Determinants of third-generation oral cephalosporin prescribing by general practitioners: A regional survey in France

Q3 Medicine

Clinical Infection in Practice Pub Date : 2025-09-17 DOI:10.1016/j.clinpr.2025.100514

Astrid Descolas , Ramassamy Jérôme , Thibaut Riom , Lellouch Jérémy , Peurois Matthieu

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Abstract

Introduction

Oral third-generation cephalosporins (3GC) are a major source of antibiotic resistance, with 70 % of prescriptions issued by general practitioners (GPs). The main objective of this study was to identify the factors that lead GPs to prescribe oral 3GCs. The secondary objective was to identify the physician profiles most likely to prescribe them.

Materials and Methods

This was an observational, descriptive, declarative study. A questionnaire was distributed to GPs in a french area (Pays de le Loire).

Results

We included 74 responses from GPs. Several determinants were identified that positively influenced the prescription of oral 3GCs: situations of therapeutic failure (64.9 % of GPs), penicillin allergy (49.5 %), altered general condition (35.2 %), age over 65 (33.8 %). Physicians practising in semi-rural and rural areas seemed to be more inclined to prescribe 3GCs in cases of altered general condition (p < 0.027) or diagnostic doubt (p < 0.025).

Conclusion

The results of this study can be used to tailor GP training to the context in which they provide care.

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全科医生开具第三代口服头孢菌素处方的决定因素：法国的一项区域调查

口服第三代头孢菌素（3GC）是抗生素耐药性的主要来源，70%的处方由全科医生开具。本研究的主要目的是确定导致全科医生开口服3gc的因素。次要目的是确定最有可能开处方的医生概况。材料与方法本研究为观察性、描述性、陈述性研究。向法国一个地区（卢瓦尔河沿岸）的普通医生分发了一份调查表。结果我们纳入了74名全科医生的回复。确定了几个影响口服3gc处方的决定因素：治疗失败（64.9%的全科医生），青霉素过敏（49.5%），一般情况改变（35.2%），年龄超过65（33.8%）。在半农村和农村地区执业的医生似乎更倾向于在一般情况改变（p < 0.027）或诊断怀疑（p < 0.025）的情况下开3GCs。结论本研究的结果可用于定制全科医生培训的背景下，他们提供护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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