Clinical Parkinsonism Related Disorders最新文献

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Longitudinal associations between physical performance and cognition in individuals with Parkinson’s disease 帕金森病患者身体表现与认知之间的纵向关联
IF 1.9
Clinical Parkinsonism Related Disorders Pub Date : 2025-01-01 DOI: 10.1016/j.prdoa.2025.100370
Andrew J. Petkus , Ryan P. Foreman , Matthew Pilgrim , Aram Kim , Elise Hong , Beth E. Fisher , John D. Van Horn , David Wing , Michael W. Jakowec , Dawn M. Schiehser , Giselle M. Petzinger
{"title":"Longitudinal associations between physical performance and cognition in individuals with Parkinson’s disease","authors":"Andrew J. Petkus ,&nbsp;Ryan P. Foreman ,&nbsp;Matthew Pilgrim ,&nbsp;Aram Kim ,&nbsp;Elise Hong ,&nbsp;Beth E. Fisher ,&nbsp;John D. Van Horn ,&nbsp;David Wing ,&nbsp;Michael W. Jakowec ,&nbsp;Dawn M. Schiehser ,&nbsp;Giselle M. Petzinger","doi":"10.1016/j.prdoa.2025.100370","DOIUrl":"10.1016/j.prdoa.2025.100370","url":null,"abstract":"<div><h3>Background</h3><div>Declines in physical performance and cognition commonly occur in people with Parkinson’s disease (PwPD) and negatively impacts Quality of Life. Understanding the cross-sectional and longitudinal associations between physical performance and cognition may provide guidance to prevent or treat their decline in PwPD.</div></div><div><h3>Objective</h3><div>This study investigated the cross-sectional and longitudinal associations between physical performance and cognition in PwPD.</div></div><div><h3>Methods</h3><div>Physical performance and cognition were evaluated at baseline and at two-year follow-up in PwPD. Physical performance was measured using Ten-Set Test, Time Up and Go, Physical Performance Test, and Short-Physical Performance Battery Test. Neuropsychological assessments included global cognition and domain-specific cognitive functions from which Mild Cognitive Impairment (MCI) status was ascertained. Regression analyses estimated baseline associations between physical performance and cognition and if changes in physical performance were associated with changes in cognition. Sub-analysis determined which physical performance test was most significantly associated with cognition.</div></div><div><h3>Results</h3><div>At baseline, better physical performance was associated with lower odds of having MCI as well as better global cognition, attention, and executive function. Baseline physical performance was also associated with changes in executive function and attention (baseline to two-year follow-up). PwPD experiencing greater decline in physical performance experienced more decline in executive function and visuospatial skills.</div></div><div><h3>Conclusion</h3><div>Physical performance and cognition are closely inter-related in PwPD. Findings are clinically relevant since impaired physical performance may inform those PwPD most likely to demonstrate greatest cognitive deficits over time and who may benefit from treatment strategies, such as neurorehabilitation, for improving cognition and reducing its decline.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"13 ","pages":"Article 100370"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesocorticolimbic dopaminergic innervation modulates Levodopa-related improvements in gait in older slow walking Adults: A [11C]PE2I PET study 中皮质边缘多巴胺能神经支配调节老年慢行成人左旋多巴相关的步态改善:一项PE2I PET研究
IF 1.9
Clinical Parkinsonism Related Disorders Pub Date : 2025-01-01 DOI: 10.1016/j.prdoa.2025.100353
N. Paalanen , S. Roytman , M. van Emde Boas , A. Biddix , A. Luker , F. Michalakis , G. Carli , P. Kanel , C. Pongmala , R. Koeppe , L.M. Chahine , C. Rosano , N.I. Bohnen
{"title":"Mesocorticolimbic dopaminergic innervation modulates Levodopa-related improvements in gait in older slow walking Adults: A [11C]PE2I PET study","authors":"N. Paalanen ,&nbsp;S. Roytman ,&nbsp;M. van Emde Boas ,&nbsp;A. Biddix ,&nbsp;A. Luker ,&nbsp;F. Michalakis ,&nbsp;G. Carli ,&nbsp;P. Kanel ,&nbsp;C. Pongmala ,&nbsp;R. Koeppe ,&nbsp;L.M. Chahine ,&nbsp;C. Rosano ,&nbsp;N.I. Bohnen","doi":"10.1016/j.prdoa.2025.100353","DOIUrl":"10.1016/j.prdoa.2025.100353","url":null,"abstract":"<div><h3>Purpose</h3><div>Slow walking in healthy older adults may result from multifactorial deficits involving the muscular, peripheral, and central nervous systems. While mobility depends on these systems, the brain’s neuromodulatory capacity may offer insights for interventions. This open-label imaging study tested whether the dopaminergic system serves as a resilience mechanism for gait in the elderly. Using [<sup>11</sup>C]PE2I dopamine transporter (DAT) PET, we assessed whether baseline dopaminergic innervation modulates the response to a one-week carbidopa-levodopa regimen in slow-walking older adults without Parkinson’s disease (PD).</div></div><div><h3>Methods</h3><div>Slow walking older adults without clinical evidence of PD (n = 9) were pre-treated with carbidopa 25 mg one tablet TID for three days, followed by carbidopa-levodopa 25/100 mg starting at one tablet TID for three days and then increased to 1.5 tablets of carbidopa-levodopa 25/100 mg TID daily for four days, as tolerated. [<sup>11</sup>C]PE2I DAT PET imaging was completed at baseline. Spatiotemporal gait parameters were evaluated at pre-intervention, following carbidopa pre-treatment, and post-intervention.</div></div><div><h3>Results</h3><div>Levodopa treatment resulted in improved gait speed (<em>β</em> = 0.69 [0.07, 1.30], <em>p</em> = 0.031), double-support time (<em>β</em> = -0.26 [-0.51, −0.01], <em>p</em> = 0.041), and cadence (<em>β</em> = 0.54 [0.18, 0.89], <em>p</em> = 0.005), but not in turn duration (<em>β</em> = 0.41 [-0.33, 1.14], <em>p</em> = 0.264). These changes were strongly predicted by pre-treatment limbic, subcortical, and neocortical DAT PET uptake, with greater improvements in gait pace observed among individuals with lower DAT availability.</div></div><div><h3>Conclusion</h3><div>These preliminary findings suggest that the mesocorticolimbic dopaminergic system may be the substrate of a resilience mechanism that can be targeted to manage gait impairments in older adults.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"12 ","pages":"Article 100353"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is practitioner appraisal of facial expressivity and emotional engagement in simulated Parkinson’s disease affected by race? 从业者对模拟帕金森病患者面部表情和情绪投入的评价是否受种族影响?
IF 1.9
Clinical Parkinsonism Related Disorders Pub Date : 2025-01-01 DOI: 10.1016/j.prdoa.2025.100356
Shana Harris , Hana-May Eadeh , Daniel Tranel
{"title":"Is practitioner appraisal of facial expressivity and emotional engagement in simulated Parkinson’s disease affected by race?","authors":"Shana Harris ,&nbsp;Hana-May Eadeh ,&nbsp;Daniel Tranel","doi":"10.1016/j.prdoa.2025.100356","DOIUrl":"10.1016/j.prdoa.2025.100356","url":null,"abstract":"<div><h3>Background</h3><div>Black people are diagnosed with Parkinson’s disease (PD) at half the rate as White people. One unexplored possibility to explain this disparity is that practitioners have a racial bias, specifically when appraising motor signs of PD in Black versus White people.</div></div><div><h3>Objective</h3><div>The current study explores whether practitioners have a racial bias when appraising/evaluating Black versus White people with or without hypomimia (a motor sign of PD that results in reduced facial expressivity, which was simulated in this current study). Such bias may cause delays in the diagnosis of PD, which could explain the large racial disparity of the disease in Black versus White people.</div></div><div><h3>Methods</h3><div>A multi-level modeling approach was used to compare practitioners’ (N = 175) <strong>(1)</strong> appraisal of facial expressivity <strong>(2)</strong> perception of pathology and <strong>(3)</strong> impression of emotional engagement, in Black versus White people (paid actors) with or without simulated hypomimia. Additional analyses explored the association between these variables and practitioners’ demographics.</div></div><div><h3>Results</h3><div>Results show that practitioners rated facial expressivity higher in Black versus White individuals with no hypomimia, <em>t</em>(500.170) = 8.916, <em>p</em> &lt; 0.001, estimate = -13.352. Additionally, more years of patient experience was associated with higher pathology ratings by practitioners, for Black and White people with hypomimia.</div></div><div><h3>Conclusion</h3><div>Although this study did not find a racial bias in practitioners’ appraisal of Black versus White people with hypomimia, the results highlight that quantity (i.e., years of experience), and possibly, quality of training could lead to a more accurate evaluation of Black patients with signs of Parkinson’s disease, which is a feasible point of intervention.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"13 ","pages":"Article 100356"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision medicine and music therapy for Parkinson’s Disease 帕金森氏症的精准医学和音乐疗法
IF 1.8
Clinical Parkinsonism Related Disorders Pub Date : 2025-01-01 DOI: 10.1016/j.prdoa.2025.100382
Peng Li-Hua , Lamarana Jallow , Yurong Tan , Ousman Bajinka
{"title":"Precision medicine and music therapy for Parkinson’s Disease","authors":"Peng Li-Hua ,&nbsp;Lamarana Jallow ,&nbsp;Yurong Tan ,&nbsp;Ousman Bajinka","doi":"10.1016/j.prdoa.2025.100382","DOIUrl":"10.1016/j.prdoa.2025.100382","url":null,"abstract":"<div><div><strong>Background:</strong> Parkinson’s disease (PD) is a complex neurodegenerative disorder requiring multidimensional treatment approaches. Recent breakthroughs in precision medicine and growing evidence for music therapy efficacy present new opportunities for comprehensive PD management that addresses both biological mechanisms and quality of life outcomes <strong>Objectives:</strong> This mini review evaluates the current state of precision medicine and music therapy interventions for PD, with three primary aims: (1) to synthesize evidence for genetic-based treatments and music-based interventions, (2) to identify potential synergies between these approaches, and (3) to highlight critical implementation challenges in clinical practice. <strong>Finding:</strong> Our analysis revealed that precision medicine approaches, including GBA1-targeted venglustat and LRRK2 kinase inhibitors, show significant promise in clinical trials when guided by genetic profiling. Concurrently, music therapy demonstrates robust clinical benefits, with RAS producing 15–20% improvements in gait parameters and group singing programs enhancing both speech function and psychosocial wellbeing. Emerging technologies, particularly wearable sensors and adaptive AI platforms, are enhancing the precision and personalization of both treatment modalities. However, we identified persistent challenges including the need for standardized biomarkers in precision medicine and more rigorous clinical validation for music therapy protocols. <strong>Conclusions:</strong> The strategic integration of precision medicine and music therapy offers a novel, patient-centered framework for PD management that simultaneously targets pathological mechanisms and functional outcomes. Future implementation should focus on overcoming accessibility barriers, conducting large-scale longitudinal studies, and developing integrated treatment protocols that combine genetic insights with personalized neuromodulation approaches.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"13 ","pages":"Article 100382"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144781478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in the olfactory tract of patients with early Parkinson’s disease: A DTI tractography study 早期帕金森病患者嗅道的变化:DTI嗅道造影研究
IF 1.8
Clinical Parkinsonism Related Disorders Pub Date : 2025-01-01 DOI: 10.1016/j.prdoa.2025.100396
Pasquale Nigro , Andrea Chiappiniello , Filippo Bucherini , Pietro Chiarini , Alessandro Mechelli , Carlo Maremmani , Federico Paolini Paoletti , Roberto Tarducci , Andrea Fiacca , Lucilla Parnetti , Nicola Tambasco
{"title":"Changes in the olfactory tract of patients with early Parkinson’s disease: A DTI tractography study","authors":"Pasquale Nigro ,&nbsp;Andrea Chiappiniello ,&nbsp;Filippo Bucherini ,&nbsp;Pietro Chiarini ,&nbsp;Alessandro Mechelli ,&nbsp;Carlo Maremmani ,&nbsp;Federico Paolini Paoletti ,&nbsp;Roberto Tarducci ,&nbsp;Andrea Fiacca ,&nbsp;Lucilla Parnetti ,&nbsp;Nicola Tambasco","doi":"10.1016/j.prdoa.2025.100396","DOIUrl":"10.1016/j.prdoa.2025.100396","url":null,"abstract":"<div><h3>Introduction</h3><div>olfactory impairment is a clinical feature of Parkinson’s disease (PD) even in the early phases. Diffusion tensor imaging fiber tracking analysis (DTI-FTA) has been able to highlight changes in the olfactory tract in PD, however in early phases of PD this analysis has not been investigated. We investigated the olfactory tract by DTI-FTA in early stages of PD (ePD).</div></div><div><h3>Methods</h3><div>All patients were assessed using the Italian Olfactory Identification Test (IOIT), the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale-Part III (MDS-UPDRS-III) and the Hoehn and Yahr (H&amp;Y) scale. Diffusion imaging was conducted by 3 T MRI.</div></div><div><h3>Results</h3><div>Overall, 26 PD patients and 20 healthy subject were recruited. Hyposmia was observed in all PD patients. DTI-FTA of the olfactory tract showed significant mean diffusivity (MD) increases and a tract volume decrease for PD group. MD and age, only in the PD group, were significant for multiple correlations.</div></div><div><h3>Conclusion</h3><div>DTI-FTA identified microstructural changes in the olfactory tract even in hyposmic ePD patients.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"13 ","pages":"Article 100396"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distinct sensorimotor cough features in a cohort of Progressive Supranuclear Palsy 进行性核上性麻痹患者明显的感觉运动性咳嗽特征
IF 1.9
Clinical Parkinsonism Related Disorders Pub Date : 2025-01-01 DOI: 10.1016/j.prdoa.2025.100305
Michela J. Mir , Justin Childers , Yuhan Mou , Bryn Taylor , Karen Wheeler-Hegland
{"title":"Distinct sensorimotor cough features in a cohort of Progressive Supranuclear Palsy","authors":"Michela J. Mir ,&nbsp;Justin Childers ,&nbsp;Yuhan Mou ,&nbsp;Bryn Taylor ,&nbsp;Karen Wheeler-Hegland","doi":"10.1016/j.prdoa.2025.100305","DOIUrl":"10.1016/j.prdoa.2025.100305","url":null,"abstract":"<div><h3>Background</h3><div>Progressive Supranuclear Palsy (PSP) and Parkinson’s disease (PD) similarly affect many neural substrates; however, some brain regions may be more impacted by PSP vs PD, giving rise to distinct cough features that could facilitate earlier differential diagnosis and inform airway protection therapies to prevent fatal lung infections, since patients may not effectively sense and clear irritants from their airways.</div></div><div><h3>Methods</h3><div>Thirteen individuals with PSP participated and were age- and sex-matched to persons with PD and healthy, unaffected adults. Using a cross-sectional study design this study aimed to 1) compare cough function in PSP using voluntary and induced reflex cough testing, and 2) compare cough airflow and sensation metrics to PD and healthy adult groups.</div></div><div><h3>Results</h3><div>Voluntary cough function, particularly cough effectiveness during the expiratory phase, was most impaired in the PSP group (P = 0.047), while expiratory phase timing outcomes only differed between PSP and healthy controls (P = 0.03) during reflex cough. There were no significant differences between groups regarding cough sensation to a cough-inducing stimulus (capsaicin), yet there were more cough responders in PSP vs. PD group.</div></div><div><h3>Conclusions</h3><div>Degeneration of distinct neural substrates in PSP versus PD may give rise to differentiating sensorimotor cough deficits. Future directions should focus on cough interventions that maintain respiratory health.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"12 ","pages":"Article 100305"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of patellar reflex in Parkinson disease patients after an acupuncture treatment protocol – Case series study 帕金森病患者针刺治疗后髌骨反射分析-病例系列研究
IF 1.9
Clinical Parkinsonism Related Disorders Pub Date : 2025-01-01 DOI: 10.1016/j.prdoa.2025.100324
Catarina Ramos Pereira , Jorge Machado , Begoña Criado , Rubim Santos , Ana Mafalda Reis , Bruno Ramos , Maria João Santos , Henry Johannes Greten
{"title":"Analysis of patellar reflex in Parkinson disease patients after an acupuncture treatment protocol – Case series study","authors":"Catarina Ramos Pereira ,&nbsp;Jorge Machado ,&nbsp;Begoña Criado ,&nbsp;Rubim Santos ,&nbsp;Ana Mafalda Reis ,&nbsp;Bruno Ramos ,&nbsp;Maria João Santos ,&nbsp;Henry Johannes Greten","doi":"10.1016/j.prdoa.2025.100324","DOIUrl":"10.1016/j.prdoa.2025.100324","url":null,"abstract":"<div><h3>Introduction</h3><div>The investigation of rigidity physiology in Parkinson’s Disease involves the examination of reflexes. Parkinsonian patients often demonstrate reduced sensitivity in polysynaptic reflexes within the leg extensor muscles, which is correlated with their postural instability. The compensatory mechanisms for impaired proprioceptive reflex function may involve alterations in intrinsic muscle stiffness. The interplay between gait and reflexes is intricately linked to the nervous system’s functioning and motor control. Certain reflexes, such as patellar reflex, play a pivotal role in maintaining walking and posture. Ensuring the integrity of these reflexes is essential for facilitating smooth and efficient walking.</div></div><div><h3>Aim</h3><div>To analyze the behavior of patellar reflex in four Parkinson’s Disease patients undergoing an acupuncture treatment protocol.</div></div><div><h3>Methods</h3><div>This study adopts a case series design. Reflex outcomes based on amplitude and velocity were assessed at six different time moments throughout a month-long treatment protocol using the MP 36, Biopac Systems.</div></div><div><h3>Results</h3><div>Over the long term, a tendency for an improvement in range of movement and velocity of the patellar reflex, was observed. Nevertheless, in specific cases, a reduction in the amplitude during acute effects was also found.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that the acupuncture protocol used may lead to a cumulative improvement in efficacy of patellar reflex in patients with Parkinson’s disease. However, further in-depth research, including a statistical evaluation with a larger participant pool, is necessary to validate and confirm these promising preliminary results.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"12 ","pages":"Article 100324"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regional changes in the prevalence of Parkinson’s disease over a ten-year period in the state of Texas 德克萨斯州十年来帕金森氏症患病率的区域变化
IF 1.9
Clinical Parkinsonism Related Disorders Pub Date : 2025-01-01 DOI: 10.1016/j.prdoa.2025.100369
Sean G. Young , Kathryn Elwell , Christopher R. Watts
{"title":"Regional changes in the prevalence of Parkinson’s disease over a ten-year period in the state of Texas","authors":"Sean G. Young ,&nbsp;Kathryn Elwell ,&nbsp;Christopher R. Watts","doi":"10.1016/j.prdoa.2025.100369","DOIUrl":"10.1016/j.prdoa.2025.100369","url":null,"abstract":"<div><h3>Introduction</h3><div>Region specific epidemiological knowledge is needed to better help government and private entities plan and develop interventions to address accelerating diagnoses of Parkinson’s disease (PD). We measured the within-state prevalence patterns of PD within the state of Texas, United States, over a ten-year period to include factors of sex and race/ethnicity, with a specific focus on county and regional patterns.</div></div><div><h3>Methods</h3><div>Publicly available data from the State of Texas Outpatient Public Use Data File (PUDF) evaluated for the years 2012 and 2022. Individuals with a PD specific diagnosis code were included. Age group, race, ethnicity, sex, and county of residence were used to calculate state and county case counts for the years 2012 and 2022. Spatial cluster analysis was applied to assess concentrations of diagnoses across Texas.</div></div><div><h3>Results</h3><div>Prevalence rates of PD increased substantially in Texas from 2012 to 2022, especially among those aged 65 and older and Hispanics. Males had a higher prevalence rate in both years, though both sexes doubled their prevalence over the ten-year period. Spatial cluster analysis showed changes in diagnosis concentration, from the central and northeastern regions to the southwestern border region.</div></div><div><h3>Conclusion</h3><div>Outpatient diagnoses of PD increased substantially from 2012 to 2022. Spatial distribution of PD risk evolved over the decade; such that risk for PD was greatest in the southwestern region of Texas in 2022 compared to all other areas. Prevalence trends in Texas mirror global trends for PD and should inform prevention and intervention strategies in the future.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"13 ","pages":"Article 100369"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Limb-Kinetic apraxia of legs in Parkinson’s disease: Prospective clinical investigation 帕金森病下肢运动失用症:前瞻性临床研究
IF 1.9
Clinical Parkinsonism Related Disorders Pub Date : 2025-01-01 DOI: 10.1016/j.prdoa.2025.100302
Yacov Balash , Evelin D. Mate , Riyad Idries , Anda Eilam , Amos D. Korczyn
{"title":"Limb-Kinetic apraxia of legs in Parkinson’s disease: Prospective clinical investigation","authors":"Yacov Balash ,&nbsp;Evelin D. Mate ,&nbsp;Riyad Idries ,&nbsp;Anda Eilam ,&nbsp;Amos D. Korczyn","doi":"10.1016/j.prdoa.2025.100302","DOIUrl":"10.1016/j.prdoa.2025.100302","url":null,"abstract":"<div><h3>Background</h3><div>The study of dynamic organization of motor acts is important for investigation of motor impairment, and a possible sign of a disorder of fronto-parietal areas of the brain in Parkinson’s disease (PD). We aimed to prospectively investigate whether limb-kinetic apraxia in legs (LKA-L) is a heretofore unrecognized manifestation of PD independent of bradykinesia and rigidity.</div></div><div><h3>Methods</h3><div>Patients with PD and healthy controls (HC) performed bipedal reciprocal coordination (BRC) and monopedal reciprocal coordination (MRC) tests as a foot modification of the Oseretzky exam (originally alternate antiphase clenching and unclenching of the fists of the right and left hands). While MRC allowed for alternating movements of one leg per unit of time, BRC required synchronous movements of both legs in antiphase. Leg movement rates and their quality were measured by video recording and compared statistically between the groups of PD and HC.</div></div><div><h3>Results</h3><div>The cohort consisted of 31 PD patients (mean age 69.3 ± 7.1 years,16 males) and 12 HC (mean age 69 ± 6.2 years, 6 males). No differences between PD and HC groups were identified in MRC rate of performance, which were used as a measure of legs movement speed, although the quality of MRC movements was poorer in PD patients (<em>p</em> = 0.022). BRC rate and its performance quality were significantly flawed in PD compared to controls (<em>P</em> = 0.002 and <em>P</em> = 0.003, respectively).</div></div><div><h3>Conclusions</h3><div>Testing for dynamic organization of LKA-L revealed disorder in individuals with PD. LKA-L analyses should be considered in the diagnosis of leg movements and gait disorders in PD.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"12 ","pages":"Article 100302"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frontiers in movement disorder therapeutics: A new era in neurology 运动障碍治疗学的前沿:神经病学的新时代
IF 1.9
Clinical Parkinsonism Related Disorders Pub Date : 2025-01-01 DOI: 10.1016/j.prdoa.2024.100263
Roongroj Bhidayasiri, Daniel D. Truong
{"title":"Frontiers in movement disorder therapeutics: A new era in neurology","authors":"Roongroj Bhidayasiri,&nbsp;Daniel D. Truong","doi":"10.1016/j.prdoa.2024.100263","DOIUrl":"10.1016/j.prdoa.2024.100263","url":null,"abstract":"","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"12 ","pages":"Article 100263"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141851170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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