Clinical Infection in Practice最新文献

{"title":"Corrigendum to “A new era in transplantation: Overcoming COVID-19 challenges” [Clin. Infect. Pract. 29 (2026) 100540]","authors":"Serena Marinello , Tea Lena , Emanuele Cozzi , Elisa Franchin , Giuseppe Toscano , Gino Gerosa , Annamaria Cattelan","doi":"10.1016/j.clinpr.2026.100635","DOIUrl":"10.1016/j.clinpr.2026.100635","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"30 ","pages":"Article 100635"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147858881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strongyloides stercoralis as etiology of abdominal pain, respiratory failure, and shock – a report of two cases","authors":"Darío S. López-Delgado , Cristian Insuasty , Héctor Fabio Sanchez-Galvez , Yamile Jurado-Hernández , Franco Rafael Camacho-Delgado , Fernando Bolaños , Alfonso J. Rodriguez-Morales","doi":"10.1016/j.clinpr.2026.100636","DOIUrl":"10.1016/j.clinpr.2026.100636","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"30 ","pages":"Article 100636"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147858591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculous meningitis with hydrocephalus: A retrospective case series in a UK hospital","authors":"Ali M. Alam ,&nbsp;Yasmin S. Milner ,&nbsp;Akanksha M. Malhotra ,&nbsp;Cristina Suarez ,&nbsp;James Barber ,&nbsp;Heinke Kunst","doi":"10.1016/j.clinpr.2026.100627","DOIUrl":"10.1016/j.clinpr.2026.100627","url":null,"abstract":"<div><h3>Background</h3><div>Patients may show signs of ventricular enlargement in the early stages of tuberculous meningitis (TBM), and the presence of hydrocephalus is a poor prognostic marker. There is limited evidence on the features which may suggest development of hydrocephalus in TBM (TBMH).</div></div><div><h3>Methods</h3><div>We studied hydrocephalus in adult patients with TBM requiring admission at a hospital in the UK between 2019 and 2024. Logistic regression was used to evaluate associations with poor outcome at 6-month follow up.</div></div><div><h3>Results</h3><div>11 of 20 (55.0%) patients developed TBMH. Among these, six (54.5%) had TBMH on the day of admission, whilst five (45.5%) patients developed TBMH following admission. Patients with TBMH on admission had lower Glasgow Coma Scale (GCS) scores on admission (10 vs 15, p &lt; 0.05). Patients who developed TBMH after admission had higher protein levels in their CSF on admission (3 vs 1.4 g/dl, p &lt; 0.05). Of patients with poor Glasgow outcome scale (GOS) scores at 6-month follow up, six (75%) had TBMH.</div></div><div><h3>Conclusion</h3><div>Abnormal GCS on admission was strongly associated with TBMH. Patients with no evidence of hydrocephalus on admission may subsequently develop TBMH and a high CSF protein count on admission may predict risk of hydrocephalus development. Early identification of patients at greatest risk of hydrocephalus may help improve outcomes.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"30 ","pages":"Article 100627"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147802413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primaquine-induced methemoglobinemia in a child treated for presumed malaria: a case report from Colombia","authors":"Mónica Duque-Arias ,&nbsp;Daniel Grisales-Nieto ,&nbsp;Heine Santiago Realpe-Marin ,&nbsp;Alfonso J. Rodriguez-Morales","doi":"10.1016/j.clinpr.2026.100633","DOIUrl":"10.1016/j.clinpr.2026.100633","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"30 ","pages":"Article 100633"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147858592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 vaccination in patients at higher risk of anaphylaxis: A safe and pragmatic approach","authors":"Karla Berry ,&nbsp;Aisling Barry ,&nbsp;David McKay ,&nbsp;Lorna Willocks ,&nbsp;Rebecca K. Sutherland","doi":"10.1016/j.clinpr.2025.100525","DOIUrl":"10.1016/j.clinpr.2025.100525","url":null,"abstract":"<div><div>At the start of the COVID-19 vaccine rollout, there was significant concern about anaphylaxis. We therefore set up a triage service and monitored vaccine clinic in NHS Lothian, UK. Despite MHRA guidance, we did not perform skin testing, as its reliability was uncertain and posed practical challenges that may have delayed vaccination.</div><div>Over 700 patients were triaged by an allergy specialist, who accepted referrals with concern of allergy to vaccine excipients, or a previous serious reaction to a COVID-19 vaccine. Vaccine type was advised at triage, and on 58 occasions pre-treatment with oral antihistamine was advised.</div><div>In total, 207 vaccinations were given in a monitored vaccine clinic run by a general physician, to 186 individuals. Fourty-one reactions occurred, with the greatest proportion in those with a previous reaction to a COVID-19 vaccine. All were observed within 30 min and were predominantly orofacial swelling and tingling, and skin reactions. All were managed with antihistamines, paracetamol, or personal rescue medications. No anaphylaxis occurred, and IM adrenaline was never given.</div><div>Out of 186 patients, 169 were advised they could have future vaccinations in a community setting. We propose that the format of this clinic could be extended to support all vaccination programmes.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"29 ","pages":"Article 100525"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual fungal infection of the spine: A case report of Acremonium-induced vertebral osteomyelitis","authors":"Hufriya Mondegarian ,&nbsp;Jibraiel Malick Rehman ,&nbsp;Syed Muhammad Hasan Naqavi ,&nbsp;Joveria Farooqi ,&nbsp;Syed Faisal Mahmood","doi":"10.1016/j.clinpr.2025.100523","DOIUrl":"10.1016/j.clinpr.2025.100523","url":null,"abstract":"<div><h3>Background</h3><div>Fungal vertebral osteomyelitis (VO) is a rare disease, typically caused by Aspergillus or Candida spp. Acremonium spp., especially in the spine, is uncommon. While classically affecting immuno-compromised patients, cases in immuno-competent hosts are increasingly reported. Diagnosis relies on beta D-glucan, MRI and galactomannan assays, with voriconazole as preferred therapy.</div></div><div><h3>Case report</h3><div>We report a rare case of fungal osteomyelitis in a 33-year-old immunocompetent adult male, with complaints of gradually progressing back pain accompanied by pain in the right leg for three months. Over the past year, this patient underwent L5-S1 laminectomy for disc radiculopathy after failed conservative treatment to resolve symptoms of left leg numbness. Magnetic Resonance Imaging showed discitis at surgical site without an abscess. After six weeks, a repeat scan revealed disease progression with an abscess and a new disc protrusion. Transforaminal lumbar interbody fusion (TLIF) with posterior instrumentation and fusion (PSIF) was performed, and fungal smears showed septate hyphae. Beta D-glucan was 99 pg/mL and galactomannan was 0.1 ODI. Cultures later yielded Acremonium spp. and voriconazole was started empirically.</div></div><div><h3>Results</h3><div>This case highlights three critical points being, fungal VO must be considered in refractory spinal infections; Acremonium can infect immunocompetent hosts; and voriconazole shows efficacy against this organism. The rising incidence of nosocomial fungal infections warrants increased suspicion for atypical pathogens, even without classic risk factors. Tests like galactomannan and beta-D-glucan, although non-specific, in addition to PCR can aid diagnosis when cultures are pending. While amphotericin B remains first-line for many systemic mycoses, voriconazole’s safety profile makes it preferable for long-term treatment.</div></div><div><h3>Conclusion</h3><div>This case will emphasize the rarity of Acremonium as a causative agent for osteomyelitis and discuss the importance of an accurate, quick diagnosis and treatment plan for similar cases. In addition, further studies should be conducted regarding similar case presentations.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"29 ","pages":"Article 100523"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new era in transplantation: Overcoming COVID-19 challenges","authors":"Serena Marinello ,&nbsp;Tea Lena ,&nbsp;Emanuele Cozzi ,&nbsp;Elisa Franchin ,&nbsp;Giuseppe Toscano ,&nbsp;Gino Gerosa ,&nbsp;Annamaria Cattelan","doi":"10.1016/j.clinpr.2026.100540","DOIUrl":"10.1016/j.clinpr.2026.100540","url":null,"abstract":"<div><div>Background: Among solid organ transplant recipients (SOTRs), lung and heart transplant recipients had the highest risk for severe COVID-19.</div><div>Methods: We present two cases of two heart transplant recipients who underwent transplantation despite perioperative SARS-CoV-2 positivity. We reviewed the clinical records of the two patients. Both patients received a five-day course of Remdesivir (200 mg loading dose, followed by 100 mg daily). Immunosuppression regimens were adapted to reflect standard protocols but included tailored modifications. Thymoglobulin induction was administered at half the usual dose (0.75 mg/kg/day for 72 h), corticosteroids were initiated at a high dose and subsequently tapered to oral prednisone by the end of the first week, and cyclosporine was started on day 3 at 50% of the standard dosage. These adjustments aimed to balance the risk of rejection with the known lymphopenic effects of COVID-19.</div><div>Results: The postoperative recovery was uneventful, with no complications related to the infection, either systemic or involving the transplanted organ.</div><div>Conclusion: These cases highlight that transplant candidates with asymptomatic or mildly symptomatic SARS-CoV-2 may safely undergo urgent transplantation when managed with careful antiviral and immunosuppressive strategies. Decisions should be individualized, considering waitlist mortality, infection status, and organ availability. Additionally, these cases underscore the need for a comprehensive review of existing guidelines to inform evolving <em>peri</em>-transplant protocols.</div><div>Conclusion: These cases highlight that transplant candidates with asymptomatic or mildly symptomatic SARS-CoV-2 may safely undergo urgent transplantation when managed with careful antiviral and immunosuppressive strategies. Decisions should be individualized, considering waitlist mortality, infection status, and organ availability. Additionally, these cases underscore the need for a comprehensive review of existing guidelines to inform evolving <em>peri</em>-transplant protocols.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"29 ","pages":"Article 100540"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emphysematous osteomyelitis complicated with liver abscess and pulmonary infection in a diabetic patient: a case report","authors":"Zidan Yang ,&nbsp;Jingxin Zhang ,&nbsp;Fan Yang","doi":"10.1016/j.clinpr.2025.100526","DOIUrl":"10.1016/j.clinpr.2025.100526","url":null,"abstract":"<div><div>Emphysematous osteomyelitis (EO) is a life-threatening bone infection. In this case, we present a 67-year-old male patient with congenital deaf-mutism, hypertension, and diabetes mellitus. He was admitted to the emergency department due to “altered mental status for 2 h”, and blood tests revealed a significant elevation of infectious markers. Computed tomography (CT) scans showed multiple gas-density shadows in the L3 vertebral body, along with pneumocele in the spinal canal at the same level, the right psoas major muscle, and the diaphragm. Abdominal CT examination indicated a liver abscess in the right lobe of the patient’s liver. Pulmonary CT suggested multiple infectious lesions in the lungs. Subsequent cultures of blood, liver abscess drainage fluid, and cerebrospinal fluid all confirmed an infection with Klebsiella pneumoniae. The final diagnosis was “emphysematous osteomyelitis”, and the patient received anti-infective treatment and other supportive therapies, leading to the remission of his condition. Diabetes and malignant tumors are recognized as major risk factors for emphysematous osteomyelitis, while iatrogenic intervention may be a potential predisposing factor in the pathogenesis of the disease. Our report emphasizes the key role of identifying EO through unique imaging features (such as the “pumice stone” sign).</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"29 ","pages":"Article 100526"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145610245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum regarding Missing Ethical Statement in previously published articles","authors":"","doi":"10.1016/j.clinpr.2025.100532","DOIUrl":"10.1016/j.clinpr.2025.100532","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"29 ","pages":"Article 100532"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of behavioral intervention on compliance of hand hygiene among health care staff in Ahvaz Naft Hospital","authors":"Fariba Mouresh ,&nbsp;Mohammad Veysi Sheikhrobat ,&nbsp;Shirin Changizi ,&nbsp;Shahram Ebrahimi ,&nbsp;Yusef Omidi Khaniabadi","doi":"10.1016/j.clinpr.2026.100538","DOIUrl":"10.1016/j.clinpr.2026.100538","url":null,"abstract":"<div><h3>Background</h3><div>Suboptimal hand hygiene compliance remains a major contributor to healthcare-associated infections, yet the effectiveness of educational interventions in routine hospital settings is uncertain. This study assessed the impact of a behavioral educational intervention on hand hygiene compliance among healthcare staff at Naft Hospital in Ahvaz, Iran.</div></div><div><h3>Methods</h3><div>A single-group quasi-experimental pre–post study was conducted between March and August 2024. Nurses, physicians, and nursing aides were assessed using covert, direct observation based on the World Health Organization’s five moments for hand hygiene. The intervention consisted of a structured three-hour educational workshop delivered by infection control staff. Hand hygiene compliance before and after the intervention was compared using standard statistical tests.</div></div><div><h3>Results</h3><div>The results showed that hand hygiene compliance was 21% before the intervention and 23% after the intervention, with no statistically significant difference. Compliance varied across the five moments, with lower adherence consistently observed before patient contact and before aseptic or clean procedures. The educational intervention was not associated with a meaningful change in routine hand hygiene behavior.</div></div><div><h3>Conclusions</h3><div>These findings suggest that stand-alone educational approaches may have limited impact on hand hygiene compliance in busy clinical settings. Multimodal and system-level strategies, incorporating ongoing monitoring, feedback, and organizational support, are likely required to achieve sustained improvements.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"29 ","pages":"Article 100538"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}