Clinical Parkinsonism Related Disorders最新文献

{"title":"Social cognition in cervical dystonia","authors":"Laura Mahady ,&nbsp;Jessica White ,&nbsp;Shameer Rafee ,&nbsp;Siew-Mei Yap ,&nbsp;Sean O'Riordan ,&nbsp;Michael Hutchinson ,&nbsp;Patricia Gough ,&nbsp;Fiadhnait O'Keeffe","doi":"10.1016/j.prdoa.2023.100217","DOIUrl":"10.1016/j.prdoa.2023.100217","url":null,"abstract":"<div><h3>Background</h3><p>Whilst traditionally considered a movement disorder, it is now generally accepted that cervical dystonia (CD) presents with additional non-motor symptoms which significantly impact quality of life. Our study primarily aimed to explore social cognition and levels of psychological distress in individuals with CD, in comparison to age- and sex-matched healthy controls.</p></div><div><h3>Methods</h3><p>20 participants with CD attending a specialist movement disorders clinic were recruited. 20 age and sex matched neurologically healthy controls were recruited in parallel. Participants completed the Hospital Anxiety and Depression Scale, and two novel social cognition tasks: The Cambridge Mindreading Face-Voice Battery (CAFMB) and the Edinburgh Social Cognition Test (ESCoT).</p></div><div><h3>Results</h3><p>Participants with CD exhibited poorer complex emotion recognition abilities for visual and auditory stimuli, compared to controls on the CAFMB task. Participants with CD did not differ significantly from controls on performance on cognitive or affective Theory of Mind tasks, or interpersonal or intrapersonal understanding of social norms, as measured by the ESCoT. The proportion of depressive symptoms was significantly higher for participants with CD than controls. 40% of participants with CD reported clinically elevated depressive symptoms, and 60% reported clinically elevated anxiety. Poorer understanding of emotional facial expressions was associated with higher levels of depression in the CD group.</p></div><div><h3>Conclusions</h3><p>Significant between-group differences between participants with CD and controls suggests socio-cognitive dysfunction is an important aspect of the non-motor syndrome of CD. Findings highlight the need for assessment of and intervention for both social cognitive difficulties and psychological distress in individuals with CD.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10272915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of unusual presentation with anti-glycine receptor (GlyR) and myelin oligodentrocyte glycoprotein (MOG) antibody","authors":"Stefania Kalampokini,&nbsp;Irina Motkova,&nbsp;Panagiotis Bargiotas,&nbsp;Artemios Artemiadis,&nbsp;Panagiotis Zis,&nbsp;Georgios M. Hadjigeorgiou","doi":"10.1016/j.prdoa.2023.100195","DOIUrl":"10.1016/j.prdoa.2023.100195","url":null,"abstract":"<div><p>Movement disorders can be a prominent feature in autoimmune encephalitis. Here we present a rare case of a 73-year-old woman, who presented with a complex phenotype with encephalopathy, parkinsonism, cervical dystonia, left-sided hemidystonia and hemifacial spasm of subacute onset and was found to have breast cancer and positive anti-Glycine Receptor (GlyR) and Myelin Oligodentrocyte Glycoprotein (MOG) antibodies.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119963/pdf/main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9381857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dutch translation, adaptation and validation of the OT-10 scale for orthostatic tremor","authors":"B.E.K.S. Swinnen ,&nbsp;M. Bergers ,&nbsp;W.A. Babeliowsky ,&nbsp;D. Torres-Russotto ,&nbsp;R.M.A. de Bie ,&nbsp;A.F. van Rootselaar","doi":"10.1016/j.prdoa.2023.100200","DOIUrl":"10.1016/j.prdoa.2023.100200","url":null,"abstract":"<div><h3>Introduction</h3><p>There are currently no effective treatments for primary orthostatic tremor (POT). An adequate disease-specific POT severity scale is a prerequisite to conduct clinical trials and monitor disease severity in clinical practice. Recently, the English OT-10 scale has been developed for this purpose. Here we aimed to obtain a scale to measure the severity of POT in Dutch speaking individuals.</p></div><div><h3>Methods</h3><p>An established translation, adaptation and validation approach was employed to obtain a Dutch version of the OT-10 scale. Validation was performed in a Dutch POT cohort (n = 46).</p></div><div><h3>Results</h3><p>A Dutch OT-10 scale was obtained which showed good internal consistency (Cronbach’s alpha &gt; 0.80), total score test–retest reliability (intraclass correlation coefficient &gt; 0.80), and concurrent validity (Pearson correlation &gt; 0.80). Item-to-total correlation was good (weighted kappa &gt; 0.40) for all items, and item test–retest reliability was good (weighted kappa &gt; 0.40) for eight out of ten items. Overall, the Dutch OT-10 scale demonstrated acceptable validity.</p></div><div><h3>Conclusions</h3><p>We obtained and validated a Dutch version of the OT-10 scale, capturing POT severity. Next to its use in clinical practice, translation and validation of the OT-10 scale in more languages will help to find evidence-based treatments for POT.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9548509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of exercise on non-motor experiences of daily living experienced in Parkinson’s Disease: A systematic review and network meta-analysis","authors":"Paige G. Tonkin,&nbsp;Timothy D. Miller,&nbsp;Tegan E. Hartmann,&nbsp;Melissa Skein","doi":"10.1016/j.prdoa.2023.100203","DOIUrl":"10.1016/j.prdoa.2023.100203","url":null,"abstract":"<div><h3>Introduction</h3><p>Whilst non-motor experiences of daily living (NMeDL) reduce quality of life (QoL) in people with Parkinson’s Disease (PD), research dedicated to NMeDL is lacking compared to motor symptoms. The aim of this Network Meta-Analysis (NMA) was to compare and determine the effects of exercise and dual-task training interventions on NMeDL for people with early-to-mid stage PD.</p></div><div><h3>Methods</h3><p>Eight electronic databases were systematically searched, identifying randomised control trials (RCTs) that assessed the effect of interventions on the Movement Disease Society - Unified Parkinson’s Disease Rating Scale (MDS-UPDRS); Part I scores. A fixed-effect pairwise and NMA were completed and confidence in estimates were assessed using the Confidence in Network Meta-Analysis (CINeMA) framework.</p></div><div><h3>Results</h3><p>Five RCTs involving exercise were identified, involving 218 participants. No dual-tasking studies were suitable. Pairwise comparisons favoured tango and mixed-treadmill training (TT) when compared to control, however 95% Confidence Intervals (CI) crossed the line of no effect (MD = 0). Indirect comparisons revealed tango had clinically meaningful reductions in Part I scores compared to speed-TT and body-weight resistance training, (MD −4.47; 95% CI −8.50 to −0.44 and MD −4.38; 95% CI −7.86 to –0.90), indicating improved NMeDL. Compared to control, low confidence evidence suggests tango and mixed-TT improves NMeDL.</p></div><div><h3>Conclusions</h3><p>Tango and mixed-TT are the most effective exercise interventions for improving NMeDL. Adoption of an exercise program in the early stages of PD, irrespective of modality, may be effective and holds potential clinical importance immediately following a diagnosis of PD.</p><p><strong>Other:</strong> Prospero Registration Number; CRD42022322470.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/39/81/main.PMC10245098.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9607712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mood symptoms in cervical dystonia: Relationship with motor symptoms and quality of life","authors":"Shameer Rafee ,&nbsp;Mahmood Al-Hinai ,&nbsp;Gillian Douglas ,&nbsp;Ihedinachi Ndukwe ,&nbsp;Michael Hutchinson","doi":"10.1016/j.prdoa.2023.100186","DOIUrl":"10.1016/j.prdoa.2023.100186","url":null,"abstract":"<div><h3>Background</h3><p>Cervical dystonia (CD) has a high prevalence of anxiety and depression. The relationship between motor severity, mood symptoms and QoL is unclear and how to adequately assess these is also unknown. Instruments like the BAI, BDI and HADS are often used but items within these relating to somatic symptoms might influence the results.</p></div><div><h3>Methods</h3><p>Patients with idiopathic cervical dystonia (CD) were included. The BAI, BDI, HADS, CIDP58 and TWSTRS2- severity score were used for assessment of motor, mood and QoL symptoms. Pearson’s correlations between motor and non-motor symptom scores were assessed. The psychometric properties of the psychiatric tools were measured and principal component analysis performed after identifying items that could correspond to somatic symptoms.</p></div><div><h3>Results</h3><p>201 participants were included. 42% of participants had either significant depression or anxiety symptoms or both when measured by BAI and BDI and 51% of patients met criteria on HADS. HADS-A and HADS-D, BAI and BDI were poorly correlated with TWSTRS2-S. The HADS-A and HADS-D both showed strong correlation with the sleep subdomain of CDIP58. Psychometric and principal component analysis on 149/201 participants did not reveal factor loadings consistent with the a priori somatic groupings. However mean scores were higher for somatic items.</p></div><div><h3>Conclusion</h3><p>A good score on the CDIP58, a commonly used tool, does not indicate mild disease severity or minimal mood symptoms. Minimal motor symptoms, similarly, also does not imply a positive QoL. Clinicians should be mindful on ideal methods for performing a holistic assessment of CD patients. This likely warrants a combination of motor, QoL and mood assessment tools.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10673825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of early-wheelchair dependence in multiple system atrophy based on machine learning algorithm: A prospective cohort study","authors":"Lingyu Zhang ,&nbsp;Yanbing Hou ,&nbsp;Xiaojing Gu,&nbsp;Bei Cao,&nbsp;Qianqian Wei,&nbsp;Ruwei Ou,&nbsp;Kuncheng Liu,&nbsp;Junyu Lin,&nbsp;Tianmi Yang,&nbsp;Yi Xiao,&nbsp;Bi Zhao,&nbsp;Huifang Shang","doi":"10.1016/j.prdoa.2023.100183","DOIUrl":"10.1016/j.prdoa.2023.100183","url":null,"abstract":"<div><h3>Objective</h3><p>The predictive factors for wheelchair dependence in patients with multiple system atrophy (MSA) are unclear. We aimed to explore the predictive factors for early-wheelchair dependence in patients with MSA focusing on clinical features and blood biomarkers.</p></div><div><h3>Methods</h3><p>This is a prospective cohort study. This study included patients diagnosed with MSA between January 2014 and December 2019. At the deadline of October 2021, patients met the diagnosis of probable MSA were included in the analysis. Random forest (RF) was used to establish a predictive model for early-wheelchair dependence. Accuracy, sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) were used to evaluate the performance of the model.</p></div><div><h3>Results</h3><p>Altogether, 100 patients with MSA including 49 with wheelchair dependence and 51 without wheelchair dependence were enrolled in the RF model. Baseline plasma neurofilament light chain (NFL) levels were higher in patients with wheelchair dependence than in those without (<em>P</em> = 0.037). According to the Gini index, the five major predictive factors were disease duration, age of onset, Unified MSA Rating Scale (UMSARS)-II score, NFL, and UMSARS-I score, followed by C-reactive protein (CRP) levels, neutrophil-to-lymphocyte ratio (NLR), UMSARS-IV score, symptom onset, orthostatic hypotension, sex, urinary incontinence, and diagnosis subtype. The sensitivity, specificity, accuracy, and AUC of the RF model were 70.82 %, 74.55 %, 72.29 %, and 0.72, respectively.</p></div><div><h3>Conclusion</h3><p>Besides clinical features, baseline features including NFL, CRP, and NLR were potential predictive biomarkers of early-wheelchair dependence in MSA. These findings provide new insights into the trials regarding early intervention in MSA.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/94/af/main.PMC9881368.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9151741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal hippocampal subfields, CSF biomarkers, and cognition in patients with Parkinson disease","authors":"Erik Erhardt ,&nbsp;Anna Horner ,&nbsp;Nicholas Shaff ,&nbsp;Chris Wertz ,&nbsp;Stephanie Nitschke ,&nbsp;Andrei Vakhtin ,&nbsp;Andrew Mayer ,&nbsp;John Adair ,&nbsp;Janice Knoefel ,&nbsp;Gary Rosenberg ,&nbsp;Kathleen Poston ,&nbsp;Gerson Suarez Cedeno ,&nbsp;Amanda Deligtisch ,&nbsp;Sarah Pirio Richardson ,&nbsp;Sephira Ryman","doi":"10.1016/j.prdoa.2023.100199","DOIUrl":"https://doi.org/10.1016/j.prdoa.2023.100199","url":null,"abstract":"<div><h3>Objective</h3><p>Hippocampal atrophy is an indicator of emerging dementia in PD, though it is unclear whether cerebral spinal fluid (CSF) Abeta-42, t-tau, or alpha-syn predict hippocampal subfield atrophy in a <em>de novo</em> cohort of PD patients. To examine whether levels of CSF alpha-synuclein (alpha-syn), beta-amyloid 1–42 (Abeta-42)_, or total-tau (t-tau) are associated with hippocampal subfield volumes over time.</p></div><div><h3>Methods</h3><p>We identified a subset of Parkinson’s Progression Markers Initiative (PPMI) <em>de novo</em> PD patients with longitudinal T1-weighted imaging (baseline plus at least two additional visits across 12, 24, and 48 months) and CSF biomarkers available at baseline. We performed cross-sectional, regression, and linear mixed model analyses to evaluate the baseline and longitudinal CSF biomarkers, hippocampal subfields, and cognition. A false discovery rate (FDR) was used to correct for multiple comparisons.</p></div><div><h3>Results</h3><p>88 PD-CN and 21 PD-MCI had high quality longitudinal data. PD-MCI patients exhibited reduced bilateral CA1 volumes relative to PD-CN, though there were no significant differences in CSF biomarkers between these groups. Relationships between CSF biomarkers and hippocampal subfields changed over time, with a general pattern that lower CSF Abeta-42, higher t-tau and higher alpha-syn were associated with smaller hippocampal subfields, primarily in the right hemisphere.</p></div><div><h3>Conclusion</h3><p>We replicated prior reports that demonstrated reduced CA1 volumes in PD-MCI in a <em>de novo</em> PD cohort. CSF biomarkers were associated with individual subfields, with evidence that the increased CSF t-tau was associated with smaller subiculum volumes at baseline and over time, though there was no clear indication that the subfields associated with cognition (CA1 and HATA) were associated with CSF biomarkers.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49818146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant use of magnesium oxide significantly decreases absorption of levodopa preparations in patients with Parkinson’s disease","authors":"Noriyuki Miyaue ,&nbsp;Hayato Yabe ,&nbsp;Masahiro Nagai","doi":"10.1016/j.prdoa.2023.100227","DOIUrl":"https://doi.org/10.1016/j.prdoa.2023.100227","url":null,"abstract":"<div><h3>Introduction</h3><p>Constipation is one of the most frequent non-motor symptoms of Parkinson's disease (PD), and magnesium oxide (MgO) is a frequently used laxative. This study aimed to investigate the effect of concomitant use of MgO on the pharmacokinetics of levodopa preparations in patients with PD.</p></div><div><h3>Methods</h3><p>We prospectively enrolled 35 patients with PD and compared the pharmacokinetics of levodopa and carbidopa and motor symptoms with and without MgO. The impact of alterations in pH and the addition of MgO on the solubility of levodopa formulations were also evaluated under in vitro conditions.</p></div><div><h3>Results</h3><p>Concomitant use of MgO significantly reduced the maximum plasma concentration of levodopa (Cmax) (from 7.66 ± 3.74 μmol/L to 5.82 ± 3.69 μmol/L; <em>p</em> = 0.006) and area under the plasma concentration–time curve 3 h after drug administration (AUC_3h, from 9.64 ± 3.23 μmol·h/L to 7.39 ± 3.15 μmol·h/L; <em>p</em> &lt; 0.001), and further decreased carbidopa Cmax (from 64.02 ± 27.02 ng/mL to 38.83 ± 21.94 μmol/L; <em>p</em> &lt; 0.001) and AUC_3h (from 130.58 ± 65.64 ng/mL to 76.48 ± 52.24 ng·h/mL; <em>p</em> &lt; 0.001). The Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale part III score also deteriorated significantly (from 30.71 ± 11.34 to 32.06 ± 11.22; <em>p</em> = 0.007). MgO significantly affected the pharmacokinetics of levodopa and carbidopa. This also applied when the findings were analyzed by sex and age. In vitro dissolution experiments revealed a decrease in the relative concentrations of levodopa, carbidopa, and benserazide as the pH increased and in the presence of MgO suspension, with the most prominent impact on benserazide.</p></div><div><h3>Conclusions</h3><p>Concomitant use of MgO and levodopa should be discouraged to improve levodopa absorption.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590112523000452/pdfft?md5=7a5497de873c6f5f8d81e3c762da9b36&pid=1-s2.0-S2590112523000452-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92043029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internal tremor in people with Parkinson’s Disease: Demographic characteristics and comorbid symptoms","authors":"Lana M. Chahine ,&nbsp;Lakshmi Arbatti ,&nbsp;Abhishek Hosamath ,&nbsp;Amy Amara ,&nbsp;Karen E. Anderson ,&nbsp;Jennifer Purks ,&nbsp;Shirley Eberly ,&nbsp;Daniel Kinel ,&nbsp;Sneha Mantri ,&nbsp;Soania Mathur ,&nbsp;David Oakes ,&nbsp;David G. Standaert ,&nbsp;Daniel Weintraub ,&nbsp;Ira Shoulson ,&nbsp;Connie Marras","doi":"10.1016/j.prdoa.2023.100229","DOIUrl":"10.1016/j.prdoa.2023.100229","url":null,"abstract":"<div><h3>Introduction</h3><p>Internal tremor (IT) occurs in &gt; 30 % of people with Parkinson’s Disease (PwPD), but remains largely uninvestigated. Our objective was to describe demographic characteristics and associated symptoms in PwPD who reported IT.</p></div><div><h3>Methods</h3><p>This was a matched case-control survey study. Data were from PwPD in the Fox Insight study who answered the Patient Report of Problems (PD-PROP) assessment, a series of open-ended questions that asks people to report in their own words their most bothersome PD-related problems. Cases were those who reported IT ≥ 1 times compared with PwPD controls who did not report IT and were matched 1:3 by age and disease duration.</p></div><div><h3>Results</h3><p>243 PwPD reported IT as a bothersome problem. Mean (SD) age of cases was 64.9 (9.4) years and disease duration was 3.8 (4.0) years. The proportion of women was greater among cases compared to controls (74 % vs 47 %, p &lt; 0.0001). External tremor as a PD-PROP symptom was reported by 98 % cases and 48 % controls (p &lt; 0.0001). Several non-motor symptoms were more common among cases than controls, including anxiety (35 % vs 20 %), fatigue (41 % vs 31 %), and pain (57 % vs 37 %). The odds of IT was significantly higher in women when adjusting for anxiety and motor experiences of daily living score (OR 3.07, 95 %CI 2.14–4.41, p &lt; 0.0001).</p></div><div><h3>Conclusion</h3><p>PwPD with IT report a range of associated symptoms, including external tremor, anxiety, and pain. Sex differences in the experience of IT may exist. Studies of IT are needed to understand its etiology and inform clinical care.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590112523000476/pdfft?md5=d0f46b1f8b7e2683b169a768bd41674d&pid=1-s2.0-S2590112523000476-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135510130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum Regarding Previously Published Articles","authors":"","doi":"10.1016/j.prdoa.2023.100193","DOIUrl":"10.1016/j.prdoa.2023.100193","url":null,"abstract":"","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201837/pdf/main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9871506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}