Health and Ecology Issues最新文献

{"title":"Role of glutamate in thymic energy metabolism","authors":"I. Nikitina","doi":"10.51523/2708-6011.2022-19-4-12","DOIUrl":"https://doi.org/10.51523/2708-6011.2022-19-4-12","url":null,"abstract":"Objective. To analyze the energetic role of glutamate in thymocytes and tissues of the thymus at different stages of its age-related involution.Materials and methods. The studies were performed on white male rats. The state of energy metabolism was determined by the rate of oxygen consumption by thymus tissues and thymocytes using a polarographic method.Results. It was found that in the thymus tissues of 4, 5 and 6-month-old rats the rate of oxygen consumption is constant and does not significantly change in response to glutamate administration. Thymocytes - the immunocompetent thymus cells of 3- and 8-month-old animals, despite similar levels of oxygen consumption on endogenous substrates, respond differently to glutamate action. In thymocytes of 3-month-old animals, the action of glutamate has a more pronounced stimulating effect on bioenergetic processes compared to 8-month-old animals. There is a reason to believe that the decrease in the efficiency of glutamate action as the animals grow older is caused by the processes of age-related involution of the thymusConclusion. Glutamate stimulates aerobic respiration in the thymocytes of 3- and 8-month-old animals, with a greater stimulating effect in the thymocytes of younger animals. At the same time, glutamate does not cause significant changes in the rate of oxygen consumption in the thymus tissues of 4-, 5-, and 6-month-old animals.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115289332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The functional state of the visual analyzer and characterological features of children at a primary school age with orthophoria and heterotropia","authors":"O. Larionova","doi":"10.51523/2708-6011.2022-19-4-10","DOIUrl":"https://doi.org/10.51523/2708-6011.2022-19-4-10","url":null,"abstract":"Objective. To analyze the functional state of the visual analyzer and characterological features of children at a primary school age with orthophoria and heterotropia.Materials and methods. Eighty-four children (168 eyes) aged 6-11 years were examined. Two groups comparable in age and gender were formed. Group 1 included 35 children (70 eyes) with orthophoria with moderate degree hyperopia Hm 4.1 [1.0; 8.75] Dptr; Group 2 consisted of children with concomitant convergent strabismus with a moderate degree hyperopia Hm 4.3 [0.75; 9.75] Dptr - 49 patients (98 eyes). To study the properties of the nervous system (NS) hardwaresoftware complex “NS-Psychotest” (Neurosoft LLC, Ivanovo, Russia, http://neurosoft. com/ru) was used. Neurodynamic indices of sensorimotor reaction were determined according to the methods “Simple visual-motor reaction” (PMR), “Distinguishing reaction” (DR), “Choice reaction” (PC), “Reaction to a moving object” (RMA), “Critical flicker fusion frequency” (CFF), Lusher’s color test.Results. Concomitant strabismus in group 2 children significantly increased “Simple visual-motor reaction” (SVMR), “Discrimination reaction” (RR) and “Choice reaction” (RС) by 43 ms, 80.8 and 57.8 ms, respectively (p<0.05), compared to the group of children with orthophoria, indicating reduced mobility of nervous processes and predominance of inhibitory processes in the central nervous system (CNS).Conclusion. It follows from the results obtained that the presence of heterotrophy in group 2 children reliably leads to a decrease in the mobility of nervous processes and the predominance of inhibitory processes in the CNS. The combination of low reaction rate and expressed inertness of nervous processes in children of the 2nd group indicates a mismatch in the relationship between the centers of the visual and motor analyzers.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121264856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wound healing after the implantation of the cartilage autograft and allograft (an experimental study)","authors":"S. Ivanou, D. Zinovkin, O. Khorov, V. V. Pohozhay, V. S. Ivanou","doi":"10.51523/2708-6011.2022-19-4-13","DOIUrl":"https://doi.org/10.51523/2708-6011.2022-19-4-13","url":null,"abstract":"Objective. To compare the wound healing after implantation of the freshly frozen allogeneic cartilage and the autogenic cartilage in a cutaneous flap.Materials and methods. Two groups of eighteen non-breed white lab rats weighing 180-200 g of both genders were studied. Each specimen had a plastic material with the inclusion of a skin flap and cartilage graft formed. Group 1 used the animal’s own cartilage, group 2 used freshly frozen allogenic cartilage. Histological examination of the flap and graft preparations was carried out on the 7th, 14th and 21st days after the intervention.Results. Semi-quantitative evaluation of inflammation and tissue reaction after cartilage autograft and allograft implantation was carried out. A gradual decrease in the evidence of the inflammatory reaction and the formation of a fibrous capsule around the implant during the study period was registered. The comparative analysis revealed no statistically significant differences in each of the indicators.Conclusion. Implantation of an allograft from freshly frozen cartilage has no negative effect on skin flap wound healing in the experiment. Freshly frozen allogenic cartilage can be used for reconstructive interventions on a par with autologous material.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"24 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130685459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indicator “Risk of harm from alcohol use” (ASSIST score ) in patients with schizophrenia and related disorders","authors":"N. V. Hmara, O. Skugarevsky","doi":"10.51523/2708-6011.2022-19-4-09","DOIUrl":"https://doi.org/10.51523/2708-6011.2022-19-4-09","url":null,"abstract":"Objective. To establish the relationship between the ASSIST score (Humeniuk R. et al. 2008) «risk of harm from alcohol use» (RHAU), impaired social functioning and manifestation of aggression in patients with schizophrenia and related disorders.Materials and methods. From 2014 to 2020 a comparative, one-stage, observational study was conducted on the basis of the Gomel Regional Clinical Psychiatric Hospital with a sampling formation using directional selection method. Patients who met diagnostic criteria of schizophrenia (F20) or acute psychotic disorder (F23) according to ICD-10 were included in the study. The following assessment methods were used: 1) screening for alcohol use – ASSIST scale (Humeniuk R. et al. 2008), 2) determination of the level of aggression OASCL (Yudofsky S. C. 1986).Results. The entire sample of 123 people examined by us was divided into 3 groups depending on the level of RHAU. The first group «ASSIST 0» (n=37) was accepted as a control group, since RHAU was equal to 0. The second group is «ASSIST up to 10» (n=42), with minimal RVUA (1-10 points on the ASSIST scale). The third group «ASSIST over 11» (n=44) combines moderate and high RHAU. The group study did not show any differences between men and women in alcohol consumption and aggression within the groups. Comparison of 3 groups, and their subsequent pairwise comparison, made it possible to establish statistically significant differences in social dysfunction groups (decrease in the working status of «ASSIST 0» – 81%, «ASSIST over 11» – 73%, «ASSIST up to 10» – 45%) and of aggression (OASCL total score H 62.4=p≤0.001: physical aggression vs. others H=45.2 p≤0.001).Conclusion. In patients with schizophrenia and disorders close to it, the «risk of harm from alcohol use» indicator (ASSIST scale) indirectly indicates the formation of psychosocial dysfunction and indicates a differentiated effect of alcohol in the display of aggression in this group of patients.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130765799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of budesonide and azithromycin on the chemotaxis of blood monocytes and lymphocytes in patients with chronic obstructive pulmonary disease","authors":"A. Kadushkin, A. Tahanovich, T. Kolesnikova, A. V. Khadasouskaya","doi":"10.51523/2708-6011.2022-19-4-14","DOIUrl":"https://doi.org/10.51523/2708-6011.2022-19-4-14","url":null,"abstract":"Objective. To evaluate the ability of a combination of budesonide and azithromycin to influence the migration of blood monocytes and lymphocytes in patients with chronic obstructive pulmonary disease (COPD).Materials and methods. Peripheral blood mononuclear cells from patients with COPD (n=8) were incubated with glucocorticoid budesonide (10 nM), macrolide antibiotic azithromycin (10 µg/mL), or their combination, and then transferred to chemotaxis chambers containing chemokines RANTES (CCL5, 10 nM) or IP-10 (CXCL10, 10 nM). Cells migrated to the lower compartment of the chamber were collected, stained with monoclonal antibodies to CD3, CD14, CD19, CD45 and counted on a flow cytometer.Results. Azithromycin alone and in combination with budesonide inhibited the migration of blood T-lymphocytes and B-cells and enhanced the migration of blood monocytes to RANTES and IP-10. The combination of azithromycin and budesonide had a more suppressive effect on the chemotaxis of blood T- and B-lymphocytes to RANTES and IP-10 than budesonide alone. The combination of azithromycin and budesonide had an effect similar to azithromycin alone on the migration of blood T- and B-lymphocytes, as well as monocytes in patients with COPD.Conclusion. The results of the study demonstrate the ability of azithromycin alone to modulate the chemotaxis of peripheral blood monocytes and lymphocytes in patients with COPD and the lack of advantages of its combination with budesonide.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131485734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of the T(-344)C polymorphism of the aldosterone synthase gene (CYP11B2) in the prognosis of cardiorenal syndrome in diabetes mellitus","authors":"V. Vasilkova, I. Pchelin, Y. Borovets, I. A. Vasukhina, T. Mokhort","doi":"10.51523/2708-6011.2022-19-4-07","DOIUrl":"https://doi.org/10.51523/2708-6011.2022-19-4-07","url":null,"abstract":"Objective. To evaluate the role of the T(-344)C polymorphism of CYP11B2 gene in the development of cardiorenal syndrome (CRS) in diabetes mellitus (DM).Materials and methods. 270 patients with type 1 and type 2 diabetes aged over 25 years were examined. All patients underwent molecular genetic analysis using deoxyribonucleic acid isolated from whole venous blood.Results. The TT genotype was associated with the risk of developing CRS manifestations such as left ventricular hypertrophy (odds ratio (OR) 2.64; 95% CI (0.93–4.19), chronic heart failure (OR 4.26; 95% CI (2.26 - 8.06), subclinical atherosclerosis (OR 4.04; 95% CI (1.89 - 8.58), chronic kidney disease (CKD) (OR 10.77; 95% CI (3.56 - 32.61), and the CT genotype (OR 3.28; 95% CI (1.02 – 10.59) with CKD risk..Conclusion. There are pathogenetic associations between renin-angiotensin-aldosterone system, cardiovascular complications and a decrease of renal function. Further research is needed for a deep understanding of the complex pathogenetic mechanisms of the development and progression of cardiovascular and renal pathology.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114198986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of assessment of heart rate variability and heart rate turbulence to identify hypertensive patients with an increased risk of adverse cardiovascular events","authors":"T. V. Aleynikova, V. Kozlovsky","doi":"10.51523/2708-6011.2022-19-4-02","DOIUrl":"https://doi.org/10.51523/2708-6011.2022-19-4-02","url":null,"abstract":"Objective. To develop a method for isolating a group of patients with arterial hypertension of the II degree with an increased risk of the total number of myocardial infarctions, strokes, lethal outcomes from cardiovascular diseases (CVD) in the next 1-3 years, taking into account the assessment of heart rate variability and heart rate turbulence parameters.Materials and methods. In the course of a prospective clinical study 214 patients with arterial hypertension (AH) of the II degree aged 35 to 70 (57,7±7,6) years and 26 practically healthy individuals aged 30-60 (51,7±7,7) years were examined. All were given a comprehensive examination, including Holter monitoring (HM), electrocardiography (ECG), echocardiography (EchoCG). Statistical processing of the results was carried out using the “Statistica 10.0” software.Results. The total number of myocardial infarctions, strokes, and lethal outcomes registered in patients with arterial hypertension of the II degree over a period of 2.6±1.3 years was estimated, the factors associated with their development were determined. A method has been developed to identify a group of patients with arterial hypertension of the II degree who have an increased risk of developing adverse cardiovascular events over the next 1-3 years, it has been shown that its sensitivity is 90.9%; specificity is 95.8%. Conclusion. It is shown that the use of heart rate variability (HRV) and heart rate turbulence (HRT) parameters provides a significant increase in the sensitivity and specificity of the identification of a group with an increased risk of developing the total number of strokes, myocardial infarctions and lethal outcomes in the next 1-3 years.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115193658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virome in the context of health and pathology of the human respiratory system","authors":"I. Stoma","doi":"10.51523/2708-6011.2022-19-4-01","DOIUrl":"https://doi.org/10.51523/2708-6011.2022-19-4-01","url":null,"abstract":"The human body, along with extensive microbial communities called the microbiome, contains various viruses, collectively referred to as the «virome», and the number of such microorganisms is characterized by great complexity and heterogeneity and exceeds the number of bacteria in the microbiome by a factor of 10. Human virome is constantly renewed due to rapid evolution and entry of viruses from the environment, and the viral community of the human body is an indicator of human health. One of the components of virome is bacteriophages, the diversity of which is determined primarily by the species comprising the bacterial component of the microbiome. Along with other anatomical structures of the body, the respiratory tract of healthy humans is represented by a huge community of viruses just as much as by bacterial communities, and analysis of the full viral diversity of the airways is vital for understanding the features of the human virome. To date, next-generation sequencing approaches, the cost of which has decreased significantly recently, are the most convenient methods for virome analysis and the use of the results in clinical practice.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125813659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacoeconomical affordability of antipsychotic drugs for patients with mental disorders in the structure of dementia at the regional level","authors":"M. N. Mirge, E. I. Mikhailova, N. Trofimova","doi":"10.51523/2708-6011.2022-19-4-03","DOIUrl":"https://doi.org/10.51523/2708-6011.2022-19-4-03","url":null,"abstract":"Objective. To analyze the pharmacoeconomical affordability of antipsychotic drugs (APD) in patients with mental disorders in the structure of dementia at the level of the Gomel region of the Republic of BelarusMaterials and methods. The study used data from the State Register of Medicines of the Republic of Belarus (2022); Clinical Protocol for providing medical care to patients with mental and Behavioral Disorders (2010); website data https://myfin.by about the average pension amount and the minimum subsistence budget of the Gomel region for 2022; data from «State Register of Medicines of the Republic of Belarus» website. For the analysis, the price list for medicines (drugs) of the largest pharmacy chains in Belarus was used, which included the state pharmacies of the Gomel UP «Pharmacy» and commercial pharmacies of the well-known brands in Belarus «ADEL» and «Dobrya Leki». Parameters such as the price affordability of the APD and 4 availability coefficients (Cd) were determined, allowing to correlate the average cost of antipsychotic drugs packaging and the cost of the average daily dose of antipsychotic drugs with the consumer income, as well as the total affordability coefficient (Cd total.).Results. According to all criteria, the most economically affordable drug from the group of typical APD was the generic Haloperidol–Ozone (Ozon, Russia), and the least affordable from the group of atypical ones was the generic Olanzapine (Belmedpreparaty, Republic of Belarus).Conclusion. There is a large selection of APD on the pharmaceutical market of the Gomel region. Generic APD predominate on sale, which are more affordable compared to the original APD. But one should not forget about the advantages of the original drugs – efficiency, safety, innovativeness, reproducibility of the effect and strict quality control, confirmed in clinical trials. However, the genetic drug Olanzapine (Belmedpreparations, RB) is not in any way more superior in terms of affordability, but even inferior to some drugs. This study allowed us to establish that in the Gomel region of the Republic of Belarus, a patient with dementia is provided with a wide choice of APD and the ability to determine the criteria for preference when buying a specific drug.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116758567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound compression elastography: possibilities for early diagnosing in case of dystrophic lesions of the long dorsal sacroiliac ligament with low back pain","authors":"I. Nazarenko, A. Yurkovskiy","doi":"10.51523/2708-6011.2022-19-4-06","DOIUrl":"https://doi.org/10.51523/2708-6011.2022-19-4-06","url":null,"abstract":"Objective. Evaluate the possibility of using ultrasound compression elastography for detecting early dystrophic changes in the long dorsal sacroiliac ligaments in case of pain in the lower backMaterials. To achieve this goal, we compared the data of compression elastography of the long dorsal sacroiliac ligament in 36 patients aged 46.0 years [23; 54] with lower back pain (experimental group) and 30 patients aged 36.5 years [29; 48] without lower back pain (control group).Results. The results of the evaluation of diagnostic significance of ultrasound compression elastography were as follows: AUC ‒ 0.81 (95% CI (0.63; 0.93)), p=0.0001; Juden index ‒ 0.64, sensitivity ‒ 90% (95% CI (0.69; 0.99)), p=0.0001; specificity ‒ 74% (95% CI (0.56; 0.99)), p=0.0001.Conclusion. Compression elastography enables to detect areas of long dorsal sacroiliac ligament structure disorganization in cases where standard B-mode can’t reveal changes in the structure of this ligament. For the long dorsal sacroiliac ligament, ultrasound compression elastography has comparable sensitivity (90%) to shear wave elastography, but lower specificity (74%) and prognostic value (81%), allowing a fairly confident diagnosis of early degenerative changes in the long dorsal sacroiliac ligament.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114257441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}