Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)最新文献
K. Momose, Y. Kimura, M. Kiyosawa, M. Senda, K. Komiya
{"title":"Measurement of temporal frequency characteristics of VEP using pseudorandom binary sequence and their correlation with cerebral blood flow in human visual cortex","authors":"K. Momose, Y. Kimura, M. Kiyosawa, M. Senda, K. Komiya","doi":"10.1109/IEMBS.1997.756998","DOIUrl":"https://doi.org/10.1109/IEMBS.1997.756998","url":null,"abstract":"Steady-state visual evoked potentials (S-VEP) have been used to derive temporal frequency characteristics, which are effective in detecting sensitivity loss for high-frequency stimuli in early glaucoma. However, this method requires independent measurements of VEPs for various frequencies. In this study, an improved technique using pseudorandom binary sequence (PRBS) stimulation to elicit VEPs (PRBS-VEP) was proposed and compared with the S-VEP. Regional cerebral blood flow (CBF) was also measured with positron emission tomography (PET), and its response to stimulation was compared with the VEP. Results showed that PRBS-VEP yielded temporal frequency characteristics similar to those obtained by S-VEP, but in a much shorter time. Furthermore, CBF response in the primary visual cortex was well correlated with the VEP amplitude, suggesting that VEPs originate in the primary visual cortex.","PeriodicalId":342750,"journal":{"name":"Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128099805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Time-course analysis of motor unit firing patterns in stroke patients using noninvasive multielectrode electromyography","authors":"T. Sun, Jia-Jin Chen, Thy‐Sheng Lin","doi":"10.1109/IEMBS.1997.756602","DOIUrl":"https://doi.org/10.1109/IEMBS.1997.756602","url":null,"abstract":"The aim of this research is to apply the surface motor unit action potentials (MUAPs) measured with noninvasive multielectrode for study the motor control ability for paretic limb in stroke patients. To investigate the firing rate variation, the measure of joint interval histogram (JIH), derived from normalized interpulse interval (IPI) train, were adopted in this research. With the limited clinical cases, the JIH parameters are only appropriate for intra-subject comparison for affected and unaffected sides. In addition, MU activities of the affected side measured from acute to stable stages were evaluated for clinical time-course study.","PeriodicalId":342750,"journal":{"name":"Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133176294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chih-lung Lin, Han-Chang Wu, Kuang-Ching Wang, S. Young, Maw-huei Lee, T. Kuo
{"title":"The design of a DSP based portable physiological signal monitor","authors":"Chih-lung Lin, Han-Chang Wu, Kuang-Ching Wang, S. Young, Maw-huei Lee, T. Kuo","doi":"10.1109/IEMBS.1997.756561","DOIUrl":"https://doi.org/10.1109/IEMBS.1997.756561","url":null,"abstract":"A portable, high performance, and multifunction physiological signal monitor is presented. The authors use a digital signal processor (DSP) instead of a general microcontroller to make all data processing including filtering and compression real-time computing. By using a well-designed analog amplifier circuit and making the signal processing digital, this system is suitable for almost all frequently used EKG, EEG, and EMG signals.","PeriodicalId":342750,"journal":{"name":"Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127457734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Fujii, K. Hosokawa, T. Nojima, S. Shoji, A. Yotsumoto, I. Endo
{"title":"A microfabricated reactor for cell-free protein synthesis","authors":"T. Fujii, K. Hosokawa, T. Nojima, S. Shoji, A. Yotsumoto, I. Endo","doi":"10.1109/IEMBS.1997.756856","DOIUrl":"https://doi.org/10.1109/IEMBS.1997.756856","url":null,"abstract":"Cell-free protein synthesis is one of the most promising techniques for discovery and production of novel biochemical compounds which are useful for medical and biological applications. MEMS (Microelectromechanical Systems) technology enables us to fabricate microscale reactor systems for protein synthesis. In this paper, we show that the target protein (polyphenylalanine) can be successfully synthesized in the fabricated reactor according to given mRNA templates (polyuridic acid) as the simplest cell-free protein synthesis system. Since the microfabrication is a suitable method to integrate such reactors in a massively parallel structure, the integrated version of the system can be a powerful tool for drug discovery, preparation of combinatorial peptide libraries, etc.","PeriodicalId":342750,"journal":{"name":"Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133182442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Tsukada, E. Sekizuka, C. Oshio, T. Nagai, H. Minamitani
{"title":"Capillary model of crystal microchannel for red blood cell deformability measurement","authors":"K. Tsukada, E. Sekizuka, C. Oshio, T. Nagai, H. Minamitani","doi":"10.1109/IEMBS.1997.756795","DOIUrl":"https://doi.org/10.1109/IEMBS.1997.756795","url":null,"abstract":"To measure red blood cell (RBC) deformability in vitro, we used microchannels on a crystal substrate as a capillary model. We observed axisymmetry deformed RBCs to estimate their deformability and decided deformability index directly from RBCs themselves. The flowing RBCs in 200 folds through microscopy were recorded with an image-intensified high speed video camera system. This system allowed us to record individual RBC images clearly. We confirmed that the crystal microchannel is a valuable tool for RBC deformability measurement. Microangiopathy is a characteristic complication of diabetes mellitus. The decrease of RBC deformability is thought to cause this complication, In order to identify the deference in RBCs deformability between normal and diabetic RBCs, we could confirm that deformability of diabetic RBCs were much lower than normal ones, and this result suggests a possibility of serious damage in diabetic microcirculation.","PeriodicalId":342750,"journal":{"name":"Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)","volume":"119 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123477243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Fantini, K. T. Moesta, Maria-Angela Franceschini, H. Jess, H. Erdl, E. Gratton, P. Schlag, M. Kaschke
{"title":"Instrumentation and clinical applications in frequency-domain optical mammography","authors":"S. Fantini, K. T. Moesta, Maria-Angela Franceschini, H. Jess, H. Erdl, E. Gratton, P. Schlag, M. Kaschke","doi":"10.1109/IEMBS.1997.756898","DOIUrl":"https://doi.org/10.1109/IEMBS.1997.756898","url":null,"abstract":"We describe an instrument for frequency-domain light mammography (LIMA), and we present clinical results obtained on patients affected by breast cancer. This instrument uses two laser diodes emitting at 690 and 825 nm. Their intensities are modulated at a frequency of 110 MHz. The amplitude and the phase of the intensity wave are the measured quantities. The breast is slightly compressed between two glass plates and the optical signal is detected in transmission, i.e. on the opposite side of the illuminated spot of the breast. The acquisition time for a full breast image is about 3 minutes. Edge effects (that are mainly due to the breast thickness variability within the scanned area) are corrected by an algorithm of data analysis which enhances the contrast of the optical mammograms. In the clinical applications, we successfully detected 27 out of 37 malignant tumors (73%). This result shows the practical feasibility and the significant potential of frequency-domain optical mammography.","PeriodicalId":342750,"journal":{"name":"Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133518233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. M. Finkelstein, Marshall I. Hertz, M. Snyder, C. E. Stibbe, N. Sabati, Bruce R. Lindgren, Pradyumna Dutta, T. Killoren, J. Slagle
{"title":"Early detection of bronchiolitis obliterans syndrome in lung transplant recipients with chronic rejection using home spirometry","authors":"S. M. Finkelstein, Marshall I. Hertz, M. Snyder, C. E. Stibbe, N. Sabati, Bruce R. Lindgren, Pradyumna Dutta, T. Killoren, J. Slagle","doi":"10.1109/IEMBS.1997.756533","DOIUrl":"https://doi.org/10.1109/IEMBS.1997.756533","url":null,"abstract":"Declining pulmonary function, as measured by staging for bronchiolitis obliterans syndrome, is considered primary indication of future chronic rejection in transplanted lungs. Staging has been evaluated in a group of transplant recipients using a paperless, electronic spirometer/diary instrument for home monitoring. Eleven of 104 lung recipients were diagnosed with chronic rejection. Seven of these subjects had performed home monitoring for a minimum of 8 months at the time of this study. Clinic and home spirometry variables were used in the staging algorithm to determine the onset and rate of clinical decline related to the rejection. Using home spirometry, the onset of decline began an average of 284 days before diagnosis of chronic rejection, which was significantly earlier (p<0.05) than the decline observed with clinic pulmonary function testing. Staging changes based on home spirometry preceded diagnosis of chronic rejection in all subjects, but only occurred in 4 of 7 subjects using clinic testing. Home spirometry can provide early and consistent indication of pulmonary decline prior to chronic rejection, and should be considered as a future component of post-transplant follow-up care.","PeriodicalId":342750,"journal":{"name":"Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132621310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Late potential analysis in Chagas disease using the vector spectral combination of orthogonal leads","authors":"R. Bravo, O. Escalona, F. Mora, G. Passariello","doi":"10.1109/IEMBS.1997.754468","DOIUrl":"https://doi.org/10.1109/IEMBS.1997.754468","url":null,"abstract":"Chagas disease is a major public health problem in South American countries, in the Venezuelan case, the heart is the mainly affected organ. The parasite that produces the disease invades the myocardium, causes muscle and conduction system degeneration, leading to abnormal ventricular contractility and conduction. Late potential (LP) analysis can detect abnormal electric behavior of the ventricles, which has been correlated with the presence of ventricular tachycardia episodes. Time domain methods for LP analysis are widely used but they are affected by other cardiac pathologies, i.e., branch blocks (BE), which are found simultaneously with abnormal ventricular conduction phenomena in chagasic patients. The use of an orthogonal lead vectorspectral combination using the Hartley transform has demonstrated to be a simple frequency domain method for the interpretation of abnormal ventricular potentials. This work uses the latter approach for LP analysis of high resolution ECG (HRECG) records of chagasic patients. The vectorspectral magnitude (S) was computed as the sum of the DHT spectra components of the XYZ leads in the frequency bands of 60 to 300 Hz and -300 to -60 Hz, for each chagasic patient group and a healthy subject control group in a time window at the end of QRS. Results showed that S is significantly lower in healthy subjects (63.5/spl plusmn/23.8 /spl mu/V) than in chagasic patients with abnormal electrocardiogram (89.2/spl plusmn/43.7 /spl mu/V), p<0.05. The vector spectral analysis is a simple frequency domain method for LP study, the results showed that the method can detect positive patients with generalized myocardial disease.","PeriodicalId":342750,"journal":{"name":"Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121718020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quantitative assessment of behavior in dementia patients by continuous physical activity monitoring","authors":"T. Tamura, T. Fujimoto, T. Togawa","doi":"10.1109/IEMBS.1997.756513","DOIUrl":"https://doi.org/10.1109/IEMBS.1997.756513","url":null,"abstract":"The aim of this study was to examine the quantitative relationship between physical activity and heart rate in dementia patients. Acceleration at the waist, wrist and ankle and ECGs were measured by an ambulatory monitor. At the same time as these measurements subject records were noted by a psychotherapist. Fourteen late stage dementia patients and fifteen normal elderly performed daily activity between 10 am and 4 pm. Changes in heart rate were associated with changes in acceleration in both groups, but intermittent activity changes were observed in dementia patients. The mean acceleration frequency and amplitude in the dementia group were significantly lower than those in normal elderly subjects. There was no correlation between the severity of intellectual deterioration and the degree of behavior disintegration in dementia patients. The elderly shifted smoothly between activities. The dementia patients showed sudden fluctuations of activity. The ambulatory monitor is an effective method for the quantitative assessment of dementia patients.","PeriodicalId":342750,"journal":{"name":"Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115146398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A portable battery operated bone fracture evaluator","authors":"K. Singh, V. Singh","doi":"10.1109/IEMBS.1997.758810","DOIUrl":"https://doi.org/10.1109/IEMBS.1997.758810","url":null,"abstract":"A low cost, battery operated portable handy electronic instrument is developed to evaluate at quicker speed the bone conditions, at site, in a novel way, say in road accidents. The cost of the instrument is less than one per cent than that of a simple conventional X-ray machine.","PeriodicalId":342750,"journal":{"name":"Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1997-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115451749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}