Oral poster abstracts最新文献

{"title":"P-035 Investigation of a novel poly(propylene glycol) material for use as a protein-resistant, bio-inert implant coating","authors":"W. Merritt, A. Ducruet, T. Becker","doi":"10.1136/neurintsurg-2021-snis.71","DOIUrl":"https://doi.org/10.1136/neurintsurg-2021-snis.71","url":null,"abstract":"","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132405301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-040 Major complications of dural venous sinus stenting for idiopathic intracranial hypertension: case series and management considerations","authors":"R. Townsend, A. Jost, M. Amans, F. Hui, M. Bender, S. Satti, R. Maurer, K. Liu, W. Brinjikji, K. Fargen","doi":"10.1136/neurintsurg-2021-snis.76","DOIUrl":"https://doi.org/10.1136/neurintsurg-2021-snis.76","url":null,"abstract":"P-041 Figure 1 (A) Axial computed tomogram (CT) of the head showing bilateral chronic subdural hematomas (cSDHs). (B-D) Cerebral angiography images showing bilateral middle meningeal artery embolization with Onyx (views: B, un-subtracted posteroanterior; C, right lateral, D, left lateral). (E) Axial head CT at 30-day follow-up shows significant improvement of bilateral cSDHs. Used with permission from barrow neurological institute, Phoenix, Arizona Abstracts A48 J NeuroIntervent Surg 2021;13(Suppl 1):A1–A156 on A uust 3, 2021 by gest. P rocted by coright. http/jnis.bm jcom / J N eurotervent S urg: frst pulished as 10.1136intsurg-2021-S N IS 77 on 26 July 221. D ow nladed fom (20%) reported chronic headaches before embolization. With a mean follow-up of 489 (173) days, 8 of the 9 patients reported improvement of chronic headaches, with 7 having complete resolution. For these 9 patients, the mean HIT-6 score before was significantly higher than after embolization (64 [7.1] vs 40 [9.1], p<0.001). Conclusion In patients with chronic headache undergoing MMA embolization for a cSDH, the majority reported improvement of headaches after the procedure. Future prospective studies are warranted to assess the utility of MMA embolization for chronic headaches. Disclosures J. Catapano: None. K. Karahalios: None. V. Srinivasan: None. J. Baranoski: None. C. Rutledge: None. T. Cole: None. A. Ducruet: None. F. Albuquerque: None. A.","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116988974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-060 Application of non-destructive mechanical characterization testing for creating in vitro vessel models with material properties similar to human neurovasculature","authors":"K. Lewis, J. Vigil, N. Norris, W. Merritt, T. Becker","doi":"10.1136/neurintsurg-2021-snis.96","DOIUrl":"https://doi.org/10.1136/neurintsurg-2021-snis.96","url":null,"abstract":"P-060 Figure 1 Left – non-destructive mechanical testing of human tissue. No disruption of tunica or endothelial layer. Middle – destructive mechanical testing, apparent tunica and endothelial disruptions. Right – coefficient of friction lubricity of the human donor, compared to VC-A30 (dark gray) and silicone (black) Abstracts J NeuroIntervent Surg 2021;13(Suppl 1):A1–A156 A61 on S etem er 3, 2023 by gest. P rocted by coright. http/jnis.bm jcom / J N eurotervent S urg: frst pulished as 10.1136intsurg-2021-S N IS 96 on 26 July 221. D ow nladed fom Materials and Methods Human vascular tissue was assessed and compared to standard silicone and new UV-cured polymers (VC-A30). Vessel materials were characterized with eight mechanical tests: compressive, shear, and tensiledynamic elastic modulus, Poisson’s ratio, hardness, radial compression, compliance, and lubricity. Half ofthese testing methods were nondestructive, allowing for multiple mechanical and histologicalcharacterizations of the same human tissue sample. Results Histological evaluation of cellular and extracellular matrix of the human vessels showed the dynamicmoduli and Poison’s ratio tests were non-destructive (figure 1 Left), whereas the destructive hardnesstest created significant tearing of the vessel layers (figure 1 Middle). Fluid absorption by VC-A30 showedstatistically significant softening of mechanical properties, stabilizing after 4 days in phosphate-bufferedsaline (PBS). VCA30 exhibited statistically similar results to human vasculature, with% error less than29%, in 5 of 8 mechanical tests, versus 1 of 8 for standard silicone. Human vessel lubricity (determinesdevice trackablility within a vessel) statistically matched the lubricity of all the VC-A30 samples (figure 1 Right). Conclusion VC-A30 provides a new option for creating translucent in vitro vascular models with anatomically-relevantproperties. VC-A30 can be formed into highly accurate models with specific mechanical properties usingthe latest 3D-printing techniques. These new vessel analogs may simulate patient-specific vessel diseasestates, improve surgical training models, accelerate the development of new endovascular devices, andultimately reduce dependencies on animal models. Disclosures K. Lewis: None. J. Vigil: None. N. Norris: None. W. Merritt: None. T. Becker: 1; C; NIH grant #5R42NS097069-03. Electronic poster abstracts E-001 ENDOVASCULAR MANAGEMENT OF TRAUMATIC INTRACRANIAL ANEURYSMS FROM CLOSED HEAD INJURY A White*, C Roark, D Case, Z Folzenlogen, D Kumpe, D Ding, J Seinfeld. Radiology, UT Southwestern Medical Center, Dallas, TX; Neurosurgery, University of Colorado, Aurora, CO; Radiology, University of Colorado, Aurora, CO; Neurosurgery, University of Louisville, Louisville, KY 10.1136/neurintsurg-2021-SNIS.97 Introduction/Purpose Traumatic intracranial aneurysms (TICAs) comprise a rare and particularly dangerous subset of cerebral aneurysms that can be difficult to both diagnose and manage, owing to their ","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128493428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-041 Chronic headaches and middle meningeal artery embolization","authors":"J. Catapano, K. Karahalios, V. Srinivasan, J. Baranoski, C. Rutledge, T. Cole, A. Ducruet, F. Albuquerque, A. Jadhav","doi":"10.1136/neurintsurg-2021-snis.77","DOIUrl":"https://doi.org/10.1136/neurintsurg-2021-snis.77","url":null,"abstract":"","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114969192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"54 Long-term radiopacity of a polymer aneurysm treatment device: neurocure® liquid embolic","authors":"B. Fennell, W. Merret, H. Sodawalla, J. Vigil, T. Becker","doi":"10.1136/neurintsurg-2021-snis.90","DOIUrl":"https://doi.org/10.1136/neurintsurg-2021-snis.90","url":null,"abstract":"04). Conclusions In this retrospective cohort, aSAH the COVID-19 era is associated with delayed presentation and attendant increases in cerebral vasospasm, delayed cerebral ischemia, aneurysmal re-rupture, and increased in-hospital mortality/hospice disposition. These data demonstrate a novel association between the COVID-19 pandemic and aneurysmal subarachnoid hemorrhage care, highlighting increases in overall mortality in non-COVID-19 associated disease driven by the ongoing pandemic.","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133226889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-009 Twisting: an intraprocedural challenge with pipeline deployment, increased with the second-generation, flex device","authors":"Rob Young, M. Bender, J. Campos, B. Jiang, D. Zarrin, Chau D. Vo, J. Caplan, Judy Huang, R. Tamargo, Li-Mei Lin, G. Colby, A. Coon","doi":"10.1136/NEURINTSURG-2018-SNIS.45","DOIUrl":"https://doi.org/10.1136/NEURINTSURG-2018-SNIS.45","url":null,"abstract":"Introduction Pipeline Embolization Device ‘twisting’ manifests with appearance of a ‘figure 8’ in perpendicular planes on DSA. We noticed increased frequency of twisting with the second-generation, PED-Flex device. Methods Case images were reviewed for instances of twisting from a prospectively-maintained, IRB-approved database of patients undergoing flow diversion for cerebral aneurysm. Results From 08/2011–02/2015, 367 PED-Classic were used in 276 cases in 239 patients. Five twists were observed in four patients (1.4%, 5/367). From 02/2015–01/2018, 628 PED-Flex were used in 510 procedures in 427 patients and 19 twists were observed in 16 patients (3.0%, 19/628) (p=0.10). Twisting is common in large, non-saccular aneurysms located along the carotid artery. In twisting cases across both device generations, the average aneurysm size was 18 mm (range 4–50 mm), morphology was fusiform or dissecting in 30% of cases, and aneurysm location was 16 ICA, 2 ACA, and 2 basilar. Larger diameter and longer devices showed a predisposition to twisting. Of the 24 twisted devices, 29.0% were 5.0 mm diameter and only 20% were less than 4.5 mm. The average length of a twisted device was 27.5 mm (range 14–35 mm). Of the four cases with PED-Classic twists, two were remediated successfully, one was removed and a second device placed without twisting, and one case was aborted after successive twisted devices were removed. Of the 19 PED-Flex twists, 13 were remediated and six were removed. Procedural success was achieved in 15/16 PED-Flex twisting cases and one procedure was aborted. Remediation maneuvers differed by device generation but included exchanging a neutral catheter, resheathing, wagging, and balloon angioplasty. Overall, two major complications (10%) were observed: one patient with giant fusiform ACA aneurysm in which PED-Classic twist was remediated experienced delayed SAH and died; one patient with mid-basilar aneurysm in which PED-Flex twist was remediated experienced perforator stroke (mRS 4) potentially related to incomplete device apposition. Occlusion outcomes for twisted devices were inferior to the overall PED population. With PED-Classic, 0/3 patients with successful PED implantation after twisting showed complete aneurysm occlusion and 2/3 were ultimately re-treated. For PED-Flex, follow-up DSA was available for 62.5% (10/16); complete occlusion was observed in 50% (4/8) at 12 months and 50% (5/10) at last follow-up. Conclusion Twisting is a rare intra-procedural event, more common with PED-Flex (3.0%) than the PED-Classic (1.4%). Although remediable, a twist can lead to major complications and diminishes occlusion outcomes. Disclosures R. Young: None. M. Bender: None. J. Campos: None. B. Jiang: None. D. Zarrin: None. C. Vo: None. J. Caplan: None. J. Huang: 6; C; Longeviti. R. Tamargo: None. L. Lin: 2; C; Medtronic. G. Colby: 1; C; Medtronic, Stryker Neurovascular. 2; C; MicroVention, Codman. A. Coon: 1; C; Stryker Neurovascular. 2; C; InNeuroCo, ","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129575879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-012 Comparison of endovascular device sizing based on conventional two-dimensional measurements and using numerical simulation software","authors":"K. Blackham, D. Zumofen, J. Ospel, V. Costalat, G. Gascou","doi":"10.1136/neurintsurg-2018-SNIS.48","DOIUrl":"https://doi.org/10.1136/neurintsurg-2018-SNIS.48","url":null,"abstract":"Background Proper sizing of intraarterial devices for aneurysm treatment is crucial to provide safety and ease of deployment while limiting torque, coverage of perforator branches and thrombogenicity. The behavior of an intraarterial device (wall apposition and foreshortening, for example) depends on several factors, including its original length, the relationship between the diameters of the device and recipient vessel as well as on the target vessel’s anatomy. Usually, the choice of device dimensions is made based on manual two- dimensional measurements from the 3D rotational angiography images and the operator’s individual experience. However, proper device dimensions and landing zonesare poorly predictable. A numerical computer-based simulation model (Sim and Cure; Grabels, France) has be shown to provide accurate and fast prediction of endovascular distention, wall apposition and final length of different sized devices based on 3D rotational angiography DICOM data. Purpose The aim of this study was to evaluate whether use of a computer based simulation model results in selection of different device dimensions than the ones chosen by neurointerventionalists based on conventional methods. Material and methods In a retrospective multi-center cohort study of 41 cases undergoing aneurysm treatment using the Pipeline Embolization Device (PED), device dimensions selected by experienced neurointerventionalists based on manual 2D measurements taken from rotational angiography were compared to PED dimensions calculated by the simulation model. Agreement between the different calculation methods wasevaluated by calculating Cohen’s Kappa. Results Software based measurements resulted in different device dimension suggestions in 92.7% (38/41 cases). In 56% (23/41), a shorter length was suggested by the algorithm, in 20% (8/41) a longer length and in 24% the same length, whereas a shorter diameter was suggested in 37% (15/41), a longer diameter in 31.5% (13/41) and the same diameter in 31.5% (13/41). Agreement between conventional and computer based measurements was low (Cohen’s K=0.125 for length; K=0.239 for diameter, p Conclusions The low agreement between conventional and software based calculations confirms that the choice of proper device dimensions is challenging. Since the software based solution allows virtual simulation of multiple device sizes and prediction of their endovascular behavior easily within a few seconds, it potentially allows a decrease in procedure time and cost. Furthermore, it may remove uncertainty related to proper device sizing by accelerating the neurointerventionalist’s learning curve and confidence. This work is part of continuing evaluation of the simulation and its translation into clinical practice. Disclosures K. Blackham: None. D. Zumofen: None. J. Ospel: None. V. Costalat: None. G. Gascou: None.","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132700053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-033 When to stop: the marginal utility of additional thrombectomy passes","authors":"S. Raymond, M. Koch, J. Rabinov, T. Leslie-Mazwi, C. Stapleton, A. Patel","doi":"10.1136/NEURINTSURG-2018-SNIS.69","DOIUrl":"https://doi.org/10.1136/NEURINTSURG-2018-SNIS.69","url":null,"abstract":"Introduction/purpose Endovascular mechanical thrombectomy is the most effective treatment for patients presenting with acute large vessel occlusion. However, recanalization is sometimes not achieved even after multiple passes of the thrombectomy device. Repeated attempts at clot retrieval come at a cost of increased procedure time and risk of complications. Clear criteria for when to halt attempting recanalization do not currently exist. We address this question by estimating the probability of recanalization after each pass and compare this with the decreased outcomes associated with multiple passes. Materials and methods We studied a retrospective group of patients treated with mechanical thrombectomy for large vessel occlusion at a single center from 2012–2017. For each patient, the TICI reperfusion score after each pass (including aspiration, stentriever, or wire manipulation) was estimated by reviewing the angiography and associated procedure report. Adequate reperfusion was defined as TICI 2b/3. Demographics were obtained from the electronic medical record and included age, gender, vascular risk factors, presenting NIHSS and mRS, procedure time, discharge mRS, and periprocedural complications. Statistics were computed using the open source, R statistics platform. Results Reperfusion with TICI 2b/3 was achieved in 146 of 198 patients (74%) after on average 1.8 thrombectomy passes (median 1, IQR 1–3). Most patients underwent stentriever thrombectomy or some combination of aspiration and stentriever. The probability of achieving TICI 2b/3 peaked on the third pass. Although many patients achieved TICI 2b/3 after three or more passes, the probability of achieving TICI 2b/3 decreased precipitously after the third pass. No patients achieved TICI 2b or 3 on the fifth or sixth pass. Patients were sub-stratified by number of passes (1–3 or >3). The group with greater than 3 passes was less likely to achieve TICI 2b or 3 (7/18 (39%) compared with 139/172 (82%), p=0.003) and less likely to achieve good functional outcome, mRS 0–2 (3/18 (17%) compared with 78/164 (48%), p=0.01). The number of passes was weakly correlated with the procedure duration (R 2 0.4). Conclusion With modern aspiration catheters and stentrievers, target reperfusion is usually achieved within 3 passes. Patients who require greater than 3 passes are less likely to achieve TICI 2b/3 reperfusion and more likely to have poor outcomes. Because the probability of recanalization markedly decreases after 3 passes, and is lost after 5 passes, the diminishing benefit of repeated recanalization attempts must be weighed against the additive risks. Disclosures S. Raymond: None. M. Koch: None. J. Rabinov: None. T. Leslie-Mazwi: None. C. Stapleton: None. A. Patel: 2; C; Medtronic, Penumbra.","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127158443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-037 Using artificial intelligence to predict vertebroplasty outcome","authors":"N. Carter, H. Asadi, H. Kok, J. Maingard, G. Anselmetti, R. Chandra, J. Hirsch","doi":"10.1136/NEURINTSURG-2018-SNIS.73","DOIUrl":"https://doi.org/10.1136/NEURINTSURG-2018-SNIS.73","url":null,"abstract":"Background Vertebral compression fractures (VCFs) are a common complication of osteoporosis and spinal neoplasms. Vertebroplasty presents a treatment option for VCFs that cause pain and disability. Predicting pain relief outcomes based on pre-treatment factors may robustly identify patients likely to benefit from the procedure, and guide clinical decision-making. Machine learning (ML) offers the ability to analyze large volumes of clinical data to formulate accurate outcome predictions. Purpose The aim of this study was to assess the feasibility of ML techniques to develop a model for accurate prediction of pain relief outcomes after vertebroplasty. Method This was a retrospective study of a prospectively collected multicenter database. All available demographic and procedural factors were integrated into ML models as predictors, including demographic data, VCF etiology, number and location, procedural details and visual analogue scale (VAS) scores pre- and post-procedure. Successful clinical outcome was defined as a reduction by at least 67% (two-thirds) in VAS pain scores. ML algorithms were trained on these data to develop a model capable of categorizing predictors into good and poor outcomes. Results We analyzed 5785 patients with 20,463 VCFs treated by vertebroplasty. The majority (75%, n=4,312) were female with a median age of 73.5 (range 19–100) years. The most common VCF etiology was primary osteoporosis (55.2%), followed by secondary osteoporosis (14.7%), metastatic disease (13.2%), primary malignancy (5.5%), trauma (6.4%) and other (5.2%). Most patients had two levels treated (23.9%) followed by one (19.2%) and three levels (17.5%). The majority also had pre-procedure MRI (89.4%). Vertebroplasty was highly effective in pain relief with 97.9% (n=5,662) reporting clinically significant reduction in VAS. ML analysis based on a naive Bayes model (figure 1) demonstrated that the number of treated levels, primary malignancy as etiology, pre-procedure brace use, thoracolumbar, cervical levels and metastatic disease predicted a good clinical outcome in decreasing order of confidence. Overall, the ML model was approximately 90% accurate in predicting the outcome for individual patients after VCF. Conclusion Supervised ML algorithms have promising potential to predict the outcome following vertebroplasty. Our results suggest that a robust computation model could optimize the decision-making process for VCF management. Incorporating additional data from larger multicenter databases could further improve the accuracy of outcome prediction through iterative learning and refinement of the ML model. Disclosures N. Carter: None. H. Asadi: None. H. Kok: None. J. Maingard: None. G. Anselmetti: None. R. Chandra: None. J. Hirsch: None.","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124562627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-028 Quantitative MR perfusion and validation against stable-isotope microspheres","authors":"N. Saadat, Y. Jeong, T. Carroll, K. Kawaji, S. Roth, G. Christoforidis","doi":"10.1136/NEURINTSURG-2018-SNIS.64","DOIUrl":"https://doi.org/10.1136/NEURINTSURG-2018-SNIS.64","url":null,"abstract":"Purpose This study sought to assess the accuracy of a quantitative MRI-based (qMRI) measure of cerebral blood flow (qCBF) against reference stable isotope neutron capture microsphere based cerebral blood flow quantification in an experimental model during normocapnia, hypercapnia and middle cerebral artery (MCAO). Materials/methods Five female, mongrel dogs (20–30 kg) were each studied over two days. On day 1, qCBF images were acquired during normocapnia (target PaCO2 range 30–40 mmHg) and during hypercapnia (target PaCO2 range >60 mmHg) induced by carbogen gas inhalation (5% CO2/95% O2). On day 2 animals underwent angiographically verified permanent endovascular occlusion of the M1 segment while in a normocapnic state. Anesthesia was selected to minimize influence on cerebrovascular reactivity. Physiologic parameters were maintained within normal range with the exception of PCO2 for hypercapnia. Neutron capture microspheres were injected at the time of qMRI acquisition to obtain reference-standard CBF values. qMRI was acquired on a 3 Tesla unit (Achieva, Philips Healthcare, Best, Netherlands) using a 15-channel receive-only head coil a ‘bookend dynamic susceptibility (DSC)’ approach, which uses pre- and post-contrast T1 maps bookended to a DSC MRI sequence to calculate parenchymal T1 changes and calibrate the DSC scan for quantitative perfusion in ml/100 g/min. T1 maps are derived using 2D EPI Look-Locker inversion recovery (FOV/Matrix=220 mm/224, Slice Thickness=4 mm, single slice) with variable delay time and DSC perfusion (FOV/Matrix=20 mm/224, single shot, EPI, fat saturated, slice thickness=6 mm, TR/TE=315/40, 200 time points). A gadolinium-based contrast agent (Multihance, Bracco, Princeton, NJ, USA) was mechanically injected followed by a saline flush. Results MRI correlated strongly with microsphere perfusion (qCBFMRI=0.93*qCBFSPHERES +3.85 ml/100 g/min; r2=0.96; p Conclusion MRI derived values of CBF are strongly correlated with reference value microsphere deposition in normocapnia, hypercapnia, and MCAO ischemic stroke. Correction for delay and dispersion significantly improved the accuracy of this quantification during MCAO, underscoring the importance for this correction under focal ischemic condition. Disclosures N. S. Saadat: None. Y. Jeong: None. T. Carroll: None. K. Kawaji: None. S. Roth: None. G. Christoforidis: None.","PeriodicalId":341680,"journal":{"name":"Oral poster abstracts","volume":"127 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115975955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}