Clinical Infection in Practice最新文献

The co-infection of lophomoniasis and tuberculosis in patients with respiratory symptoms; case series and literature review

Clinical Infection in Practice Pub Date : 2025-01-01 DOI: 10.1016/j.clinpr.2025.100408

Mohammad Hadi Tajik Jalayeri , Rahmat Allah Sharifi far , Narges Lashkarbolouk , Mahdi Mazandarani

{"title":"The co-infection of lophomoniasis and tuberculosis in patients with respiratory symptoms; case series and literature review","authors":"Mohammad Hadi Tajik Jalayeri , Rahmat Allah Sharifi far , Narges Lashkarbolouk , Mahdi Mazandarani","doi":"10.1016/j.clinpr.2025.100408","DOIUrl":"10.1016/j.clinpr.2025.100408","url":null,"abstract":"<div><h3>Background</h3><div><em>Lophomonas blattarum</em> is an emerging important cause of bronchopulmonary infections in immunocompromised patients. Moreover, Tuberculosis (TB) continues to be a significant factor in the mortality of infectious diseases, particularly in developing nations, serving as a primary cause of pneumonia.</div></div><div><h3>Cases presentation</h3><div>Our study reported six cases of lophomoniasis with tuberculosis co-infection. The median age of all cases reported was 51.83 years old, and 50 % of patients were male. All the adult patients had respiratory signs, with common symptoms of fever and dyspnea. The presence of leukocytes and anemia in the patients was common. We treated them with metronidazole 500 mg twice a day for two weeks and a combination of TB regimens.</div></div><div><h3>Conclusion</h3><div>We recommended identifying lophomoniasis during differential diagnoses of patients with pulmonary tuberculosis. Moreover, Timely diagnosis and treatment of lophomonas is crucial, as it requires a different treatment approach from pneumonia or TB. Clinical laboratories should consider the active search for this protozoan in these patients’ bronchoalveolar and tracheal liquid samples.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"25 ","pages":"Article 100408"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143101407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Guillain-Barré Syndrome in Pune, India: Epidemiological and clinical insights into a potential waterborne outbreak

Clinical Infection in Practice Pub Date : 2025-01-01 DOI: 10.1016/j.clinpr.2025.100415

Sourav Sudan, Himanshu Jindal, Vaishnavi Akshay Patel, Manali Verma, Gopi Krishna, Vinay Suresh, Amogh Verma, Shubham Kumar, Rachana Mehta, Ranjana Sah

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Schistosomiasis infection in Europe: A climate-driven public health challenge

Clinical Infection in Practice Pub Date : 2025-01-01 DOI: 10.1016/j.clinpr.2024.100402

Amogh Verma , Hrithik Dakssesh Putta Nagarajan , Vaishnavi Jaiswal , Hadirou Tamdamba , Sanjit Sah , Rachana Mehta , Ganesh Bushi , Ashok Kumar Balaraman , Sakshi Pandey , Manvinder Brar , Benjamin Wafula Simiyu

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Successful treatment with aztreonam of a patient with disseminated hypervirulent Klebsiella pneumoniae infection

Clinical Infection in Practice Pub Date : 2025-01-01 DOI: 10.1016/j.clinpr.2025.100413

Yewande Adegeye, Anna Wild, Karmel BandyWebb

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Resurgence of polio: Global challenges and the way forward

Clinical Infection in Practice Pub Date : 2025-01-01 DOI: 10.1016/j.clinpr.2024.100401

Amogh Verma , Vaishnavi Jaiswal , Ajeet Singh , Ranjana Sah , Manvinder Brar , Sanjit Sah , Rachana Mehta , Ganesh Bushi , Ashok Kumar Balaraman , Sakshi Pandey

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Disease X: Unraveling a mysterious outbreak in the Democratic Republic of the Congo

Clinical Infection in Practice Pub Date : 2025-01-01 DOI: 10.1016/j.clinpr.2025.100409

Manali Verma , Amogh Verma , Rahul Singla , Siddharth Sharma , Vinay Suresh , Hajira Karim , Samriddhi Srivastava , Hrithik Dakssesh Putta Nagarajan , Shubham Kumar , Rachana Mehta , Ranjana Sah , Chelsea Rachael Tafawa

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A case of brainstem encephalitis with acute neuropathy associated with prolonged chikungunya viraemia

Clinical Infection in Practice Pub Date : 2025-01-01 DOI: 10.1016/j.clinpr.2024.100398

Tembe Carveth-Johnson , Benjamin McLoughlin , Daniel Rice-Wilson , Fiona Chatterjee , Teresa Cutino-Moguel , Matthew Buckland , Apeksha Shah , David Harrington

{"title":"A case of brainstem encephalitis with acute neuropathy associated with prolonged chikungunya viraemia","authors":"Tembe Carveth-Johnson , Benjamin McLoughlin , Daniel Rice-Wilson , Fiona Chatterjee , Teresa Cutino-Moguel , Matthew Buckland , Apeksha Shah , David Harrington","doi":"10.1016/j.clinpr.2024.100398","DOIUrl":"10.1016/j.clinpr.2024.100398","url":null,"abstract":"<div><div>A 66-year-old man presented to hospital in London, United Kingdom, with back pain and reduced mobility shortly after returning from Chandigarh, India. Examination revealed flaccid paralysis in his lower limbs with absent reflexes and an initially normal upper limb neurological exam. He subsequently developed upper limb weakness with areflexia and truncal, bulbar, and respiratory weakness, and was intubated and ventilated. MRI brain showed features of a brainstem encephalitis centred on the ventral medulla. Neurophysiology showed widespread peripheral acute axonal degeneration, consistent with Guillain-Barré syndrome (acute motor sensory axonal neuropathy variant). He had positive serum chikungunya IgG and IgM and the virus remained detectable by PCR at 34 days post-symptom onset. He had detectable anti-cytokine antibodies. He was treated with high dose steroids, intravenous immunoglobulins, and plasma exchange. He made a good clinical recovery with near normal upper limb and bulbar function, and mild residual leg weakness. In this case we describe a unique neurological presentation of chikungunya infection resulting in concurrent brainstem encephalitis and axonal Guillain-Barré syndrome, associated with a protracted viraemia. Immunological investigations revealed the presence of anti-cytokine antibodies, highlighting the need for improved understanding of host susceptibility to severe manifestations of chikungunya infection.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"25 ","pages":"Article 100398"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143101405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Marburg Virus Disease in Tanzania: A Review

Clinical Infection in Practice Pub Date : 2025-01-01 DOI: 10.1016/j.clinpr.2025.100414

Vaishnavi Akshay Patel , Amogh Verma , Manali Verma , Sourav Sudan , Amna Zaheer , Anil Kumar , Hajira Karim , Shubham Kumar , Rachana Mehta , Ranjana Sah

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Kerala’s fight against Nipah Virus: Surveillance and safety measures intensify

Clinical Infection in Practice Pub Date : 2025-01-01 DOI: 10.1016/j.clinpr.2025.100412

Shriyansh Srivastava , Sharib Raza Khan , Pranav Gupta , Molakpogu Ravindra Babu , Aroop Mohanty , Prakasini Satapathy , Sanjit Sah , Rachana Mehta

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Delayed diagnosis of parapoxvirus infections and a review of pox infections other than mpox in the United Kingdom

Clinical Infection in Practice Pub Date : 2025-01-01 DOI: 10.1016/j.clinpr.2024.100400

Ameeka Thompson , Aysha Jameel , Christina Petridou , N Claire Gordon

{"title":"Delayed diagnosis of parapoxvirus infections and a review of pox infections other than mpox in the United Kingdom","authors":"Ameeka Thompson , Aysha Jameel , Christina Petridou , N Claire Gordon","doi":"10.1016/j.clinpr.2024.100400","DOIUrl":"10.1016/j.clinpr.2024.100400","url":null,"abstract":"<div><h3>Background</h3><div>Orf virus is a member of the genus parapoxvirus. Orf is an infection of sheep and goats but humans can become infected after direct contact with an infected mammal. It is normally a self-limiting cutaneous infection but it has the potential to cause more severe infection in immunosuppressed individuals.</div></div><div><h3>Case Report</h3><div>We report two cases of delayed diagnosis of orf. The first case was a fifty-year-old sheep farmer who presented with a painful lesion on her finger. The second patient was a twenty-five-year-old veterinary nurse who presented with a painful lesion on her finger after being bitten by a lamb. Both cases were mis-diagnosed by a number of different clinicians and the second case received multiple courses of inappropriate anti-microbial therapy.</div></div><div><h3>Results</h3><div>Skin swabs from both cases were sent to the UKHSA Porton Rare and Imported Pathogens Laboratory (RIPL) for parapoxvirus PCR. Parapoxvirus DNA was detected in both cases, indicating presumptive orf infection.</div></div><div><h3>Conclusion</h3><div>A thorough history, including occupation and animal exposure, is key to making a prompt diagnosis of orf. Early recognition is required in order to prevent unnecessary anti-microbial therapy and surgical intervention, and to allow for prompt treatment in those severe cases where it is required.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"25 ","pages":"Article 100400"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143101404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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