Clinical Infection in Practice最新文献

{"title":"26 An evolving landscape in patient-orientated clinical research","authors":"Shethah Morgan, Lisa Kerr","doi":"10.1016/j.clinpr.2025.100451","DOIUrl":"10.1016/j.clinpr.2025.100451","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"25 ","pages":"Article 100451"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"74 Spectrum and trends in bacteraemia in children attending the emergency department in a large tertiary hospital in East London, UK","authors":"Yuxing Jonathan Xia , Danai Christina Kardassi , Giannis Siamptanis , Mildred Adaku Iro , Emre Basatemur","doi":"10.1016/j.clinpr.2025.100480","DOIUrl":"10.1016/j.clinpr.2025.100480","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"25 ","pages":"Article 100480"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality in the thirteen years following invasive pneumococcal disease","authors":"William P.W. Smith ,&nbsp;Chloe Walsh ,&nbsp;Gavin Barlow","doi":"10.1016/j.clinpr.2025.100411","DOIUrl":"10.1016/j.clinpr.2025.100411","url":null,"abstract":"<div><h3>Background</h3><div>Traditionally considered an acute disease, there is increasing evidence that Invasive Pneumococcal Disease (IPD) is associated with higher longer-term mortality than might be expected (Floeystad et al., 2017 May; Versluys et al., 2022 Aug; Versluys et al., 2022).</div></div><div><h3>Aim</h3><div>To investigate IPD mortality over a prolonged time period and identify predictors and causes of early versus later mortality.</div></div><div><h3>Design</h3><div>A previous retrospective cohort study was undertaken with 207 consecutive adult patients diagnosed with IPD at Hull University Teaching Hospitals NHS Trust, 2007–2009. The present study followed this cohort to 2023.</div></div><div><h3>Methods</h3><div>Clinical notes were reviewed and patient characteristics and causes of death recorded. United Kingdom life expectancy tables were used to calculate expected remaining years of life according to patient age and calculate the difference between the observed and expected life years, stratified by potential predictor variables to identify associations with loss of life-years. Piecewise multivariate Cox Proportional Hazards (CPH) models were constructed to identify statistically significant predictors for early, medium-term, and long-term mortality.</div></div><div><h3>Results</h3><div>21 % of patients died within 30 days, 39 % by 2 years, and 69 % by 13 years. Most early deaths, according to death certification, were due to infection, whereas later deaths were predominantly due to malignancy or infection. Compared to the Hull region, there were significantly more deaths from infection and malignancy, and fewer from cardiovascular disease. The total difference between observed and expected was 985 life years for the cohort. Age, Charlson score, and pyrexia on admission were significant predictors of late mortality.</div></div><div><h3>Conclusions</h3><div>Age and comorbidity burden are predictors of mortality after IPD with infection and malignancy being important causes of later mortality. Clinicians should be mindful of undiagnosed malignancies when managing IPD and consider reviewing the stability of existing comorbidities either prior to or shortly after discharge from hospital.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"26 ","pages":"Article 100411"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The co-infection of lophomoniasis and tuberculosis in patients with respiratory symptoms; case series and literature review","authors":"Mohammad Hadi Tajik Jalayeri ,&nbsp;Rahmat Allah Sharifi far ,&nbsp;Narges Lashkarbolouk ,&nbsp;Mahdi Mazandarani","doi":"10.1016/j.clinpr.2025.100408","DOIUrl":"10.1016/j.clinpr.2025.100408","url":null,"abstract":"<div><h3>Background</h3><div><em>Lophomonas blattarum</em> is an emerging important cause of bronchopulmonary infections in immunocompromised patients. Moreover, Tuberculosis (TB) continues to be a significant factor in the mortality of infectious diseases, particularly in developing nations, serving as a primary cause of pneumonia.</div></div><div><h3>Cases presentation</h3><div>Our study reported six cases of lophomoniasis with tuberculosis co-infection. The median age of all cases reported was 51.83 years old, and 50 % of patients were male. All the adult patients had respiratory signs, with common symptoms of fever and dyspnea. The presence of leukocytes and anemia in the patients was common. We treated them with metronidazole 500 mg twice a day for two weeks and a combination of TB regimens.</div></div><div><h3>Conclusion</h3><div>We recommended identifying lophomoniasis during differential diagnoses of patients with pulmonary tuberculosis. Moreover, Timely diagnosis and treatment of lophomonas is crucial, as it requires a different treatment approach from pneumonia or TB. Clinical laboratories should consider the active search for this protozoan in these patients’ bronchoalveolar and tracheal liquid samples.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"25 ","pages":"Article 100408"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143101407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guillain-Barré Syndrome in Pune, India: Epidemiological and clinical insights into a potential waterborne outbreak","authors":"Sourav Sudan,&nbsp;Himanshu Jindal,&nbsp;Vaishnavi Akshay Patel,&nbsp;Manali Verma,&nbsp;Gopi Krishna,&nbsp;Vinay Suresh,&nbsp;Amogh Verma,&nbsp;Shubham Kumar,&nbsp;Rachana Mehta,&nbsp;Ranjana Sah","doi":"10.1016/j.clinpr.2025.100415","DOIUrl":"10.1016/j.clinpr.2025.100415","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"25 ","pages":"Article 100415"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schistosomiasis infection in Europe: A climate-driven public health challenge","authors":"Amogh Verma ,&nbsp;Hrithik Dakssesh Putta Nagarajan ,&nbsp;Vaishnavi Jaiswal ,&nbsp;Hadirou Tamdamba ,&nbsp;Sanjit Sah ,&nbsp;Rachana Mehta ,&nbsp;Ganesh Bushi ,&nbsp;Ashok Kumar Balaraman ,&nbsp;Sakshi Pandey ,&nbsp;Manvinder Brar ,&nbsp;Benjamin Wafula Simiyu","doi":"10.1016/j.clinpr.2024.100402","DOIUrl":"10.1016/j.clinpr.2024.100402","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"25 ","pages":"Article 100402"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treatment with aztreonam of a patient with disseminated hypervirulent Klebsiella pneumoniae infection","authors":"Yewande Adegeye,&nbsp;Anna Wild,&nbsp;Karmel BandyWebb","doi":"10.1016/j.clinpr.2025.100413","DOIUrl":"10.1016/j.clinpr.2025.100413","url":null,"abstract":"<div><div><em>Klebsiella pneumoniae</em> is a highly pathogenic and resilient Gram negative bacterium often found colonising the gastrointestinal (GI) tract in humans. The hypervirulent strain of bacterium possesses unique virulence mechanisms which can cause primary liver abscesses with septic metastatic complications. In recent decades, there has been a continual rise in global health concern regarding the emergence of antimicrobial resistance for this organism.</div><div>We present a case of a hypervirulent <em>Klebsiella pneumoniae</em> infection with liver abscesses and central nervous system (CNS) embolic disease which was treated successfully with the monobactam aztreonam. Although the isolate tested sensitive to a wide range of antibiotics including third-generation cephalosporins and carbapenems, her treatment regime was altered due to a lack of clinical response and adverse drug reactions. The patient made significant improvement clinically, biochemically and radiologically on aztreonam, despite lesser use in CNS disease than conventional beta-lactams.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"25 ","pages":"Article 100413"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resurgence of polio: Global challenges and the way forward","authors":"Amogh Verma ,&nbsp;Vaishnavi Jaiswal ,&nbsp;Ajeet Singh ,&nbsp;Ranjana Sah ,&nbsp;Manvinder Brar ,&nbsp;Sanjit Sah ,&nbsp;Rachana Mehta ,&nbsp;Ganesh Bushi ,&nbsp;Ashok Kumar Balaraman ,&nbsp;Sakshi Pandey","doi":"10.1016/j.clinpr.2024.100401","DOIUrl":"10.1016/j.clinpr.2024.100401","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"25 ","pages":"Article 100401"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143101408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease X: Unraveling a mysterious outbreak in the Democratic Republic of the Congo","authors":"Manali Verma ,&nbsp;Amogh Verma ,&nbsp;Rahul Singla ,&nbsp;Siddharth Sharma ,&nbsp;Vinay Suresh ,&nbsp;Hajira Karim ,&nbsp;Samriddhi Srivastava ,&nbsp;Hrithik Dakssesh Putta Nagarajan ,&nbsp;Shubham Kumar ,&nbsp;Rachana Mehta ,&nbsp;Ranjana Sah ,&nbsp;Chelsea Rachael Tafawa","doi":"10.1016/j.clinpr.2025.100409","DOIUrl":"10.1016/j.clinpr.2025.100409","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"25 ","pages":"Article 100409"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marburg Virus Disease in Tanzania: A Review","authors":"Vaishnavi Akshay Patel ,&nbsp;Amogh Verma ,&nbsp;Manali Verma ,&nbsp;Sourav Sudan ,&nbsp;Amna Zaheer ,&nbsp;Anil Kumar ,&nbsp;Hajira Karim ,&nbsp;Shubham Kumar ,&nbsp;Rachana Mehta ,&nbsp;Ranjana Sah","doi":"10.1016/j.clinpr.2025.100414","DOIUrl":"10.1016/j.clinpr.2025.100414","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"25 ","pages":"Article 100414"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}