Oral poster abstracts最新文献

{"title":"P-023 Spoke-administered intravenous alteplase and outcomes for large vessel occlusion stroke patients in a hub-and-spoke telestroke model","authors":"R. Regenhardt, J. Rosenthal, A. Awad, N. Nolan, J. McIntyre, C. Whitney, N. Alotaibi, J. Vranic, C. Stapleton, A. Patel, N. Rost, L. Schwamm, T. Leslie-mazwi","doi":"10.1136/neurintsurg-2021-snis.59","DOIUrl":"https://doi.org/10.1136/neurintsurg-2021-snis.59","url":null,"abstract":"Conclusion This study presents novel population-level data on national trends in the frequency and characteristics of venous stenting in IIH. EVS was associated with shortest length of hospital stay. A continuous increase in venous stenting with a relative stable use of shunting and ONF suggests an increasing role for endovascular therapies in IIH","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129600317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-006 Update on the reperfusion with cooling in cerebral acute ischemia II (RECCLAIM II) trial","authors":"Rishi Gupta, S. Zaidi, M. Jumaa, N. Badjatia, A. Yoo","doi":"10.1136/neurintsurg-2021-snis.42","DOIUrl":"https://doi.org/10.1136/neurintsurg-2021-snis.42","url":null,"abstract":"Introduction Endovascular therapy for large vessel occlusion has become the standard of care for appropriate patients treated under 24 hours from onset. Despite being superior to standard medical management, roughly 50% of patients still do not achieve independent neurological functioning. Therapeutic hypothermia (TH) impacts multiple pathways to provide neuroprotection in stroke by lower metabolic demand. Prior trials with TH may have failed due to inconsistent reperfusion therapies at that time. The RECCLAIM II study was designed to test if the addition of TH to endovascular reperfusion is feasible and safe. We intend to provide an update on the progress and status of the study as enrollment continues. Methods Prospective, multi-center, randomized-controlled study with a target enrollment of 120 patients to assess the safety and feasibility to achieve rapid hypothermia to under 34 degrees C with the ZOLL Intravascular Proteus system prior to achieving reperfusion. Cooling will be maintained for 6 hours with rewarming to 36.5-37 degrees C over the next 3-6 hours. CT studies will be assessed for hemorrhagic complications 24 hours post-procedure and 90-day blinded outcomes will be obtained on each patient. Up to ten centers will enroll up to 120 patients for the study. Each center will perform 4 Roll-in cases prior to entering the randomization phase. The primary feasibility endpoint is that the majority of patients will achieve a temperature of 34 degrees C within one hour of arterial puncture without significant delays to reperfusion when comparing the control and treatment arms. The secondary endpoints include rates of hemorrhage and clinical outcomes in both arms. Results A total of 30 patients have been enrolled to date. Times for each procedure, ability to achieve rapid hypothermia, 90 day blinded Modified Rankin, and core lab adjudicated hemorrhagic complication rates will be evaluated. The DMC will review significant adverse events and mortalities. Workflow time metrics will be assessed for both arms to assess for how quickly TH can be commenced in conjunction with thrombectomy. These results will serve as the basis for powering a phase III study to assess the efficacy of TH in conjunction with reperfusion therapy compared to reperfusion therapy alone. Conclusion There is limited evidence demonstrating the clinical benefit or impact of neuroprotection in conjunction with endovascular reperfusion therapy for acute ischemic stroke. Combining intravascular therapeutic hypothermia with endovascular reperfusion therapy may provide an opportunity to enhance clinical outcomes in patients with large vessel occlusion. Disclosures R. Gupta: 1; C; Stryker Neurovascular PI ASSIST Registry, Zoll PI RECCLAIM II (No compensation), Cerenovous Steering Committee MEMBRANE study, Medtronic Steering Committee ELEVATE Study, Penumbra CEC MIND Trial, Vesalio PI CLEAR Study, Rapid Medical PI Tiger Study. S. Zaidi: None. M. Jumaa: None. N. Badjatia: None. A. Yoo:","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128242708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-051 Treatment of acutely ruptured intracranial aneurysms with woven endobridge device: a systematic review","authors":"A. Monteiro, A. Lazar, M. Waqas, H. Rai, A. Baig, R. Dossani, F. Almayman, J. Cappuzzo, J. Davies, K. Snyder, E. Levy, A. Siddiqui","doi":"10.1136/neurintsurg-2021-snis.87","DOIUrl":"https://doi.org/10.1136/neurintsurg-2021-snis.87","url":null,"abstract":"Introduction The Woven Endobridge (WEB) device is a barrelshaped nitinol mesh deployed within the aneurysmal sac. The absence of metallic mesh in the vessel lumen obviates the need for potent antiplatelet therapy, which makes this devices interesting for acutely ruptured aneurysms not amenable to clipping or coiling. Methods We performed a comprehensive systematic search of Pubmed, MEDLINE and EMBASE databases following the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA) guidelines.","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133360929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"55 Large, wide-neck aneurysm canine model treated with neurocure® liquid embolic – 12-month survival","authors":"T. Becker, W. Merritt, N. Norris, A. Ducruet","doi":"10.1136/neurintsurg-2021-snis.91","DOIUrl":"https://doi.org/10.1136/neurintsurg-2021-snis.91","url":null,"abstract":"","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132847072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-034 Assessment of female authorship in journal of neurointerventional surgery (JNIS) publications in 2019–2020","authors":"K. Javed, D. Altschul, F. Albuquerque, J. Hirsch","doi":"10.1136/neurintsurg-2021-snis.70","DOIUrl":"https://doi.org/10.1136/neurintsurg-2021-snis.70","url":null,"abstract":"P-034 Figrue 1 Abstracts A44 J NeuroIntervent Surg 2021;13(Suppl 1):A1–A156 on A uust 7, 2021 by gest. P rocted by coright. http/jnis.bm jcom / J N eurotervent S urg: frst pulished as 10.1136intsurg-2021-S N IS 71 on 26 July 221. D ow nladed fom encapsulation around the material. A protein-resistant, liquidto-solid curing material could have expanded use as anon-fouling, protein-resistant coating for a variety of metal-based implants. Materials and Methods The resistance to protein adsorption is quantified via protein depletion from the blood, as well as through analysis of desorbed proteins from sample surfaces via Tween-20. Detection and quantification of proteins is performed via PPODA-QT samples (n=12) were prepared and cured in 4mm diameter cylindrical molds with a height of 10mm. PPODA-QT samples were each immersed in 1.5mL of heparinized rabbit whole blood within a 2mL polypropylene vial. Vials were placed on a shaker plate for15 minutes to ensure maximal interfacing between blood and the samples. With the majority of protein adsorption happening within seconds, 15 minutes is sufficient for protein adsorption. Positive controls(n=4) were created by preparing 4mm diameter and 10mm thick polyurethane cylinders and subjecting them to the same blood immersion procedure. Negative controls (n=4) were created by filling vials with blood and no sample to give a baseline level for protein adsorption onto the vials themselves. Proteins will be identified and quantified via label-free spectroscopy techniques. Results PPODA-QT has been shown to exhibit exemplary protein-resistant properties as well as minimal encapsulation and inflammatory response when implanted while providing a relatively uniform surface for neointimal tissue growth across the device at the neck of the aneurysm. Comparison of PPODAQT to the positive controls results in statistically significant reduction of protein depletion from blood samples. Verification of this result via analysis of desorbed proteins is underway. Conclusion The protein-resistance of PPODA-QT as shown in this study makes it an interesting material candidate for a variety of surgical applications. A liquid-to-solid curing material with inherent protein-resistant properties could be utilized not only as a novel liquid embolic for treatment of intracranial aneurysms and AVMs, but could also be used as a nonfouling, bioinert coating for metallic implants such as stents, flow diverters, and coils. Disclosures W. Merritt: 1; C; Northern Arizona University, Aneuvas Technologies, Inc.. 5; C; Aneuvas Technologies, Inc. A. Ducruet: 1; C; Northern Arizona University, Aneuvas Technologies, Inc. T. Becker: 1; C; Northern Arizona University, Aneuvas Technologies, Inc.. 4; C; Aneuvas Technologies, Inc.. 5; C; Aneuvas Technologies, Inc. P-036 SENSITIVITY OF THE RACW SCORE IN THE DETECTION OF LARGE VESSEL OCCLUSIONS DURING WORKING AND NON-WORKING HOURS E Hitomi, M Jumaa, S Zaidi, J Shawver, A Korsnack, A Castonguay, R Burgess, ","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"228 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121069184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-002 Perceived limits of endovascular treatment for secondary medium vessel occlusion stroke","authors":"P. Cimflova, R. McDonough, M. Kappelhof, J. Ospel, N. Singh, N. Kashani, A. Demchuk, B. Menon, M. Chen, N. Sakai, J. Fiehler, M. Goyal","doi":"10.1136/neurintsurg-2021-snis.38","DOIUrl":"https://doi.org/10.1136/neurintsurg-2021-snis.38","url":null,"abstract":"Background Medium-vessel occlusions (MeVOs) account for 25%-40% of all acute ischemic stroke (AIS) cases. With peri-procedural embolization occurring in up to 9% of all EVT cases, secondary MeVOs are of particular interest to neuroin-terventionalists. There is currently no reliable evidence regarding whether EVT is safe and effective for MeVO strokes. We sought to gain insight into the current management approaches regarding EVT in AIS caused by secondary MeVOs. Methods We conducted an international case-based survey (MeVO-Finding Rationales and Objectifying New Targets for IntervEntional Revascularization in Stroke; MeVO-FRON-TIERS) among stroke physicians to gain insight into the current management approaches regarding EVT in AIS caused by secondary MeVOs. Survey participants were presented three cases involving secondary MeVO, each consisting of three case-vignettes with differences in the neurological status of the described patient (improvement, no change, unable to assess due to general anaesthesia). Univariate and multivariate logistic regression analyses clustered by respondent identity were performed to assess factors influencing the decision to treat.","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125154449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-028 Ophthalmic artery flow direction changes in intra-arterial treatment of retinoblastoma","authors":"M. Feldman, H. Grimaudo, S. Roth, H. Vance, A. Daniels, M. Froehler","doi":"10.1136/neurintsurg-2021-snis.64","DOIUrl":"https://doi.org/10.1136/neurintsurg-2021-snis.64","url":null,"abstract":"(DMSO)). Aqua Embolic System (AES) is a new LEM, which is mainly composed of multiple polysaccharides. AES, when injected via a microcatheter, immediately forms a solid and elastic hydrogel cast upon exposure to Ca2+ in the bloodstream. The use of organic solvents, e.g., DMSO, is not required. The performance of AES was evaluated using an established AVM model utilizing swine rete-mirabile. Methods Under general anesthesia, the left ascending pharyngeal artery (APA) of Yorkshire swine (40 kg) was catheterized using a microcatheter (ID:0.013 inches), and AES was slowly injected into the rete-mirabile under fluoroscopy. The following parameters were assessed to evaluate the embolization performance of the AES; 1) the amount of AES required for the complete occlusion of the feeding artery, 2) injection speed, 3) radiopacity during the deployment, and 4) incidence of catheter entrapment after the injection. The same evaluation was performed on the contralateral rete-mirabile and the left renal artery as well. Results 12 arteries in 4 swine were treated, and all arteries were completely occluded without technical complications. The injected materials immediately formed AES cast in all vessels, followed by the reflux over the tip of the microcatheter. All catheters were withdrawn without any sign of catheter entrapment. The AES mixed with tantalum-based contrasts medium showed sufficient radiopacity under fluoroscopy. With the injection speed of 0.02ml/sec, the average volume required was 0.85mL for the APA and 2.9mL for the renal artery. No increased thrombogenicity or vasospasm near the treated lesion was observed during the procedure. Conclusions AES, which is a DMSO free, non-adhesive polysaccharides based LEM, may be used as an embolic material for the treatment of hemorrhagic stroke caused by cerebrovascular diseases, such as brain AVM. A: common carotid artery injection (AP view) shows left ascending pharyngeal artery (APA) and left rete mirabile (red arrow). B: AES is injected from the microcatheter. The AES reflux is reaching the tip of the microcatheter. C: With continuous injection of AES, the microcotheter tip is embedded ¡n the cost of AES. D. Post treatment angiogram shows complete occlusion of the left rete mirabile and APA Disclosures I. Yuki: 1; C; ICTS Grant, POP Grant. K. Ohkawa: None. S. Li: None. E. Steward: None. B. Nguyen: None. F. Hsu: None. J. Xu: None. S. Suzuki: None.","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126341167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-009 An angled tip is associated with improved technical outcomes when using 0.064–0.074 aspiration catheters: analysis from a multicenter retrospective cohort","authors":"J. Vargas, S. Majidi, H. Hawk, S. Nimjee, A. Zakeri, M. Mokin, R. Kellogg, G. Cortez, A. Aghaebrahim, E. Sauvageau, R. Hanel, R. Leacy, A. Siddiqui, A. Turk, M. Oselkin, E. Marlin, R. Turner, I. Chaudry, J. Milburn","doi":"10.1136/neurintsurg-2021-snis.45","DOIUrl":"https://doi.org/10.1136/neurintsurg-2021-snis.45","url":null,"abstract":"gios: None. E. Peterson: None. D. Yavagal: None. A. Spiotta: 1; C; Penumbra, Medtronic, Stryker. 2; C; Cerenovus, Terumo, Siemens, Penumbra, Stryker. R. Starke: 1; C; NREF, Joe Niekro Foundation, Brain Aneurysm Foundation, Bee Foundation, NIH, Miami Clinical and Translational Science Institute, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities. 2; C; Penumbra, Abbott, Medtronic, InNeuroCo, Cerenovus.","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128296526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-029 Impact of in-hospital delirium on outcomes of acute ischemic stroke","authors":"D. Pujara, H. Kamal, O. Mir, S. Reddy, K. Parsha, S. Patil, B. Gogia, P. Rai, C. Sitton, M. Chen, M. Abraham, M. Hussain, A. Hassan, A. Sarraj","doi":"10.1136/neurintsurg-2021-snis.65","DOIUrl":"https://doi.org/10.1136/neurintsurg-2021-snis.65","url":null,"abstract":"46% had left-sided disease (n=7), 33% had right-sided disease (n=5), and 20% had bilateral disease (n=3). The majority were male (n=10). Average age at the start of treatment was 1 year 5.5 months. A total of 66 treatments were performed, with a median of 4 per patient or 3.5 per involved eye. Of the 18 eyes treated, 12 (66%) initially had anterograde ophthalmic artery flow. Drug delivery was accomplished using direct ophthalmic catheterization (n=35), ICA balloon technique (n=18), ECA balloon technique (n=7), and via ECA branch catheterization (n=6). A flow reversal event was observed a total of 5 times (28% of eyes), each necessitating a change in drug delivery technique. All 5 events were in patients receiving multi-agent chemotherapy. These events occurred in 4 patients and involved 5 separate eyes, never more than once per eye. Flow reversal events were seen in both eyes (left=3, right=2). On average, events occurred between the third and fourth treatment (range 2 to 6). No correlation was found between reversal event and treatment technique. Conclusions Ophthalmic artery flow is variable in RB patients treated with IAC. Further, mid-treatment shifts between anterograde and retrograde ophthalmic artery filling are common and necessitate variation in delivery methods throughout a single treatment course. In our analysis all flow reversal events were associated with multi-agent chemotherapy (as opposed to Melphalan alone). Although the correlation was not statistically significant,our analysis is limited by power. Future investigation is necessary to elucidate the nature of these variations, such as if they are a direct response to the number of chemotherapy agents utilized. Regardless, interventionalists should be comfortable and prepared to use various techniques independent of a given patient’s treatment history. Disclosures M. Feldman: None. H. Grimaudo: None. S. Roth: None. H. Vance: None. A. Daniels: None. M. Froehler: 1; C; Genentech, Medtronic, Stryker, Microvention, and Penumbra. 2; C; Genentech, Medtronic, Stryker, Balt USA, Viz.ai, and Corindus.","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"166 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122838371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-001 Non-contrast CT alone versus combined CT plus CTA or MRA selection for thrombectomy in acute ischemic stroke: analysis of the angel-act registry","authors":"G. Ma, M. Mokin, B. Jia, Aparna Jadhav, X. Tong, D. Mo, N. Ma, F. Gao, X. Huo, G. Luo, L. Song, X. Sun, Y. Deng, A. Wang, X. Zhang, L. Gui, C. Song, Y. Peng, J. Wu, S. Zhao, J. Zhao, Z. Zhou, Z. Miao, Z. Ren","doi":"10.1136/neurintsurg-2021-snis.37","DOIUrl":"https://doi.org/10.1136/neurintsurg-2021-snis.37","url":null,"abstract":"Background Medium-vessel occlusions (MeVOs) account for 25%-40% of all acute ischemic stroke (AIS) cases. With peri-procedural embolization occurring in up to 9% of all EVT cases, secondary MeVOs are of particular interest to neuroin-terventionalists. There is currently no reliable evidence regarding whether EVT is safe and effective for MeVO strokes. We sought to gain insight into the current management approaches regarding EVT in AIS caused by secondary MeVOs. Methods We conducted an international case-based survey (MeVO-Finding Rationales and Objectifying New Targets for IntervEntional Revascularization in Stroke; MeVO-FRON-TIERS) among stroke physicians to gain insight into the current management approaches regarding EVT in AIS caused by secondary MeVOs. Survey participants were presented three cases involving secondary MeVO, each consisting of three case-vignettes with differences in the neurological status of the described patient (improvement, no change, unable to assess due to general anaesthesia). Univariate and multivariate logistic regression analyses clustered by respondent identity were performed to assess factors influencing the decision to treat.","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130682756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}