心理健康的影响：一项基于人群的研究

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-10-01 DOI: 10.1016/j.jdin.2025.08.013

Kan-Hsuan Lin MD , Yu-Jun Chang PhD , Tung-Ming Chang MD, PhD , Kuender D. Yang MD, PhD , Ching-Yuang Lin MD, PhD , Ko-Huang Lue MD, PhD , Hai-Lun Sun MD, PhD , Pei-Fen Liao MD , Jun-Kai Kao MD, PhD , Yi-Giien Tsai MD, PhD

{"title":"Impact of sleep disturbance on mental health in schoolchildren with atopic dermatitis: A population-based study","authors":"Kan-Hsuan Lin MD , Yu-Jun Chang PhD , Tung-Ming Chang MD, PhD , Kuender D. Yang MD, PhD , Ching-Yuang Lin MD, PhD , Ko-Huang Lue MD, PhD , Hai-Lun Sun MD, PhD , Pei-Fen Liao MD , Jun-Kai Kao MD, PhD , Yi-Giien Tsai MD, PhD","doi":"10.1016/j.jdin.2025.08.013","DOIUrl":"10.1016/j.jdin.2025.08.013","url":null,"abstract":"<div><h3>Objective</h3><div>This Taiwanese population-based cross-sectional (CARE) study examined associations between sleep disturbances and mental health symptoms in adolescents with atopic dermatitis (AD).</div></div><div><h3>Method</h3><div>A cross-sectional analysis was conducted among 14,675 adolescents (median age: 12.6 years; 49.7% male) using validated self-report questionnaires to assess anxiety (Screen for Child Anxiety Related Emotional Disorders) and depression (Patient Health Questionnaire-9). AD was identified via physician diagnosis and self-reported symptoms. Sleep quality, frequency of disturbances, and daytime sleepiness were evaluated using self-report. Logistic regression models adjusted for sex and psychosocial factors were used to assess associations with mental health outcomes.</div></div><div><h3>Results</h3><div>Adolescents with AD (<em>n</em> = 3470) had higher anxiety (18.7% vs 16.0%) and depression (4.2% vs 2.4%) prevalence than health controls (<em>n</em> = 7865) (<em>P</em> < 0.001). Among adolescents with AD, weekly sleep disturbances, poor sleep quality, and daytime sleepiness were independently associated with 2.1, 1.8, and 1.6-fold higher risks of anxiety and 4.4, 2.7, and 2.1-fold higher risks of depression, after adjustment for sex and psychosocial factors. A dose-response relationship was observed between the sleep disturbance frequency and symptom severity.</div></div><div><h3>Conclusion</h3><div>Sleep disturbances are strongly associated with increased anxiety and depression symptoms in adolescents with AD. Interventions focusing on sleep and psychosocial stress may improve mental health outcomes in this vulnerable population.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"24 ","pages":"Pages 50-60"},"PeriodicalIF":5.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical 1.5% ruxolitinib cream for facial refractory segmental vitiligo: A retrospective single-center study 局部1.5%鲁索替尼乳膏治疗面部难治性节段性白癜风：一项回顾性单中心研究

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-10-03 DOI: 10.1016/j.jdin.2025.08.016

Hequn Huang MM , Dawei Duan MM , He Huang MD , Xianfa Tang MD , Caihong Zhu MD , Yaohua Zhang MD , Min Li MD , Yujun Sheng MD , Leihong Xiang MD, PHD , Yong Cui MD , Youwen Zhou MD , Xuejun Zhang MD, PHD , Bo Zhang MD, PHD

引用次数: 0

Gaps in phototherapy and Mohs surgery access: A cross-sectional survey of dermatology residency programs in the United States 光疗和莫氏手术的差距：美国皮肤科住院医师项目的横断面调查

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-09-29 DOI: 10.1016/j.jdin.2025.08.012

Dahyeon Kim BS , Lauren Pineda MS , Amylee Martin MD , Christina Kraus MD , Harry Dao MD

引用次数: 0

Real-world effectiveness and safety of lebrikizumab maintenance dosing every 4 weeks starting at week 4 after 2 loading doses in Japanese patients with atopic dermatitis 在日本特应性皮炎患者中，2次负荷剂量后，从第4周开始，每4周给予lebrikizumab维持剂量的实际有效性和安全性

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-11-28 DOI: 10.1016/j.jdin.2025.11.014

Yoshiki Okada MD, Masahiro Kamata MD, PhD, Shoya Suzuki MD, Ayu Watanabe MD, PhD, Chika Chijiwa MD, PhD, Yayoi Tomura MD, PhD, Ryosuke Takeshima MD, PhD, Azusa Hiura MD, PhD, Kotaro Hayashi MD, PhD, Atsuko Fukuyasu MD, PhD, Takamitsu Tanaka MD, PhD, Takeko Ishikawa MD, PhD, Yayoi Tada MD, PhD

引用次数: 0

Tralokinumab for moderate-to-severe atopic dermatitis: A viable option for dupilumab nonresponders 曲单抗治疗中重度特应性皮炎：对杜匹单抗无反应的可行选择

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-10-07 DOI: 10.1016/j.jdin.2025.09.010

Christine T. Olagun-Samuel BA, Christine C. Akoh MD, PhD, Nnaemeka Anyanwu BS, Elizabeth F. Sher PhD, Carli D. Needle BA, Jamie Widawsky PA-C, MPAS, David E. Cohen MD, MPH, Emily Milam MD, Alexandra Flamm MD, Vikash Oza MD, Theodora K. Karagounis MD, MS

引用次数: 0

Oral tranexamic acid use for melasma is not associated with thromboembolism: Findings from a multicenter propensity score–matched electronic health record cohort 口服氨甲环酸治疗黄褐斑与血栓栓塞无关：来自多中心倾向评分匹配电子健康记录队列的研究结果

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-09-30 DOI: 10.1016/j.jdin.2025.09.005

Tyler Hernandez MD , Kayla Penny MD , Nicholas Culotta MD

引用次数: 0

Chronic venous insufficiency increases postoperative complications after Mohs micrographic surgery for lower extremity nonmelanoma skin cancer: A propensity-matched retrospective cohort study 慢性静脉功能不全增加下肢非黑色素瘤皮肤癌莫氏显微摄影手术后并发症：一项倾向匹配的回顾性队列研究

IF 5.2

JAAD International Pub Date : 2026-02-01 Epub Date: 2025-10-03 DOI: 10.1016/j.jdin.2025.09.008

Sahithi Talasila MD , Umer Nadir MD , George M. Jeha MD , Stanislav N. Tolkachjov MD

引用次数: 0