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Superior performance of two combined polygenic scores for predicting skin cancer risk and differentiating risk of melanoma from keratinocyte carcinomas in two cohorts 在两个队列中,两种联合多基因评分在预测皮肤癌风险和区分黑色素瘤与角化细胞癌风险方面表现优异。
IF 5.2
JAAD International Pub Date : 2025-08-01 DOI: 10.1016/j.jdin.2025.03.004
Luzheng Liu MD, PhD , Huy Tran MS , Ashley J. Mulford MS , Zhuqing Shi PhD , Jun Wei PhD , Annabelle Ashworth BA , S. Lilly Zheng MD , Jason B. Waldinger MD , Ross M. Levy MD , Alan R. Sanders MD , Jianfeng Xu MD, Dr PH
{"title":"Superior performance of two combined polygenic scores for predicting skin cancer risk and differentiating risk of melanoma from keratinocyte carcinomas in two cohorts","authors":"Luzheng Liu MD, PhD , Huy Tran MS , Ashley J. Mulford MS , Zhuqing Shi PhD , Jun Wei PhD , Annabelle Ashworth BA , S. Lilly Zheng MD , Jason B. Waldinger MD , Ross M. Levy MD , Alan R. Sanders MD , Jianfeng Xu MD, Dr PH","doi":"10.1016/j.jdin.2025.03.004","DOIUrl":"10.1016/j.jdin.2025.03.004","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"21 ","pages":"Pages 70-72"},"PeriodicalIF":5.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermatoscopic markers of disease activity in vitiligo 白癜风疾病活动的皮肤镜标记物
IF 5.2
JAAD International Pub Date : 2025-07-28 DOI: 10.1016/j.jdin.2025.04.017
Saâdia Boughaleb MD , Meryem Soughi MD , Ghita Sqalli MD , Aida Oulehri MD , Marwa El Baldi MD , Zakia Douhi MD , Sara Elloudi MD , Hanane Baybay MD , Karima El Rhazi MD , Fatima Zahra Mernissi MD
{"title":"Dermatoscopic markers of disease activity in vitiligo","authors":"Saâdia Boughaleb MD ,&nbsp;Meryem Soughi MD ,&nbsp;Ghita Sqalli MD ,&nbsp;Aida Oulehri MD ,&nbsp;Marwa El Baldi MD ,&nbsp;Zakia Douhi MD ,&nbsp;Sara Elloudi MD ,&nbsp;Hanane Baybay MD ,&nbsp;Karima El Rhazi MD ,&nbsp;Fatima Zahra Mernissi MD","doi":"10.1016/j.jdin.2025.04.017","DOIUrl":"10.1016/j.jdin.2025.04.017","url":null,"abstract":"<div><h3>Background</h3><div>Determining vitiligo activity is essential for prognosis and treatment planning.</div></div><div><h3>Objectives</h3><div>To describe the dermoscopic findings and correlate them with the activity of the disease.</div></div><div><h3>Methods</h3><div>A single-center, descriptive, analytical study included 233 patients (330 lesions). Lesions were categorized as progressing, repigmenting, stable, or recent. Dermoscopic analysis was performed using a DermLite 4 dermatoscope, with statistical testing through Pearson’s chi-square.</div></div><div><h3>Results</h3><div>Progressing lesions were associated with trichrome pattern, reverse network, nacreous white globules, starburst, comet-tail pattern, micro-Koebner phenomenon, residual peripilar pigmentation with leukotrichia, perilesional polka dots, perifollicular depigmentation, and reverse network (<em>P</em> &lt; .01). Stability was indicated by sharp borders (<em>P</em> &lt; .01). Repigmenting lesions exhibited perifollicular or border hyperpigmentation, erythema, and telangiectasias (<em>P</em> &lt; .01). Early vitiligo was suggested by hypopigmented lesions with attenuated network or perifollicular depigmentation (<em>P</em> &lt; .01). Newly identified markers included distally pigmented bicolored hair for recent lesions and proximally pigmented bicolored hair for repigmentation.</div></div><div><h3>Limitations</h3><div>Most patients had prior treatment, potentially influencing dermoscopic patterns.</div></div><div><h3>Conclusion</h3><div>This study, based on a large sample size, identifies specific dermoscopic markers for vitiligo activity and introduces novel findings like bicolored hairs. These insights can refine clinical assessment and serve as a foundation for future research.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"23 ","pages":"Pages 29-37"},"PeriodicalIF":5.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decreased incidence of hidradenitis suppurativa and psoriasis in diabetic patients treated with GLP-1 receptor agonists: A retrospective cohort study GLP-1受体激动剂治疗糖尿病患者的化脓性汗腺炎和牛皮癣发病率降低:一项回顾性队列研究
IF 5.2
JAAD International Pub Date : 2025-07-24 DOI: 10.1016/j.jdin.2025.07.003
Lauren M. Ching BS , Christopher A. Guirguis DMD , Nicholas L. Iskandar , Joe K. Tung MD, MBA
{"title":"Decreased incidence of hidradenitis suppurativa and psoriasis in diabetic patients treated with GLP-1 receptor agonists: A retrospective cohort study","authors":"Lauren M. Ching BS ,&nbsp;Christopher A. Guirguis DMD ,&nbsp;Nicholas L. Iskandar ,&nbsp;Joe K. Tung MD, MBA","doi":"10.1016/j.jdin.2025.07.003","DOIUrl":"10.1016/j.jdin.2025.07.003","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"22 ","pages":"Pages 97-99"},"PeriodicalIF":5.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144879241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Otitis externa due to allergic contact dermatitis to earphones and earplugs: A case control study 耳机和耳塞过敏性接触性皮炎所致外耳炎:一项病例对照研究
IF 5.2
JAAD International Pub Date : 2025-07-18 DOI: 10.1016/j.jdin.2025.05.020
Youyou Jin MSc , Wei Hua MD , Qingfeng Liu MM , Zili Zheng EngD , Xinyi Yao MSc , Xiangling Zhang MSc , Mei Li MM , Xiaoyun Zhang BS , Ran Gao BS , Xiaoyu Wang BS , Yueyi Sun BS , Li Li MD , Wei Zhang MD , Chengchen Guo EngD , Yu Zhao MD , Haotian Liu MD
{"title":"Otitis externa due to allergic contact dermatitis to earphones and earplugs: A case control study","authors":"Youyou Jin MSc ,&nbsp;Wei Hua MD ,&nbsp;Qingfeng Liu MM ,&nbsp;Zili Zheng EngD ,&nbsp;Xinyi Yao MSc ,&nbsp;Xiangling Zhang MSc ,&nbsp;Mei Li MM ,&nbsp;Xiaoyun Zhang BS ,&nbsp;Ran Gao BS ,&nbsp;Xiaoyu Wang BS ,&nbsp;Yueyi Sun BS ,&nbsp;Li Li MD ,&nbsp;Wei Zhang MD ,&nbsp;Chengchen Guo EngD ,&nbsp;Yu Zhao MD ,&nbsp;Haotian Liu MD","doi":"10.1016/j.jdin.2025.05.020","DOIUrl":"10.1016/j.jdin.2025.05.020","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"23 ","pages":"Pages 1-3"},"PeriodicalIF":5.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When topicals fall short, oral Janus kinase inhibitors offer a needed solution in chronic hand eczema 当局部药物不足时,口服Janus激酶抑制剂提供了慢性手湿疹所需的解决方案
IF 5.2
JAAD International Pub Date : 2025-07-17 DOI: 10.1016/j.jdin.2025.06.007
Christopher G. Bunick MD, PhD
{"title":"When topicals fall short, oral Janus kinase inhibitors offer a needed solution in chronic hand eczema","authors":"Christopher G. Bunick MD, PhD","doi":"10.1016/j.jdin.2025.06.007","DOIUrl":"10.1016/j.jdin.2025.06.007","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"22 ","pages":"Pages 86-87"},"PeriodicalIF":5.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improved outcomes of pediatric patients with vascular malformations treated at a multidisciplinary vascular anomaly clinic 在多学科血管异常门诊治疗血管畸形的儿科患者改善的结果
IF 5.2
JAAD International Pub Date : 2025-07-17 DOI: 10.1016/j.jdin.2025.07.002
Sofía Valdés-Loperena MD, Andrea González-Moreno MD, Itzel Guadalupe Elizalde-Jiménez MD, Carola Durán-McKinster MD, María Teresa García-Romero MD, MPH
{"title":"Improved outcomes of pediatric patients with vascular malformations treated at a multidisciplinary vascular anomaly clinic","authors":"Sofía Valdés-Loperena MD,&nbsp;Andrea González-Moreno MD,&nbsp;Itzel Guadalupe Elizalde-Jiménez MD,&nbsp;Carola Durán-McKinster MD,&nbsp;María Teresa García-Romero MD, MPH","doi":"10.1016/j.jdin.2025.07.002","DOIUrl":"10.1016/j.jdin.2025.07.002","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"22 ","pages":"Pages 83-85"},"PeriodicalIF":5.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic therapy targeting psoriatic inflammation is associated with decreased incidence of dementia: An observational retrospective cohort study 针对银屑病炎症的全身治疗与痴呆发病率降低相关:一项观察性回顾性队列研究
IF 5.2
JAAD International Pub Date : 2025-07-16 DOI: 10.1016/j.jdin.2025.06.006
Madison P. Olexson BS , Ana Ormaza Vera MD , Chunghwan Ro BS , Clinton W. Enos MD, MS
{"title":"Systemic therapy targeting psoriatic inflammation is associated with decreased incidence of dementia: An observational retrospective cohort study","authors":"Madison P. Olexson BS ,&nbsp;Ana Ormaza Vera MD ,&nbsp;Chunghwan Ro BS ,&nbsp;Clinton W. Enos MD, MS","doi":"10.1016/j.jdin.2025.06.006","DOIUrl":"10.1016/j.jdin.2025.06.006","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"22 ","pages":"Pages 88-90"},"PeriodicalIF":5.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ofatumumab for the management of refractory pemphigus vulgaris: A case series Ofatumumab治疗难治性寻常型天疱疮:一个病例系列
IF 5.2
JAAD International Pub Date : 2025-07-15 DOI: 10.1016/j.jdin.2025.05.018
Sera Sarsam MBBS, BMedSc , Ailin He , Dédée F. Murrell MA, BMBCh, MD (UNSW), DSc
{"title":"Ofatumumab for the management of refractory pemphigus vulgaris: A case series","authors":"Sera Sarsam MBBS, BMedSc ,&nbsp;Ailin He ,&nbsp;Dédée F. Murrell MA, BMBCh, MD (UNSW), DSc","doi":"10.1016/j.jdin.2025.05.018","DOIUrl":"10.1016/j.jdin.2025.05.018","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"22 ","pages":"Pages 94-96"},"PeriodicalIF":5.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144879240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acral lentiginous melanoma demonstrates more aggressive pathological features than non-acral melanoma in Jamaica: A 10-year multicenter study 在牙买加,肢端黄斑性黑色素瘤表现出比非肢端黑色素瘤更具侵袭性的病理特征:一项10年多中心研究
IF 5.2
JAAD International Pub Date : 2025-07-10 DOI: 10.1016/j.jdin.2025.06.005
Chico J. Collie MBBS, DM , Simone L. Jean-Marie MBBS , Rory K. Thompson MBBS, DM , Nadia P. Williams MBBS, DM , Jonathan D. Ho MBBS, D.Sc, Dip.Dermpath
{"title":"Acral lentiginous melanoma demonstrates more aggressive pathological features than non-acral melanoma in Jamaica: A 10-year multicenter study","authors":"Chico J. Collie MBBS, DM ,&nbsp;Simone L. Jean-Marie MBBS ,&nbsp;Rory K. Thompson MBBS, DM ,&nbsp;Nadia P. Williams MBBS, DM ,&nbsp;Jonathan D. Ho MBBS, D.Sc, Dip.Dermpath","doi":"10.1016/j.jdin.2025.06.005","DOIUrl":"10.1016/j.jdin.2025.06.005","url":null,"abstract":"","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"22 ","pages":"Pages 91-93"},"PeriodicalIF":5.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cosmetic and functional outcomes of excisional surgical wounds healed by secondary intention: A systematic review 手术切除伤口继发性愈合的美容和功能结果:一项系统综述
IF 5.2
JAAD International Pub Date : 2025-07-05 DOI: 10.1016/j.jdin.2025.05.016
Jalal Maghfour MD , John Meisenheimer MD , Jonathan Kantor MD, MSc, MSCE
{"title":"Cosmetic and functional outcomes of excisional surgical wounds healed by secondary intention: A systematic review","authors":"Jalal Maghfour MD ,&nbsp;John Meisenheimer MD ,&nbsp;Jonathan Kantor MD, MSc, MSCE","doi":"10.1016/j.jdin.2025.05.016","DOIUrl":"10.1016/j.jdin.2025.05.016","url":null,"abstract":"<div><h3>Background</h3><div>Data regarding short-term and long-term cosmesis and functional outcomes of excisional surgical wounds healed by secondary intention healing (SIH) are limited.</div></div><div><h3>Objective</h3><div>To conduct a systematic review and assess the cosmetic and functional acceptability of SIH for acute excisional surgical wounds.</div></div><div><h3>Methods</h3><div>Full-text articles queried from PubMed and Embase databases between January 1964 and April 2024 with cosmetic outcome data of human subjects with acute surgical wounds healed by SIH were included. Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines were followed.</div></div><div><h3>Results</h3><div>A total of 1655 surgical wounds, of which 1518 (91.7%) healed by SIH, from 35 studies, were included in this review. The most frequent indication for SIH was a defect resulting from excision of nonmelanoma skin cancer (keratinocyte carcinoma), which was identified in 1439 (86%) of patients. Common sites for SIH included the nose (23.3%), periocular region (15.46%), and forehead (13.5%). The majority of wounds on the forehead, medial canthus, lower eyelid, nasal ala, cheeks, lips, postauricular area, and feet resulted in good to excellent cosmetic results, whereas those on the scalp, nasal dorsum, nasal tip, nasal sidewall, and chin yielded less acceptable cosmetic results. Given the baseline variability in cosmesis of primarily closed wounds in some anatomic locations, however, these data suggest the need for future prospective studies.</div></div><div><h3>Summary</h3><div>SIH may produce an acceptable cosmetic and functional outcome for selected defects and may be of clinical benefit in the appropriate setting. This must be weighed against the potentially improved cosmesis and more rapid healing seen with primarily closed defects.</div></div>","PeriodicalId":34410,"journal":{"name":"JAAD International","volume":"22 ","pages":"Pages 100-110"},"PeriodicalIF":5.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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