Clinical Infection in Practice最新文献

{"title":"Monsoon-driven dynamics of infectious diseases: Climatic determinants, outbreak patterns, and public health implications","authors":"Amogh Verma ,&nbsp;Prakasini Satapathy ,&nbsp;Divya Venugopal ,&nbsp;Soumya V Menon ,&nbsp;Nasir Vadia ,&nbsp;Rajashree Panigrahi ,&nbsp;Shubham Kumar ,&nbsp;Sorabh Lakhanpal ,&nbsp;Tweheyo Ronald ,&nbsp;Sanjit Sah","doi":"10.1016/j.clinpr.2025.100516","DOIUrl":"10.1016/j.clinpr.2025.100516","url":null,"abstract":"<div><div>Monsoon rainfall drives substantial shifts in infectious disease transmission through changes in hydrology, vector ecology, and human-environment interactions. Elevated humidity, flooding, and water stagnation create conditions that favor the propagation of pathogens, such as <em>Vibrio cholerae</em>, <em>Leptospira interrogans</em>, and arboviruses transmitted by <em>Aedes</em> and <em>Culex</em> mosquitoes. Respiratory viruses and invasive fungal infections also increase owing to overcrowding and compromised air quality during monsoon-induced displacement. Climatic thresholds, including sea surface temperature, relative humidity, and rainfall anomalies, correlate strongly with epidemic peaks. Intensifying monsoon variability due to climate change alters the geography, seasonality, and burden of these diseases, challenging existing public health models and demanding integrated climate-pathogen surveillance systems.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"28 ","pages":"Article 100516"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Largest cholera outbreak since Jajarkot: Lessons from Birgunj, Nepal","authors":"Shriyansh Srivastava ,&nbsp;Dheeraj Sharma ,&nbsp;G.S.N. Koteswara Rao ,&nbsp;Sachin Kumar ,&nbsp;Aroop Mohanty ,&nbsp;Sanjit Sah ,&nbsp;Sakshi Sharma ,&nbsp;Rachana Mehta","doi":"10.1016/j.clinpr.2025.100519","DOIUrl":"10.1016/j.clinpr.2025.100519","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"28 ","pages":"Article 100519"},"PeriodicalIF":0.0,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First case report of Rahnella bacteremia in a healthy child","authors":"Gioele Ballarò ,&nbsp;Fabian Spigariol ,&nbsp;Yves Fougère","doi":"10.1016/j.clinpr.2025.100515","DOIUrl":"10.1016/j.clinpr.2025.100515","url":null,"abstract":"<div><h3>Background</h3><div><em>Rahnella</em> species are environmental Gram-negative bacilli rarely reported as human pathogens, typically in immunocompromised individuals or those with chronic medical conditions. We report the first known case of bacteremia caused by <em>Rahnella</em> species in a paediatric patient without comorbidities or identifiable risk factors.</div></div><div><h3>Case Report</h3><div>A previously healthy 4-year-old Swiss girl presented with prolonged fever and abdominal pain without a clear infectious focus. Laboratory tests showed leukocytosis and elevated inflammatory markers.</div></div><div><h3>Results</h3><div>Blood cultures grew <em>Rahnella</em> sp. Empirical treatment with intravenous ceftriaxone, later switched to meropenem due to a mild allergic reaction, led to rapid clinical improvement. The patient completed a 10-day antibiotic course and fully recovered without complications.</div></div><div><h3>Conclusion</h3><div>This case highlights the capacity of <em>Rahnella</em> sp. to act as a true pathogen even in patients without significant comorbidities. Our findings suggest a need to reconsider the clinical relevance of <em>Rahnella</em> sp., which may cause invasive infections in immunocompetent hosts—not just opportunistic disease in vulnerable populations.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"28 ","pages":"Article 100515"},"PeriodicalIF":0.0,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated neurocysticercosis of the 4th ventricle presenting as Brun’s syndrome – A rare case","authors":"Abhishek Patil ,&nbsp;Abhishek Gautam ,&nbsp;Vinayak Pillai ,&nbsp;B.N. Nandeesh","doi":"10.1016/j.clinpr.2025.100513","DOIUrl":"10.1016/j.clinpr.2025.100513","url":null,"abstract":"<div><div>Neurocysticercosis (NCC) is the most common helminthic disease of the nervous system in humans and it is caused by the larvae of the pork tapeworm, Taenia solium. Isolated affection of any of the ventricles including the fourth ventricle is very uncommon. We present a case of microsurgical removal of a fourth ventricle NCC cyst via a suboccipital craniotomy in a 34-year-old male who presented with varying intensities of headache with change in position of the head due to obstructive hydrocephalus – characteristic of Brun’s Syndrome.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"28 ","pages":"Article 100513"},"PeriodicalIF":0.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of third-generation oral cephalosporin prescribing by general practitioners: A regional survey in France","authors":"Astrid Descolas ,&nbsp;Ramassamy Jérôme ,&nbsp;Thibaut Riom ,&nbsp;Lellouch Jérémy ,&nbsp;Peurois Matthieu","doi":"10.1016/j.clinpr.2025.100514","DOIUrl":"10.1016/j.clinpr.2025.100514","url":null,"abstract":"<div><h3>Introduction</h3><div>Oral third-generation cephalosporins (3GC) are a major source of antibiotic resistance, with 70 % of prescriptions issued by general practitioners (GPs). The main objective of this study was to identify the factors that lead GPs to prescribe oral 3GCs. The secondary objective was to identify the physician profiles most likely to prescribe them.</div></div><div><h3>Materials and Methods</h3><div>This was an observational, descriptive, declarative study. A questionnaire was distributed to GPs in a french area (Pays de le Loire).</div></div><div><h3>Results</h3><div>We included 74 responses from GPs. Several determinants were identified that positively influenced the prescription of oral 3GCs: situations of therapeutic failure (64.9 % of GPs), penicillin allergy (49.5 %), altered general condition (35.2 %), age over 65 (33.8 %). Physicians practising in semi-rural and rural areas seemed to be more inclined to prescribe 3GCs in cases of altered general condition (p &lt; 0.027) or diagnostic doubt (p &lt; 0.025).</div></div><div><h3>Conclusion</h3><div>The results of this study can be used to tailor GP training to the context in which they provide care.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"28 ","pages":"Article 100514"},"PeriodicalIF":0.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Onchocerciasis identified with anterior segment ocular examination and FDG-PET/CT imaging","authors":"Benjamin Griffin ,&nbsp;Lara Payne ,&nbsp;Laura Nabarro ,&nbsp;Neda Minakaran ,&nbsp;Gauri Godbole","doi":"10.1016/j.clinpr.2025.100511","DOIUrl":"10.1016/j.clinpr.2025.100511","url":null,"abstract":"<div><h3>Background</h3><div>Ocular onchocerciasis, commonly known as “river blindness,” is a parasitic infection caused by the filarial nematode <em>Onchocerca volvulus</em>. Although presentation within the United Kingdom is extremely rare, with no reports evident within the literature, it is the second leading cause of infectious blindness worldwide. Diagnosis is traditionally made through skin snip biopsy, serological testing and, where available, quantitative-polymerase chain reaction. Diagnostic imaging is not traditionally utilised due to limited availability within endemic regions.</div></div><div><h3>Case Report</h3><div>In this case, of a man presenting to a tertiary London ophthalmology unit with recurrent anterior uveitis, both anterior segment ocular examination with paracentesis, demonstrating microfilariae, and fluorodeoxyglucose – positron emission tomography / computed tomography, demonstrating an onchocercoma, play a crucial role in allowing targeted ultrasound-guided fine needle aspiration which confirmed the diagnosis.</div></div><div><h3>Conclusion</h3><div>This case highlights the role of anterior segment examination and diagnostic imaging in the diagnosis of infectious diseases. It also demonstrates novel anterior segment ocular imaging findings of in vivo microfilariae as seen in ocular onchocerciasis.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"28 ","pages":"Article 100511"},"PeriodicalIF":0.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community-acquired Pseudomonas aeruginosa meningitis − A rare case presentation","authors":"Sara Hamid ,&nbsp;Krishna Girotra ,&nbsp;Timothy Kemp ,&nbsp;Sajeed Mohammed Abdul ,&nbsp;Jooly Joseph ,&nbsp;Krishna Banavathi","doi":"10.1016/j.clinpr.2025.100512","DOIUrl":"10.1016/j.clinpr.2025.100512","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Gram-negative bacterial meningitis has a high mortality rate. We present a case of community acquired bacterial meningitis caused by</em> Pseudomonas aeruginosa <em>with a successful outcome following prolonged intravenous antibiotics.</em></div><div>Pseudomonas aeruginosa <em>is an uncommon Gram-negative bacterial cause of meningitis. In its rarity, it has no well-established optimal antibiotic therapy</em> (2)<em>.</em></div><div><em>Patients with the above face a severe clinical picture − of the etiological agents, Gram-negative bacilli have the highest fatality rate; 54%.</em>(3) <em>Therefore, the occurrence of</em> Pseudomonas aeruginosa <em>meningitis in the absence of predisposing factors is both an exceptionally rare, and dangerous, finding</em> (3) <em>– here, we describe such a case.</em></div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"28 ","pages":"Article 100512"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An unwanted souvenir: Case report of delayed diagnosis of a coccidioidomycosis prosthetic joint infection","authors":"F.D. Halstead ,&nbsp;E. Yates ,&nbsp;C. Onwukwe ,&nbsp;E. Tennant ,&nbsp;E. Leakey ,&nbsp;M. Roberts ,&nbsp;D. Braganza Menezes ,&nbsp;J. Bartlett ,&nbsp;A.M. Borman ,&nbsp;E.M. Johnson ,&nbsp;A. Johnson ,&nbsp;G.B. Wijayaratne","doi":"10.1016/j.clinpr.2025.100509","DOIUrl":"10.1016/j.clinpr.2025.100509","url":null,"abstract":"<div><h3>Background</h3><div><em>Coccidioides</em> spp, are dimorphic fungi endemic to arid and semi-arid regions of the Western USA, Central America, and South America, which can cause coccidioidomycosis. Although the majority of infections are mild or sub-clinical, disseminated coccidioidomycosis can occur, typically affecting immunocompromised individuals. This report presents a case of disseminated coccidioidomycosis that remained undiagnosed for decades.</div></div><div><h3>Case report</h3><div>A 68 year old Caucasian female presented to the Accident and Emergency (A&amp;E) Department of a UK hospital in late 2024 with fever, chills, vomiting, and joint pain. On examination she was febrile and hypotensive, with a clear chest and unremarkable cardiovascular and abdominal examinations. She had an extensive past medical history, involving rheumatoid arthritis and sarcoidosis (treated with a range of immunosuppressive agents), and knee swelling and pain, for which she underwent a unilateral total knee replacement with no resolution of symptoms.</div><div>During the most recent presentation, a range of microbiology samples were collected, including a knee aspirate (inoculated into a blood culture bottle). A fungus was isolated which was later identified by the National reference laboratory as <em>Coccidioides immitis.</em> The patient was treated with dual-antifungal therapy and remains on lifelong suppressive fluconazole (alongside steroids), under regular follow up.</div></div><div><h3>Conclusion</h3><div>Although there was an extensive travel history to endemic countries, and compatible clinical features, no diagnosis was made for many years. The recent laboratory investigations which clinched the diagnosis were also challenging as no travel history was provided, and our diagnostic equipment was not set up to detect this pathogen.</div><div>This case underscores the diagnostic challenges of coccidioidomycosis in non-endemic regions, emphasizing the critical role of a detailed travel history. It also highlights the occupational risks associated with handling <em>Coccidioides</em> in the laboratory, and the need for increased awareness of rare pathogens, particularly in immunocompromised patients with relevant travel histories.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"28 ","pages":"Article 100509"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145027407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryptic hepatitis E virus infections in immunocompromised hosts: A silent threat in high-income settings","authors":"Parth Aphale,&nbsp;Shashank Dokania,&nbsp;Himanshu Shekhar","doi":"10.1016/j.clinpr.2025.100508","DOIUrl":"10.1016/j.clinpr.2025.100508","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"28 ","pages":"Article 100508"},"PeriodicalIF":0.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bringing the heat to non-tuberculous mycobacterial infections: a comprehensive review inspired by a striking case of successful treatment","authors":"Marisa B. Kaelin ,&nbsp;Lukas A. Walker ,&nbsp;Vera Ihle ,&nbsp;Lisa Jungblut ,&nbsp;Martina Greminger ,&nbsp;Bettina Schulthess ,&nbsp;Johannes Nemeth","doi":"10.1016/j.clinpr.2025.100503","DOIUrl":"10.1016/j.clinpr.2025.100503","url":null,"abstract":"<div><div>The incidence of extrapulmonary non-tuberculous mycobacterial (NTM) infections is increasing globally, particularly among immunosuppressed patients. These infections are notoriously difficult to treat and often require long-term multidrug therapy leading to significant side effects. Although anecdotal evidence supports thermal therapy as beneficial, it remains underutilized and absent from treatment guidelines.</div><div>We present a case of chronic tenosynovitis and osteomyelitis in the index finger caused by <em>Mycobacterium chelonae</em>, where the patient showed minimal recovery with surgery and antibiotics but experienced rapid improvement after starting local thermal therapy.</div><div>Our literature review reveals multiple case reports supporting thermal therapy in treating NTM infections. Given the observed benefits and low toxicity, we recommend further exploration and incorporation of thermal therapy as a potential adjunct in the management of infections with heat-sensitive NTM.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"27 ","pages":"Article 100503"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}