Clinical significance of the T(-344)C polymorphism of the aldosterone synthase gene (CYP11B2) in the prognosis of cardiorenal syndrome in diabetes mellitus

Health and Ecology Issues Pub Date : 2023-01-03 DOI:10.51523/2708-6011.2022-19-4-07

V. Vasilkova, I. Pchelin, Y. Borovets, I. A. Vasukhina, T. Mokhort

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Abstract

Objective. To evaluate the role of the T(-344)C polymorphism of CYP11B2 gene in the development of cardiorenal syndrome (CRS) in diabetes mellitus (DM).Materials and methods. 270 patients with type 1 and type 2 diabetes aged over 25 years were examined. All patients underwent molecular genetic analysis using deoxyribonucleic acid isolated from whole venous blood.Results. The TT genotype was associated with the risk of developing CRS manifestations such as left ventricular hypertrophy (odds ratio (OR) 2.64; 95% CI (0.93–4.19), chronic heart failure (OR 4.26; 95% CI (2.26 - 8.06), subclinical atherosclerosis (OR 4.04; 95% CI (1.89 - 8.58), chronic kidney disease (CKD) (OR 10.77; 95% CI (3.56 - 32.61), and the CT genotype (OR 3.28; 95% CI (1.02 – 10.59) with CKD risk..Conclusion. There are pathogenetic associations between renin-angiotensin-aldosterone system, cardiovascular complications and a decrease of renal function. Further research is needed for a deep understanding of the complex pathogenetic mechanisms of the development and progression of cardiovascular and renal pathology.

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醛固酮合成酶基因(CYP11B2) T(-344)C多态性在糖尿病心肾综合征预后中的临床意义

目标。探讨CYP11B2基因T(-344)C多态性在糖尿病(DM)心肾综合征(CRS)发生中的作用。材料和方法。对270例年龄在25岁以上的1型和2型糖尿病患者进行了调查。采用从全静脉血中分离的脱氧核糖核酸对所有患者进行分子遗传学分析。TT基因型与发生左心室肥厚等CRS表现的风险相关(优势比(OR) 2.64;95% CI(0.93-4.19)，慢性心力衰竭(OR 4.26;95% CI(2.26 - 8.06)，亚临床动脉粥样硬化(OR 4.04;95% CI(1.89 - 8.58)，慢性肾脏疾病(CKD) (OR 10.77;95% CI (3.56 ~ 32.61)， CT基因型(OR 3.28;CKD风险的95% CI(1.02 - 10.59)。肾素-血管紧张素-醛固酮系统、心血管并发症和肾功能下降之间存在发病关系。需要进一步的研究来深入了解心血管和肾脏病理发生发展的复杂发病机制。

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Health and Ecology Issues

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