GIANTPub Date : 2024-03-30DOI: 10.1016/j.giant.2024.100259
Congyi Yang , Yifan Jia , Weiwen Yuan , Guoxing Liao , Qianqian Yu , Zhe Tang , Yuan Ji , Guanghui Liu , Fangrong Tan , Paul D. Topham , LinGe Wang
{"title":"Enhanced contrast imaging with polyamide 6/Fe(OH)3 nanofibrous scaffolds: A focus on high T1 relaxivity","authors":"Congyi Yang , Yifan Jia , Weiwen Yuan , Guoxing Liao , Qianqian Yu , Zhe Tang , Yuan Ji , Guanghui Liu , Fangrong Tan , Paul D. Topham , LinGe Wang","doi":"10.1016/j.giant.2024.100259","DOIUrl":"https://doi.org/10.1016/j.giant.2024.100259","url":null,"abstract":"<div><p>Nanofibers serve as widely employed tissue engineering scaffolds in diverse biomedical applications. When implanted <em>in vivo</em>, it is crucial for tissue engineering scaffolds to be visualizable, enabling the monitoring of their shape, position, and performance. This capability facilitates the effective assessment of implant deformations, displacements, degradations, and functionalities. However, in many biomedical imaging techniques such as magnetic resonance imaging (MRI), the contrast of tissue engineering scaffolds is often inadequate. MRI is particularly notable for its effectiveness in imaging soft tissues. Previous endeavors to enhance the contrast of tissue engineering scaffolds in MRI have involved the use of negative contrast agents (CAs). Nonetheless, negative CAs can result in artifacts, thus favoring the preference for positive CAs due to their ability to generate clearer boundaries. In this study, we successfully prepared composite polyamide 6 nanofibrous scaffolds with ultrafine dispersion Fe(OH)<sub>3</sub> nanoparticles using electrospinning and <em>in-situ</em> growth techniques. The relaxation properties of the magnetic nanofibrous scaffolds confirmed the successful production of scaffolds suitable for positive imaging. <em>In vitro</em> cell seeding experiments demonstrated the efficient proliferation and adhesion of endothelial cells and fibroblasts. <em>In vivo</em> studies further revealed the biocompatibility and functionality of the scaffolds. These findings indicate that the prepared PA6/Fe(OH)<sub>3</sub> composite nanofibrous scaffolds can enable straightforward, safe, and efficient <em>in vivo</em> positive contrast MRI monitoring, thereby playing a pivotal role in the integration of diagnosis and treatment within tissue engineering scaffolds.</p></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"18 ","pages":"Article 100259"},"PeriodicalIF":7.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666542524000249/pdfft?md5=7b4f97a2bbd01d00ff50de3dfe931ee4&pid=1-s2.0-S2666542524000249-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140345441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recyclable ionic liquid-mediated synthesis of quinazolin-4(3H)-ones under metal-free and solvent-free conditions","authors":"Xue Ma, Peng Li, Xuerou Chen, Siqi Li, Wuji Sun, Qidi Zhong","doi":"10.1016/j.giant.2024.100255","DOIUrl":"https://doi.org/10.1016/j.giant.2024.100255","url":null,"abstract":"<div><p>A metal-free and solvent-free method for the synthesis of quinazolin-4(3<em>H</em>)-ones is proposed by condensation cyclization of 2-aminobenzamides and aldehydes using 1-butyl-3-methylimida-zolium tetrafluoride ([Bmim]BF<sub>4</sub>) as ionic liquid catalyst. In this reaction, [Bmim]BF<sub>4</sub> acts as both a catalyst and a solvent without need for additional catalysts and solvents. This method exhibits favorable functional group tolerance in substrates and affords a series of desired products in moderate to excellent yields. In addition, it is noteworthy that the reaction yield is still as high as 87% after [Bmim]BF<sub>4</sub> is recycled at least four times.</p></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"18 ","pages":"Article 100255"},"PeriodicalIF":7.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666542524000201/pdfft?md5=cb66995979f1c6c7d115a4402a2e6423&pid=1-s2.0-S2666542524000201-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140342493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GIANTPub Date : 2024-03-26DOI: 10.1016/j.giant.2024.100256
Xinrui Dong , Hu Liu , Haibao Liu , Xiaoqin Zhang , Xiaoran Deng
{"title":"Carrier-free nanomedicines: Mechanisms of formation and biomedical applications","authors":"Xinrui Dong , Hu Liu , Haibao Liu , Xiaoqin Zhang , Xiaoran Deng","doi":"10.1016/j.giant.2024.100256","DOIUrl":"https://doi.org/10.1016/j.giant.2024.100256","url":null,"abstract":"<div><p>In recent years, significant advancements in nanotechnology have yielded remarkable improvements in biomedical applications. Nanocarriers, harnessed from the principles of nanotechnology, have garnered widespread utilization in medicine delivery and diagnostics. However, the progression of nanocarriers has been hindered by two key challenges: low drug loading capacity and the potential for carrier-induced toxicity. To surmount these obstacles, the rapid development and expansion of carrier-free drug delivery systems (CFDDSs) composed of pure drugs and prodrugs have emerged as a promising solution. Extensive endeavors have been undertaken to explore novel excipients, therapeutic agents, self-assembly processes, and therapeutic mechanisms, aimed at expanding the horizons of CFDDSs and enhancing their therapeutic efficacy. This comprehensive review provides an overview of CFDDSs, elucidating their self-assembly mechanisms. Additionally, we examine their diverse biomedical applications while shedding light on the challenges ahead for the future development and clinical implementation of CFDDSs. This review serves to enhance our understanding of the intricate mechanisms governing drug nanoassembly formation and fosters the advancement of CFDDSs in the expansive realm of biomedical research.</p></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"18 ","pages":"Article 100256"},"PeriodicalIF":7.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666542524000213/pdfft?md5=b9e4ba90f3133f3bf0ca392b0b3cc3de&pid=1-s2.0-S2666542524000213-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140339044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GIANTPub Date : 2024-03-19DOI: 10.1016/j.giant.2024.100253
Shengbo Ge , Guiyang Zheng , Yang Shi , Zhongfeng Zhang , Abdullatif Jazzar , Ximin He , Saddick Donkor , Zhanhu Guo , Ding Wang , Ben Bin Xu
{"title":"Facile fabrication of high-strength biocomposite through Mg2+-enhanced bonding in bamboo fiber","authors":"Shengbo Ge , Guiyang Zheng , Yang Shi , Zhongfeng Zhang , Abdullatif Jazzar , Ximin He , Saddick Donkor , Zhanhu Guo , Ding Wang , Ben Bin Xu","doi":"10.1016/j.giant.2024.100253","DOIUrl":"10.1016/j.giant.2024.100253","url":null,"abstract":"<div><p>The emerging interests in high-performance biocomposites grows significantly driven by their superior environmental sustainability. This study proposes a unique biocomposite strategy by implementing an acetic and ball-milled treatment to disrupt the bamboo cell wall structure, thereby facilitating further processing by effectively increasing the active sites and specific surface area in the bamboo fiber. The fibers are subsequently carboxymethylated to introduce carboxyl groups which facilitate physical bonding between the fibers and Mg<sup>2+</sup> ions that are added to the system. These ions form metal-coordination bonds with the carboxyl groups, acting as ion bridges that significantly strengthen the inter-fiber bonding. The resulted biocomposite exhibits impressive mechanical properties, including a high tensile strength (94.24 MPa) and flexural strength (104.14 MPa), not only that, changes in elastic modulus also highlight changes in fiber bonding, the flexural modulus is 21.29 GPa and the tensile modulus is 7.01 GPa. Moreover, it maintains a low water uptake capacity of only 6.8 % despite being submerged for 12 h. The thermal conductivity and fire retardancy have also been improved. The synergic bonding ability between the cellulose and lignin in the fibers, coupled with the glue-free thermoforming process, enhances the material performance and renders it fully recyclable, thus reducing environmental pollution and providing cost-effective engineering materials to society.</p></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"18 ","pages":"Article 100253"},"PeriodicalIF":7.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666542524000183/pdfft?md5=b14ce1af812666a7cbb5cbf4d664d0e3&pid=1-s2.0-S2666542524000183-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140268892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GIANTPub Date : 2024-03-15DOI: 10.1016/j.giant.2024.100252
Li Yu , Baiyang Chen , Ziying Li , Yue Su , Xuesong Jiang , Zeguang Han , Yongfeng Zhou , Deyue Yan , Xinyuan Zhu , Ruijiao Dong
{"title":"Computer-aided automated flow chemical synthesis of polymers","authors":"Li Yu , Baiyang Chen , Ziying Li , Yue Su , Xuesong Jiang , Zeguang Han , Yongfeng Zhou , Deyue Yan , Xinyuan Zhu , Ruijiao Dong","doi":"10.1016/j.giant.2024.100252","DOIUrl":"10.1016/j.giant.2024.100252","url":null,"abstract":"<div><p>Synthetic chemistry has played a vital role in miscellaneous fields of human civilization over the past century. The synthetic stage yet remains time-consuming and labor-intensive. To overcome these limitations, automation has been introduced to transform synthetic chemistry, leading to the development of high-throughput methods for molecular discovery. Automated flow chemical synthesis (AFCS) has recently emerged as a promising candidate, offering improved efficiency, scalability, and sustainability over the well-known automated solid-phase peptide synthesis. To further advance AFCS, elements like artificial intelligence-based computer-aided structure design and synthesis planning, autonomously assembled compatible synthesis with enhanced automated process control, and autonomous optimization can be considered. This review focuses on recent advances in computer-aided automated flow chemical synthesis (CAAFCS) of polymers in living polymerization and iterative synthesis strategy. The current challenges and outlook are finally discussed for developing more powerful CAAFCS systems and expanding their applicability across numerous fields, potentially providing brand-new perspectives and guidelines for future developments in this field.</p></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"18 ","pages":"Article 100252"},"PeriodicalIF":7.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666542524000171/pdfft?md5=587ecd8af97aad0e89d35b6f2c949f02&pid=1-s2.0-S2666542524000171-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140150355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GIANTPub Date : 2024-03-07DOI: 10.1016/j.giant.2024.100249
Syaifullah Muhammad , Yonss M. Albadn , Esam Bashir Yahya , Samia Nasr , H.P.S. Abdul Khalil , Mardiana Idayu Ahmad , Mohamad Anuar Kamaruddin
{"title":"Trends in enhancing the efficiency of biomass-based aerogels for oil spill clean-up","authors":"Syaifullah Muhammad , Yonss M. Albadn , Esam Bashir Yahya , Samia Nasr , H.P.S. Abdul Khalil , Mardiana Idayu Ahmad , Mohamad Anuar Kamaruddin","doi":"10.1016/j.giant.2024.100249","DOIUrl":"10.1016/j.giant.2024.100249","url":null,"abstract":"<div><p>Biomass conversion is pivotal in promoting sustainability and mitigating environmental pollution. In the quest to address the daunting challenge of oil spills, bioaerogels have surfaced as a beacon of hope. Their unique attributes, including remarkable porosity, lightness, and eco-compatibility, position them as ideal candidates for this purpose. Nonetheless, their application is not without challenges. Key issues such as limited capacity for oil absorption, specificity in oil-water separation, mechanical robustness, stability, and control over buoyancy are areas of active research and development. This comprehensive review delves into the current trends and advancements in augmenting the efficacy of bioaerogel composites specifically tailored for oil spill remediation. It meticulously examines a spectrum of modification strategies. Through a detailed analysis of recent research and technological breakthroughs, the review sheds light on innovative approaches and methodologies. It underscores the potential of these advancements in elevating the performance of bioaerogel composites in the realm of oil spill management. The insights gathered here are instrumental in charting the course for future research directions. They also underscore the importance of interdisciplinary collaboration in tackling environmental crises.</p></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"18 ","pages":"Article 100249"},"PeriodicalIF":7.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666542524000146/pdfft?md5=2d87cf0a3a571b93cfbbe14add362a16&pid=1-s2.0-S2666542524000146-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140098401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GIANTPub Date : 2024-03-06DOI: 10.1016/j.giant.2024.100251
Lin Shi , Dawei Song , Cong Meng , Yuhao Cheng , Baojun Wang , Zhengyang Yang
{"title":"Opportunities and challenges of engineered exosomes for diabetic wound healing","authors":"Lin Shi , Dawei Song , Cong Meng , Yuhao Cheng , Baojun Wang , Zhengyang Yang","doi":"10.1016/j.giant.2024.100251","DOIUrl":"10.1016/j.giant.2024.100251","url":null,"abstract":"<div><p>The treatment of diabetic wounds is a major challenge faced by the medical system, and there is a growing interest in developing innovative therapies to accelerate wound healing. Regenerative medicine with cells has shown promising potential in skin repair, with the regenerative properties primarily attributed to the paracrine effects of secreted products, including exosomes. Compared to cell-based approaches, using exosomes as a cell-free therapy for chronic wounds has several advantages. Exosomes can regulate intercellular communication by releasing their contents, including mRNA, miRNA, lipids, and proteins, which further promote wound healing. Exosomes are well explored in biomedical application owing to their advantages such as their biocompatibility and low immunogenicity. However, the common method of exosome administration is through injection, but due to their rapid clearance rate in the body, maintaining the necessary therapeutic concentration around the wound is challenging. Therefore, it is necessary to develop a new biocompatible scaffold as a carrier for extracellular vesicles, allowing them to sustain the therapeutic concentration at chronic non-healing wound sites and continuously promote wound healing. Engineered exosomes are kinds of exosomes modified with internal treated molecules, surface decoration or delivered through engineered platform. In addition, some researchers have further processed and modified exosomes, known as engineered exosomes, with internal treated molecules, surface decoration, or delivery through engineered platforms. Compared to regular exosomes, engineered exosomes have greater advantages in promoting wound healing. In this review, we summarize the molecular mechanisms of exosomes from different sources with varying modifications in wound healing. Advantages and limitations of different engineered exosomes for chronic wound repair were also discussed. Finally, we highlight the challenges and future development directions for translating our knowledge of engineered exosomes into clinical practice.</p></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"18 ","pages":"Article 100251"},"PeriodicalIF":7.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266654252400016X/pdfft?md5=4817ec417744b2381181104f17eebe47&pid=1-s2.0-S266654252400016X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140098329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GIANTPub Date : 2024-03-04DOI: 10.1016/j.giant.2024.100250
N. Stefan , A.I. Visan , V. Grumezescu , V. Kuncser , A. Kuncser , N. Iacob , G. Schinteie , M. Socol , C. Florica , I. Zgura , R.C. Popescu , A.M. Holban , G. Socol
{"title":"MAPLE deposition of hybrid PLGA-Fe3O4- Cypress-PEDOT: PSS coatings","authors":"N. Stefan , A.I. Visan , V. Grumezescu , V. Kuncser , A. Kuncser , N. Iacob , G. Schinteie , M. Socol , C. Florica , I. Zgura , R.C. Popescu , A.M. Holban , G. Socol","doi":"10.1016/j.giant.2024.100250","DOIUrl":"10.1016/j.giant.2024.100250","url":null,"abstract":"<div><p>We report on the Matrix Assisted Pulsed Laser Evaporation, laser technology for depositing biocompatible, antimicrobial, hydrophilic, and biodegradable complex hybrid polymeric system loaded with essential cypress-oil and magnetite nanoparticles as resorbable implants, capable of targeting possible hyperthermia applications, an anticancer moderate field heating therapy. Magnetite nanoparticles based on iron oxide (Fe<sub>3</sub>O<sub>4</sub>) coated with <em>Cypress essential oil</em> (denoted: Fe<sub>3</sub>O<sub>4</sub>- Cypress) and embedded in PLGA (poly(lactic-co-glycolic acid) (denoted: PLGA-Fe<sub>3</sub>O<sub>4</sub>- Cypress-) and PLGA - poly(3,4-ethylene dioxythiophene) doped with poly(styrene sulfonate) anions) (PEDOT: PSS) mixture (denoted: PLGA-Fe<sub>3</sub>O<sub>4</sub>- Cypress- PEDOT: PSS) were used as MAPLE targets. The controlled drug delivery of the active Cypress oil, an antimicrobial therapeutic agent from Fe<sub>3</sub>O<sub>4</sub>- Cypress nanoparticles could be possible by applying an external radio frequency (RF) magnetic field. The Fe<sub>3</sub>O<sub>4</sub>-Cypress-based powders as well as the final hybrid coatings have been characterized in terms of stoichiometry, morphology, magnetic, antimicrobial properties, biocompatibility, and response to external physical stimuli. FTIR analyses confirmed the quasi-stoichiometric laser transfer of organic compounds while the XRD evidenced the semicrystalline structure of deposited thin films. SEM and AFM images evidence that conductive polymer addition led to the films' relief flattening and a decrease in the coatings' thickness and roughness by changing the polymeric packaging. The samples containing conductive polymer exhibited 3 times higher current and corrosion rate values. All coatings are hydrophilic and revealed enhanced cellular viability when cultured with osteoblast-like MG-63 cells. The composite structures exhibited significant antimicrobial activity against Gram-positive (<em>Staphylococcus aureus</em>), and Gram-negative (<em>Escherichia coli</em>) bacteria, as well as to the opportunistic yeast <em>Candida albicans</em>.</p></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"18 ","pages":"Article 100250"},"PeriodicalIF":7.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666542524000158/pdfft?md5=02d20c2b28a637db03ec9bdbf9d83e38&pid=1-s2.0-S2666542524000158-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140098391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GIANTPub Date : 2024-03-01DOI: 10.1016/j.giant.2024.100248
Tibor Nagy , Gergő Róth , Ákos Kuki , Veronika Pardi-Tóth , Dávid Nyul , Zuura Kaldybek Kyzy , Isaac Alexander Iglesias Palacios , Máté Benedek , Lajos Nagy , Miklós Zsuga , Sándor Kéki
{"title":"The triumvirate of effective and rapid synthesis, analysis, and artificial intelligence to explore the structure-property relationship of copolymers","authors":"Tibor Nagy , Gergő Róth , Ákos Kuki , Veronika Pardi-Tóth , Dávid Nyul , Zuura Kaldybek Kyzy , Isaac Alexander Iglesias Palacios , Máté Benedek , Lajos Nagy , Miklós Zsuga , Sándor Kéki","doi":"10.1016/j.giant.2024.100248","DOIUrl":"10.1016/j.giant.2024.100248","url":null,"abstract":"<div><p>Understanding the structure-property relationship is of paramount importance for tailoring copolymers for specific applications. Poly(N-acryloylmorpholine)-block-poly(N-isopropylacrylamide) (PNAM-b-PNIPAM) diblock copolymers were synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization with varying <em>M<sub>n</sub></em> and composition, providing the basis for deducing structure-property relationships. The chemical structure of the copolymers was analyzed by mass spectrometry (MS). A novel and efficient mass spectrum processing methodology was developed for the detailed analysis of polymers/copolymers that greatly expands the upper mass limit of the time-of-flight (TOF) analyzers in the linear mode up to 20,000 Da. Our method “makes visible” the mass peaks of the individual copolymer species and their isotopologues providing effective and fast automatized analysis. The self-assembly property of the thermoresponsive PNAM-b-PNIPAM diblocks in aqueous solutions was investigated by dynamic light scattering (DLS) experiments, and quantified by determining the incipient temperature of the phase transition. For rapid evaluation, an artificial neural network (ANN) was created to explore the hidden relationships between the structural information obtained by our novel mass analysis method and the properties as well as to predict the self-assembly behavior of the copolymers.</p></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"17 ","pages":"Article 100248"},"PeriodicalIF":7.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666542524000134/pdfft?md5=cdc3384016e7dd66472422686fecda3d&pid=1-s2.0-S2666542524000134-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140033800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GIANTPub Date : 2024-02-24DOI: 10.1016/j.giant.2024.100247
Quang Van Duong , Chanho Park , Yujeong Lee , Seungmin Lee , Thu Thi Nguyen , Vinh Phu Nguyen , Kyuho Lee , Fabrice Domingues Dos Santos , Cheolmin Park , Seung Tae Choi
{"title":"Corrigendum to “High-temperature electromechanical actuation of relaxor ferroelectric polymers blended with normal ferroelectric polymer” [Giant, 17(2024), 100208]","authors":"Quang Van Duong , Chanho Park , Yujeong Lee , Seungmin Lee , Thu Thi Nguyen , Vinh Phu Nguyen , Kyuho Lee , Fabrice Domingues Dos Santos , Cheolmin Park , Seung Tae Choi","doi":"10.1016/j.giant.2024.100247","DOIUrl":"https://doi.org/10.1016/j.giant.2024.100247","url":null,"abstract":"","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"17 ","pages":"Article 100247"},"PeriodicalIF":7.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666542524000122/pdfft?md5=ca086a0267059ac823b84fd7ff734aab&pid=1-s2.0-S2666542524000122-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139942195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}